modernization in terms of modernization of reconstruction of introduction of hybrid x-ray vascular operating room, which in general using all these methods will allow to develop new operations in obstetrics, in gynecology, in terms of even treatment of uterine fibroids, this and placenta accreta of rendering medical care, when earlier there was a question of organ removal, now we use these methods, we already preserve the reproductive organ, reproductive potential for women, this is also one of the directions, of course life dictates some of its own... and treatment stem cells, so there are a lot of plans for the development of the center.

in the braslav region, lakes of blue like the sky in the early morning , which are right in the dense forest, at the beginning of the dawn, the stars shine, wash the creatures and light, and prevent fall, the lakes of the slavyansk region are woven with charms,

ready for an exciting adventure through the cities of belarus, you are waiting for unique ... the temple meets with simplicity, high windows, and a belfry tower, it is the only entrance to the shrine. here, in the family estate, mikhail oginsky, together with his wife and children, spent, perhaps, the most fruitful years of his life. and today the composer's family, cordially welcomes guests. bow and... exit to the polonaise, this is

a regular walking dance, they take the usual three steps, the fourth step is from a half-step, and the most interesting historical facts, then. chev surrounded the fortress, now only the name of the ancient settlement, the castle hill, reminds us of it. and therefore its complete disappearance was only a matter of time, but still something interesting for tourists has been preserved. watch the program of the city of belarus on the belarus 24 tv channel. a native of menka goes to the village to find out how it is better than the city.

house in the stable, now you save horses, why horses, because other animals also need help, to each his own, well, by and large, horses are such a disease from childhood, what i can say, the only thing that relaxed in me is something somewhere down there, that's all that here cheeks in particular the entire speech apparatus, eyes, spine, everything for some reason tensed up, i'm from the village. watch on the belarus 24 tv channel. we resounded to rejoice in the crush, to unite, to feel the connection of time and

sorry, just respect it. the skin of the day is built up from the past: autumn, year, or stagodze there, everything that was old-fashioned was almost new, we ourselves do not respect it, and we do not respect such familiar ones from simple, happy moments. we are developing our own traditions, we are dedicated to the production of our products, we appreciate our daily life, belarus 244.

the production of medicines is quite a responsible mission, we, of course, understand for ourselves where we work, we know that in the future these drugs will be people take, for some this drug may be the only hope for improving their health, so we approach our work with the utmost responsibility. the goal is one - to develop an effective and safe drug that will subsequently help save the life and health of people. my name is olga zakharevich, i am the head of the drug development laboratory , borisov plant of medical

preparations. our enterprise is trusted with the most valuable thing - health. my working day begins at 8:00 in the morning, i i come to work, assess the situation, each drug is at its own stage of development, and it is necessary to determine.

ph 6.8, volume 900 ml, speed - spare stirrer 50 revolutions, dissolution time 120 minutes. okay, we have many laboratories, but each performs its own function, that is, there is an analytical laboratory in which tests of drugs are carried out during the production of drugs. each series is subject to quality control. there is a microbiological laboratory, it is also responsible for quality control, but already microbiological characteristics. there is a production and technological laboratory, which... is engaged in improving existing technologies,

the sanitary and industrial laboratory conducts tests of maximum permissible concentrations in the air in the working area. in our laboratory , the first steps of a drug begin and , accompanied by our specialists, it takes an honorable place in the product line of our plant. now we are in the room of process engineers and chemists, where employees are engaged in work with documents, victoria is currently working on a drug that is at the initial stage of development, she is selecting the composition and suggests a technological process for the treatment of diabetes, the laboratory. drug development is engaged in the development of drugs, as a rule, these are reproduced

drugs, the molecule of which is already on the market, the so-called generics. development of drugs is a complex multi-stage process. the development period varies from 3 to 5 years. the average amount development from 400 thousand belarusian rubles, sometimes the amounts and... are in the millions, but everything depends on the specifics of the drug. development of drugs is carried out within the framework of the import substitution program, the state scientific and technical program, sometimes with the involvement of budget funds, within the framework of the enterprise's working program. today, there are 40 drugs in the working prospective program, each is at its own stage of development. where does development begin? based on the

market analysis, the marketing department offers for development this or that medicinal product. we receive an offer from either a holding, but it is included in the development program only after the possibility of production on the existing equipment has been assessed. some forms require purchase to be released. the choice of the manufacturer of the substance and

auxiliary substances, the quantitative composition, the qualitative composition of the medicinal product occurs at the development stage. the purchase of the substance and auxiliary materials is carried out in different countries. there are indian, chinese, italian substances. we are in the storage department. raw materials, active pharmaceutical ingredients, excipients. mainly in the production of solid dosage forms, excipients such as microcrystalline cellulose, sodium starch glycolate, lactose, sodium carbonate, glucose monohydrate and others are used. it should be said that our laboratory is well equipped, this is high-precision equipment.

very similar to the production one, only smaller in size. in this case, the mass production was carried out first moistening, at this stage the granulate is dried, the next stage will be granulation to obtain a more uniform zero, followed by powdering, after that we will have

tableting, coating, and after that we will work out quality control methods in our laboratory on our analytical base. these experimental batches are produced in small quantities, necessary for further testing. after completing the development work in laboratory conditions, we need to develop pilot industrial series for registration of a medicinal product. pilot industrial. series is developed in industrial conditions, will be used for conducting clinical studies, or for testing quality control methods. as a rule, clinical studies are not conducted for all dosage forms, injection solutions, ointments, clinical studies are usually not conducted. a mandatory condition

for conducting clinical studies on humans. it is necessary to have a report on the comparative dissolution kinetics test in laboratory conditions, which is what this test is, imitates the human gastrointestinal tract, the tablets dissolve in three environments: in an acidic environment, hydrochloric acid and alkaline, and when dissolving the original drug and the drug developed in our laboratory, we must achieve ... a certain similarity coefficient, a report is compiled, the methods of this test are validated, in the future, we can say with confidence that the drug can be used in human studies. groups of volunteers take at the same time the original drug and the drug

being developed by our plant. equivalence is determined by the level. of the active substance in the volunteer's blood, as if the drug is recognized as equivalent or not equivalent to the original. clinical trials are conducted to prove the effectiveness and safety of the drug and equivalence to the original drug. after conducting clinical trials, receiving an equivalence report, a registration dossier is formed. this is a collection of yes.

the series is selected for quality control by the republican control and analytical laboratory, only after this the products can be delivered to the warehouse. after this the process is considered mastered and then industrial production of the drug is carried out. borisov plant of medical preparations produces broad-spectrum drugs , twelve pharmacotherapeutic groups for the treatment of cardiovascular diseases, neurological diseases , infectious diseases, diabetes. the plant produces liquid dosage forms are injection solutions, tinctures, soft dosage forms, liniment, ointments, gels, solid

dosage forms, tablets, this is a solid dosage form. before the production of tablets , a preparatory operation takes place. cleaning of equipment, a mandatory condition is compliance with the microclimate, therefore , the workshop personnel always monitor the preparation of air,

the temperature of the production premises. we receive permission to manufacture products from the quality control service after a conclusion on the proper cleaning of the equipment. we are in the workshop for the production of solid dosage forms number four. in this workshop, the production of tablets, capsules, film-coated tablets , modified -release tablets is carried out. now we are at the first stage of production, this is weighing the necessary components for a batch of a drug. now we are in the department for the preparation of tablet mass method.

the mass is passed through a sieve of a certain diameter and we get a homogeneous granulate, we just need to add sliding substances to fill the matrix of the rotary tol in the tablet press , the tablets are uniform in weight and uniform in dosage. next comes the tableting stage. tableting of the tablet mass on a high-speed tablet mold, with a capacity of 2,000 tablets per hour. each tablet size has its own

set of pressing tools, which allows you to get the required geometric dimensions. tablets that are covered with a film shell are transferred to the next stage of applying a film coating, for which no film coating is required and are transferred to the packaging stage. film coating can serve to mask the taste of the tablet, to facilitate swallowing, there are enteric coatings and other coatings that are needed for a specific function in the body. tablets have different shapes, and can be spherical, flat-cylindrical. tablets can have a risk for dividing the dose into two equal parts. tablet size. depends on the dosage of the drug, there are large-dose, there are small-dose medicinal preparations, as well as auxiliary components that

are part of the tablets. the sizes of tablets can vary from 6 mm in diameter to 14 mm in diameter, tablets have different heights, the size of the tablet determines the equipment in which it will be further ... packed, after the packaging stage, the gestors are sent to the packaging line, the line is equipped with control systems, one control system allows you to assess the correctness of the insertion of glitters into the pack, that is, if the insertion is insufficient, then the system rejects this pack, here we see that there is nothing in this pack. the next control system is the correctness and clarity of the application of data on the expiration date of a series of drugs. if

the data is not clearly visible, the system will also stop the machine or reject this or that mouth. during the production process , quality control of intermediate products is carried out before packaging, samples are taken. tests, a quality certificate is issued, and then the product is transferred to the packaging stage, and after the stage packaging, it undergoes repeated quality control, a passport for the finished product is issued, which indicates compliance with quality control, and this product can be sold. the plant has five production workshops, the first workshop produces ampoules, injection solution in ampoules in production areas related

to the red class of cleanliness of the premises, since the production of injectable drugs is a sterile production. the workshop is the largest at the enterprise, it employs about 600 people. work schedule three-shift, production is almost continuous, since we are obliged to ensure the release of sterile injection drugs. now we are in the heart of ampoule production, here the filling and sealing of ampoules takes place. this line is in the highest class of purity b and is equipped with local zones a. the filled ampoule comes out and then goes to the autoclave, in which the hermetic check or sterilization of the anfu is carried out, depending on what drug we are producing. we produce

preparations. 6.5 million vials per year, in particular this is the name of sterile piglets for injection in a dosage of 0.5 and 1 g. the chef receives raw materials in sterile containers, which are then moved to raw material rooms, class b cleanliness, and then from these first rooms, after all the studies have been carried out, it is moved directly to the stage of the shoots, then with

the help of ... microgalzirovanie machines, the middle is scattered in vials, sealed with sterile rubber stoppers and crimped with sterile aluminum caps with plastic flip, then undergoes the procedure of dust removal of the stushka, visual control, marking of the package, in this form the finished product is moved to the quarantine storage, and then loaded by the workshop to the warehouses of finished products and from there ...

storage conditions, if the drug is photosensitive, then under the influence of light there may be some changes , the effectiveness of this drug may decrease. each leaflet indicates how to take the drug before meals, after meals, before bedtime, in the morning, etc. further. the information specified in the instructions for use. is written for a reason, but so that the consumer strictly follows it, the effectiveness and safety of this drug and its effect on the body will depend on this. the pharmaceutical industry in belarus is at a fairly high level. our drugs are in no way inferior in quality to imported drugs, since

the raw materials used for the production of these drugs are of the proper quality. pakistan, iraq, syria, afghanistan and others countries. borisov plant of medical preparations.

will be 60 years old, our enterprise began its journey with a small pharmaceutical factory, with 257 employees, produced a limited...

nick or an acquaintance who works at our enterprise. the enterprise is a city-forming one, i have been working at the plant for 19 years, my career path began with a blue-collar job, i got into the production technological laboratory, where engineers and technologists worked, received higher education in absentia, graduated from the belarusian. technological state university, worked as an engineer-technologist for a long time, gained my experience, since the nineteenth year i worked as the head of the production and technological laboratory of solid dosage forms, in the twenty-second

year i became the head of the laboratory for the development of drugs. this work requires some non-standard approaches, increasing the level of their knowledge and qualifications, this is an interesting job, everyone to... understand the responsibility for the implementation of production tasks, since these the products then go to the consumer, the health of our people depends on their quality. ideally, of course, to come up with a single pill to cure all diseases, or to wish that no person on the planet would get sick, but this is only a dream for now and... that is why almost 300 people work at our enterprise so that people are healthy.

the natural wealth of belarus is a real treasure, many secrets can be found in the belarusian region, there is a magical lake with an extraordinary name - god's word. the name of the lake i tried my hand at my abras, as if i were telling my wok. vozera is in the shape of a regular circle, which does not change for many hours. yes. unfortunately, there are so many people on the right who are in trouble, and the size of such charming lyusteraks in belarus.