"the riches of the azimaga can be saved on the fields of the republic, on the new road there is a skin gadzina, more and more work is being done with harvesters and horse harvesters, with every day there is an increasingly large load for the kalgas automachines, that is it’s from the field, the field workers need this kind of technology, what kind of help “take precautions.”

today, a number of enterprises of the ussr ministry of automotive industry, such as automobile factories, plants, suppliers of electrical equipment components , are delaying our development and supply of these products. well, this car is certainly more complicated much, if we assemble, of course, conscientiously, the machine is good.

but the design and so-called industrial development of these machines needed in the national economy took years: new equipment, spare parts, mineral oils came to the address of the grain growers in strong and unsweetened streams , agricultural equipment established overhead preventive maintenance and repair of machines, the dispatch service must be responsible for the state of agricultural equipment, you look, you look, as if everything is so simple, as if ... here and before everything was so bright, as if and there was no swamp at all, it seems, only hands created everything, their sons and grandchildren will remember them forever.

production of medicines is a rather responsible mission, we, of course, understand where we work, we know that in the future these drugs will be taken by people, for some this drug may be the only hope for improving their health, therefore we approach our work with the utmost responsibility, the goal is one, to develop an effective and safe drug, which will subsequently will help save people's lives and health. my name is olga zakharevich, i am the head of the drug development laboratory at the borisov plant of medical preparations. our enterprise is trusted with the most valuable thing - health.

my working day begins at 8:00 in the morning, i come to work, assess the situation, each drug is at its own stage of development, and it is necessary to determine what work to do on this or that drug, with some colleagues we discuss the conduct of experimental work, with some discussing the writing of process instructions. the working day consists of a different range of activities. what environments have we prepared for today? dissolution testokinetics environment, phosphate buffer solution with... we have many laboratories,

but each one performs its own function, that is , there is an analytical laboratory in which drugs are tested during the production of drugs. each series is subject to quality control. there is a microbiological laboratory, it is also responsible for quality control, but already microbiological characteristics, there is a production and technological laboratory, which is engaged in.

now we are in the room of engineers-technologists and chemists, where employees are engaged in work with documents, at present victoria is working on a drug that is at the initial stage of creation, she is selecting a composition and suggests a technological process for the treatment of diabetes mellitus, the laboratory for the development of drugs... drugs is engaged in the development of drugs, as a rule, these are reproduced medicines, the molecule of which is already on the market, the so-called generics, the development of medicines is a complex multi-stage process, the development period

varies from three to 5 years, the average amount of development is from 400,000 belarusian rubles, sometimes the amounts are calculated in millions. well, it all depends on the specifics of the drug. the development of medicines is carried out within the framework of the import substitution program, the state scientific and technical program, sometimes with the involvement of budgetary funds within the framework of the enterprise's work program. on today , there are 40 drugs in the working prospective program, each at its own stage of development. where does development begin? based on the market analysis, the marketing department proposes development of one or another drug. we receive an offer from the ministry of health or a holding company, but it is included in the development program only

after an assessment of the possibility of production on existing equipment. the release of some forms requires the purchase of additional equipment. materials, and sometimes it is necessary to build a new production site, a drug that is suitable for assimilation is included in the development program. then there is a search for substances, source materials, a patent search is carried out, that is, whether the drug has any patent protection, after which we begin development in laboratory conditions. the choice of the manufacturer of the substance and excipients, the quantitative composition, the qualitative composition of the drug, occurs at the development stage. purchase of the substance auxiliary materials are carried out in

different countries. there are indian, chinese, italian substances. we are located in the storage department of raw materials. active pharmaceutical ingredients auxiliary substances. mainly in the production of solid dosage forms auxiliary substances are used, such as microcrystalline cellulose, sodium starch vecolate, lactose, sodium carbonate, glucose, monohydrate and others. it should be said that our laboratory is well equipped, this is high-precision equipment. we have technological equipment that is as close as possible to production equipment in its design features, which allows us to reduce the risks when transferring technologies to industrial conditions. after the process engineer has calculated the cost of

preparing the tablet mass and prepared the substances and excipients, he begins experimental laboratory loadings. this type of production is as close as possible to production, there is equipment in terms of design features.

have a report on the comparative test

dissolution kinetics in laboratory conditions. what is this test? simulates the human gastrointestinal tract. tablets dissolve in three environments. in an acidic environment , hydrochloric acid and alkaline. when dissolving the original drug and the drug we are developing in our laboratory, we must achieve a certain. similarity coefficient, a report is compiled, the methods of this test are validated, and in the future we can say with confidence that the drug can be used in research on people. groups of volunteers take the original drug and the drug being developed by our plant at the same time. equivalence is determined by the level of the active substance. in the blood of a volunteer, as if the drug is recognized as equivalent or not equivalent

to the original. clinical trials are conducted to prove the effectiveness and safety of the drug and equivalence to the original drug. after conducting clinical trials, receiving an equivalence report, a registration dossier, this is the collection of data on the drug. documents that will confirm the quality of the drug, it is still necessary to conduct quality control, but obtaining a registration certificate is not the final stage, and in order for us to be able to sell our products, three industrial series must be developed, validation of the technological process must be carried out, the first industrial series is selected: quality control of the republican control and analytical laboratory, only

after this, the products can be delivered to the warehouse, after which the process is considered mastered and then industrial production of the drug is carried out. borisov plant of medical preparations produces drugs of a wide range of action, in twelve pharmacotherapeutic groups. treatment of cardiovascular diseases, neurological diseases, infectious diseases, diabetes. the plant produces liquid dosage forms, these are injection solutions, tinctures, soft dosage forms, liniment, ointments, gels, solid dosage forms, tablets, capsules, powders.

for injections, what is a normal life for belarusians, may seem truly exotic to others? good morning, friends, rooster, yes, we have it like that, good morning, and how are you, rooster, treats, kikiriki, kikireki, yes? any journey in an unfamiliar city should start in the museum, where i will tell you how to build the right route to see interesting places. however, it is easy to become your own in a foreign country, you just need to get acquainted with its history and culture. this five hundred year old oak, yeah, which can

fulfill a wish. therefore, of course, the largest production of our enterprise is solid dosage forms, before the start of tablet production, a preparatory operation takes place, equipment cleaning, a mandatory condition is compliance with the microclimate,

therefore the workshop personnel always monitors the preparation of air, temperature, production. premises permission to manufacture products we receive from the quality control service after the conclusion of the appropriate cleaning of equipment. we are in the workshop for the production of solid dosage forms number four. in this workshop , the production of tablets, capsules, film-coated tablets, modified-release tablets is carried out. now we are at the first stage of production, this is weighing the necessary components for a batch of a drug, now we are in the department for preparing tablet mass using the wet granulation method. unfortunately, not all components are free-flowing. and they can be

produce by direct reduction method. wet granulation method, initially the components are moistened, then transferred to the drying stage, thus we obtain granulate that is heterogeneous in fractional composition, then, in order to have a homogeneous granulate, we transfer it to the granulation stage, the mass is passed through a sieve of a certain diameter and we obtain a homogeneous granulate, we only need to add sliding substances in order to fill... the matrix of the rotary table in the tablet press, we obtain tablets that are homogeneous in mass and homogeneous in dosage. next comes the tableting stage. in this department , tableting of the tablet mass is carried out on a high-speed tablet press

with a capacity of 2.0 tablets per hour. each tablet size has its own set of presses. which are needed for a specific function in the body. tablets have different shapes, can be spherical, flat-cylindrical. tablets can have a risk for dividing the dose into two equal parts. the size of the tablet depends on the dosage of the drug, there are

large-dose there are small-dose drugs, as well as auxiliary components that are included in ... becoming a tablet, the size of the tablets can vary from 6 mm in diameter to 14 mm in diameter, tablets have different heights, the size of the tablet determines the equipment in which it will be packaged later. after the packaging stage, the glysters are sent to the packaging line, the line is equipped with control systems. one control system allows you to assess the correctness of the insertion of listers into the pack, that is, if the insertion is insufficient, then the system rejects yes... a pack, here we see that there is nothing in this pack, the next control system is the correctness

and clarity of the application of data on the expiration date of the drug series, if the data is not clearly visible, then the system will also stop the machine or reject one or another, in the production process, the quality of intermediate products is carried out before packaging, samples of the drug are taken, transferred to the quality control laboratory, tests are carried out, a conclusion on the quality is issued and then the product is transferred to the packaging stage, and after the packaging stage it undergoes repeated quality control, a passport for the finished product is issued, in which ... compliance with quality control and this product can be sold. there are five production workshops at the plant. the first

workshop produces ampoules, injection solution in ampoules. the workshop produces about 25 million ampoules per month. we work in eight production areas, related to different frequency classes. filling and sealing of ampoules occurs, this line is in the highest class frequency b is equipped with local zones a.

the filled ampoule comes out and then gets into the autoclave, where the tightness is checked or the ampoules are sterilized, depending on what drug we produce. we produce drugs in ampoules from one to ... the second workshop produces liquid and soft drugs. the third and fourth workshops are solid dosage forms, tablets, capsules. the fifth workshop specializes in the production of sterile antibiotic powder. cefe number five is produced up to 28.5 millions.

when taking medications, you should take into account the dosage, if the instructions for

use contain the doctor's recommendations, then this must be done without fail, also after you have purchased the drug at the pharmacy, even my big request, be sure to take into account the storage conditions, if the drug is photosensitive, then under the influence of light there may be some changes , the effectiveness of this drug may decrease. each leaflet indicates how and when to take the drug before food, after food, before bed, in the morning , etc. the information provided in the instructions for use is not written just like that, but so that the consumer strictly follows it, the effectiveness and safety of this drug and its effect

on the body will depend on this. the pharmaceutical industry in belarus is at a fairly high level. our drugs are in no way inferior in quality to imported drugs, since raw materials of the appropriate quality are used for the production of these drugs. quality. its effectiveness and safety are proven during the development process, all production stages and quality control of the medicine are carried out during the production process. every year, about 50% of the products are exported, the sales geography covers such countries as the republic of moldova, the eac countries, the cis countries, turkmenistan, tajikistan, uzbekistan, iraq, syria, afghanistan and other countries.

you see how painfully the international agenda is experiencing this transformation from unipolar to multipolar world, and of course, today the most important task of diplomats of all countries, politicians of all countries, is to find a place for their state in the architecture that will come after, the virus of fear.

watch on the belarus 24 tv channel. the borisov plant of medical preparations will turn 60 years old next year, our enterprise began its journey as a small pharmaceutical factory with 257 employees, produced a limited number

of solutions, ointments,

works at our enterprise, the enterprise is a city-forming enterprise, i work at the plant i have been working for 19 years now, my career path began with a blue-collar job, i ended up in a production-technological laboratory where engineers and technologists worked, i received higher education in absentia, graduated from the belarusian...