a special atmosphere of silence and calm. here you can not only learn a lot about the famous polotsk educator, but also read a book. the chairs are wooden, there is nothing soft on them, but it is incredibly comfortable to sit, and for people of different heights. the museum's new multimedia stand. you can read a book of that time in the original, flipping through virtual pages using the keyboard. this two-level library can boast. not only a large number of books, but the largest globe in belarus. on it, polotsk is just a small dot, but you and i know that in fact, hidden under it, at least, an ancient underground city, which stores riches and legendary secrets, here you will be able to reveal the real secrets of the modern city yourself, and this will be only your polotsk.

10 weaving traditions are in the list of elements of the intangible cultural heritage of belarus.

the production of drugs is a fairly responsible mission, we ... for ourselves, of course, we understand where we work, we know that in the future these drugs will be taken by people, for some it may be the only hope for this drug for in order to improve their health, so we approach our work with the utmost responsibility. the goal is one - to develop an effective and safe drug that will subsequently help save human life and health.

my name is olga zakharevich, i am the head of the drug development laboratory of the borisov plant of medical preparations. our enterprise is trusted with the most valuable thing - health.

what environments have we prepared today for conducting environments test dissolutions phosphate buffer solution with the meaning ph6.8, volume 900 ml, speed of spare grinder 50 revolutions per minute. grinding time 120 minutes, well, we have many laboratories, but each performs its own function, that is, there is an analytical laboratory in which tests of drugs are carried out during the production of drugs. each series is subject to quality control, there is a microbiological laboratory, it is also responsible for quality control, but already according to microbiological characteristics, there is a production. laboratory, which

is engaged in the improvement of existing technologies, the sanitary-industrial laboratory conducts tests. products of our plant. now we are it occupies a place of honor in the line in the room of engineers-technologists and chemists, where employees are engaged in work with documents. at present, victoria e is working on a drug that is at the initial stage of development, she is selecting the composition and suggests a technological process for the treatment of diabetes. the

drug development laboratory is engaged in the development of drugs drugs. as a rule, these are reproduced drugs, the molecule of which is already on the market. so-called generics, the development of drugs is a complex multi-stage process, the development period varies from 3 to 5 years, the average amount of development is from 400 thousand belarusian rubles, sometimes the amounts are calculated in millions, but everything depends on the specifics of the drug. the development of drugs is carried out within the framework of. market analysis, the marketing department offers to

where does development begin? based on the development of this or that drug. drug: we receive an offer from the ministry of health or a holding company, but it is included in the development program only after an assessment of the possibility of production on existing equipment has been made. for the production of some forms , it is necessary to purchase additional equipment, additional materials, and sometimes it is necessary to build a new production site, a drug that is suitable for development is included in the development program, then a search for substances, starting materials takes place, a patent search is carried out, that is, does the drug have any patent protection, then we begin development in laboratory conditions, the choice of the manufacturer

of the substance and auxiliary substances, quantitative composition, qualitative composition of the drug. occurs at the development stage, the purchase of substances, auxiliary materials is carried out in different countries, there are indian, chinese, italian substances, we are in the storage departments of raw materials, active pharmaceutical ingredients, auxiliary substances. basically, in in the production of solid dosage forms are used. auxiliary substances such as microcrystalline cellulose, sodium starch glycolate, lactose, sodium carbonate, glucose, monohydrate and others. it should be said that our laboratory is well equipped, this is high-precision equipment, we

have technological equipment that is as close as possible to production equipment in its design features. which allows us to reduce the risks when transferring technologies to industrial conditions. after the process engineer made a calculation for preparation of tablet mass and prepared substances and excipients, he begins experimental laboratory loadings. this type of production is as close as possible to production, there is equipment.

we will work out quality control methods in our laboratory, on our analytical base. this experimental batch is produced in small... quantities necessary for further testing. after completing the development work in laboratory conditions, we need to develop pilot-industrial series for registration of a medicinal product. the pilot-industrial series is developed in industrial conditions, will be used for conducting clinical studies, or for testing quality control methods. as a rule, clinical studies are not conducted for all dosage forms, injection solutions,

ointments, clinical studies are usually not conducted. mandatory conditions for conducting clinical studies on people, it is necessary to have a report on the comparative dissolution kinetics test in laboratory conditions. what is it? the test imitates the human gastrointestinal tract. the tablets dissolve in three environments: in an acidic environment, hydrochloric acid and alkaline. and when dissolving the original drug and the drug developed in our laboratory, we must achieve a certain similarity coefficient. a report is compiled, the methods of this test are validated, and in the future we can say with confidence that the drug can be used in human studies, groups of volunteers take

at the same time the original drug and the drug being developed by our plant, equivalence is determined by the level of the active substance in the volunteer's blood, as if the drug is recognized as equivalent or not equivalent to the original. studies are conducted to prove the effectiveness and safety of the drug and equivalence to the original drug. after conducting clinical studies, receiving an equivalence report, a registration dossier is formed, this is a collection of data on the drug, documents that will confirm the quality of the drug. it is also necessary to conduct quality control.

the process is considered mastered and then industrial production of the drug is carried out. borisov plant of medical preparations produces drugs of a wide spectrum of action. twelve pharmacotherapeutic groups, for the treatment of cardiovascular diseases, neurological diseases, infectious diseases, diabetes. the plant produces liquid dosage forms, these are

injection solutions, tinctures, soft dosage forms, liniment, ointments, gels, solid dosage forms, tablets, capsules, powders for injections. the hosts of the travel show know exactly how to behave when visiting! foreign students travel around belarus! hello everyone! today we are traveling in the pominsky district, i was told that we need to start our excursion in the village. called gorobishche, some are wonderful, excellent, they study its

history, explore the sights, wow, beautiful, friends, today we are in the city of orsha, here probably 10 kg, kayla, looks like napoleon, does it feel strong? yes, because here 10 kg, advenata kayla, watch on the channel: belarus 24. solid dosage form, yes, this is a really accessible form, uh, which you can always take with you, therefore,

of course, the largest production of our enterprise is solid drugs. form before the start of tablet production , a preparatory operation takes place, equipment cleaning, a mandatory condition is compliance with the microclimate, therefore the workshop personnel always monitor the air preparation, temperature of production facilities, we receive permission to manufacture products from the quality control service after. we are in the workshop for the production of solid dosage forms number four. in this workshop, the production of tablets, capsules, film -coated tablets, modified -release tablets is carried out. now we are at the first

stage of production, this is weighing the necessary components for ... a batch of a drug, now we are in the department for the preparation of tablet mass wet granulation method. unfortunately, not all components are free-flowing, they can be produced by direct reduction. for this, there is a wet granulation method. initially, the components are moistened, then transferred to the drying stage. we get granulate that is heterogeneous in fractional composition, then, in order to have a homogeneous granulate, we transfer it to the granulation stage, the mass is passed through a sieve of a certain diameter and we get a homogeneous granulate, we only need to add sliding substances to fill the matrices

rotary table in the tablet press produces tablets of uniform mass. and uniform in dosage, followed by the tableting stage, in this department the tablet mass is tableted on a high-speed tablet mold, with a capacity of 2,000 tablets per hour. each tablet size has its own set of pressing tools, which allow you to get the required geometric dimensions. tablets. which are covered with a film shell, are transferred to the next stage of applying a film coating, for which no film coating is required are transferred to the packaging stage. film coating can serve to mask the taste of the tablet, to facilitate swallowing, there are enteric coatings and other coatings that are needed for

a specific function in the body. tablets have different shapes. can be spherical, flat-cylindrical, tablets can have a risk for dividing the dose into two equal parts, the size of the tablet depends on the dosage of the drug, there are large-dose, there are small-dose medicinal preparations, as well as auxiliary components that are part of the tablets. the sizes of the tablets can vary. from 6 mm in diameter to 14 mm in diameter, tablets have different heights, the size of the tablet determines the equipment in which it will be packed later. after the packing stage, the sheets are sent to the packaging line, the line is equipped with control systems, one control system allows you

to evaluate the correctness of the insertion of sheets into the paste, that is, if ... insufficient insertion, then the system rejects this pack, here we see that there is nothing in this pack. the next control system is the correctness and clarity of the application of data on the expiration date, series of drugs. if the data is not clearly visible, the system will also stop the machine or reject a particular pack. during the production process , quality control of intermediate products is carried out before packaging, samples of the drug are taken. transferred to the quality control laboratory, tests are carried out, a quality certificate is issued, and then the product is transferred to

the packaging stage, and after the packaging stage it undergoes repeated quality control, a passport for the finished product is issued, which indicates compliance with quality control, and this product can be sold. the plant has five production workshops, the first workshop produces ampoules, injection solution, in ampoules. the workshop produces about 25 million ampoules per month. we work in eight production areas, which belong to different classes of cleanliness of the premises, since the production of injectable drugs is a sterile production. to the enterprise, it employs about 600 people, the work schedule is three-shift, production is almost continuous, since we are obliged to ensure

the release of sterile injection drugs. now we are in the heart of ampoule production, here the filling of isopaika ampoules takes place. this line is in the highest frequency class b. and is equipped with local zones a. the filled ampoule comes out and then gets into the obtokvalv, where the tightness test or sterilization of ampoules is carried out, in depending on what kind of drug we produce. we produce drugs in amphoules from 1 to 5 ml. the second workshop produces liquid and soft drugs, the third and fourth workshops are solid dosage forms, tablets, capsules. the fifth workshop specializes in

the production of sterile bulk antibiotics. cefe number five is produced up to 28.5 million vials per year, in particular, this is the name of the speril powders for injection in a dosage of 0.5 and 1. raw materials are received in sterile containers, which are then moved to raw materials rooms, cleanliness class b, and then from these damp rooms, after all the research has been carried out, it is moved directly to the salting stage, then with the help of a micro-galvanizing machine, the silie is scattered into bottles, sealed with sterile rubber stoppers and crimped. visual control, marking the packaging. in

this form, the finished product is moved to the storage facility, and then loaded by the workshop to the finished product warehouses and from there it is moved to the consumer. when taking medications, you should take into account dosage, if the instructions for use are written doctor's recommendations, then this must be done without fail, also after you have purchased the drug at the pharmacy, even my big request, be sure to take into account the storage conditions, if the drug is light-sensitive, then under the influence of light there may be some changes fall effectively.

covers such countries as the republic of moldova, the eac countries, the cis countries, turkmenistan, tajikistan, uzbekistan, iraq, syria, afghanistan and other countries. borisov plant of medical preparations will celebrate its 60th anniversary next year. our enterprise started its journey as a small pharmaceutical factory with 257 employees. we produced a limited number of solutions, ointments, tablets. in the process of work , modernization was carried out.

technological potential, qualified personnel. we always keep up with the times, and the requirements for the production of dosage forms are changing, so we must always keep our finger on the pulse, always be in the center. events. each family has either a relative or a friend who works at our enterprise. the enterprise

is a city-forming one, i have been working at the plant for 19 years, my career began with a blue-collar job, i got into the production technology laboratory, where engineers and technologists worked, i received higher education in absentia, graduated from the belarusian technological state university, worked as an engineer and technologist for a long time, gained my experience, developing medicines. this the work requires some non-standard approaches: increasing the level of your knowledge and qualifications. this is an interesting job. everyone should understand the responsibility of fulfilling production tasks, since these products subsequently go to the consumer.

the health of our people depends on their quality, ideally, of course, to come up with a single pill to treat all diseases, or to wish that no person on the planet would get sick, but this is only a dream so far, so almost 3,000 people work at our enterprise so that people are healthy. fertile land, in caring hands, our main wealth, when you want to share the joy of what has been achieved.

create and develop, carefully preserving traditions, in the name of a successful happy future, where everyone's contribution to the common cause is significant, and life with others in unity. love, that's true happiness, there is always warmth from soulful moments and familiar views, together at one table. belarus 24 - what unites us.