they're growing earnings next year 22% that's light i would be a buyer here. >> grasso? >> overstock has been as low as $20, as high as $90, base at 35. overstock, buy. >> i'm melissa lee thank you for watching see you back here at 5:00 for more meantime, "mad money" with jim cramer starts now. my mission is simple -- to make you money i'm here to level the playing field for all investors. there's always a bull market somewhere. i promise to help you find it. "mad money" starts now [ applause ] hey, i'm cramer. welcome to "mad money. welcome to cramerica other people want to make friends. and i actually have some with me tonight. [ applause ] i'm just trying to make you some money. my job isn't just to entertain but to teach you call me at 1-800-743-cnbc. or tweet me @jimcramer

okay you take one part great earnings, another part tremendous skepticism. you add in low inflation and you end up with the dow gaining 197 points the s&p up 0.94% and the nasdaq advancing 0.89%. >> house of pleasure >> it's a rally that's -- it's astonishing. entertaining astonishing everybody. astonishing everyone who believed we were headed for the worst of all possible worlds instead, the worlds collided and now the bulls are back in the driver's seat. what's driving this? it all started with three days in tech. the stock market equivalent of three days in may. i'm talking about april 25th, april 26th and then may 1st. why those days they're when facebook, amazon and apple reported and everything began to turn around.

let's set the scene. tech had been taking a beating, right, remember? it had been taking a beating for more than a month. going foo facebook's quarter and the beating centered around these three names. i remember how bad it was because i took a vacation right before earnings season and i was singing myself "dough, ra re mi singing faa being facebook, apple and amazon what it had to go through before it could mount a rally going into facebook's quarter it seemed ridiculous it would have anything good to say everyday new revelations about how it had utter contempt for user' privacy with the hearings and the consensus people would leave facebook and instagram in droves every day it seemed like some new celebrity left the platform

because of the company's transgressions >> boo >> the newspapers in particular were relentless and congress took its cue from print. when they raked mark zuckerberg over the coals, there was only one problem with the story, zuckerberg went to the hill and he apologized. he expressed sorry, not contempt he actually sounded human. at the same time you can feel the collective consciousness of america start to puzzle over what exactly this scandal was about. i mean who was this cambridge analytica anyway what did they do did they get me to vote for someone, did they embarrass me, have me say something i didn't want to, did they harass me? despite the headlines the whole thing became kind of boring. so sit still when facebook reported wall street was all set to hear about how this scandal had hurt the business and figured it was a wounded tiger their needed to be put to sleep but in reality their business

accelerated versus the previous quarter. accelerated. turns out no slowdown and it remained strong in the month of april, right into the teeth of the hearings now, you have to understand the short sellers had built up a considerable position in facebook ahead of the quarter and after these blow-out numbers, the stock surged higher it almost felt like the mother of all short squeezes for $700 billion company. money managers went from hating facebook to loving it, pretty much overnight. >> sell, sell, sell, sell. >> how about amazon, which reported the next day. remember, amazon's stock had a tough time in april. why, president trump decided to go after them for allegedly ripping offer the post office. more likely mad at jeff bezos which hasn't been flattering with his coverage of the white house. either way his endless twitter tirades made the stock tough to own. then april 18th amazon announced out of the blue it had 100 million prime members, amazon doesn't typically tell you how

many members they have they don't tell you much about membership at all. the stock spiked momentarily and close to the quarter it went right back down. then amazon reported and again we got a monster blow-out. just a gigantic upside surprise but the company earning $3.27. wall street only expected $1.25. i thought there was a typo i thought amazon made 1.27, not 3.27 nope, the stock opened up 120 bucks. as it happens the president's peak had driven a lot of weak hands out of the stock only still in it the hearty and sellers seemed to disappear. that's how explosive it was. finally the biggest surprise of all. apple's quarter of may 1 the numbers were utstanding particularly in china. apple sold far more iphones than the bears expected because we heard about suppliers' surveys that suggested apple would have an astonishing shortfall

no, just like we saw with facebook, the negative rap turned out to be bogus and that was just the tip of the iceberg. all of the analysts who fretted about how apple's best days are behind it crashed right into the company's burgeoning revenue stream and suddenly you had everyone talking about apple like it has some sort of razor blade business model rather than being a slow boat hardware story those who hated the stock were luckily had to admit it was a much better narrative and apple's $100 billion buyback didn't hurt either a second win from warren buffett buying apple the whole way down. we got through the gauntlet with flying colors and given how many companies are touched by these three -- i'm talking about the sem semis, the cloud kings, e-commerce, the social media brigade it came back to life would have taken out and been shot if the macros had been troublesome.

strong growth without much inflation and that was confirmed by benign producer and consumer price index numbers yesterday and today. now, with we get this confluence of positive earnings and low inflation the market does tend to go higher but the issue is that all of the talk of trade wars have been scaring people away with president trump back being more diplomatic i was the first saying he would be gunning for the nobel peace prize in north korea. maybe he'll come to an accommodation with the chinese on trade we saw it with amazon and apple and facebook and it's about converting the unbelievers as the bears became bulls the market suddenly got its mojo back now the real fear on wall street is not of losing money, instead their hashtagfomo, afraid of missing out and without any big reports you can't blame the skeptics for changing their minds. when the bulls stampede, you

either join the rush or you get trampled let's take a question. >> hi, jim, i'm raj from new jersey big fan of the show. my we is regarding kansas city southern freight volumes are up but we have a half that decision looming. what is your take? >> it is the one that is most levered to that have that. tremendous trunk line. incredibly well run railroad i would like to hedges my bet and go with i think norfolk southern which had a beautiful number squire has done a great job. question, sir. >> boo-yah, i'm demetrios with my son, a young investor and consider ourselves citizens of crameri cramerica. when a stock is gone below the bullpen initiation price, why don't the why doesn't it reset >> that's a great question

i have to address that on tuesday's conference call. i think a lot of times what happens is the facts are changed and i should up the bullpen -- update the bullpen more often. lockheed martin. we liked it reported a quarter light on cash flow so indicted to go the other way and we went with textron so the facts change so i will address that next week and thank you for subscribing and being a member of the club yes, sir >> boo-yah, jim. >> raymond yu. if interest rates drift a little higher do you think mortgage reits have bottomed? those i don't like and don't like them because i don't know what they really own theoretically they should bottom but don't know exactly how they're positioned and that is the problem with that and i want to throw in the mezzanine interest rate place is also similar too opaque for me and would rather not be there. this is what fear looks like, fear of missing out, that is how astonishing. "mad money" today, if it's good

enough for the funniest woman in hollywood tiffany haddish, could it be good enough for your portfolio. groupon's ceo and the big pharma have been wandering the wilderness can the group find its way why isn't the market more fearful of a spike in oil here i'll tell you what's behind the action in the commodity so stick with cramer. [ applause ] >> announcer: don't miss a second of "mad money." follow @ of jimcramer on twitter. have a question, tweet cramer, #madtweets send jim an mail at madmoney@cnbc.com or give us a call at 1-800-743-cnbc miss something, head to madmoney.cnbc.com.

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everybody is like, tiffany, you're a celebrity now why do you still use groupon aren't you worried people will think you're cheap shut up, amber i can't stand you sometimes. groupon makes me look good >> has groupon found a marketing strategy that works? they seem to be paying off the marketplace that offered you

huge local deals reported yesterday morning while the numbers look very strong the action has been confusing. we got a clear top and bottom line beat. the stock opened up more than 10% then groupon gave back nearly all the gains but today bounced right back climbed 6%. so is this rally make sense? let's check in with rich williams, the ceo of groupon the man reinvented the company and better sense of how his company is doing and mr. williams, welcome back to "mad money." good to see you, rich. have a seat. [ applause ] >> all right first everyone on my staff wants tiffany so that was actual, right, the initial contact point was she was talking about it and you didn't even know she used it. >> we had no idea. i was as surprised as everybody else i had all of a sudden just literally hundreds of people sending me this clip and, you know, i called my pr guy and said, hey, is this real? is this absolutely real and, you know, he did a little checking and we were blown away she is a literal top 1% customer

for us and completely genuine at the top of the pile in a true superfan and it just snowballed from there and had an amazing run. great. >> what i find is interesting even in the ad what she is displaying is the vast platform you now have. >> yeah. >> whether it be the gym or a hotel, but also you -- tell us about major league baseball and about a course horse which i love. >> we've been on a bit of a tear on the partnership side here lately and a big piece of it was a couple of quarters ago, you know, when we stepped back and looked at what we were doing, we said, okay, we know that getting great brand, great inventory, more small businesses on the platform as fast as possible was incredibly critical. so why are we trying to do it on our own? whooef an amazing asset of 50 million active customers that a lot of these other companies and brands don't have. but we can open up our platform to them and give them access to those 50 million people and bring that inventory to our

customers who are looking for it so we since that strategic decision a couple of quarters ago we've just been on a roll. as you point out, we brought on, you know, major league baseball and we're now half of major league baseball, we're bringing on their ticket, not just discounted ticket, full price tickets because a big piece of what we do is help people discover what's happening in their neighborhoods and around. >> well, but when on the facebook call sheryl sandberg says we're laser like focus on local. you're local how do you go up against facebook >> i think this has been an interesting space and lots of people have tried to play as we play in the local space and we have seen almost all of them fail and a big advantage that we've this is we've built a lot of competency and built some tools and have a lot of software and a lot of data from selling almost a billion and a half groupons on how to connect with small businesses in a way that works for them in a way that can help them grow in a way that drives transactions for them and

i think most of the other platforms that have tried have been ad platforms and missed that piece that a small business wants so badly which is i want to sell stuff. i just don't want to have my name out there and billboard but sell stuff that's what we do. >> i was checking groupon this morning. you know, you have artificial intelligence i don't think it's as good -- i'm going to the beach and you actually had deals at the beach. now, i don't know -- that would be super artificial intelligence that's pretty good. >> you're using -- you have machine learning. >> it's been a part of our business from the very start because even in the early days as we started to expand the marketplace, we had to try to find the needle in the haystack and that sea of thousands of things to do in a city, we had to find the one most interesting for you. we're now taken the machine learning and a.i. side and completely different directions and are using it now really heavily and in customer service where we're using chat box and using all of our -- the folks on the phones and working with our customerss aways to tune it and

they're taking active roles and making it smart to help find answers to people's questions fast and without having to pick up the phone, without having to chat with a rep unless there's something complex so it's all over our business in a huge part of what we do. >> in my twitter follow i asked if people used it. universal theme was customer service was really, really good. there were some people who did not like the trajectory of regular groupon customers saying it dropped off a bit. >> yeah. >> but you explained to people that groupon plus, you're trying to kind of upgrade your own customers. >> that's right so with groupon plus is, you know, one of a number of initiatives that we're doing to really reinvent the customer experience and to say, a couple of years from now how do you want to use groupon do you want to have a voucher you hand over to a merchant or be completely seamless and be just something that happens that you get a better experience and save some money and may have something you theek or special and it just happens and is

delightful and groupon plus is really an early rendition of that that happens to work really, really well and we're purring it very hard so we are actively trading off selling vouchers for getting people introduced to something that can change how they experience a small business and really win at a small business in a way that hasn't been possible we're making that trade-off every day. >> you mentioned seamless but not in the context that i'm about to ask which is grubhub. the most exciting partnership even more than the course wars >> we launched with grubhub, basically back in q4 or q3 we had a food delivery business and sold some of those assets to grubhub and struck a partnership in the process. >> great deal. >> and made a lot of sense for us and for our customers and shareholders and just launched with a grubhub integration very recently and you'll see that expand and i think it's amazing,

again, 50 million customers looking for places to go when they're hungry and should be able to find places that have amazing delivery service and should be delivered by an amazing partner and have that and you'll see it expand. >> i didn't even get to international but rich williams has reinvented the company and it's a great buy rich williams, ceo of groupon. "mad money" is back after the break.

at a time when the market is making a major comeback all sorts of groups have fallen out of favor with the wall street fashion show suddenly getting their groove back. what about biotech specifically what about the four horsemen, celgene, biogen, gilead and regeneron they seemed like they were mounting a comeback but lately they've once again been sent to the glue factory b sell -- regeneron down 23%. gilead down 9% why are these once beloved biotech starts so darn hated i think there's a lot of justice but at some point you have to wonder if they've become too cheap to ignore. first though let's talk about why these big biotechs keep stinking up the joint.

here's the thing even if biogen and celgene and regeneron were firing on all cylinder, the economy is too strong. when business is tepid biotech is loved when business is great, biotech is ignored who wants consistent teddy eddie growth when they can produce year over year earnings increases. that's only part of it because in reality the four horsemen are not firing on all cylinders. with biogen, for the last few years their ms business has been fading too much competition and the company's attempts to come up with major new blockbusters hasn't always gone smoothly sure they had a giant hemophilia franchise and a spin-off a company that then sold itself for nearly $12 billion and last

year launched a treatment for spinal muscular atrophy and also worked on an alzheimer's treatment but in december we got bad data on the alzheimer's formulation, very hard disease, everyone has been trying to work on it one time or another and hasn't been working. while the spinal muscular atrophy drug has been selling well, the problem is it's kind of what we call front loaded as patients need to take fewer and fewer doses over time. in short biogen ain't what it used to be but got a heck of a lot cheaper. celgene, used to be a favorite after holding up for awhile it imploded and discontinued a trial for phase three crone's disease drug and the company slashed its long-term earnings forecast and the stock got slammed. it really hasn't looked back since. now, so far this year these guys

have tried to change the narrative. first paying up for june knau therapeutics then announced a partner cybill to develop treatments for neurodegenerative diseases the stock has been punished because their last acquisition, $7.2 billion purchase in 2015 hasn't gone too well receptos was only about one drug they he they don't want to give them the benefit of the doubt. gilead is a slow low grinder gilead lost roughly half of its value. the problem, gilead has been the vic of its own success from 2012 to 2015 the stock caught firebased on the strength of the company's cure, not chronic maintenance, but cure for hepatitis c. it was so successful maerck

rolled out a similar product when they were flush with cash they bought back their own stock and ended up paying high finally last year they took over another stock many asked about to get in on the cancer immu immunotherapy space. in the meantime, gilead doesn't have much to offer you that's why the company reported such a hideous quarter last week a big, fat top and bottom line miss >> boo >> that pushed it to the mid-mid-60 mid-60s. it was shocking. regeneron in 2005 we recommended it under $5 at its peak in 2015 it was trading at 557. that's right, $557 that's why i say the bulls make money, bears make money but hogs, they get slaughtered

because since then it's plummeted to $289. it was all about the revolutionary macular degeneration drug and makes up 60% of the company's sales but the big fear is potential competition from novartis and roche. they had an interesting anti-cholesterol drug where they partnered with sanofi because the competition and it's been hard for a lot of doctors to figure out what to do with it. i think it's a great drug. still the company announced a new plan that could jump start sales by lowering the drug's price. where? regeneron has a new eczema treatment and so far the sales of this hasn't been as strong as i'd like promising skin cancer drug in phase two and has a lot of shots on goal. the four horsemen are cheap. celgene for eight, gilead for ten, and the reasons regeneron

held up so much better than expected even as results were almost universally panned by analysts they aren't the growth powerhouses they used to be but trading like the world is coming to an end at least in biogen and regeneron. the numbers aren't that bad and growth could still reignite with the combination of new drugs in the pipe these big bioteches are hated because they lost all the characteristics of great growth stories and that would bother me except they trade like value stocks and i think biogen and regeneron are worth checking out. it'll be years before we know if the other two will pay off at least for the moment much more "mad money" ahead. many relationships are built on trust. is it lucky whether it comes to the oil futures? a key look inside the biotech

sector what can biomarin tell us. i'll talk to the ceo and special edition of the lightning round so stick with cramer (siren wailing) (barry murrey) when you have a really traumatic injury, we have a short amount of time to get our patient to the hospital with good results.

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it has happened more than 200 times in 5 years. dianne feinstein and a new generation are leading the fight to pass a new assault weapons ban. say no to the nra and yes to common-sense gun laws. california values senator dianne feinstein boo-yah! how can this market be so blase about the spike in oil prices? why don't we freak out when the price of crude runs up in response to tensions in the middle east.

first, i don't think the market is actually ignoring oil when missiles fly back and forth between iranians and syrians and israelis over the somewhat peaceful golan heights area it should be unnerving. if there is going to be a hot war besides the one in yemen, but here's the thing, the stock market know has it can't necessarily trust the oil futures. equity traders know oil traders are a very skittish bunch. they take up crude on any and all tensions if buy, buy, buy >> they see one thing buy oil and bad news so the stock people have become suspicious of these big runs when driven by geopolitical risk. the ridiculous spike in oil in 2008 which ended up in a total collapse of the oil market so for those who don't remember, let's go over what happened back then because it's pretty instructive for this moment.

while the u.s. economy had begun to fall apart in the year 200le, the dmroeblg economy was still going strong led by china we knew there was demapped for oil overseas now, the price of oil had been steadily rising for years going into 2008 but it was a gentle ascent that all changed in february of 2008 when venezuela cut off oil sales to exxonmobil and crude surged into the 80s. march two major pipelines were taken out by terrorists and in april a nigerian worker struck took barrels off line and strike by scottish workers took out half of the uk's production and in may pipelines were blown up that took out barrels and mexico announced shortfalls and oil is breaking out above 100 and flirting with 120 then on june 19th, nigerian rebels shut down the shell and chevron pipelines and it blast through 120

in the first week of july oil takes out 140 and briefly touches 147. but what happened after that shows you just how fragile, skittish and easily manipulated the oil market is. because the price of crude collapsed pretty much in a straight line all the way down to $31 from december 22nd of the same year. that is a spectacular $110 swan dive gasoline which had gone to an average of $4.11 a gallon was cut in half by year's end. considering the whole way up and whole way down we are headed into the depths of the great recession the entire pivot looks like it was pure manipulation. a lot of people felt that way but it's also fair to say higher prices simply met with little selling all the way up almost as though there was no compare capacity not to sell there was tons of compare capacity the new supply just couldn't be ramped up fast enough but when it did, the market collapsed and that's what i think could happen here now

the market is terribly inefficient as supply chains supplied by the short sellers when they cover when there is no oil for the market no time to find real sellers or all holding out for higher prices investors in the stock market know from this lesson thought to trust these spikes we learned that in 2008. how about the damage to the economy? it wasn't clear how much damage it did back then there was so much other noise but cars certainly get a lot more gas mileage than they did a year ago as phil lebeau told me today ais the new $4 and we're nowhere near $5 so, sure, oil has gotten up there, no doubt about it but the future and the real deal, that's keeping investors in the stock market from panicking out as we watch the price of crude climb inexorably higher. i think that's the right attitude let's take some questions. let's go over here >> hi, jim >> hi, how are you >> i'm good. aim anne from west milford, new jersey >> thanks for coming >> i have a question

i wanted to know how you think the changes in ford's production plans will impact the stock prices. >> i think that -- first of all it's a great question because the ford 150 is offline, the best most profitable thing they sell what's going to happen is the stock will probably do nothing but only because it's down so much it is by the way the cheapest tock in the s&p 500 on earnings but that's because a lot of people feel the earnings will be down you can't touch it it's just maybe a value trap we don't know what's going to happen but it's bad news about the f-150. yes, over here >> hi, jim i'm sean kayna from west milford, new jersey, also. i have a vehicle question also freeport mcmore rein, fcx, how do you think that they are poised with the increase in demand for electric vehicles do you think that stock still has room to head upward? >> it's still much more controlled by chinese demand the

biggest market that last quarter was horrendous they missed on every line and told negative stories about political consequences i was shocked at how bad it was and the stock has not come back. i cannot recommend that stock. that quarter was that terrible but thanks for the question. over here, sir >> hey, jim, dan from the suburbs outside philly. >> excellent >> way to go, eagles >> go, birds >> crazy hey, jim, any sectors out there that have been lagging that might be an opportunity for investing now? >> i still think -- you know, look, i've got to tell you, i keep on getting drawn tothe airlines because i don't think they're that bad but we need to have just one upside surprise would ignite that group and you know the one i like is the one that's unfortunately had that tragic accident southwest. i think that one will come back. that's a very well run company so that is what my thinking is, but, remember, i am a f.a.n.g. guy and those are not going to be left behind it's all about trust sure, oil is up there but the future is suddenly real keeping

the market from tanking. i say stick with cramer. duncan just protected his family

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>> announcer: "lightning round" is sponsored by td ameritrade. the earnings are relentless and the schedule is grueling but cramer has burned the midnight oil and he's ready to run the gauptlet to find you a raging bull market. powerful executives, scores of tough questions, all week cramer sits down with some of the

market's most influential players. join "mad money" on air and online from must-see interviews you can't afford to miss it is time it's time for "the lightning round. >> buy, buy, buy >> sell, sell, sell. 1234r and with you hear the sound then "the lightning round" is over and i've got guests here tonight so let's start over here >> hi, jim alison from new york how are you? >> all right how are you? >> good. bofi hold or accumulate >> oh, i would hold it pretty big run i like the majors more than that yes. >> boo-yah, nick from new york melco. >> no, we like mgm want a little less beta, so to speak. yes. >> good evening, jim this is joan from west chester, pennsylvania >> okay. >> my question is about verizon.

should i buy, hold -- >> you can hole it should go up to 50, 51 stock under pressure and rates went higher. >> hi, professor cramer. >> thank you >> this is paul from brick, new jersey i wanted to ask you we've seen chipotle peek its nose out of the house of pain in the last couple of weeks and i know maybe you could give us some insight as to whether that looks like a trend or a blimp. >> i think it's for real because i really like this guy brian nichol very polished. out of -- look, he's out of the taco bell world but you know what, that's what they need, discipline he had a good conference call in i'm andreas from show boek archbishop what do you think about oracle >> i still favor salesforce and oracle is not a cloud king even as i think they think they are yes, sir. >> hey, jim, i'm chris from penn state. what do you think about paypal. >> it's one of the best in show.

i've got to tell you the things he said were incredible. i will look at the video and think it goes much, much higher. yes. >> hey, bob from new jersey. what do you think about raytheon, buy, sell or hold. >> it's one of the best, unfortunately, one of the best names because everybody needs business that's just one unfortunate but that's the world we're in and that's what raytheon has and the defense stock is the best place to be. >> hey, richie from brooklyn and -- >> really. >> yeah, and it's so great to be here to see the show live. >> one of my neighbors he's a neighbor. i love it. >> my question is about tall grass energy partners, lp with a 10% dividend. >> i know but, sir, i don't -- you know that we've seen a lot -- we've seen a lot of distributions cut in the last few weeks. and i fear tall grass because of that i know it doesn't look like -- we should worry but that group has become torture so that's the house of pain.

i'm not going there. yes, sir >> hey, jim, george from atlantic highlands, new jersey what do you think about melon kraut. >> nope, nope, i know they had a better than expected quarter i'm as worried about sales as everybody else and staying away interest that from 30 points not getting near it now. >> jim, how are you? longtime viewer, first time speaker. i wanted to act you if it's a time for roku because of increased competition. >> i have to say roku had a good quarter and numbers were amazing but i do know amazon is coming in which is why i'm concerned and why the stock went up and then came back down even though the numbers look good. good question. yes, ma'am. >> i'm from new jersey and i'm raquel scott's miracle-gro which has delivered on promise. >> this is scott's weekend let's give them that the stock was up for a lot more at one point but, you know, a lot of the problem is cannabis people looked at it as a

cannabis play and in the end it is a garden play so and the weather has been really bad for them but i say hold here, not sell yes, sir. >> i'm elliott from tenefly and i'm a terrific fan and i'd like to know about mcdonald's -- >> i think it's fabulous i think they're doing cartwheels the franchisees love it. one line is you can tell them ahead on the -- imagine, hey, i want a cheeseburger. now let's go right through and it's a screaming buy and that, ladies and gentlemen, the conclusion of "the lightning conclusion of "the lightning round. >> announcer: "the lightning round" is sponsored by td ameritrade his? had a coach in high school. really helped me up my game. i had a coach. math. ooh. so, why don't traders have coaches? who says they don't? coach mcadoo! you know, at td ameritrade, we offer free access to coaches

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earlier we talked about the market's intense hatred for many of the big biotechs but some have been holding up better than the four horsemen. take biomarin. brmn the maker of drug for rare diseases with a stock that's basically flat most of the others are down. they make orphan drugs, expensive therapies for uncommon conditions biomarin has six drugs on the market including a bunch of treatments for rare metabolic disorders but it's a business that doesn't have a lot of competition. meanwhile at the end of this month they are launching a new treatment for pku.

it's a brutal genetic condition that requires lifelong management it's great for people who suffer from it and for their shareholders as it could be a billion dollar opportunity let's like at j.j.bienaime and find out how it's doing. welcome back >> thank you >> thank you [ applause ] j.j., i think your company is chronically underrated because you have just delivered and delivered and delivered and have very big revenues but you have a new drug that could be approved and i know in your conference call you don't want to say it will be because there's no sure thing. how big is this drug >> so, yes, so the drug we're going to address, this condition pku you mentioned initially only in adults, and the adults pku parke between the u.s. and north america and europe is about

26,000 patients. the current therapy on the market is one of ours. and it's about $150,000 per year so if we price it at the same amount this is -- i mean the market opportunity is close to $4 billion >> wow >> so we only need to pitch it by 5% to reach a billion dollars. >> if you can explain to people, it's not -- you have to have clinics. you have to -- >> yes. >> teach people there's this drug out there that is so incredible. >> very good question in the sense that although the market opportunity is large, it would be a slow ramp on purpose, we want to make sure conditilinicir well trained slow tie trace to prevent side effects and they are 125 pku clinics in the united states we know all of them because we've been selling the product to them. 35 of them have already used the product so they're pretty well trained but need to train the balance of them and that will

take place over several quarters. >> do people foe if they have this illness from early on. >> yes, actually that disease since the mid '60s is diagnosed at birth because before there was diagnosis -- the disease has been managed so far thanks to a very strict diet that's impossible to follow when you're not a kid anymore and before -- before newborn screening, pku was the number one cause of mental retardation in the world and most pku patients were born before the '60s are in mental institutions today. >> oh, my. >> it's a pretty serious disorder. >> you're also working on another one for hemophilia that you have promising opportunities for, correct. >> that is a very exciting product. different area hemophilia so relatively large indication about 120,000 patients in the world. and we are developing either first gene therapy for hemophilia which going to replace two to three injects

every week by one injection potentially in the lifetime of the patient. >> one >> that's the goal obviously we don't have one to last a whole lifetime. only treat patients -- give an youdate next week at the world heel feel ya federation meeting with two years of data but in animals we have data that shows the animals once treated with the hemophilia are imagined for their whole life ten years so we hope it will last several year. >> if you have a drug like that we learned from gilead that -- we all want diseases cured but a chronic condition tends to use more medicine. will this be a one and done so to speak >> so this actually could be a one and done but the penetration will not be kit as fast as the gilead penetration with their product because it is such novel therapy some patients are going to upon it but some patient also want to see several years of data before they get treated so

the market is not going to disappear after thee years but will take a while to penetrate. >> most exciting this is the most exciting. >> very exciting >> a big year for biomarin and that means this is probably the year if you haven't looked at it, you should that's j.j. bienaime if you like these stocks, buy them "mad money" is back after the break.

you know me when we're up

this long this far this fast i always say come on, don't be foo greedy right. maybe take a little something off the table. the market is really soaring i don't want anybody to get hurt i do like the fundamentals but we don't like to be greedy in cramerica. i always say that's a bull market somewhere i promise to find it right here for you on "mad money. i'm jim cramer i will see you tomorrow. [ applause ] mr. cramer, i love the show. >> boo-yah to my kids in elementary school learning so much from you. >> boo-yah, mr. cramer. >> i know you hear this all the time, but thank you, thank you so much. >> this has been my best year by far and away in the market >> i just want to thank you for looking out for the regular guys out there. >> i am trying to teach people to be better investors and dog my darn best that's the goal here. >> great to hear your voice and know you're there for us

>> welcome to the shark tank, where entrepreneurs seeking an investment will face these sharks. if they hear a great idea, they'll invest their own money or fight each other for a deal. this is "shark tank." ♪ tank are jeff stafford and dusty holloway with a product they believe is going to explode in the fishing market. hello, sharks. my name is jeff stafford, and this my longtime hunting and fishing buddy dusty holloway. our product is the shell bobber. we are seeking $80,000 in exchange for 20% equity --