christine o'donnell. that's a better -- more effective. >> good luck, christine o'donnell and thank you for watching. stay engaged. think for yourself. i'm pete dominick. we'll see you next week. >> larry: does the brain have a mind of itself own? making us do and say things we know we shouldn't? >> your brain fools you. >> larry: causing us to eat and drink too much or stay in abusive relationships? >> it's actually works on the heroin or morphine centers of brain. >> larry: can we rewire all of that or is the brain more powerful than any drug or therapy?

that's next on "larry king live." jimmy carter will be here on monday. bad behavior is it all in our heads? we'll talk to dr. drew pinsky, author of "the mirror effect." and cara santa maria, neuroscience researcher, queens college. dr. daniel amon, author of "breaking the addictions that are stealing your life." and noted clinical psychiatrist, author too of "code to joy."

first, cara, what is a neuroscience researcher? >> somebody who studies the rain, really, i mean in all aspects. neuroscience is actually a broad term. it can be neurobiology, it can be neuropsychology. >> larry: do you write or teach or both? >> i have in the past some teaching while i was on my way to my degree. >> larry: let's get to the overall topic, the brain. why does the brain not stop us from doing things we know are wrong. >> it would make sense if you had an evolutionary point of view that the brain was a perfect instrument that only increased our survivability or. and trying to decide why the brain isn't a perfect system in how to operate, what tease correlation between the mind and a brain.

the best way i can communicate to it me. music has an existence of its own, it can be shaped and changed, but it's dependent on the violin and the bow to be creative. >> larry: dr. amon, let's talk about overeating. anybody would know it's wrong to overeat, it's bad to be fat, so why would you overeat? doesn't the brain tell you that's too much? >> not really. in fact, as your weight goes up, the actual physical size of your brain goes down. so your judgment -- >> larry: you get dumber? >> you get dumber, your reasons goes down in the studies that we have done so being healthy is critical to thinking right. but if you have had a brain injury, overeating goes up. if you have been eating badly for a long time, you become addicted to the bad foods, the fat, sugar and salt when you put them in certain combinations,

they actually work on the heroin or morphine centers of the brain. >> larry: they say to exercise, can you exercise your brain. >> yes, you can. the first thing to do would be besides taking good care of yourself physically and proper supplementation would be use it to use various strategies to strengthen certain connections and also remove and release trauma, stress and those elements that are interfering with your quality of life. >> larry: practical exercises you can do. >> actually there are. there's an exciting new development in energy psychology which is using the body's energy system, actually the accupressure or acupuncture system to help create some changes in the feeling state and also have an effect on the brain, but the nice thing is

these little simple techniques can be learned and practices in five minutes. >> larry: the more you research, is more imponderable it gets? is the brain a great mystery? >> definitely. and i think what dr. drew was speaking about is really important because a lot of individuals in field that are kind of related to neuroscience have been struggling with the question of mind and brain for as far back as we can remember, you know, and there are a lot of people out there who still believe that the mind is an entity that exists outside of the brain and can exert power on the brain and we're starting to see changes in research that are showing that we do have very plastic brains. but -- >> larry: meaning? >> meaning that neuronal connections can sometimes change and we can have new pathways based on experience. there's an interesting kind of feedback loop where the brain

creates mind and then the mind can exert power on the brain and physically exert structure on the brain. >> can a poor learning brain have a good mind? >> thomas edison did terrible in school, got beaten in school, and we would say he had an amazing mind. >> larry: how do we separate them, let's say on obesity. >> the mind-body dualism goes too far back. millions and millions of years went into our brain development and we develop in such a way to maybe live maybe to the age of 20 that will increase our probability of surviving, things that we crave and are deeply rewarded in our brain system. i don't want to get too heady on your guys. the brain has many different systems there's a rash system, an emotional system and the system gets very -- and that can trigger an addictive process.

>> does the stomach tell me i'm hungry or the brain? >> it's your brain that tells you you're hungry. but we think of the stomach as our second brain because your intestinal tract actually produces more chemicals that work on the brain than the brain does itself. so your body is really one system. i think of your brain as the supercomputer that is running everything, but it's all kper connected. >> larry: so would the brain tell me to overeat? >> sometimes it does. if people have damage to some parts of the brain, it can have faulty signals, we were just discussing a case of a woman that was 490 pounds and had a lap band and she was 280 and she couldn't move lower on the scale with it so they experimented with deep brain stimulation and running wires to certain parts of the brain to help her to feel a lack of craving, feels satiation, it shows some progress, but what are the

circumstances besides the physiology that are going on that can be affected. >> larry: why does the brain do dumb things. >> that's a great question. >> it's a difficult question. i think that we a lot of -- the brain, as dr. drew was saying is messy, it's evolutionarily messy and being higher order and higher thinking mammals, sometimes our executive function can kind of get in the way of our deeper and lower brain processes, our more instinctual brain processes, we have a lot of cognitive fallacies that we have to -- one fallacy is that people who have been experiencing overeating, once they can get their exercise in check, and get their eating in check, we often try to overcompensate how well we can put ourselves amidst stressors

in our lives so we'll be around people who are eating rich foods, we'll be around people who are smoking cigarettes in our presence. and study after study shows that we don't have the control that we think we do. that's the chipotle and cilantro. it's one of our new mexican soups. it reminds me of guadalajara. a special man. his delicious soups. sheila? [ male announcer ] progresso. you gotta taste this soup. his delicious soups. boss: and now i'll turn it over gecko: ah, t, ecko.sheila? as we all know, geico has been saving people money on rv, camper and trailer insurance... ...as well as motorcycle insurance... gecko: oh...sorry, technical difficulties. boss: uh...what about this? gecko: what's this one do? gecko: um...maybe that one. ♪ dance music

boss: ok, let's keep rolling. we're on motorcycle insurance. vo: take fifteen minutes to see how much you can save on motorcycle, rv, and camper insurance. that advertise flights for 25,000 miles? but when you call... let me check. oh fudge, nothing without a big miles upcharge. it's either pay their miles upcharges or connect through mooseneck! [ freezing ] i can't feel my feet. we switched to the venture card from capital one -- so no more games. let's go see those grandkids. [ male announcer ] don't pay miles upcharges. don't play games. get the flight you want with the venture card at capitalone.com. [ loving it ] help! what's in your wallet?

why go there when there's olay regenerist? [ male announcer ] microsculpting cream hydrates better than some creams costing $500. [ female announcer ] and not only that, [ male announcer ] 80% of women find olay to be a luxurious experience. [ female announcer ] olay. challenge what's possible.

>> larry: one of the definitions of insanity is doing the same thing and expecting different results. >> one of the things you were talking about is does will power work, what you have to understand is that the usual systems that we deploy to decide and to affect volition actually get usurped by the distorted drives of addiction so you start thinking the wrong things, you start feeling that the wrong things are the right thing. >> larry: you're fooling your brain? >> your brain fools you. my patients all the time say i

got it, i'm sober, but i got to visit joe, he's a good guy, but joe lived right next to my crack dealer. that kind of thinking emerges in all addictions. so the simpsons we use to rely upon what we call will actually lie at the surface of the deeper brain systems to which we are completely helpless. >> larry: since drug addiction, drugs are illegal, is there a criminal mind toward the brain, you know you're doing wrong, not only for the addiction, but you would even steal it for the addiction, what is the brain doing there. >> when we talk about addiction or will power, we have to talk about the front of the brain. so the front third of the brain, the prefrontal cortex, largest in humans than in any other human. 7% of your dog's brain, 3% of your cat's brain, when you're prefrontal cortex works right

and it's not fully developed until we're about 25 years old, when it's weak, it's like the supervisor in your head is taking a break or the child who's having tantrums or who wants the crack cocaine or wants the third piece of cheese cake, if your frontal corps text is not right, you're not going to think right. if you don't eat breakfast, you're going to make bad decisions about food the rest of the way. if you don't sleep right, lower blood flow to the brain. >> so until you're 25 years -- >> when we're 4, when we're talking about will power or mind power, we have a subconscious mind. it's called different things. freud called it the unconscious, or the subconscious, what happens is it's busy doing things for us all the time that

we're not taking conscious awareness of. because if we did, we would be overloaded with all of the things that are on my mind. cellular reactions or the movement of my arm as i'm speaking. when you think of when you write the check, when you write the first letter, the rest of your name is automatic, when you're walking, it's automatic, unless you're climbing very special stairs. this is busy doing this all day long, but sometimes you can't get from the conscious to the subconscious mind. as a psychologist, change how you think, change how you feel. that goes so far, because you cannot think your way out of some of these things, it is not connect. so you have to use tools to ute lyle the subconscious, which is the number of neurons firing at the conscious level 40, at the subconscious neuron firing per second, 30 million.

>> larry: is the mind in conflict with the brain. i know this girl is wrong for me, i know that. >> that's a different thing. >> this is actually really important because it speaks to what some of the panelists have been saying about the prefrontal cortex, specifically the limbic system, which is generally thought of to be responsible for emotion, even in a healthy brain, we have neuron tracts, we have fibers that connect neurons in certain areas of the brain to other areas of the brain. there are a lot of neuron tracks connecting the limbic system to the prefrontal cortex. but there's almost none connecting the prefrontal cortex back to the limbic system. >> larry: meaning? >> meaning that that emotional cell really has control over our executive function. our conscious being sometimes cannot handle and can not tell our emotions what to do, we're victims to them.

>> and when you talk about them, we're sort of moving into bad relationships now. >> larry: i don't want to be conflicted or controlled by one topic. topic is the brain. >> the heart is the body and i come from a sort of theoretical framework where we don't pay enough attention to the brain-body connection. >> larry: i'm going to take a break, i'll pick up after this. ♪ [ female announcer ] yoplait's real fruit and the goodness of dairy... gives you a little slice of happy. and happiness comes in 25 delicious flavors. explore them all. yoplait. it is so good. now the yoplait you love in a new four pack.

try it today.

fascinating subject tonight, the brain. >> you mentioned about two brains, in terms of particularly solving these problems we're talking about, we have left the notion of a single skull condition and entered into a co-creator trial work. we were talking about how i see the mind-body connection is so important. when i'm work with an addict, i don't want to hear what they're saying or what they're thinking because i know it's all distorted. so i try to tune my body with them, try to empathize with where they're act, reflect that to them and that creates the

kind of connection that creates the possibility of the changing of the wiring of the kinds of systems we're talking about here. >> larry: how, dr. amon do people change? how does the brain change it's behavior for the better. >> we see that all the time at our clinics, we do brain imaging. >> larry: that's what you do, right? >> we're in the middle of a big nfl study now, so we scanned 105 football players who have brain damage. and on the right program, which is getting them to sleep, getting them to lose weight. optimizing their vitamin d level for example, using some simple supplements, we improve their brain 80% of the time and then their thinking is better and their relationship is better. when your brain works right, that's what i have always said, you work right. when your brain is troubled from a concussion, from an illness, you're going to have trouble in your life.

>> this may sound stupid, dr. pratt, what makes one person smarter than another? >> that's an interesting question. i would say what makes one person smarter than another is their ability to adapt and to accept and to determine the course to go with, which requires a clear brain to maximumly use iq, you have to have -- eq is in some ways even more important than iq because it's your ability to maximize your iq and get things accomplished. >> larry: i know there's kidney disease in my family, can you inherit brain problems? can you be born stupid? i don't mean stupid, you can be born with deficiencies in the brain? >> you can be born with problems with brain structure, with your neurochemistry that can cause disease states later in life.

and there are some things that can be changed and there are some things that are somewhat fixed in the brain, i mean we know that behavioral interventions can be -- there are some things that you have to kind of hit in the right developmental period before they get pretty well set. >> larry: can you spot this in a 3-year-old? >> i think that we're starting to see that with autism, for example, which used to be diagnosed around age 4 and 5, we can see changes in their brains as early as 1 1/2 years old because they're starting to realize that autistic boys generally have larger brains than nonautistic brains. there are some organic things, but lots of times the behavior has to come out before somebody can recognize the problem. >> larry: can you study a brain, look at it under a microscope and tell me something about that person?

>> in our studies, i can look at a scan and tell you a lot about that person, whether they're going to be impulsive or compulsive. >> larry: just looking at the scan? >> just looking at the scan. but back to your point, my daughter's pregnant. and how her health is during her pregnancy will have a huge impact on that baby. and for the baby's rest of their life, how smart they are, how adaptable they are, how anxious they are. so taking care of pregnant mothers is just critical. and a lot of people don't know they're pregnant until, you know, week six and the brain starts to develop at week three. so if they're drinking early and they don't even know that they're pregnant, it can potentially have a huge impact. >> larry: we'll talk about drug addiction right after this. ♪ ♪ ♪ another day

♪ another dollar ♪ daylight comes ♪ i'm on my way [ indistinct shouting ] ♪ another day ♪ another dollar ♪ working my whole life away [ dogs barking ] ♪ the boss told me ♪ i'd get paid weakly ♪ and that's exactly [ bull lows ] ♪ how i'm paid ♪ another day ♪ another dollar ♪ working my whole life away ♪ another day ♪ another dollar ♪ daylight comes ♪ i'm on my way thanks. i got the idea from general mills big g cereals. they put a white check on the top of every box to let people know that their cereals have healthy whole grain,

and they're the right choice... (announcer) general mills makes getting whole grain an easy choice. just look for the white check. [ bottle #2 ] what? he takes out twice the soap scum per swipe i do, and kills bacteria. and leaves febreze freshness. ohm with me... oohhhmmmm. stop. please. thank you. [ male announcer ] remove soap scum, kill bacteria, and leave febreze freshness with mr. clean disinfecting bathroom cleaner.

>> larry: dr. pinsky, the late lenny bruce, very funny guy once said there must be a good side to drug addiction or else why would so many people take it and they say it kills you and they race down to the store to get it or steal it or whatever you k how does the brain deal with

that? why would any person with a brain take cone cane? >> there's two answers to that question, one is why you start using it and why you can't stop using it. the starting is you're trying to find a solution to a problem, you're trying to feel better. >> larry: and your brain tells you this? >> culture tells you that, and guess what? it works. they use drugs because they work. they do feel better, a lot better for an extended period of time many times and then a second phenomenon kicks in which is the disease of addiction and in spite of out no longer working, i would like to call it the do it again part of their brain has been altered in such a way to require them to do it again, do it again. >> larry: what does the addiction, the need for the cocaine do to the brain?

because it's damaging. >> the brain is clearly damaged. so the emotional center of the brain, the pleasure center of the brain is hijacked and it's damaging your prefrontal cortex so over time you have less and less and less control. once somebody gets clean, it can take months before they given to feel clear headed, which is why i sort of hate 28-day programs because i'm like they haven't really learned anything because their brain's still not clear. >> larry: are there drugs for the brain? >> absolutely. >> larry: i mean to help the brain. >> we have many, both natural medicines. fish oil being one. >> larry: anti-depressants. >> we have anti-seizure medicines which interestingly help a lot of people with anxiety and depression. i always say food is your best medicine, if you eat a bad diet, you have a higher risk of dementia and/or depression.

>> larry: what causes depression. >> depression is the result of various factors, what happens within a person in their brain obviously and also usually in their environment. depression occurs it has an affect on every aspect of a person's life. we all know the standard phenomenon, sleep disruption, appetite disruption, concentration problems, difficulty maintaining relationships and that creates a huge problem for individuals and then families. so my job as a clinical psychologist is to help use cognitive and energy and hypnosis, tools to go back and find out what the problems are and if you can get them and go back to grief or trauma and you can clear those traumas, you can create a huge affect. >> and we see it in the brain,

that's the exciting thing. if you do a treatment like hypnosis or emdr for people with post-traumatic stress disorder, i published a study a couple of years ago that said we actually calm down the emotional structures in the brain. so therapy can help enhance brain function. >> larry: in an autopsy, did we discover anything about the brains of suicide? >> suicide. oh -- >> just last week there was a study of this kid that was an nfl player that committed suicide and they found a lot of trauma on the surface of the brain. >> larry: so concussions could cause you to go over the top? >> i published a study a couple of years ago on suicide. and what we found was the under side of the prefrontal cortex in people who killed themselves was really low in suicide. suicide is a permanent solution to a temporary problem. >> larry: do you study the brains of drug addicts?

have you looked a at their brains? >> i have looked at the neuropsychological -- sensory disabilities. blindness, defenseness, paralysis and then later turned to abusing drugs, this was kind of my field of research when i was younger and so i would look more at -- >> larry: you were younger? >> when i was in my undergrad and i would like at the neuropsychological outcomes. i was doing more behavioral testing using their own measures so i wasn't actually technically looking at their brains, but we were trying to make inferences about their brains based on their behavior. >> larry: blindness is caused from the brain? >> blindness is a pretty complicated pathway that's both .

we love your weight watchers endorsed soups but my husband looks the way he did 20 years ago. well that's great. you haven't seen him... my other can is ringing. progresso. hey can you tell my wife to relax and enjoy the view? (announcer) progresso. you gotta taste this soup.

i think i read somewhere that einstein had 14% memory which made him a genius. is that true? >> einstein's brain was actually a little bit smaller than the average brain. >> larry: doesn't memory bring genius, in other words the more you remember the smarter you're going to be? >> not necessarily. what brings genius is being able to look at things, common things in a different way.

and he certainly had that ability. >> larry: but do you study memory? >> oh, yeah. and memory is important for certain things, but the higher order of things is things like problem solving. if you can solve a problem in a novel way that has never been thought of before. >> larry: wouldn't you go nuts if you had 20% memory? >> if you would be overloaded? we would have to be doing a lot of stress management. >> larry: but are you a genius, though? >> to be optimally functioning you want to be able to utilize all of the tools you have and that means making sure that you're taking proper care of yourself, your hard drive is clear, and, again, trauma is so powerful and affecting and disrupting memory and most people have a lot of untreated

and even unrecognized trauma. >> this is a very important point. in my world, i have noticed increasingly that trauma is the problem of our time and trauma actually shrinks your hippo campus. trauma not meaning physical trauma, i assume you mean interpersonal trauma. physical abuse, sexual abuse, neglect at the hands of caretakers has dramatic affects on the brain and there's a lot of research on how the right brain manages these things versus the left. this is a massively growing area. >> at ucla they have recently determined that if you have one trauma, there's a permanent, unless you take it out, 20% elevation of inflammation that leads to illness. >> cara, do you study alzheimer's? >> i have in school, but i have never done alzheimer's research personally. >> larry: what happens in the brain of a --

>> new research was always coming about, we thought it had to do with the plaques and the tangles and this theory. and there are some conflict within the scientific community that maybe not specifically alzheimer's but dementia, some people would say this is a normal function of living a very long life. and others will say this is a pathology. >> what we see in brain scans is the back half of the brain in people with alzheimer's disease completely deteriorates. the nfl players, they don't have alzheimer's as a group. it's the frontal lobe that's damageded. >> larry: what is dementia. >> dementia is the big category, that's when you lose coggive function. there's blood vessel dementia where you have a stroke. i wrote a book about preventing alzheimer's. did you know obesity is a risk

factor for alzheimer's disease. so the more fat on your body, the worse it is. diabetes is a risk factor, depression is a risk factor, alcohol abuse is a risk factor. so really focusing on living what i call a brain healthy life is critical to keeping your memory. >> larry: we'll be right back.

>> larry: neurosurgeons from the university health science center -- targets the brain and not the belly. here to talk about it is dr. julian bales, he's a neurosurgeon at west virginia university. what have we discovered? explain what this dbs is, doctor. >> this is inserts electrodes deep in the hypothalamus, this study will see if this possibly will have some benefit for patients with morbid obesity, the ones that really their life expectancy will be affected. >> larry: does it work? >> electrodes are placed in the hypothalamus into the center that makes you feel full.

the other part is your appetite center where your drive to eating is. these electrodes have contacts on them that go through these areas and a pacemaker type generator is inserted under the skin and from that we're able to change the settings and try to see if we can affect the appetite drive these patients have. >> larry: what have you learned so far? >> we have learned in the first series we have done that the procedure can be done safely, we have learned that we don't think we're having side effects and that we can affect the urge to eat, decrease the urge, we're looking at it being well tolerated. but the real -- the jury's still out where we don't have all the results yet, we're now working on trying to refine the settings to see if we can get the weight loss that we and the patients desire why only very obese people?

>> patients who have failed all medical diets, patients who have failed gastric or bypass surgery. and again their life expectancy is significantly reduced if they can't get this morbid obesity under control. >> larry: fascinating and we're going to do a lot more investigation. can i ask you a couple of questions about concussions? >> sure. >> larry: west virginia has a major football team, it's a major problem in the informal, now in college football and other sports. morneau of the twins sat out almost the entire year. what is a concussion, what causes it? >> well concussion is either the head gets hit or maybe the head gets moved back and forth violently such as the brain moves inside the skull. and our brain floats in this bath of sir cerebral spinal fluid and most of the time it recovered. there's also maybe a genetic predisposition. it can lead to long-term

problems in a minority of players. >> larry: could a problem be in the helmet. >> helmet design is important, but in my opinion, helmets aren't the whole answer. i think we need to take the head impact, the motion of the brain inside the skull out of the game. >> larry: the nfl is fearing it may shorten life, can it? >> we have autopsied quite a few athletes who have had a shortened life because of this syndrome. i support football, i think it's america's greatest sport. we want to make it safer, in certain cases there have been long-term detrimental affects of concussions.

>> we'll be calling on you again. fascinating study. back with your panel after this. >> i used to be a nice place, now nobody can go out. this moment of crisis, people have to have a secure place where healing goes on. my name is guadalupe, we have been working for 37 years with the community. every day have 1,000 people. some of them can pay, some of them cannot pay. but we don't turn anybody away. i believe that health is the

most important of the human drives. life is all about empowering people and it's very important to have an institution giving them hope for the future. wloip. both new covergirl lashblast fusion. our biggest brush meets our fiberstretch formula for a blast of volume and length. new lashblast fusion. from easy, breezy, beautiful covergirl. so, you can eat them right here... or eat green giant beans at home... ...frozen within 8 hours to lock in nutrients. up to you. [ green giant ] ho ho ho ♪ green giant.

>> larry: we're back with our panel dr. drew pinsky, dr. daniel amos and george pratt.

what do you make of that study they're doing. dr. amon, we'll start with you about that obesity study in west virginia. >> i think it's very interesting and psychiatrists and neurosurgeons are starting to work together. these electrodes in the brain using imaging for things like resistant depression, obsessive compulsive disorder and morbidly obese and better than the psycho surgery in the 1940s and '50s. >> larry: what did you think of it, cara? >> i think where the research is limited is the problem of knowing why certain people eat or certain people abuse drugs. it would be -- we like to put them all under an umbrella of there's something wrong with their deep mean system or they don't get enough neurotransmitters that tell them they're full but everybody's

pathology is differently and until we can diagnose why they have addictive behaviors it will be difficult. >> let me say as a follow-on to that i deal with a lot of people that end up losing the weight and they are not right emotionally after they lose the weight. there's all kinds of reasons that the weight was there and those things have often not -- when they have gastric -- alcohol gets to them very different. we see lots of -- >> even when they lose 100 pounds you think, wow, you'd be doing well. >> after losing. >> larry: we have a question, a facebook question, do we know what part of the brain causes obsessive/compulsive behavior?

>> there's a lot and the prefrontal cortex rather than being low, what we see in impulsive disorders, it works way too hard in people with ocd so we call it hyperfrontality and some medicines we use calm them down. >> larry: we posted to the "larry king" facebook page and asked for questions and we have one interesting well. 12 years ago i got into an accident in the snow. i don't drive in the snow anymore. i'm a terrified passenger if it's snowing. i've become paralyzed. i cry. i know it's irrational. what's going on within my brain, carr? do you know. >> sounds like it could be a posttraumatic stress -- >> larry: what is that? something happens to you -- >> and you experience heightened levels of stress and have

behaviors in your life that are so difficult that they, you know, they make your life difficult to navigate. we see it obviously in wartime and see it after trauma, after abuse and rape and after things like car accidents. >> we didn't hear it until after vietnam. >> we still. >> one thing about this case, ptsd can create all of those as well as triggering panic attracts, in a situation that's highly negative and then you have a problem driving in snow because you have an association. >> larry: how do you get rid of it? >> desensitization issues. >> there's a thing about how it works. it locks things in. part walls off and to be healthy we have to function as an entire brain. the trauma locks off parts from the part of the brain that's conscious. >> even with scans with people with ptsd you can see the prefrontal cortex and the limbic

system is overdriven and see direct correlations of what they can be. >> larry: back with -- don't go away. i got the idea from general mills big g cereals. they put a white check on the top of every box to let people know that their cereals have healthy whole grain, and they're the right choice... (announcer) general mills makes getting whole grain an easy choice. just look for the white check. rheumatoid arthritis going? they're discovering simponi®, the first self-injectable r.a. medicine you take just once a month. taken with methotrexate, simponi® helps relieve the pain, stiffness and swelling of r.a. with one dose once a month. visit 4simponi.com to see if you qualify for a full year of cost support. simponi® can lower your ability to fight infections, including tuberculosis. serious and sometimes fatal events can occur, such as infections, cancer in children and adults, heart failure, nervous system disorders, liver or blood problems, and allergic reactions. before starting simponi®, your doctor should test you for t.b.

and assess your risk of infections, including fungal infections and hepatitis b. ask your doctor if you've been to a region where certain fungal infections are common. tell your doctor if you're prone to infections, or develop symptoms such as fever, fatigue, cough or sores. you should not start simponi® if you have an infection. [ woman ] ask your rheumatologist about simponi®. just one dose, once a month.

>> larry: we only have a few moments left. i don't get permanent but i had heart surgery. i'm in new york, i'm post surgery and my doctor, famous surge on on the cover of "time." into the man comes a man who says he's a brain surgeon. i don't mind the doctor. he's getting all this attention but heart surgeons are plumbers. i'm a brain surgeon. one move of my hand can change your memory forever. and with all of this no one knows me and i saint "i didn't leave my brain in san francisco."

the heart does command us, doesn't it? the heart wins. >> the body. >> the brain tells the letter what to do. >> the brain and the heart work together. >> the heart has to work. >> if you're a malfunctioning relationship -- >> you're right. we're all into our -- the fact is what you're saying when we have a deep drive and a desire to be with somebody that's what we're going to do. >> i -- >> larry: i can't talk you out of love can you talk one out of a relationship. >> not using the literal mind so if suffering from love pain or anguish these work? >> larry: why did you decide to make a career of this? >> it's the only option i feel like i had. when i first started school -- >> larry: it had to be the brain. >> it's the only thing i father. my father is an engineer my

mother is an educator. i started in music then i went into psychology and as i was studying psychology and philosophy i decided i needed to know more and grew from here. >> larry: what fascinates you the most about the brain? >> exactly what she's talking about. all these different fields, anthropology, philosophy are coming together up the rubric -- >> larry: what about you? >> neuroplasticity. dr. rama chandra had amputees with phantom limb pain and developed a mirror and would insert one hand -- the intact arm, the person would see the other arm is intact and rewired the brain within minutes. i love neuroplasticity. >> larry: dr. amen? >> i think of the brain as the hardware of the soul who you really are has to do with the physical functioning of your brain and it can change and that is so exciting.