these have been going on and growing for the past week. certainly the largest one was yesterday in new york. they're also spreading to other cities around the country. also, the u.s. state department has issued a worldwide alert for americans traveling anywhere to be mindful of possible retaliation against u.s. citizens and interests. the warning comes after friday's drone strike that killed militant cleric anwar al-awlaki. the bottom of the hour now, i'll be back you at the top of the hour with more live news on cnn sunday morning. hey, there. it's been five years since anthrax killed five people, terrified millions, and shut down the postal service. there are questions about the case and the prime suspect. also a surprise from hollywood. a comedy about cancer. i talk with seth rogen and the writer. first i'm outside the courthouse in los angeles where twiers after the stunning death -- two years after the stunning

death of michael jackson his doctor is on trial for involuntary manslaughter. conrad murray. he was hired as jackson's private physician to get ready for the big comeback tour. within week the singer was dead. prosecutors say the cause was an overdose of propofol administered by murray. defense lawyers insist the doctor isn't to blame and say that jackson gave himself the fatal dose. >> it was dr. murray's repeated incompetent and unskilled acts that led to mr. jackson's death on june 25, 2009. >> michael jackson swallowed up to eight pills on his own without telling his doctor, without permission from his doctor. and when dr. murray gave him the 25 milligrams and dr. murray left the room, michael jackson self-administered a dose, an additional dose of propofol. and it killed him. >> watching the beginning of the trial, you realize this whole

thing may boil down to propofol and how michael jackson and conrad murray were using it. now when i first heard this, the whole thing sort of, frankly, struck me as bizarre. this is a drug used almost exclusively in the hospital to essentially induce general anesthesia for an operation. i decided a picture is worth 1,000 words. take a look. we are here inside the operating room with dr. gershon, chief of anesthesiology. propofol's a medication he uses all the time. is this it here? >> yeah. >> it looks like -- milk of manage endangered specie magnesia. >> milk of magnesia. you okay? we have to monitor his ekg, his co2, have to make sure he's breathing, his ventilation. >> that's typical -- >> standard of care. yes. >> okay. so the propofol -- >> we'll start infusing this.

you'll get sleepy, okay? give me some good deep breaths. >> look at his eyes. how quickly -- >> deep breath, vincent. doing great. may feel a little burning, okay? >> ten -- >> deep breath. >> nine, eight, seven, six, five, four, three, two, one. >> there's a reason for his heart rate increasing -- >> i'll switch -- >> see his eyes have closed. >> his eyes closed. what else -- >> look up here. he stopped breathing. so this is watching his co2 and he's not breathing anymore. and my wonderful anesthetivity is going to help him breathe. >> all the breathing is taking place with this bag and mask. that medication, he wouldn't be able to breathe on his own without those things. there you see part of the problem just with that much propofol he stopped breathing and needs a breathing tube.

>> easy? >> easy. he's good. >> what's so attractive about the medication? >> well, people -- it's really been in the advent the last 10 years, 15 years. it's a quick on, quick off. that may answer why people think they could do this at home. if it gets out of hand it goes away quickly. the problem is, it gets out of hand, there's nobody there to resuscitate you, nobody can bring you back. >> that was pretty quick. you just gave someone the medication, you're going to -- >> five, ten minutes. >> he went from being completely awake to completely asleep. >> he's not breathing. i'm breathing for him. >> one thing worth pointing out is that this is a hospital that uses this medication thousands and thousands of times a year. they do use the medication in non-hospital settings like outpatient clinics. the doctors here will tell you they've never heard of it being used in a home. a little sneak peek there inside the operating room. lots of thing to pay attention to. also, prosecutors say that murray failed to call 911 right

away. get this -- a witness who was jackson's head of security described this -- murray was doing cpr with just one hand, with jackson still lying on the bed. now, to me, some important things jumped out. these are basic, basic mistakes. for example, to do cpr correctly, as you can take a look, you need to use both hands. you squat down over the person whose heart has stopped, you get your arms straight and press hard and fast straight to the chest until help arrives. you call 911 first. to make it work, you have to do this on a hard surface, not something soft like a bed. any case, the trial of dr. murray does continue on next week. another court case we've been following for some time, as well, a federal judge ordered gerald loughner to undergo four more months of mental health treatment to try and make him fit to stand trial for shooting arizona congresswoman gabrielle giffords and more than a dozen others. as you may remember, loughner has been diagnosed with schizophrenia. the judge said his condition has

improved so far. health insurance costs are on the rise again. except faster than usual and three times faster than nation. the average annual premium for family coverage through an employer is up to $15,073. an increase of 9% over last year. also marking ten years since the anthrax attacks. remember these? 500 interviews, 1,700 subpoenas, and one controversial suspect. we'll take you inside the investigation next. y of powder . what if there was a makeup that didn't just hide your breakouts... but actually made them go away. neutrogena skin clearing makeup. it has our proven blemish fighting formula blended with silky gorgeous makeup. so it gives you a beautiful flawless look while undercover it works to clear breakouts. does your makeup do that? neutrogena® cosmetics. just having some tender chicken and some tasty noodles. let's see...south western vegetables...60 calories. ya' know those jeans look nice.

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it was ten years ago when americans were in the grip of terror, not just from the september 11th attacks but also from a series of anthrax letters mailed to news organizations and capitol hill. remember this? it ended up killing five people. after years of twists and turns in 2008 investigators had their sights set on the government scientist named bruce ivins. he was never charged because he killed himself as this case heated up. that left this whole taste of controversy, something cnn takes a look at in a special "cnn presents" which premieres this weekend. joe? sanjay, one of the things we take a look at is how federal investigators came up with the name of a suspect in the anthrax attacks. it was not easy. in the first few months of the

attacks they didn't have much to go on at all, and they were casting a very wide net. what we do is zero in on one very important lead that they got in the early days of the investigation which, frankly, took them years to fully track down. check this out. when the anthrax letters hit in october 2001, nancy haigwood is an up-and-coming scientist in seattle specializing in hiv. a few months after the attack, january 2002, the fbi e-mailed the american society of microbiology members. fbi profilers believe it is very likely that one or more of you know this individual. >> in my mind, it was as though something clicked. >> who did you think of? >> bruce ivins. >> bruce ivins. a scientist at the research

institute for infectious diseases, ft. dietrich, maryland. this is the main lab for studying biological weapons to develop protective vaccines. ivins is an expert on anthrax. in fact, he is supposedly helping federal agents. >> in january of 2002 bruce ivins was in the thick of it. >> what the feds do not see is the hidden side of bruce ivins, e-mails where he says, i am being eaten alive by paranoid, delusional thoughts. >> bruce ivins has led a double life. >> psychiatrists will later describe ivins as a secretive, paranoid and rage-filled man. >> he was a guy who had a definite dark side to him that no one else knew about. >> i met bruce in chapel hill, north carolina. >> it was the mid-'70s. nancy haigwood was a graduate

student at the university of north carolina. bruce ivins was there, too. ivins asked incessantly about haigwood's sorority, kappa kappa gamma. he seemed obsessed. >> every time i talked to him he would mention it. finally i said, bruce, that's enough. >> as their careers took shape over the years, ivins kept in touch. shortly after the anthrax attacks, he e-mailed these photos of himself with what he called the now infamous strain of anthrax. >> he wanted his former colleagues and friends to know that he was doing important work. >> one detail stands out. >> he said he was working in the containment lab, and he wasn't wearing gloves. and that is a bio safety hazard. we don't ever do that. and what that is, to me, a sign. i'm immune. >> turns out there were a lot of things that didn't look right

but it took federal authorities a long time to put together all the pieces and, to this day, some people say they're still not sure the investigators got the right man. sanjay? >> fascinating report, joe johns. i'll tell you one of the people who still isn't convinced is laurie garrett, a pulitzer prize winning journalist who writes about infectious diseases and took a close look at this specific case. do you believe what the final investigation showed? >> i think that the case against bruce ivins is essentially circumstantial. i'm not sure any of it would have held up in a court of law if, for no other reason, than the fbi never had chain of custody of the actual anthrax evidence and bruce ivins had possession of the evidence for quite a bit of the time. any lawyer could get that tossed right out of court. >> it's called "death by mail: the anthrax letters" this sunday night at 8:00 and 11:00 p.m. on this week.

diana nyad attempted to swim from cuba to key west without a shark cage. third time was not a charm for her. in the end her nemesis proved to be much smaller. there's no way to counter toxic jelly fish that brought intense pain and partial paralysis. nyad was forced to abandon her record attempt 92 miles into the swim. nyad says she will not attempt the swim again. she said that before, though. all of this got me thinking, though, what kind of fuel does it take to power the body for such an extreme feat, extreme nutrition in this week's "food for life." as one expert puts it, diane is in a race against her own body, to finish the swim before she physically can't move at all. in the water she burns about 700 calories an hour and her swim lasted more than 40 hours. she refuels once every hour with sports drinks, gels, powders, energy bars, and her favorite,

peanut butter. she also drinks about 40 ounces of water per hour to stay hydrated. but even that doesn't quite keep up with her energy needs. eventually diana's body turns to burning fat and finally protein, the very building blocks of the muscles that keep her swimming. during her last swim, she lost almost 16 pounds. [ male announcer ] welcome to transamerica. where together, we're transforming tomorrow. ♪ here's where we deliver steady income - month after month.

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let's take some time now for a look at a truly extraordinary individual. eight years ago sheila may advento's hands and feet were amputated after a bout with meningitis. she lived with prosthetics until a year ago when she had a chance to undergo a hand transplant which changed her life. imagine having to learn how to use someone else's hands as your own. >> pinch. pinch. >> that's the reality for sheila may advento, the first woman in the united states to undergo a

double hand transplant. >> i just remember being rushed to the hospital and that's it. i was out. >> advento's hands and feet were amputated after she contracted bacterial infection. >> they were so lifeless and so black. >> she got prosthetics for her hands and feet but the possibility of a future hand transplant was always on her mind. when the opportunity came from the university of pittsburgh medical center, she went for it. >> i'm amazed by my own progress. i have no expectations. >> it's been a year since she got her new hands and already advento has hit several milestones, she can feel temperature, pain, various textures. it's the result of a lot of hard work. she undergoes six hours of physical therapy five days a week. >> for me to finally feel these things again, my hair, my face, or even my jeans, it's something big for me. >> advento says her ultimate goal is to live as independent a life as possible.

>> this is actually my very first painting. >> she draws, she paints, she drives, she puts on makeup, finds her way around the kitchen, even clips her nails. >> i'm not able to pinch the nail clipper that well. i was able to figure out how i would do this myself. that was my other way of figuring out how to be independent. >> the last eight years have been difficult. figuring out how to be independent. >> reporter: the last eight years have been difficult but she says she's overcome so much by believing it all happened for a reason. no matter how painful she tries to always be positive. >> i don't give myself much of a choice but to keep going despite of whatever obstacles i encounter in my life. >> just amazing to see her use those hands that way and what she's able to do. in addition to her physical therapy she continues to work and hopes to be able to display her artwork at a local gallery soon. wish you all the best, sheila. still ahead, it is true what they say.

laughter really is the best medicine. seth rogan, will riser will join me to talk about their new move "50-50" right after the break. our 4 new rich & hearty soups really have people talking... [ guy ] ring, ring. progresso... i love your new loaded potato with bacon. that's what we like to hear. ring, ring. progresso... ...switch our phone service? ...no, i think we're pretty happy with our phones. [ male announcer ] progresso. you gotta taste this soup. while i took refuge from the pollen that made me sneeze. but with 24-hour zyrtec®, i get prescription strength relief from my worst allergy symptoms. so lily and i are back on the road again. with zyrtec®, i can love the air®.

what kind of cancer? what's the name of the cancer? >> some rare kind of cancer. >> what's it called? >> schwanoma. >> what's that. >> that means tumor basically. >> what are your chances? what are your odds in. >> i don't know. i look it up and it said 50-50 but that's like the internet so -- >> you're watching a clip here from the movie "50-50," a new movie opening nationwide about a guy in his 20s who's diagnosed with a rare form of cancer. it is a funny movie about a serious, often devastating

topic, all inspired by real life. i sat down with seth rogen and his good friend will riser who was inspired to fight movie after fighting his own battle with a rare sarcoma. >> will, first of all, how are you doing? >> i'm great, cancer-agree six years. i'm in remission. >> maybe you could help us answer this question? how long does remission last? until you just die of something else? >> this is all based on studies they say that the chance of something coming back after a certain point is so statistically insignificant that they call it -- >> they call it remission. so you're always in remission. >> no, with certain cancers they'll say within seven years your chance of recurrence is -- >> i think for me is ten years. maybe i got four more years and i'm out of remission. >> we should have an out-of-remission party. >> we should. >> you had to pitch this movie. do people say how do you do comedy with cancer? >> we knew that it wasn't an easy pitch so will wrote the

script before we even attempted to make it so we had a completed script which was pretty representative of the movie we wanted to make. i think, you know, we're not making fun of cancer. we're making fun of how people behave in that situation and that's something that i think we're good at, is taking, you know, situations and showing the funny side of how people might realistically act in those situations. >> for us, those are our favorite movies, are the ones that deal with really dramatic situations but find the comedy in them. when i was sick actually people would come up to me and their impression of what having cancer was like was based on movies they had seen which were really overdramatic and really sad in which the person always has some great epiphany and the next day dies. >> a lot of it is about your frndship as well. your relationship. seth, had you known somebody who had cancer? you had dealt with this in your life before? >> no, i had never dealt with anything remotely serious really, honestly. it's when i realized everything

i knew about this kind of thing was from movies and it was instantly so different than any movie i had seen. and i think that's honestly one of the reasons we wanted to do it, is that it was the first time i'd ever experienced something like this and it was so different than how i'd seen it artistically portrayed. >> when you were writing this, did you have a goal for this besides telling this story? >> i think, yeah. my goal was really to show what it's like and to -- i mean just had so much i had to say, so much of the experience of what it was like to go through it, through friends and through family and doctors and hospitals and all of it and i just sort of felt like no one had any clue what it was like and i felt like if i could -- if i could show a bit of the lighter side of it, it would allow people to not be so afraid to talk about it.

>> and give them something they probably wouldn't normally want to think about but if it is funnier it is a lot easier to think about that kind of thing. >> right before i went in for my surgery -- i mean this is a really ridiculous store. i was in the hospital like on the gurney about to be put under for my surgery to remove the tumor from my spine and the nurse came in with all these papers for me to sign. i mean literally like second before i'm about to go under. organ donor, hospital liability and in case we need to fuse your spine or remove vertebrae. it was really intense. and i said, are you really going to do all these things? and she said, well, you'll have to talk to the doctor. and i said -- can i talk to him? and she said well he's gone into surgery. and i said well can he come back? i said, no. if you want to talk to him, we'll stro cancer the surgery. this is like a minute i'm supposed to go under to remove his tumor. i said you trust him, right? he's a really great surgeon. and she went -- well -- >> come on!

>> and then she said he's not very nice. and i thought -- i mean oh, my god! i'm in an episode of gr"gray's anatom anatomy". >> lesson for all surgeons. you got to be night. >> that was in the script at some point, i was like this is insane! he goes that actually happened! >> i always wonder how loved ones should behave, they have guilt, don't know whether to talk about it, not talk about it. >> there is no right answer. along the way you're goinging to say the wrong thing, you're going to do the wrong thing, you're going to make a mistake. we're all human and i think it is important for people on both sides, whether you're sick or you're the loved one of someone who is sick, to just realize that, to know that it is a lot easier on everyone if you can just take a step back and just sort of admit to yourself. i really have no clue like how to appropriately handle this. >> i can't believe how young you guys are. i feel very old. but thank you and i