services the students clearly see as being in one of these colleges as a career enhancing move and others e not so sure. i will pick on the marine cor. the marine corps seems to get the best kudos for both looking at the students before they get there, but also furing out where they are going to go afterwards in terms of yeswe know thiis going to help your career both as a faculty member and as a student. i may be wrong. these are just anecdotal things. would ea of you respond? to think there is variability amongst the services in terms of how go about selecting the students, selecting faculty for the contribution to your organization's and then how they look at where these careers are going to go after the students have graduated and i'm talking about the military faculty now. admiral hall, we will start with

you. >> i discussed this topic often beuse i say there are service cultures, so is speaking from the naval service, there times in your career where you need expertise at sea tactically whether it be in the cockpit, on amphibious ships or submarines of therefore you don't need somebody to be thinking strategically at that point. you need them to excel in leadership positions at sea and that is part of our service culture. ..

>> so i don't see the experience coming to the national war college as anything but a

positive benefit to the military member when they are competed and selected and attend the national war college. again the quality of student that the services are providing is high. as i shared with you yesterday, this being my second class experience. the only thing that i have seen struggled in fulfilling the student list has been sometimes with the - on our army side to the offtempo, usually they are little bit late getting their slate in. but they always fill it. and the quality is extremely high just as admal hall shared. >> you're talking about students, how about faculty? >> for faculty we're very selective. the service members can nominate.

that faculty is interviewed, screened, and evaluated and the recommendation is made to me through a faculty hiring committee as to whether they meet the standards or not. >> i understand that. my question about in the service and the service culre, do people come to you'm a dead-end career, i'm a faculty here, is there anything amongst with these military services assign faculty, and i know you go through the selective process with the top-no,notc people, and their career is enhanced by being a faculty member for a couple of years. >> right. st of them have had a teacher background or experience, and they know what they are getting into and they seek out the national war college as a way to broaden their teaching credentials. so i think they come to the --

all the services ty come to the college aware of what they are experience is going to be. it's a national war college. i don't think they look down on it as somethi negative. they know they are getting into a teaching realm, and most of them already have at the phd level, so they are rather senior in their service careers already. and i think they look at it as a positive years to spend in the remaining time that they are going to serve with their servicer. >> all right. i think it's positive. the people who come to the naval war colleges, military faculty, they may not have sought it out. but at some point there is lot of input of where you are going with your life.

for example, one of our military faculty was just selected to be the air carrier commander. everyone is not going to go on to be chief in operations, they all view it as positive. they are doing meaningful work. here's the way we can help the person coming right off the flightline. for example, in our strateg policy we can put a very experienced civilian professor in with the newer strategy and policy professor. but the point being that the people who i talk to, remember i have only been there seven months. i've talked to a lot of military faculty. almost all view it as a positive. >> i'llpeak for the army war college, our colonels in a unique way, to answer your question. the colonelsho come and teach

are in their 25th and 30th year of service. they don't come back to get promoted to general officer. i think that's very important to say he. i vould welcome lieutenant, senior lieutenant colonels or junior colonels, but perhaps one of the second or third order effects of goldwater have been nickels is that whe a student finishes athe war college, it's very hard for him or her to have the time, the discretionary time to serve a tour of duty as an educator in the war college and still remain competitive. in part because the need to get jointed. and we'vectually had students to the key. but if we kepthem they would not be competitive for general

officer. now having said that, i believe that the colonels who do serve, i don't think we've had to drag anyone back to do this. i think they are at a point in their career that they want to gi back, and they want to be outstanding educator. and representation in the institution is such, they are very pleased to come back. they have great maturity, they have experience, and they fit this job particularly well at this particular time in their career. so i think that the quality of my faculty,articularly the military faculty, is absolutely outstanding. th are terrific educators. i hope i've answeredour question. >> sir, i wod agree completely with general williams at the quality of the faculty i fabulous. i would say that the

expectations of the faculty and military faculty are different in that they run the full spectrum. there are those tha as you've heard come there knowing that's probably their last, sometimes because they want it toe, sometimes because of their timing in their career. i have one data point, we lost one faculty member this year is all. and she got a great joint assignment here in the d.c. area, basically what she wanted. so it was looked upon favorly there. we have five volunteers to get their phds to come back and teach. it expanded the entire gambit in the last general nomination board. one of theeople had been a faculty member. and so i think it's -- you know, what maybe in the past looked at

as a dead end assigent. i think it was looked at as a luable assignment to the service. they can contribute, depending no matter where they are in that spectrum. whether it's their career, the last assignment, or where they want to continue on. >> sir, the president of the marine corp university has made it his policy that he's willing to sacrifice continuity for pability. so it's been the policy of the university throughout out of the serves to select the best and the bitest to become instruct or direct at the various colleges. there's some risk in that in that you'll have an oscar for a year maybe t years before he's selected for command or promotion. bu that's a risk we're willing to assume to get the confidence that he brings from his past operional experience. for myselas the director, i

competed. the other marine that will be coming on board this year, similarly coming out of the national war college was hand selected for this, and has a potential for future service and promotion. in fact, among my sister colleges at war fare school, the last two were general during their school year showing the value in education. among the other services that we have on staff, u.s. air force has sent qs top-notch officers. my doesn't was just selected to command at patterson air force base. the past ones sitting behind me deciding to become the dean of academics because of his academic proficiency.

and as a active pilot. i've been very impressed with the staff that we've had from all of the services and couldn't have asked for a higher quality faculty to go forward with. thanks. >> thank you, mr. chairman, i want to again take you to another step in the chairman's question. isked about how do we go about attracting the best in our top-tier civilian faculty? what are the things that we need to be looking at to address that? are there things like tenture, copyright, pay, the government retirement, research, administrative assistance? what do we need to be doing to attract and rape the best and

and -- retain the best and brightest. >> let me start by saying we work very hard to bring in talented civilian faculty as well. many are by the way former military officers who have received their degree and so they serve us very well. we also, and i mentioned this, we have a program at the united states army war college where we bring in thoseolonels in the 25 to 30 year mark who have a particular pension for academics and being outstanding educators. and we send them off to work on their doctorate. i currently have 10 officers at are -- that have reived their phd i my faculty, i have five working on it, and i have five civilians professors who were a product of that particular service.

we, of course, advertise throughout the united states for openings that come up. d we do very well with the standard professors of history, former planners, those kinds of leadship. but we are not competitive in a number of certain areas, as an example, economist, behavior scientists, military sociologist, we do not pay competitively. i'd ask dean johnson if he'd like to add tohat and offer up to any insigs as what we can do differently. >> sip, thank you. one of the things that we find is given the professional nature of it, we have a hard time from the liberal arts background that this is the place for them to come and teach. i believe like many of the other

schools, if we c get someone to an interview and demonstrate that we are open to have academic freedom, the quality of our students, in particular the faculty and ability to influence, we have a strong possibility of bringing them and retaining them. it's doing the proper advertising and netrks within the various disciplines that will allow us. >> thank you. general steve? [cuffing] >> sir, i would on that list you read off of just echo that there should be some work done on the copyright issue. and t discussion that's out there. i know that affec the faculty that we hire in. yes, we do need to do some homework there. we are fortunate again in the

washington area to have a little bit of a draw on some of that high talent that's out there because people like to live and work around this city. and teaching over at national defense university is a pretty good job if that's what you like to do. that of a draw, we don't have any problems getting people to apply for an opening at faculty, at national defense uversity. we usually end up whittling it down. i believe we are getting top-tier talent with our civilian hires. as i shared with you yesterday, one of the things that i would like to see considered for the national war college was that

kind of a doubt chair position to try to draw on the high policy, national security agency, talent that when folks leave those positions thathey have an opportunity to come over and teach at the national war college and we can tap into theirecent experienc. and that would add ain to the college as fars becoming a preeminent national security strategy institution. i want to look into that kind of in doubt bhair possibility that would be hpful. >> admiral hall. >> we have many similarities with the national war college. our location gives us a great pool of faculty to pull from. one thing that general steel mentioned is accreditation. both o our schools are

accredited. we wt to maintain that. why would a faculty member work that doesn't give an accredited masters degree so they can go to georgetown. the other thing is there's always concern are we paying them equivalent if they could go down to george washington. tenture, i don't think i would want to go down the tenure route. now at icaf my faculty members are 95 members, 30 are military, 45 are title ten, but i have an additional 17 to 19 that are faculty chairs including industry chair. right now it's from ibm, it was a vy competitive process. her relief in american express is our next industry chair.

there are some chairs that come from interagency, everything from fema, nga, state department, et cetera. so we have a very dynamics faculty that way. but our title ten is going to be an accreditation and all of the other points that bob pointed out. thank you. >> congressman, thank you very much. it's been a topic of debate and is very timely. let me by again byelling you what it's not. it's not high salaries. it's competitive salaries that are important. but i have not had a professor that the salary had been the deciding point when it's in the competitive range with our salaries in the area. at it is is first the ability and the opportunity to teach and get in the classroom. the professors want to be in the there with the students on a routine basis. to assistant that we try to

remove as much of the administrative orhead from the faculty as possible and move away from documenting each course to death and allowing more freedom of how they develop and run their classes and aid cromanaging their work bringing them up to spend time mentoring and working with the students. secondedly, it's the opportunity to research in their fields. they love their fields and want to go deeper and broader into them. the more we can give them opportunities through time to do that, whether that be sabbaticals, short-term research opportunities, involveme in panels welcome , lectures, it's to our benefit. also to have. -- having top-notch research

would be beneficial. the research assistance program, we are looking at that currently. again to free them up and go deer and broader into their fields of study for research. two items that i would like to addrs that i think this distract from r recruiting effort. first it to some degree folks that look at war college. they have perceptions about what the war colleges are and lack of academic freedom or lack of topic matter that they will be able to cover. they are still looking at the war, our father's war colleges, not e war colleges of today. we need to broaden our strategic communication, the more civilian institutions, academic institutions, and think tanks, so they know what we are about and we have a broader pool to recruit from. it is up to up to broaden that

pool. when job announcement go out and professor that w might not consider otherwise will come in and challenges curriculum and other professors. and thereby, it makes us all better, not to continue to hire from the same pool of professos that we may have in the past. and that way i think we also broaden t educational opportunity for our students. thank you. >> sir, it's not always been easy to hire folks that come to maxwell, alabama. i've only been there a year, but i have not seen the pushback with respect to that, in fact, i've seen exactly the opposite. and i know if it has to do with the economy or what have you, we're in the process of hiring a political economist that's coming to us from london, has his harvard phd, and he get those kinds of people routinely. our faculty is littered with

that kind of talent. i couldn't be more pleased with the folks that we have and the peoplehat we get. part of what we can offer at maxwell is not necessarily available everywhere else say from washington. we have all the schools there. d we have the air force research institute there where people with go and do research and publish and do those kinds of things that many of them want to do. and i haven't seen it as an issue where i'm at. and i'm very pleased with what we have. >> thanks, sir. i benefit from changes that admiral turner put in place in the early 50*e -- '70s. we had a vibrant military faculty. we have 78 civilian and 64 military.

but as an experience, we had 275 people in research working analysis that might teach an elective. my point of the 22 strategy and policy, all are phd. from some of our most prestigious universities. we're certified by the colleges. other schools have taken our strategy curriculum, yale has a grand strategy course they are starting, duke, princeton, all based on the policy model. i'm trying to hire an academic dean right now. we're down to about the last 16 of my of whom that could do this strong phd ademic leader that can help us with faculty. o vibrant series of chairs that we have in place.

're establishing regional chrs. the faculty tell me it's also the unique student body. they know they are not goi to have to deal with a lot of nonsense from our students. these are mid-career motivated students who are going places and coming right off the front lines. there's also facul development aspect which one of my colleaguing illuded too. we're on trimester. one of those trimester, the faculty can go and down their own search and curriculum and development. we have a budget of almost, i think we've spent over $600,000 on faculty development. i'mware of the copyright issue. i think it's a question of good policy. we have to watch that carefully. but i think we're okay on that. and the fact that we just

recently went to .edu on the web. it tries to spell what's going on and turn the light on the conferences. those are the attractors. >> thank you. mr. wittman i'm trying very hard. but can we have an abundance of questions left that we can be for almost two hours. we almost certainly have questions for the record. questions go slower. we appreate you all being here today. we appreciate your testimony. i'm sure we'll haveome follow-up questions both formally and informally in the future. >> we are adjourned. [inaudible conversations]

>> today is one of our final days of shooting or documentary. we've been in there for two months or so in the different rooms and talking with nine of the justices now about their job to give us an inside window of how the court operates, the processes of the court, and humanizing it. and what we're doing is just having a couple of final shots

today. then we're going to add that into theocumentary. >> supreme court week. october 4th on c-span. >> now a discussion on direct-to-consumer genetic testing. providing it directly to purchaser, instead of health care providers. we'll hear about the privacy concerns and future research opportunities. the national academy in sciences in ashington hosts this event. it's about two and a hal hours. >> goomorning, everyone. i'd like to welcome you to the direct-to-consumer genetic

testing forum that the committee on science, technology, and law and its collaborators elsewhere in the national academy put together this morning. around the table you see members of panels who will speak during e next day and a half two days, as well members of the planning group who over the past two weeks and months have organized this discussion that you will participate in this week. barbara bierer and i, colleague on science, technology, and law, will moderate the discussion, which is to say we will stay out of the way. and we will follow a format that may be familiar to you. the presentations according to

an agenda which has been distributed to everyone in the audience, and around the table. then a bit of interaction among the planning group and speakers with prompt opening up of the floor to everyone here who has taken the trouble to attend. and i'm sure is very interested in this matter. cosponsors and collaborators in this within the national academy complex includes our colleagues in the institute of medicine. i think most everyone knows that the national academies i a complex of the national academy of sciences, the national academy of engineers, and the institute of medicine, and an active reform arm of convening and policy review arm, the

national research council, which came into existence during the presence of president wilson. the board on life sciences within the national research council joins us as well in the planning and execution of our program. so we want to welcome all members of the planning committee o panelists. and our audience and we will encourage panist toover their subject, as you will see in most cases power points. we do have about 20 minutes for discussion, andf the audience -- when the audience participatesnotice that there are a couple of microphones, two

there may beore, and you will need to go to microphones in order to be heard and second in order that you words exist for posterity. we will issue a report, it will t be the recommendations, it will not afford a platform for policymaking as some academy studies do. the report will be available to you, and you can access it through the committee on science technology and law web site. in time, it will be a period of time that will elapse for the edits process. but it will be prompt. other materials can be made available to you in the shorter run. i hope i've cover the preliminaries. if i'm missed anything, barbara, please chime in. >> nope. >> we think it would be a good

idea your quickly to run around the table and to have each of our planning group and panelists introduce themselves. i have say though it's not barbara's and my intention to introduce each panelist at length when the panelists speaks because you have in your possession of very ample resumés and i urge you to consult those fromour listening to. i will bin -- i'm the only lawyer that survived through the triage to participate, and i know that's deliberate. in the committee on science technologynd law we're pretty

well balanced 50/50 lawyers and scientists. but for this particular program we thought it important to draw heavily on the science and science policy involved for the direct-to-consumer testing. so that explained the formation of our panel. i practice here in washington, and i'm involved in law science issues. barbara? >> i barbara bierer. and may e remind everyone to press the button when you speak. and also to turn off your rious electronic reminders. i'm barbara bierer, i'm ofessor at medicine at harvard medil school and senior vice president for the restroom at brigman institute. >> good morning, my name is trish gamms.

i'm from the schoolf public health and also theohnson cancer center, and'm no medical oncologist by training. >> good morning, i'm susannah. i have to admit i too am an attorney. until very recently i was at the genetic and public policy center at john hopkins at director of law and policy with a focus on genetic information, discrimination. i will be the policy director for generations ahead in organizing their policies. >> i'm tim aitman, i'm professor of clinical and molecular

genetics in the clinical science center. byraing i'm a clinical lipiddologist. and my genetics of college diseases. most recently i've been a specifkist for the uk parliament and genomic medine. so i've had an interest in this area for a little while. >> i'm dick merrill. i'm a retired member of the faculty. pardon me, at the university of virginia and here in that capacity, i give fred some company. i'm also the cochair of the panel of sce technology and law that is the sponsoring organization for this event. >> scott woodward, i've been

working with the foundation for about 10 years. our background is in molecular genetics. >> i'm sandra lee from the stanford center, i'm a medical anthropologist. my work has generally based onager. based genomic. >> my background is in molecular genetics. >> jonathan, teach science at penn. >> joe, i'm director of the national coalition for genetibs, and i was trained originally in genetics counseling, but have been involved in genetic

education for about a decades. >> i'm age -- a genetic dealologt. >> i'm a pediatrician and genetic geneticist. >> i'm a genetic open deemologist by training. i also have an appointment at the national institute. >> good morn, i'm david korn, for the past nine month i've been the director of research and i'm also a member of the committee. >> ann marie mozda.

>> so thank you all. and welcome. i want to before we begin officially thank emory and steve kendall for really an unbelievable job putting this today panel together including last-minute changes and an enormous amount of organizal ability. so i thank you. with that david korn is go to introduce the scope of the workshop and the first pan today. david? >> is this on? thank you again. and welcome to all of you. i want to give a special note just because they travel to -- one of them traveled the furthest. that's tim aitman, who is sitting right here, who is professor in clinical and

molecular genetics. i believe it's the fact that imperial academic health science center is the first and only academic health science center in the uk. and maybe in western europe for that matter. it's really quite a uniquely american institution. and i had the pleasure of dining with the vice chancellor, i guess, of imperial when she was in the throes of trying to go ahead and create this. as you know for most university president, this is not trivial decision at all. i am a member of the board, i just wanted to acknowledge dick merrill, not only the vice chairman of the committee, but

he and fred anderson with a couple others of the committee which is 10 years old, 11 perhaps, the committee is an interesting one. this is an relevant to the meeting, by the way, because it is made up of half scientists half members of the leg profession, including academics. and it has a broad charge if you will which is to scan the environment at the interface of science, law, and look for interesting problem or interesting challenges. and it as in the process of such standing tt the matter of direct-to-consumer genetic testing caught our attention. we did have a session or two about it in regular panel meings and committee meetings. it was worth putting together

this workshop. the reasons for interest i think are dramatic. first the american publics very concerned in general about privacy. and particularly the privacy on the information which is a special kind of information. and particularly concerned especial, especially about genetic information for a whole host of reasons, many of them misconceived as a diary of a person's future which i think an eminent war professor write about a decade or 15 years ago and so forth. but given all of that and the incredible amount of political activity that taken place both at state and federal levels in this country around the protection of medical

information and of genetic information, it's very interesting now that we have a phenomenon where commercially there are organizations that were offering to provide genetic information to individuals. this is voluntary, nobodi is forcing them to spit in a cup or whatever one does, you got the genes analyzed. and we are amassing an amount of information about people. contributed voluntarily by the persons who are seeking these services. what we don know, and what we hope this meeting will illuminate for all of us is our -- a number of questions that have to do with how the testing is don what indicators of quality and validity, both

analytical and quarrel are not inherent in the system? what sort ofversight of the activities of these companies r from either legal or regulatory stand point? and wwill have an fda speaker early tomorrow morninghom -- who i hope will address some of theseatters. what happened to the information that the companies collect? who's is it? who does it belong to? to the pemple who do the testing or alysis? what protection are those who contribute this information. now, you may say gee, i'm being kind of picky about this. but the fact is with jonathan and marino and others in this room have many srs to show for battles exactly what medical and genetic information when it can be accessed, by whom, who's

going to use it, and i speak with humility about this matter. and there's a pathologist w has a lot tissue samples, those are also with the who can use this? who owns the fragments? who owns them? this is unrerolved in the united states. this has been three, at least, cases ruled that an individual no longer owns or controls the disposition of the piece removed from his or her body. but on a national level there is no consensus at all. another factor to consider that for a long time in the hiory of the evolution of genetics and medicine became familiar with single gene

disorders where if you have a particular genetic default or whatever, -- defect, or whatev, you have a clinical presentation. there wasn't any doubt about it. we are now dealing with a whole family of significant chronic major diseases of humans where the information that's rapidly assumelating is very strongly that there maybe no dominant gene that's going to be the include to this, rather one finds the informationith dozens or hundreds. and the contribution of each to congestive heart failure or whatever it is is entirely unclear. we know the contributionf very, very smallf the individual locus, maybe a percent on less. but clearly that's a lot more

going on in theses than simply finding one or two genes that are going to give us the magic bullet. with all of this uncertainly and all of promise, the rise of the dtc industry has been note the. and people clearly have interest in sending their sames in. some of them want to do is because they want to know about their aunts or relational kinships of that sort. but some of them maybe interested to know about their reaction to various diseases and whether or not they aht to be adviced to change their lifestyles. and yet when one wonders what real value i that ladder sense this points. i'm not sure it's clear to anybody to reason answer tt question. so this is a very rich anda of topics both specic, legal,

public policy, and i'm hoping very much that during the day we will learn a lot about this, and see where we will go from here. thank you all very much for participating. >> thank you, david. al guttmacher will talk to us about therivers of innovation, the human genome project, and the $000 genome. [lauter] >> the slides are behind se of us a little bit inconvenient, but for the rest of you it should work. if individualsant to get up and go over ifou can't see, feel free to move for the time being. >> go any place, if you leave the room i'll take it personal. i'd like to thank the organizers, i'd like to blame them fou minutes a piece for the topics.

so i'll need to. this is going to be 30,000 foot kindf look a basically the questions of where we are, how did we get her and where are we headed in terms of the some of the things we are all dealing with now. where are we? it depends who you ask. if yot ask a sciensts at the end of year 2007, many of the talks that you went to, this cover with the breakthrough of the year for human genetic variations many people are nowearing that t-shirt. but this certainly sets the stage for the kinds of things we're going to be talking about people. if you look more recently, the 2008 genomics had slipped. but in terms of sequencing, number ten, with a bullet, i think, and cancer genes at number three, we were talking

about application of genomics, as well as the tecology moving forward. if for some reason you d't like this side of the pond, we have the risk as intel that thoughthere was something here nature w the end of the issue in 2008, the year in which genomics goes mainstream. that's certainly what we are talking about during the day to day. they give several examples of that. but the fact that direct direct-to-consumer testing is available is not only getting the attention of public but scientists. and in fact in their write about, they talk about the fm 23andme now offered genetic testg for $399. you can also look at a copy of nature before that in november of 2008 and read "your lifen

your hands:instructions for the personal genome age." that cub -- could be the cover for the conference. look the at best invention of 2008, it is the retail dna test. i'll led you decide whether it's the best or that hassiest. they call it the best. how did we get here? in several ways. one of the human the human genome project. it's that in 50 years we went from the sequences of the distribution of the dna to the sweet sequences of our dna wiin 50 years. and in fact now the application of that knowledge are moving -- if there's anything we now about the medicine and technology that they move each year more quickly

than they did the year before. some of the applications and genetic testing is going to be moving very quickly. i think there was a sort of genome bubble back right around the time that the genome project ended where everyone expected the next day for everyone to be having all kinds of applications. i think every technology, people tend to overestimate t immediate impact of these new technologies. but in the other hand to really underestimate the long-term impact which i think is we're dealing with here tay. this can be seamannic or important, or perhaps it's both. many people are talking about where we are in the genome era or post-genome era. if there's anything we know, we were in pregenome until april

14,2003. if we are now in the post, that would suggest that the genome er itself was april shh, - april 14, 2003. if you slept in that day, you missed it. think we are just at beginning. we have not yet come to grips with how we're going t use this new technology and this new kind of information. so if that's where we are, very quickly, what's next? we face this question back actually as we're coming to the end of the genome project. this is the move i think a number of people this was peer science in 2002 which shows the grh for the number of human traits basically disorders for ich we know the genes involved. and it was very interesting.

if y look at some good new look at the pink line, there's 1700 or so, human diseases for which the new gene is invold. that's good until you realize the single disorders that are described there, there are probably to 5 to 6,000 of those. but i guess what really depressed me, look at the blue line and youeed to use the scale at the right. these are for common complex kis of conditions. some things like heart disease, stroke, diabetes, schizophrenia. for those you can see it's only about 30. but in fact theews is worst, because that in all species. nowf you look at human genes. that seems like a problem. we did the back of the envelope

population in 2002. the problem is that we keep using these candid gene applications. they were inadequate. we need to take an agnostic approach. what if you took 1,000 people and you searched agnostically to see where they differ and then focus in there to define the genes that were involved. it seemed like a nice idea. we knew that there were the so-called snips placed in the genome that we varied. and it turned out that instead of all three 3 billion of the genome, you can get a pretty good first order of approximation by looking at 10

million. take 1,000 cases and 1,000 controls, you do gee genome types. okay. do 20 million, it was 50 cent to figure out one position. so that was the nice as you can see $10 billion study. and the budget in 2002 was probablying? like $25 billion. it didn't seem that we would get very far if we ran around, and why don't we spent 40% of the budget for one disorder. we put the envelope back in the desk and kept it to ourself. then something happened. international hazmat. if the genome was about

anything, it was the variations for all of the differences that we see biologically. and the hazmat told us something about the structure and it demonstrated beyond a shadow of the dbt many of us had long suspected. we are a young species a we have not evolved very far. because we have not evolved very far, we have inherited or genome in large chunks. if you tell me someone has a a or c, i can again for the first order tell you with great accuracy exact what the genome sequence is going to be. it varies. but that allowed us to recalculate the problem. now instead of 10 million, you

can take 5,000 or so. so that's only 1 billion. also what's happened is new technologies had reduced the price to 50 cents to 1/12 of a penny. it's keeps getting cheaper and cheaper. it's the only thing that's growing faster than your ira in terms of value. it now took less than $1 million. if you have a budget of $25 billion, this is something you could think of doing it. people did. this is what led to genomewide association studies. the first of these is this one that was completed before the hapmap and looking at the generation or the first or second leading cause of the

cases. and that was interesting in that using actually fewer than 1,000 cases, eventually this was t this was able to identify three different gened involved in amd. and the gened contribute to something a little bit over 50% of the risk for the disease. this is for disease and particularly for genetic before. we knew the family history that someone would increase their chances. so these are common. this offers the possibility for people to begin the test individuals to see who would that genetically increase risk developing the disease. that's where we will focus on and a lot of people have focused on. i have to say i think that is less important than something el that the studies and other studies have showed us. that is it tells us about the

fundamental biology of beside. all three of the genes that were owed to play a role are involved inflammatory pathways. before this, almost nobody thought that amd had a large inflammatory component. was thought to be the disease that had to do with revas ration, et cetera. but this huge hint was that inflammation is very important one might think about using inflammatory to treat or prevent the diseas from occurring. trials are ongoing lking at those kinds of approaches. and it tells us something about fundamental biology. it sas broken up in the chromosomes, starting in 2005. then things start to pick up. you can see that we have added a

few more by the first quarter of 2007. we have probably doubled the numbers. :

will do in terms of pre- emblematic risk, it tells us a the first thing to say is the genome-wide studies are wonderful but they do not explain the most ability. ifyo]1do testing that is purely based on genome-wide service, you will not tell anybody about most of their inheritable risk for disease. by definition, it will be incomplete information.

i think it is more of these other mechanisms that re >> it will take some time to really be able to provide information. so what else is genomics going in ways that just to be one of some of what to what we're talking about today? some way to hapmap project, in finer detail. getting down to variation that's less, b still common enough t be a biological importance. and looking across many population groups. this is the encode project which is the pilot from which now full projects, buthis is probably the leading one. to really understand how does the genome function. it has been years now since we have at the old ideal but the one we all, the medical student, probably many of us in this room, i remind myself that

medical students have forgotten everything that i taht them. the idea that one gene makes one protein and all the rest that dna, that junk dna will o course, that joke refers to our ability to understand it. so the idea of really understanding complete genome. until we do that, you'll be able to really get people complete information and perhaps even accurate information about wha their risks for various diseases are. of the things that are happening in terms of genomics. this is the area of chemical genomics, which is getting into the question of the kind of drug rehab, drug development. if we took all of the drugs that we know today, tt is the over the counter drugs, under the counter drugs, streetcorner drugs, whatever drugs across the world, what percentage of the genome into proteins that the genes encode do you think we are targeted with all of those drugs? multiple-choice test. come up th an answer that you don't have to tell the person sitting next to you.

but it's only 2.5 present, about 500 genes out of this 20000á in so at we have all of the drugs we know today here maybe they are not draggable but that was to me that 95%, the viable space we haven't even gone to get. so that'something we are beginning already to see some al inroads creating ways for academia to have available to it, things that pharma had before, a collaboration and research at illinois state. didn know much about drug developer. coming up with new possible drs for schistosomiasis which is incredibly promising at this point. the cancer genome atlas, the idea of really trying to find all of the genetic variations that have to do with common

human cancers and eventually with the on common human cancers as well. this is a publication last fall in nature about glioblastglioblastoma which revolving reminded about over the last two years with the death of senator kennedy from this to have by far and away the best understanding we've had before of this tumor. other things that are happening. you will see here a thousand dollar genome and how much does it cost, how much does the sequencing of it, maybe a couple billion dollars, it was a coupl billion dollars to do this in the 2003 how much of it will cost in a few years. we think a thousand dollars. that may seem really ludicrous, that you could drive something from couple billion to a thousand over less than a couple

decades. but in fact we have reason to believe that is true. this is the co of genome sequencing over the last 10 years. and the cost is bically a fraction of what it was 10 years ago. and we are at the end of the curve where we talk about we were very proud of genomics. you know we had driven cost down to follow the law, just the computer may have been better or better. we could do much better that nobody stopped to plodded until recently. we are at the end of this kerrville. and the question is where do we go from here? so you can see methodologies guinea to come online now that we think if anything will cause the curve for a few years anyway to fall even more sharply before it levels off. so the idea of being able to completely see anyone'senome for only a thousand dollars is a few years ago. i think one of the things for you to be thinking about as we

have these discussions is not just about what can be done today, but what happens in a few years when you can offer to sequence anyone's entire genome for $1000, potentially keep getting less than that in fact. and how do we maka meaningful information? how do we use that and help, for private individuals, etc. etc., i think is something to certainly be aware of as we are having a discussion. so where are we headed? we are headed there so i will stop at that point and if you have some time for discussion. >> thank you, alan. questions? >> i really enjoy the fact that you approached that with respect to the expential growth and

knowledge and an amazing decpease and cost of doing this. last week i was reading a couple of pieces who points out that this thing has a thousand times the capacity of the computer that uses, and of an mit student at 50 years ago that took up a huge building. this seems to be happening in all human knowledge in the last 50, 60, 70 years in every field. and spite of the inherent differences between biology and as you've mentioned artificial intelligence. i was gng to ask you actually to extend that third curve, which you did, a make a point about the growth and knowledge inhis field. i wonder if i can challenge you to go back to that 2.5 present targeted genes.

if it's true as iteems to be that we keep underestimating how quickly these things change, and the last 50 or 60 years, where are we on that curve, if y are generous in your imagination with respect to how man genes we can tget? where would we be 20 years from now or 30 years from now? and i probablyon't be around to enjoy the fruits of that progress. and is our ability to imagine that limited by the element in your previous slide as to say and so forth? >> i thi that's a very good question, thank you. i think first of all there probably is a footnote in that ticle you are reading that developing new pharmaceuticals is the one thing which is actually asking that curve over the last 50 years. >> i don't read footnotes. >> you know, chemical genomics and it's not just using genomics. it is using tools and other

kinds of robotics, all kind of things that allow this to happen. but havi genome sequence, the map, certainly helps. clearly i think we can come up with new drug targets much more quickly than we have. what happened of course in the pharmaceutical industry is because of the weight industry in feneral is working with shorter and shorter time horizon, it's much more subjective if one is the head of a corporation for stockholders and etc. to think about tweaking some drugs or they can be used ce a day instead of twice a day because of their would-be market share for that. and it's much less up front work. they come up with a new completely category of drug. i think there will be some issues in term of even if we tarfet translate that into drugs. i think there is a reason to think that some of those steps, so-calle valley of death in drug development, can also be changed into how one gets through the valley of death. some of you may know that there

is a new congressional appropriations for the first time in fiscal year 2000 night and that gives nih $24 million a year. to specifically after you get targets to go further down, the road in terms of rare and glected diseases, rare ones being those that fit the definition of occurring in fewer than 200,000 people. and neglected being those that might be much more common worldwide, but they happen t folks who can't afford pharmaceutical. so the nih has some money and a mandate to see what he can do in terms of at least getting things further down the field to make it more attractive torivate entities. i think that's going to be a real challenge. yes, i think we'll ce up with completely new kd of drug targets because who understand biology better than we did before. think about amd as an inflammatory process, whether

you develop against small molecular things that are particular targets at the genetic mechanism at the underlying disease, even for people who have the same disease with some of the mechanisms. maybe that's why people say those rare variants and that's probab the biggest gwa, the rare variants by definition, how many people are going to affect? not that many, but what they tell us about the biology of disease may be incredibly valuable. even for people who don't have that, what tt tells us about the basic biological pathway of disease gives us new ways to interpret. >> david? >> a signal feature of much of the genome institute investment in unraveling genetic sequence and such has been making the data publicly available, posting the data within 24 hours, or

however the rules work. could you just described briefly, because i think it will come up later in the program, the precautions that the genome institute has imposed with regard to accessibili to all of this new information that's flowing in? >> that is a very important question. i think if you look, if someone looks back at the human genome project 100 years from now or even later and said what was his contribution to biology, in fact it's a major contribution was not the human genome sequence. we would have gotten that eventually we. we would have taken aot longer anderved its major contribution was the fact that it became a cardinal feature of the genome project international governmental genome project, that all of the data was going to b every 24 hrs uploading anybody who had a computer and played their electricity bill could download the entire informatn. that h been, you know, as part of our age, the age of wiki,

etc. etc., for sharing information andoming up with new ways to evaluata the that everything is new, and second of all, the field is unlike any artificial surface i've ever seen. i have hard time believing that any player is going to get their cleats caught up in this thing. the way it comes apart when you touch the grass is really amazing. >> what are the players saying? i mean, here's b.y.u. going to play oklahoma, joe. what are these players saying about getting the opportunity to play in this amazing facility? >> bomb -- b.y.u. didn't bring their players over to the stadium, but the coach made a point to bring them over here. they asked them to crank up the music. they had the dallas cowboy cheerleaders going, the introduction on the tv. oklahoma is doing a real walk through. b.y.u. had their cameras out,

walking around, big eyed, taking pictures of each other, taking pictures of the scoreboard. i see trevor mad itch, one of our colleagues taking a picture of the scoreboard. he's impressed by this thing, too. b.y.u. is definitely more starry eyed coming into this game. >> let's talk about the game. last time we saw the sooners, of course, they were losing to florida in last year's national championship showdown. how have they changed from then until now? >> linda, the big thing is that oklahoma loses four of their five offensive line starters, and in fact the guy who is going to start tomorrow at center for oklahoma is a con veried tight end, which is critical considering star tight ediger main gresham is going to miss this game and probably miss several weeks with a knee injury. that's the biggest thing. you know, how does sam bradford react, how does he hold up without the offensive line? they kept his jersey crisp and clean and white last year. who emerges at the wide receiver

position because he loses three key receivers from last year, too. >> and b.y.u. are coming off a third straight ten-win season. what are the key for the cougars to continue their success this year? >> also a big key is the b.y.u. offensive line. they also only bring back one offensive line starter, and his name is matt reynolds. he's going to play this game with a broken hand. so watch early in the game. if you see oklahoma's powerful defensive line getting penetration, that's terrible news for the cougars. bronco mendenhall told me a few minutes ago if his offensive roadside line cannot hold up early in the game, that could pose major problem for his stand-up quarterback matt carl. >> great insight. make sure you take a picture of that big screen and send me a copiment. >> it's on twitter. check it out, linda. check out twitter. >> that's right. i'm following you. well done. i'll do it. >> thanks. >> nice of them to turn down th volume when people speak, right

no one is above the rules, not even brett favre, who was fined today $10,000 for an illegal crackback block. favre went low on houston's eugene wilson on a running play in the third quarter. >> grady sizemore out for the season because of soreness in his left elbow, an injury which has nagged him for most of the year. it's an injury that requires surgery. he's only hitting .278 but it's a career -- hitting .248 but he's a career .278 hitter. he's a career .278 hitter. >> why today's m speak. speak. arf! that's it? ( ding ) ( engine racing ) ( crashing, spraying, honking ) ( tires screeching )

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>> day five at the u.s. open. tom rinaldi with bud owens. day when the sister act is in full effect, the williams sisters. "we sing. we dance. we steal we begin with serena. >> bad blood in paris, the french open. serena won it in three sets. during a furious rally, she hate ball that she thought struck sanchez' body, and she called it on her, but the point continued and sanchez won the point, so serena thought she was being cheated. he thought a player who was hit by a shot during a rally should identify it. >> in fact, she labeled her opponent outright a cheater after that round, and it was heard to say, she better not

come to the net again during that match. neither seemed to address the controversy prematch and serena seemed to take care of business as usual. >> you talked to serena. >> i did. i had chance to speak with her. she really didn't go there per sea. out on court she looked to be in strong form. she's getting better with every match. >> serena the defending champion rolls forward. her sister plays tonight. before we get to her, another american woman who has really captivated the crowd, and you know who i'm speaking of, melanie oudin. she's in mixed doubles actionment next up on the singles' side will be maria sharapova. >> the fair maid of marietta, georgia. 17 years old. what is she trying to do to the russians? she beats dementieva. now she's going to go after maria sharapova. there may be more. >> give you some credit. you have noticed her game from all the way back in wimbledon when she stretched it into the second week. what is she doing so effectively, bud? >> she's moving the ball very well and moving herself very well. she keeps, as she did with

dementieva, kept her in corners and kept her running, and she's a terrific competitor, and when it came down to match point, after she had blown two match points, she hits a service winner, a jammer into the ribs and what a shot on a winning point. >> certainly when it comes to movement. , there are some question marks about venus williams and all the attention focused on her knee. how serious do you think the injury is and is there any gamesmanship in it? >> i think it's serious. she's well strapped up. she tiewght get a golf cart. it would help her move better. i think she's hurting. test test test test test test test test test test test test test says. and she's always been a great competitor, as haser is row nap. so i don't think the injury is being blown up. it's there, and i think it's going to hurt her. >> certainly someone else who is effective in playing with adrenaline and whose knees are in question is rafael nadal. he's also in action.

for bud collins, i'm tom rinaldi. let's go back to bristol. >> >> at the 30, at the 20, at the 10. touchdown. touchdown bears. >> touchdown. passing left, touchdown matt forte. >> breaks the tackle. the 30, 20, 10, 5, matt forte. >> good job, bears! wow. >> it's time to blitz, and our focus is on the chicago bears who by the way today found out that kevin jones, running back, out for the year. the bears won three of the final four games in '08 to fin irk 9-. rookie running back matt forte now their number one led the team in rushing touchdowns. as for this coming season, the big move for the bears came in april when they acquired q.b. jay cutler from the broncos. here's mark schlereth with his

take on the '09 bears. >> well, a lot of new faces in chicago right now. jay cutler and the crew, but let's not worry about the offensive side of the ball. the biggest concern for the chicago bears, this is a proud franchise, a franchise that's always based itself on defense, the monsters of the midwest. well, to me there is one key linchpin for this defense, and that man, tommy harris. he has got to get back to an elite level. if he doesn't, this bears' defense, which ranked 21st overall last year, is going to struggle again. he's got to be the guy that penetrates, that ties up offensive linemen and keeps them off that elite line yakking core. if he can do that, they can go back to place of prominence. if not they'll struggle on defense one again. >> thank you, mark. you can see what our experts think of the bears. all you have to do is log on to espn.com and check out our three and out series. find that in the nfl home page.

>> i know i'm only supposed to choose one sleeper, but there's two guys i love on chicago this year, so i'm breaking the rules and giving you two sleepers. what can i say? i'm the bad boy of fantasy. first devin hester. listen, you know he's speedy, and now he has a strong-armed quarterback to get him the ball. he led the bear in targets and receiving yards last year, and this is the year devin hester puts it all together. i also really like tight end greg olsen. we've seen cutler use a tight end very effectively with tony scheffler in denver. now he gets greg olson, whose reception, yards and scores have gone up for two straight years. if you don't get one of the top tight ends, greg olsen makes a nice pick later in your draft. that's why he and devin hester are my fantasy sleepers for the chicago bears. >> coming up, avert your eyes and ears if the name brett favre infour yates -- infuriates you.

are you one of those people? >> perhaps. >> all leading to the season opener one week from today, espnews up bright and early, previewing all 32 teams division by division. it's "the blitz" preseason countdown special heading into the kickoff with the titans and steelers. mike hill your host right here on espnews. >> coming up, our top story, extensive coverage ahead on the season-long suspension of oregon's legarrette blount by oregon. stay tuned. let's hear it for nickelback!

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where winners eat. it's back to being hit with all the stresses of work. how was your weekend? it's day one of that 3 o'clock lull. and that guy who always asks, mind if i jump in? but monday night football is returning to espn, where adrian's moves will be making the guys in the booth say lean back! re-donk-ulous! play on playa! so relax and run steady. because on monday nights you roll with us-

three deep in the booth.  will be batting third, the lead off patter is pie, and he's batting .382. chris tillman will pitch for the orioles, the orioles and the rangers begin a 3 game series next, here on masn.   welcome to an evening of

orioles baseball. the first of a 3 game series. the orioles and 3 and 4 against texas. the rangers trail boston by 3. o's extra pregame brought to you by at&t. the orioles start chris tillman. 1-2. the rangers start scott felt man who's 14-4, a 3.72. welcome to o's extra pregame. kind have an interesting story with texas. nolan ryan the president of the rangers made his pitchers show up for two mini camps before spring training. they showed up able to pitch batting practice and the end result the rangers are in a pennant chase, they have 10 shut out and the fourth best e.r.a. in the american league. someone has figured it out.

this is a major problem in baseball. how pitchers get themselves ready for season. i don't think they are near close to being where they should be. if there's any team that could prove that point it's the orioles. we have one of if not the best bullpen in the american league and we would never know it. they get overworked. starters don't go enough innings. we have as good as talent as you can get in young starters, but they have to continue themselves to come into spring training ready to pitch, 3 to 4 innings and this takes a good long distance running program. i've been talking about this for years. the conditioning is the key for them to pitch longer and deeper into games. they have to have that endurance, the arms will fall in place. running is the key. nolan ryan has a great idea

bringing them to mini camp. s that juan area we -- one area we have lost. the better your legs are in shape the better you are in shape. >> you have to last long and hard. no tougher place to play than baltimore. it's hot, humidity and wears on. if you are not in condition you are nerving go be to win. >> our record proved that. let's look at the rangers lineup. the rangers have a potent offense. and joining us now is dave, the orioles bench coach, tell us about how you get kinsler out. >> kin less has more home-run power than roberts but a similar type hitter.

very good offensive player. can run, can hit for power. you have to go ahead and straighten him up inside. you have to straighten him up. >> dave, nelson cruz is a big home run hitter. he leads the club with 30 home runs, big rbi guy. he's a guy we have to be careful work stay out of the middle of the plate with him. s that right. a lot of home run hitters can only pull the ball. he can hit it everywhere. texas is a great place to hit fly balls, so is this park. you straighten him up to get him out down. mix in breaking balls so he chased. >> the rookie shortstop the andres. batting .268. tell us what you know about anderson. >> i mentioned one of guys we

should talk about. we're talking about young players the orioles young player. this is a young player for texas had a heck of a year. last time we faced him hitting number 9. now that he's hitting 2, we have to handle him as a 2 hitter. with a speedster on beforehand he's wanting the fastball. that doesn't mean we shy away from the fast ball. we do have to get to the breaking ball. >> we appreciate your comments and we'll look forward to them when the visiting teams lineup. the texas rangers do not have michael young, he injured himself yesterday and josh hamilton is not in the lineup. let's look at the orioles lineup. roberts making his first career start. third in the lineup. pie, 7 game hit streak, batting

.382 with 6 home runs and 13 rbis and 5 home runs in his last 9 games he will bat lead off. how about the switch and roberts third. not a bad idea considering the injury problem with the orioles. brian roberts hits well with men on base. hitting on a .298 clip with runners in scoring position. brian getting one less at-bat hitting with men on base and has a good average and driven in quite a few runs, 62 i think, brian robert. >> excellent with two strikes, one of the best in baseball and who late about the ball game is a threat. he is a guy i don't mind him hitting third. pie needs a shot in the lead off spot. we'll find out if he can do that tonight. pie batting lead off. we'll have more on that.

amber theoharis will join us now. that story is next when we continue on has in. on masn. (jim koch) hops are the soul

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 back. welcome back.  tom davis with rick dempsey in our coverage. orioles and rangers. pie is batting lead off and roberts in third. >> i spoke to felix about batting lead off and he's happy to be in the lineup. he does not care where he bats. that's because over the course of the season we saw his career flatline and come back to life. back in may, he had a chance to be the orioles every day left

fielder he didn't cut it. the orioles called up reimold. then for the next two months felix sat on the bench. he felt people gave up on him. the one person that did not was terry crowley. they working to in the cages over that period and now that felix had a chance the play. -- to play, we're seeing the results of that hard work. when i is spoke to the felix he got emotional when speaking about his success. >> the first half of the season. i keep working, he tell me i'm going to be fine. everything changed because, i work with him, what happened now, everybody can see him. i defend the home late.

i play the game better in was there a point in the season you felt people gave up on you and crowley stuck with you? >> it's very tough, very tough for me. early in the season. the only guy that stabbed -- stayed with me was him, with my family. call me and you know,. >> meant a lot you to? >> yeah. they have worked a lot together. this is a turn afternoon in the first 36 games of his season he batted .195 with 2 homers and four rbi. the last of a games a .382 with 6 home runs and 13 rbi. felix is working hard to prove he belongs to club.

he wants a roster spot in the future. remember, that outfield is locked up with markakis, jones and reimold. he's fighting to be the fourth out fielder of the future. >> thank you. amber will be along in the game and in the postgame. how about pie. putting pressure to team for the playing time with what he's doing. >> i've seen another side of felix. this is a side i like. we have seen that he makes a lot of mistakes and doesn't seem he knows how to play the game the way he should. which is true. the basic tools are there. he can hit and hit with power. he's proved that. after he lost his job the first month of the season he sat on the bench and watched and see how guys do thing and knew he had to make adjustment and he did. i love his spirit. put somebody in charge of him and ever othery time he steps

out of line you impress he has to be disciplined if he'll be one of the best in baseball. i think we have a gem here. we have to polish it up. bergen pitched against the yankees the other day. 5 1/3. pitched effectively and evaluated what he did. >> yeah, i think obviously, missing the off speed punishes and i was able to get ahead tonight against a team like this. it takes a lot of pitches it's important to get ahead. the ability to get the breaking balls over, change-up over, fastball count. >> happy about the way you pitched in. >> yeah. thinks are better. i feel i've been getting

better. and tonight i was happy the way i threw the ball. the thing was to keep the ball in the park and on the ground. matt did an awesome job. we are on the same page the whole night. it was good. >> berken 2 wins, no losses, 4 and 11, and rick, it appears berken has pitched in more games than the rookies and his e.r.a. comes down. >> i like about this guy, he's a bulldog. he's been slapped around the first few ball games he realized the adjustment he has to make. he has to keep the ball down. i have to say, one thing you have to do, improve to fastball, improve on to change up if you're staying in the rotation and be successful he needs more movement to fastball, change of speed to

change-up. right now he does not have afternoon out pitch. if he's flying to win ball games he'll get hit. he will give up 3, 4, 5 runs a game and try to win. that won't work. make the two improvement. fastball, change-up. we may have something there, he has the heart. the experience he's getting in the starting rotation. not a lot of pressure other than they wants to stay in the starting rotation. >> he's out there every day. he got a break where that's a couple of injuries and didn't get sent back. 10-1, or 1-10, he has no choice. go out there and make the adjustment, because other way he won't be back next year anyway. may get an opportunity at spring training. the adjustment he's making will help him a lot. forget the win-always. cut the amount of runs he's throwing. cut getting deep in the ball

game. the pitch up to 100 pitches. he needs to work the change-up. the experience is coming. he doesn't look like he's afraid, it's a matter of him taking his time and thanks the game out bet near it will be inning to see how it involved with the orioles. by the way, tomorrow national television for the orioles and the rangers, 4:00 start. a 4:00 start, it will be on fox network tomorrow on the orioles radio network. on sunday 1-30 game, 1:00 pregame. the orioles are off on monday. go to boston for 2, tuesday and wednesday, off oned this. a team that plays 30 games in 41 days is in the mid-/of 3 off- days in -- midst of 3 off-days in 7. it's an afternoon game

starting at 4:00. we'll be back and take a look at the starting pitch where's we continue in just a moment on masn. ♪ ♪ i always feel like somebody's watching me. ♪ (announcer) it's right here, it's easy... ♪ always feel like mebody's watching me. ♪ ...it's the money you could be saving with geico.

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 getting ready to fly ranger dave trembley talked about the check in lineup for brian roberts batting third tonight. >> my thought process is my number 3 hitter adam jones is out for an extended period of

time, as soon as he did that, that night i sat in the clubhouse, and said what can i go to put the best lineup out there, what can i do to see how we can help the team, plus pie has swung the bat well. i talked to brian. i don't know if you talked to him. i talked to brian on wednesday, and i said if you're comfortable with it i would like you to consider hitting third, jones is out, and if you're not comfortable with it, that's fine. but i think it gives the team more balance and i've got you and mar cageis hitting,:00 markakis hitting third and fourth. you want to try the put your two best hitters in the middle of the lineup. i lost one of my best hits in jones.

gives us an opportunity to see what pie can do. brian said he was fine. don't tell me that if you are don't feel that. he said i will do what you need to help the team. this is more about roberts than me hitting third. you're trying to protect the pitchers and shut down the season early for tillman and mathis. you will be in tune to body language and stuff like that. >> with all of them, i mean, you guys have followed the club, you can see it just as capably as i can see it. you look for guys yanking, trying to hard. overthrowing. forcing it. too many pitches to get 3 out. too many tough jams to get out early in the game. we start friday the other

night. 2 strikes and foul 'em off. foul 'em off. pitch counts get out of sync, not total, but in an inning. that's what you look at. luckily, tell man got an -- tillman got an extra day. madison on 6. the next time they pitch they are on a full 7. we're giving, it works out well for them. i mean, there's a day off gone back to hernandez and berken, another day off and go back to tillman, madison, guthrie at yankee stadium. they are getting extra days but you monitor closely the amount of effort that they have to put in. each time they go out.

>> dave trembley. chris tillman for the orioles. 1-2 with earned run average at 1.24. dempsey's scouting report and the rangers starter comes up next on the orioles xtra pregame show on masn. rushing in unprepared may prove overwhelming... with all that juicy, 100% angus beef. there! you found a point of entry! the bacon beckons like a springboard to paradise. one small bite for man... etcetera, etcetera. angus axiom number 11: bring on the bacon. the astonishing new angus third pounders. all angus. all mcdonald's. ♪ ba da ba ba ba

 the scouting report. chris tillman. >> he's doing a good job, holding his own, in his last 5 starts given up 3 earned runs or less. that shows me something that he's moving in the right direction and showed the orioles and rick that he's starting to understand what pitching at the manger league level is about. hebers down when he's in trouble. the opposition is only hitting .217 off him and with runners

on base only hits .222. the young man bears down. he has the pitches to pitch at the major league level and shows it. >> scott feldman for texas. >> he's looking for a road record. he's 10-1 on the road. that's the highest road winning percentage in baseball right now. 909. very tough to pitch on the road. he's about to set the record, 11 would tie him with rick hellings for the most win. 12 would give him the record. he's considered the trouble with right-handed hitters. those are the guys he should get out easy. they hit .275. lefties have trouble, that's odd. they only hit .228. he uses more off speed against lefties than right niece the key of the game is keep kinsler

corralled. look at the numbers he hit. two 5 game hit strikes and both against the orioles. his average at camden yard .3 skate. he's only -- .358. he hits most against the orioles. >> the player to watch. brian roberts a double away from setting the record. hit .452 again the rangers. he's a killer. now he's in the number 3 slot. he will come up with a big hit tonight. >> you surprised texas is a contender? >> they figure it it out with the pitching. you won't win without good pitching and nolan ryan is to right track. >> it's will be the orioles and the rang terse first of a 3 game certifies. chris tillman for orioles.

scott held man for texas. jim hunter and buck coming up. ♪

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