hello read welcome to in good shape coming up. against blood therapy how does it work. liquid biopsy a new tool for cancer diagnosis. and blood transfusions what are the risks. and. and here's your host dr coston they could talk. imagine me writing this bike 3 times around the world i would surely have to see a mechanic to get a few paired sometimes not so hot and this is the distance our blood travels around in our bodies have rolled times because our optimism veins at

a distance of more than 100000 kilometers and this is not all blood down as it helps us doctors to diagnose certain diseases sometimes even before a patient gets symptoms and. that's why i'm here at that today this is where 65 moving blood samples are examined every year the scientific director office all this and with help he knows everything about not he will tell us how a few drops of it can tell us everything about all heart these are all people. not testing is an essential part of modern medicine. scientists are discovering more and more in the blogs telephone place is doing research because of the team belief on how to be take cancer in an early stage or to specifically target you. nowadays way to treat constipation. he will he with the

help of the what biopsy. for instance does blood was like aspirin is for us today it was a cure for many things like behaving and blood against leprosy or drinking fresh schuman blood against seizures or just think about bloodletting to get rid of all the evil forces in the body well blood is not that creepy any war but it's amazing what blood can do. the heart continuously pumps blood around the body up to 10000 liters flow through its chambers every day enough to fill 50 bathtubs. the largest artery is the aorta and it says thick as a garden hose while the tiny compare eats affinity than a human head. they form a kind of transport network. and blood is the body's delivery service it supplies the cells with everything they need like sugar ion fat oxygen and hormones

. blood flows through the arteries at speeds of up to 2 meters a 2nd. and on its way back to the heart it brings waste products from the body cells like c o 2 and urea. more than half the blood is made up of a plasma which is mostly water. some of the bloods components are made in sight the bones. they yellow marry contains he made a attic tissue where billions of new blood cells are produced every day the different types of blood cells start off a stem cells through a process called cell differentiation they become white blood cells platelets and red blood cells and they all have completely different jobs. blood

platelets prepare the wounds white blood cells such the body for dangerous viruses bacteria and toxins certain white cells called plasma cells produce up to 2003 bodies a 2nd they target foreign substances in the body known as antigens to neutralize or destroy them red blood cells contain hemoglobin which binds to oxygen this is how blood gets its red color the more oxygen it contains the brighter the red. blood is sometimes referred to as a liquid organ which is no exaggeration considering the many vital functions it performs. i'm here with professor wood of tell by the scientific director of ghrelin lab thanks for having me today it's more pleasant you're a left physicians and a blast specialist so what's so fascinating about blood well

a lot is a peculiar fluids a very very complex mixture and it reflects like a mirror or a looking glass the condition of a patient both pursue respect to health and disease and we can find out a great lots of informations about the patient so are there any alarm sides that you can see in the blood before the patient even have to see his symptoms yes you address the matter of early diagnostics or what would even be better of prevention in germany we take a chinese drop of blood from a newborn child and any lawyer sits for markers of seaview diseases there are new methods in the lab like aspect of the tree where

do you use mass spectrometer for. he used in the clinical lab is a quite new development and mass spectrometry allow the identification and detection even of molecules which have been to this state unknown of course when the patient takes a rock which has potential side effects it's essential to monitor the concentration. and since to date many new drugs are happily for the patients benefits introduced into therapy it's essential that we in the lab able to detect and to quantitatively measure these new drugs and this is feasible by the use of mass spectrometry are there any tests that everyone should take essential tests include for instance cholesterol since

cholesterol is a real important risk factor for coronary heart disease 2nd i would recommend to do basic testing for liver diseases kidney model function i would have a white and red blood count and for female patients i recommend to enter law is the concentration in the clouds so if you don't want to see your g.p. there are some companies that offer blood tests over the internet what you think about this i personally have my serious reservations about blood testing over the counter without the it why is of a medical doctor or a general practitioner the reason for this is that a test result must be interpreted and evaluated and this requires medical

knowledge. it's the interpretation of the sentence to link the tests for solids with the personal history of the patient the medication the symptoms and other medical conditions and this is really important to come to the right conclusion based on the tests for so it's always see you trape 1st except you know when the 1st blood transfusion was performed it was 1492 when the pope was sick so he did fresh blood and he was given that from 3 young children unfortunately 3 children died and the pope didn't get well got transfusions and now it is routine procedure in medicine but they're not without danger. because alamut is about to have bypass surgery it's a procedure with a high risk of blood loss and the host is understandably worried. pretty

frightening sure as. it's standard practice to have blood reserves on hand during the procedure but the doctors here at the university in frankfurt taking a different approach. because of. major operations are a bit like running a marathon so we get the patients ready the way people prepare for a sporting challenge from the system to in terms of hemorrhaging hemoglobin plays a big role due to the higher the hemoglobin levels ahead of an operation the more of a buffer you have if they drop during surgery. that's the key factor in deciding if the patient needs a blood transfusion that's why the patient's blood is fortified with iron before surgery and doctors establish if there's any likelihood of a coagulation disorder a transfusion is always a risk. of blood transfusion introduces a range of foreign cells it's comparable to an organ transplant and howes

immunological consequences fictive. even a transfusion from the same blood group doesn't rule out a defensive reaction like fever hemorrhage or nausea. but we know that you can give a patient too much blood and overtaxed their circulation it could even cause a problem an area deemer so it's extremely important to be very careful and only give the patient the exact quantity they need. to keep in addition it's better to err on the side of caution hospitals have developed patient blood management programs to prevent blood loss during and after surgery for example doctors can use what's called cell salvage during an operation that's a way of collecting the blood lost during the procedure. it can then be infused back into patients if necessary. they are also kept warm with heated blanket it's. keeping the patient warm helps optimize blood coagulation so the patient loses less

blood germ surgery something of that $36.00 degrees is the baseline temperature for blood platelet function platelets react to bleeding by clumping thereby initiating a blood clot researchers at the university hospital in frankfurt have developed a small heart lung machine that helps limit blood loss after surgery lost can also be limited by taking smaller amounts of blood during tests. nation blood management programs can help possibly. cut blood transfusions by 50 percent. they also ensure the hospitals have sufficient reserves for patients such as was left which we definitely will need donor blood. and was in the we've noticed that your hemoglobin levels are on the low side. in him. she requires

a transfusion after her hip operation for some patients it can be a lifesaver so every drop of blood matters. i'm still in burlap with professor talbot. black is also very important for the diagnosis of rare diseases can you give me some examples yes this example is for a new kettle nuria it is east caused by this order of amino acid metabolism children affected by the d.c.s. suffer from them it shows of the brain and suffer from mental retardation if the disease is they are going or was early enough that children can develop normally through a diet and all this can be diagnosed from

a very small drop of blood. if there is something special about. it is that it's very closely connected to research can you leak some secrets what kind of research is going on yes. we are very keen quite hard. to improve analytics of rai lot spots this means. a drop of blood put onto a small paper card and draw it and it will ask why we are doing that the reason for this is that it may be difficult to transport liquids plot samples in some areas geographical regions and it's much more easy to transport a dry plot spot on or caught in an envelope put into the mail a 2nd example is analytics and diagnostics to

detect and to monitor or malfunction of kidney diseases or at kidney disease and here we develop new markers which allow and facilitate to properly estimate the degree of kidney malfunction many of my patients ask me if it's possible to detect cancer in the blood so is it possible well early detection of cancer in the blood is a real challenge. and with the exception of prostate specific antigen p.s.a. to my personal view we have no screening chil marker which allows early detection of cancer. but there are prospects that we will be able to develop such tests based on genetic or and epi

genetic testing and biochemical testing and possibly also based on liquid biopsy thanks so much for this interesting talk thank you it was my pleasure let's take a closer look on the test called liquid pipe see college to get some client you feel a little jam but you know that already taken essential. to book so has come for a checkup. just 2 more and we're done. the blood test spares cancer patients are paying for a risky procedure to extract tissue from the tumor a standard biopsy wasn't an option for her anyway. it was. there in such all could positions in both the lungs but they're hard to reach. she hopes this liquid biopsy will help or switch to a targeted medication and come off chemotherapy which affects the entire body. and

i felt awful at the start the chemo wreaked havoc it really affected my blood values. the clinic that treating belongs to a network of experts by testing the tumour d.n.a. in the blood samples they can often determine which subtype of cancer the patient might have targeted medications had been developed for certain types of the disease including. this week when we might be able to give you medication in tablet form. but so far the medication has only been approved for ovarian cancer not for a tumor in the long so i. was there one day an oncologist will treat pretty much every type of tumor regardless of whether it's breast cancer or ovarian cancer or something else the aim is to characterize tumor cells more and more precisely and to develop more drugs that allow us to move away

from chemotherapy. that would be of great benefit to patients who would have less hair loss or other side effects the problems you otherwise get don't happen when the therapy targets only the cells which help patients quite a bit. has been having chemotherapy for 5 years now and she still has her ups and downs. i have a lot of support from my family my husband my daughter my grandkids they always pull me back up when i'm feeling low. milage mother. she's hoping the drug will soon be approved for her cancer too so she can switch to the targeted medication. and gives dr claudia foible at the berlin charity you're performing the so-called liquid pipe see what thread currently guide aspects of star

tissue so-called sections of buyers sees. this collection and that can be difficult in patients with poor general conditions like cancer patients and status and nowadays we have the option to do this analysis that others us off to more south genetic information on that because biopsies so that means you're taking a blood sample of the patient and you're looking for diego for tumor cells right we start with the collection off a little mound of a lot that we isolate the d.n.a. of from the patient which contains the genetic information of the benign cells and also information of our selves what kind of information do you gain from this boxing actually we're looking for resistance mutations that this means we're looking for changes in the genetic information of the tumor cell which lead to probably a progress of the tumor in the patient and so that we can change the therapy of the

patient accordingly so does it mean that it helps you to find the right kind of repeal or just to just. it's a bit of both so actually we are of course hope that we can change the therapy of the patient in order to have a better chance for the patient and other any other advantages of method one is that it is minimal and base enough so you can probably do a kind of money touring for the patients you can collect the blood. in serious and check if the resistance cures and you can do it many times before you see a change in probably c t e r m i t. right now you're performing this kind of examination of tumors so if you look into the future with other tumors you can do this examination you know this is a very promising method and very valid so we expect to have this kind of analysis

whole breast cancer and very near future thanks so much for the interesting talk this is a very modern method doctors are doing with the patients blood but doctors have been taking that from patients for centuries and they're not just taking it they're giving it back to the. autologous one therapy is the treatment of disease by using a patient's own blind. to begin with i found it a bit spooky the idea of having my blood taken twice a week and then getting it reinjected over a fairly long period of time. but claudia hoff gave it a try she suffered from herpes for a number of years and kept on getting blisters forming on her back at 1st she tried a conventional approach. as if one long haul my dermatologist prescribed anti-viral drugs which i was supposed to take for 3 months. but fairly

quickly after a few weeks it was obvious i wasn't tolerating it well. this is familiar with the problem antiviral drugs can be an effective treatment against her peace but he's also found that for some patients alternative treatments work better such as calling his blunt therapy something he's researched himself but the shouting hospital in berlin. says that it was in the cards he says for cancer treatment that dates back to antiquity in the past it was seen as magic the significance of blood also played a role nowadays autologous blood terror being also called also him a therapy is used in alternative medicine as a stimulation therapy designed to alter our modulating immune system. so says i'm someone who says she. it affects my whole body. the last. cloudy off began the treatment in the spring to start with samples of blood were taken from a vein in her arm over

a period of weeks. each time the blood that was removed was then immediately injected back into her gluteal muscle with a 2nd sterilized syringe with no additional processing. the whole blunt there of being involved gradually raising the dosage to 5 millimeters per session then reducing it again. how exactly does the therapy work. as i was in news of the. blood drawn from a patient's brain and reinjected into their muscles triggers a complex immune reaction that the details of this reaction have not yet been fully researched and understood but the reaction is triggered over and over we can boost it further by increasing the dosage which boosts the stimulus to. the cereal application gives rise to a sort of training effect that stimulation the immune system and thereby improving

the body's immune competences it's also a regulation. on this couple. studies appear to confirm the efficacy of autologous blood therapy. that only given. it's a few studies have shown that it's effective in treating hives or to cardio. is good now there's new research from a bomb for example that shows that therapy is also helpful with chronic fatigue. a clinical observation study at the shopping today has also shown that it's effective in treating her piece and the positive effect is still apparent a year after the treatment that's encouraging news for cloudy hoff. other forms of the treatment and false some change to the blood before it has reinjected such as oxygenation ozone nation or the addition of homeopathic remedies

designed to further stimulate the immune system as yet there are no scientific studies on this. during and after the antichrist blunt therapy claudia hopes condition did improve a bit she gets blisters and they also clear up faster. i felt very good during the treatment. there was a positive experience much more so than i would have expected. that positive effect could be further boosted by a refresher round of treatment the treatment should always be done in a specialized practice hygene is of course essential. fans in the meantime decided to go for a 2nd round of autologous blood therapy. which. i can see there's been a change so i feel it was worth it in the end and there was nothing spooky about it at all. there's still no scientific proof that alter him with

a repeat works so if you want to have a go with it 1st check with your g.p. like us g.p.'s always like your questions like i do. want to help coming show we'll be looking at sleep a many people take sleeping pills but they can be addictive how often can they be used and what are the risks if you have a question about that senator in good shape at d w dot com don't forget to write sleep aids in the subject line we look forward to hearing from you. that's enough for today. and until then let's all try to stay in good shape.

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