but never gives up just like his on. 60 minutes. what secrets lie behind these memos. but find him an immersive experience and explore fascinating blue and cultural heritage sites at the end of the d w world heritage 360 the good. hello and welcome to any good shape coming up. autolycus blood therapy how does it work. liquid biopsy a new tool for cancer diagnosis. and blood transfusions what are the

risks. and here's your host dr cost and they could tough to. imagine me lighting this bike 3 times around the world i would surely have to see a mechanic to get a few paired sometimes not so hot and this is the distance our blood travels around in our bodies have are at all times because our optimism veins at a distance of more than 100000 kilometers and this is not all blood down as it helps us doctors to diagnose certain diseases sometimes even before a patient gets symptoms. and that's why i'm here at berlin's that today this is where 65000000 lots and lots are examined every year the scientific director office all the above told us he knows everything about not he will tell us how few drops of youth. tell us everything about all of these are. not testing

is essential part of medicine. discovery more and more of your focus is doing research with the study. on how to take in early stage or to specifically target. nowadays where you go to treat cancer patients with the help of the biopsies. for instance just blood was like aspirin is for us today it was a cure for many things like believing and lot against leprosy or drinking fresh schuman blood against seizures or just think about bloodletting to get rid of all the evil forces in the body well blood is not that creepy any war but it's amazing what blood can do. the heart continuously pumps blood around the body

up to 10000 liters flow through its chambers every day enough to fill 50 bathtubs. the largest archery is the aorta and it says thick as a garden hose while the tiny affinity than a human head. they form a kind of transport network. and blood is the body's delivery service it supplies the cells with everything they need like sugar ion fat oxygen and. blood flows through the arteries at speeds of up to 2 meters a 2nd. and on its way back to the heart it brings waste products from the body cells like c o 2 and urea. more than half the blood is made up of plasma which is mostly water. some of the blood's components are made inside the bones. they yellow mary

contains he made by attic tissue billions of new blood cells are produced every day the different types of blood cells start off a stem cells through a process called cell differentiation they become white blood cells platelets and red blood cells and they all have completely different jobs. blood platelets prepare the wounds white blood cells urge the body for dangerous viruses bacteria and toxins certain white cells called plasma cells produce up to 2000 dandy bodies a 2nd they target foreign substances in the body known as antigens to neutralize or destroy them red blood cells contain hemoglobin which binds to oxygen this is how blood gets its red color the more oxygen it contains the brighter the red.

blood is sometimes referred to as a liquid organ which is no exaggeration considering the many vital functions it performs. i'm here with professor would have told by he's the scientific director of berlin lab thanks for having me today it's my pleasure you're a laugh physicians and the blood specialist so what's so fascinating about blood well a lot is a peculiar floyds a very very complex mixture and it reflects like a mirror or a looking glass the condition of a patient both pursue respect to health and disease and we can find out a great lots of informations about the patient so are there any alarms sides that you can see in the blood before the patient even have to see his symptoms yes you

address the matter of early diagnostics or what would even be better of prevention in germany we take a chinese drop of blood from a newborn child and any law use it for markers of severe diseases there are new methods in the lab like aspect of the tree where do you use most bitterly to form. the you in the clinical lab is a quite new development and mass spectrometry allows the identification and detection even of molecules which have been to this date unknown of course when the patient takes a rock which has potential side effects it's essential to morny tore the concentration. and since to date many new drugs are

happy early for the patients benefits introduced into therapy it's essential that we in the lab able to detect and to quantitatively measure these new drugs and this is feasible by the use of mass spectrometry are there any tests that everyone should take essential tests include for instance cholesterol since quest or is a real important risk factor for coronary heart disease 2nd i would recommend to do basic testing for liver diseases kidney model function i would have a white and red blood count and for female patients i recommend to enter law is the concentration of the lot so if you don't want to see your g.p.

there are some companies that offer blood tests over the internet what you think about this i personally have my serious reservations about blood testing over the counter without see it why is of a medical doctor or a general practitioner the reason for this is that the test result must be interpreted and evaluated and this requires medical knowledge. it's the interpretation of the symptoms to link the tests for solids with the personal history of the patient the medication the symptoms and other medical conditions and this is really important to come to the right conclusion based on the test result always see you drippy 1st except you know when the 1st blood transfusion was performed it was 1492 when the pope was sick so he needed fresh blood and he was

given that from 3 young children unfortunately 3 children died and the pope didn't get well the transfusions routine procedure medicine but they're not without danger . because alamut is about to have bypass surgery it's a procedure with a high risk of blood loss and the house is understandably worried. on some pretty frightening shore so. it's standard practice to have blood reserves on hand during the procedure but the doctors here at the university in frankfurt are taking a different approach. of course it's a warning to us as major operations are a bit like running a marathon so we get the patients ready the way people prepare for a sporting challenge from the system to in terms of hemorrhaging him a globe and plays a big role due to the higher the hemoglobin levels ahead of an operation the more

of a buffer you have if they drop during surgery. that's the key factor in deciding if the patient needs a blood transfusion that's why the patient's blood is fortified with iron before surgery and doctors establish if there's any likelihood of a coagulation disorder because a transfusion is always a risk. if you bring enough blood transfusion introduces a range of foreign cells it's comparable to an organ transplant and house immunological consequences fictive. even a transfusion from the same law group doesn't rule out a defensive reaction like fever hemorrhage or nausea. but we know that you can give a patient too much blood and overtaxed their circulation it could even cause a problem an area deemer so it's extremely important to be very careful and only give the patient the exact quantity they need. bookkeeper in addition it's better

to err on the side of caution hospitals have developed patient blood management programs to prevent blood loss during and after surgery for example doctors can use what's called cell salvage during an operation that's a way of collecting the blood lost during the procedure. it can then be infused back into patients if necessary. they are also kept warm with heated blanket it's. keeping the patient warm helps optimize blood coagulation so the patient loses less blood germ surgery something of that $36.00 degrees is the baseline temperature for blood platelet function platelets react to bleeding by clumping thereby initiating a blood clot. researchers at the university hospital in frankfurt have developed a small heart lung machine that helps limit blood loss after surgery lost can also be limited by taking smaller amounts of blood during tests.

patient blood management programs can help hospitals cut blood transfusions by 50 percent. they also ensure the hospitals have sufficient reserves for patients such as was left which we definitely will need donor blood. and was induced there but we've noticed that your hemoglobin levels are on the low side to meet. him. she requires a transfusion after her hip operation for some patients it can be a lifesaver so every drop of blood matters. i'm still in burlap with professor talbot. black this also very important for the diagnosis of rare diseases can you give me some examples yes this example is for cattle nuria it is east caused by this order of amino acid

metabolism children affected by that is nice suffer from them it shows of the brain and suffer from mental retardation if the disease is diagnosed early enough that children can develop normally through a diet and all this can be diagnosed from a very small drop of blood. if there is something special about. it is that it's very closely connected to research can you leak some secrets what kind of research is going on yes. we are very quiet heart. saw improved analytics of ra a lot spots this means. a drop of blood put on to a small paper card and draw it and it will ask why we are doing that the reason for

this is that it may be difficult to transport liquids plot samples in some areas geographical regions and it's much more easy to transport a dry lot spot on a card in an envelope put into the mail the 2nd example is analytics and diagnostics to detect and to monitor or malfunction of kidney diseases or at kidney diseases and here we develop new markers which allow and facilitate to properly estimate the degree of kidney malfunction many of my patients ask me if it's possible to detect cancer in the blood so is it possible well early detection of cancer

in the blood is a real challenge. and with the exception of prostate specific antigen p.s.a. to my personal view we have no screening chill marker which allows early detection of cancer. but there are prospects that we will be able to develop such tests based on genetic or and epi genetic testing on biochemical testing and possibly also all based on liquid biopsy thanks so much for this interesting talk thank you it was my pleasure let's take a closer look on the test called liquid pipes the polish to get some client you feel a little jam but you. no there already. go to book so has come for a check up. so soon just 2 more and we're done. the blood test spares cancer

patients a pain for a risky procedure to extract tissue from the tumor a standard biopsy wasn't an option for her anyway. isn't. there in such all quit positions in both the lungs but they're hard to reach. she hopes this liquid biopsy will help her switch to a targeted medication and come off chemotherapy which affects the entire body. and i felt awful at the start of the chemo wreaked havoc it really affected my blood values. the clinic that street in turbulence to a network of experts by testing their tumor d.n.a. in the blood samples they can often determine which subtype of cancer the patient might have targeted medications have been developed for certain types of the disease including hooter's. in this movement where we might

be able to give you medication in tablet form. but so far the medication has only been approved for a very in cancer not for a tumor in the long. you know. one day an oncologist will treat pretty much every type of tumor regardless of whether it's breast cancer or ovarian cancer or something else the aim is to characterize tumor cells more and more precisely and to develop more drugs that allow us to move away from chemotherapy. that would be of great benefit to patients who would have less hair loss or other side effects all the problems you otherwise get don't happen when the therapy targets only the tumor cells which helps patients quite a bit. has been having chemotherapy for 5 years now and she still has her ups and downs so i have

a lot of support from my family my husband my daughter my grandkids they always pull me back up when i feel. she's hoping the drug will soon be approved for her cancer too so she can switch to the targeted medication. and gives dr claudia photographed at the berlin charity you're performing the so called good pipe see what thread currently aspects of star tissue so-called trisection is a buyer of sleaze. this collection and that can be difficult in patients with poor general conditions like cancer patients and status and nowadays we have the option to do this and now there's another source of 2 more south genetic information on because biopsies so that means you're taking a blood sample of the patient and you're looking for d.n.a. of the tumor cells right we start with a collection of a little mound of a lot that we isolate the d.n.a.

of from the patient which contains the genetic information of the benign cells and also information off of your selves what kind of information do you gain from the spot saying actually we're looking for resistance mutations so this means we're looking for changes in the genetic information of the 2 muscle which lead to probably a progress of the tumor in the patient and so that we can change the therapy of the patient accordingly so does that mean that it helps you to find the right kind of repeat or just a just a very it's a bit of both so actually we have of course hope that we can change the 1st year of patients. in order to have a better chance for the patients and other any other advantages of theirs method one is that it is minimal and they sniffed so you can probably do

a kind of money touring for the patients you can collect the blood. in serious and check if the resistance of cures and you can do it many times before you see a change in probably c t e r m i t. right now you're performing this kind of examination of tumors so if you look into the future with other tumors you can do this examination you know this is a very promising method and very valid so we expect to have this kind of analysis for breast cancer and very near future thanks so much for the interesting talk this is a very modern method doctors are doing with the patients blood but doctors have been taking that from patients for centuries and they're not just taking it they're giving it back to them. autologous blood therapy is the treatment of disease by using a patient's own blind. to begin with i found it a bit spooky the idea of having my blood taken twice

a week and then getting it reinjected over a fairly long period of time. long. but claudia hoff gave it a try she suffered from herpes for a number of years and kept on getting blisters forming on her back at 1st she tried a conventional approach. as if it was my dermatologist prescribed anti-viral drugs which i was supposed to take for 3 months. but fairly quickly after a few weeks it was obvious i wasn't tolerating it well. michelle answers is familiar with the problem antiviral drugs can be an effective treatment against her piece but he's also found that for some patients alternative treatments work better so just calling this blunt therapy something he's researched himself at the shoddy to a hospital in berlin. says that of others in the crowds this is for cancer treatment that dates back to antiquity in the past it was seen as magic the

significance of blood also played a role nowadays autologous blood terror being also called although he meant therapy is used in alternative medicine as a stimulation therapy designed to alter modulating immune system. it affects my whole body. of. cloudy off began the treatment in the spring to start with samples of blood were taken from a vein in her arm over a period of weeks. each time the blood that was removed was then immediately injected back into her gluteal muscle with a 2nd sterilized syringe with no additional processing. the whole blood therapy involves gradually raising the dosage to 5 millimeters per session then reducing it again. how exactly does the

therapy work. this was the news of. fresh blood drawn from a patient's brain and reinjected into their muscles triggers a complex immune reaction that the details of this reaction have not yet been fully researched and understood but the reaction is triggered over and over we're going to boost it further by increasing the dosage which boosts the stimulus to. the cereal application gives rise to a sort of training effect that stimulation the immune system and thereby improving the body's immune competence it's also regulation. competence which in this couple . studies appear to confirm the efficacy of autologous blunt therapy. given. it's a few studies have shown that it's effective in treating hives or to carry out. this could there's new research from a bomb for example that shows the pair of b. is also helpful with chronic fatigue. a clinical observation study at the shopping

team has also shown that it's effective in treating her b.s. and the positive effect is still apparent a year after the treatment that's encouraging news for claudia hoff. other forms of the treatment and follow some change to the blood before it is reinjected such as oxygenation ozone nation or the addition of homeopathic remedies designed to further stimulate the immune system as yet there are no scientific studies on this. during and after the oncologist blunt therapy cloudy hearts condition did improve a bit she gets fewer lester's and they also clear up faster. i felt very good during the treatment. it was a positive experience much more so than i would have expected. that positive effect could be further boosted by

a refresher round of treatment the treatment should always be done in a specialized practice hygene is of course essential. cloudier hoff has in the meantime decided to go for a 2nd round of on thomas blunt therapy. i can see there's been a change so i feel it was worth it in the end and there was nothing spooky about it at all. there's still no scientific proof that all to him with therapy works so if you want to have a go with it 1st check with your g.p. like us g.p.'s always like your questions like i do. on a boat coming show we'll be looking at sleep a many people take sleeping pills but they can be addictive how often can they be used and what are the risks if you have a question about that send it to in good shape at d w dot com don't forget to write sleep aids in the subject line we look forward to hearing from you.

that's enough for today see what i freak and then let's all try to stay a good check. the book.

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the day w. news live from berlin and south africa the governing a.n.c. of the cleared election winner but is the party that has ruled the country's in the end of apartheid losing its appeal after 6 election victories in a row we find out from our correspondent in cape town also coming up. 3 of the 4 tourists rescued from kidnappers in working on faso arrive in france to be welcomed

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