bacteria that are resistant to antibiotics have become a serious problem. in germany alone 35000 people are infected with these bacteria every year we do this and it's a difficult situation and it's getting worse. in the u.s. scientists are looking for solutions by studying medicinal plants used for centuries by indigenous peoples. it's especially important to find new ways to treat infectious diseases today. in the caucasus republic of georgia doctors are treating some of these infections without antibiotics. but the fair appeal in germany didn't morph a few. experts say that resistance to antibiotics represents a major threat to public health around the world.

treatment programs in georgia have given some patients new hope echo heard in a from maria traveled more than 3000 kilometers from their home in eastern germany to the georgian capital tbilisi. well the result i was desperate to find a solution for can i when i heard about these alternative therapy programs and peace from europe or from georgia serve them all small boy are both good ones well you know all good. hard is being treated at the ailey off a therapy center. he and his wife are accompanied by an interpreter. after eckart had heart surgery the surgical scars became infected with back to. the

infection spread to the membrane that surrounds the sternum or breastbone. he had numerous surgeries an antibiotic treatments to try to correct the problem but nothing worked. jailed or changed the therapy in germany didn't work. i tried everything. during my last hospital stay in germany i came to the conclusion that the usual therapy of surgery and had no effect at all it's those the infections always came back quickly as i gave this. before. one doctor actually recommended removing the entire sternum. i didn't like that idea at all so i started looking for alternatives. and i decided that this program in georgia might work and get all the right foolishness which is.

hard since his medical records to the clinic in tbilisi the medical staff then told him that they could treat the infection with a process called phage therapy. and this involves the use of bacteria phages which are viruses that infect the bacteria and kill it. dr cook is preparing the 1st dose of phages. this sort of therapy is not approved in western europe as for over your 4 years what i'm going toto. i'm here at the beginning we use a very general type of fish. then we take a sample from the affected area and analyze it to see whether we need a more specialized type of phage that is sort of its own then we can create those in our laboratory under its. size to your for. doctor proceeds are now injects the pages into the area around the sternum. phages are viruses that

break into a bacterial cell and start reproducing this kills the cell then if age looks around for more bacteria to infect once all the bacteria in the problem area are destroyed the phages die. phages are also injected into the 2 surgical scars in eco hearts chest. this clinic is home to the world's largest phage bank. here at home in western germany is home to another couple who know firsthand about the problems of bacteria that are resistant to antibiotics sibylla i had foot surgery and the area around the incisions later became infected doctors could do

nothing to treat the problem and eventually had to amputate her left leg below the knee. let's read affection just wouldn't go away the doctors kept treating it with antibiotics but it didn't help i was running a fever the whole time and i finally asked them to remove the leg this hour. gets me on a flight for almost 2 years she had extreme pain in her leg and then out of the hospital. i watched her go through. and then finally we realized that amputation was the only option left lets the. thought. that was 8 years ago. and in germany today alternative therapy for treating bacterial infections is still not allowed. sibylla

says this situation makes no sense at all. it's that nice. it would be great if we had access to alternative treatment programs. and have our 6 they used way too often in just about every operation that's a huge problem isn't liza won't name. some bacteria have developed the mechanisms that protect them against the effects of antibiotics so the drugs kill only one resistant bacteria. and these super bacteria pose a serious threat to public health not least because they multiply quickly. sibylla is all too familiar with the situation but she's grateful that she was able to recover successfully from her surgery and to get on with her life her pride is still intact and to stay physically fit she exercises a lot. that i don't want to walk with

a limp thought it would make me feel like i'm handicapped and this is according to . but now she's dealing with a new medical problem she's been diagnosed with ask you arthritis in her right leg . below who's 61 years old was deeply concerned about having another operation. from the avalon for i've been putting it off for years but now that's no longer possible i'm getting in the uni. well and i'm really worried because of what happened the last time i had surgery. she delayed the operation because she was concerned about bacterial infection. bacteria phages research is becoming more common in germany. sewage treatment plants provide scientists with the rich resource of phages and resistant bacteria

they contest. dr christina woodard a microbiologist works at the lightness institute in the city of bronx fight. says that this treated sewage may help them to understand better how features work . is open but having only done for bacteria phages has viruses that can destroy specific pathogens. the other there are a lot of different kinds of bacteria in this move or bacteria phages are among the world's most common organisms on hog hogs and where it's leaving them off the. road is current research is based on that of her colleagues in georgia she's trying to find 3 specific features that could be used together to treat a dangerous kind of lung infection. the w.h.o. has identified 12 families of antibiotic resistant bacteria that pose

a serious threat to human health 3 are especially dangerous dr rohde has found phages that could control these bacteria. that one of our i mean the great thing about bacteria phages is that we know that they're effective based on the research of our colleagues in eastern europe. man and we're always finding new faces and in the. e.u. requires that phages be subjected to various testing prosy. ager's just like new medicines. in the past have hey it's therapy office a marvelous opportunities but we need clinical studies to prove that it's safe and effective. fix it hasn't worked for. good it is working with dr hold good cheer from the from hope for institute to produce features that can be officially classified as medicines. and. obviously this is how it subsided thus far that's and this meets our goal is to demonstrate the pages should

be considered vaccines and i want to take the procedures developed by our colleagues in georgia and develop phages that can be officially approved as medicinal products here in europe and you know what parts of tablets it's about a matter of justice to be put us out we should exist us at this project 10 years ago and worked harder to develop phage therapy because so many patients need it right now you know have stamper about it for me. the 1st german phage drug is now being tested at the showy 2 hospital in berlin. deep in the swamps of the southeastern u.s. state of georgia if no botanist cassandra quit even her research team are also looking for alternatives to antibiotics. all right we're going to look for that cheesy alba which i believe is over in this

area here they have the big black fruits on them in the bean family this is used as a treatment for wounds and and kind of cuts they would dig up their roots and make it a caution to rinse infected wounds so this one's of interest for us to collect so really shovels are in need of the 1st vouchers the whole work of. the researchers wear leggings to protect against. and snakes. because sundra is lower right leg was amputated when she was a child then she developed an infection caused by antibiotic resistant bacteria that prompted her interest in this kind of research. you know she's studying indigenous people's use of medicinal plants to fight bacterial infections. we should be able to try this in a couple of days or dryers. get ready for the lab. it's

especially important to find new ways to treat infectious diseases today because we're facing a big crisis in medicine and that's the rise of you know by the resistance and i think that plants may be able to share some of the answers. the researchers have been working for 4 hours in hot weather and now it's time to wrap up for the day. the plant samples will be identified and catalogued. because sandra is doing all she can to prevent the spread of bad about it resistant bacteria for example she's found a way to fight bacteria that are often found in body wounds in the gray areas of the brazilian pepper tree. each plant tissue in this leaf actually contains hundreds if not thousands of unique molecules the fruits might have different chemicals plants make these compounds for their own defense. the big challenge now is figuring out which

compounds are responsible for activity are they safe to use and can they be developed into the next generation of the right back to drugs. the plant samples are crushed and dried and then sent to a laboratory. no cassandra starts looking for the active elements that will contribute to her research. what we're trying to do with these kind of therapy is is to avoid direct killing of the mice. probes instead or disabling their ability to create toxins and other factors that destroy human tissues by doing that it essentially weakens the microbes to the point where our own immune system can wipe them out the goal here is not to eradicate all microbes in our on the body we need a lot of our microbes. it's a lot of hard work but the researchers believe the effort is worth and.

meanwhile eko heart eisler has been it's a clinic in tbilisi for 2 weeks in germany he had faced the prospect of surgeons removing his breastbone because of infection problems. know he's undergoing feed treatments 5 times a week. the material is injected into the affected area and is also administered to the 2 surgical scars that have not yet healed. how does a look dr drew. the upper one is closed. the lower one is still open but the discharge of fluid has decreased significantly so. i used to feel a certain amount of tightness in my chest just right around the sternum. but it's

gone down this post and its witnesses. oh patient from the netherlands is also being treated here natasha hartman suffered from a viral infection that turned even minor bruises into serious wounds the virus is spread throughout her body the clinic staff developed a batch of phages specifically designed to fight the infection. charbonneau costs less a settlement last summer a doctor told me that if i was lucky i might have 10 years to live if not i must have just one year. back in holland they treated me with several kinds of antibiotics of a 14 years but it didn't help so i decided to come to this clinic. the treatment seemed to be working and i hope that the wounds will heal by making progress i don't want to have to worry about dying i just want to get on with my life i saw that's not my let's just say this i want to finish it i leave. the patients pay for

the therapy treatment plus the cost of travel and accommodations out of their own pocket the therapy alone cost $3900.00 euros. these people have one thing in common in fiction treatments in their home countries didn't work. the therapy is working right it's absolutely. it's hard also takes regular doses of faith is in liquid form this distributes them throughout the bloodstream. the money will bleed if you take a serious look at the problem of and i bow to resistance and it's clear that they have to try some new treatment methods with modest. as far as what that means fate just like the ones they use here it is so big that little.

bacteria that can resist and about x. are spreading rapidly they've become a serious problem in hospitals. dr martin did some raw test to deal with the situation every day in his work at berlin's sherry tate hospital the bacteria can get into the respiratory tract of patients through medical equipment like ventilators. which is a sin because nothing for we have a real problem with multi resistant bacteria panic it's affecting our ability to treat some patients and we've even started using older supplies around to bionics and. we didn't do that for years because these medicines could cause serious side effects. at the same time a lot of the new drugs don't combat bacteria effectively so that's why we're looking into alternative therapy strategies that has a sense of comfort. and at least i think. the european

medicines agency estimates that multi resistant bacteria kill 25000 people in europe every year this issue ation represents a serious challenge for health care providers that's been ordered for i know who and feel you go off and on and we'll be seeing higher medical costs more patients in the health care systems and a big increase in treatment programs. and that's when i can't say at this point how long i'll be able to keep this problem under control. but i think that over the medium term perhaps in just a few years we'll have to deal with even more pathogens that we simply won't be able to treat. dr vincent wright and his team are conducting preliminary laboratory evaluations of phage based medicines developed by the likeness institute. the medicines are being tested on human lung tissue. into

the bacteria phages are being used in some creeping programs in europe thus far off the hook so you've seen a number of case studies that indicated there are effective. about the best of my knowledge there have been no definitive tests on possible side effects. that's the of these medicines are to receive official approval for use with patients so we'll have to evaluate all the possible risks of the ones you saw. no such studies have been done in georgia but doctors there used phages to treat patients anyway the e.u. however requires extensive tests. as a matter of minutes it's a race against time but we definitely need more evidence before we can put these medicines on the market and sources for to sell for us to the.

well bio features technology is still being tested in germany it's actually being used in poland here at the hirschfeld institute in price watch. they are turmel exidy forstner and her husband come run live in vienna the artist suffers from a chronic bladder infection caused by multi resistant germs only one at of out of has proven effective in treating the problem. isn't a fact it's had he done it he says and we have no idea how long that mets and will continue to work. the bacteria could develop the resistance against it. fadden company but face therapy can be used again and again until the bacteria are destroyed. believe that this therapy will help me to live long in. many finding out i. still fade therapy is not widely available in poland.

it can only be used if recommended by a doctor and only after standard therapy options have failed as in the autist case . the. doctor. just insurgent is in charge of her treatment programs. is using phages developed specifically for this patient. he's been working with just for 13 years and says the therapy requires some patients. affect everyone differently. but in general we see the 1st improvements after 2 to 3 weeks of treatment. the full program usually lasts $4.00 to $6.00 weeks but of course every patient's immune system is different and so are the bacteria that we're dealing with. to look at folks that information should be. at this point

doctor treats only patients for whom all other kinds of treatment have failed in poland pages can be used as experimental therapy. it says that phage therapy has saved the lives of several patients. so. we can successfully treat 40 to 60 percent of patients who suffer from infections caused by resistant bacteria and cannot be effectively treated with antibiotics because. the fetus will be administered to the patient splatter for 3 days in a row. the therapy program cost $650.00 euros. this is the artist 3rd round of treatment after the 1st session she was free of symptoms for 14 weeks. she hopes to not be him i'm still hoping for a full recovery came. garden

eva maria eisler have now returned home to germany after 4 weeks at the clinic in georgia. if a maria administers the phage treatments and she sees some progress. only theists the bottom ones closed and it looks like the top one is too it's not. that would be great if it wasn't quite closed yesterday can you put a bit more on it. both wounds on echo hard chest are now closed for the 1st time in months it looks like the phages have managed to destroy the bacteria.

done. it guard says his doctor has been following his progress closely. for it so i know i went to see your 2 weeks ago and she was quite pleased with the results of the phage therapy golden gun says it swiftly so she says it was a good idea for us to sign up for that program go as doesn't scoot for us for this enough time. echo heart who is now 73 years old still takes a dose of phages in liquid form 3 times a day. she's a nice little taller they don't cause as much trouble as and iyonix do. those drugs can destroy good bacteria in the intestines but these have few. side effects of the call i have no problems with us their appeal at all to them not me. that card will have some tests soon to see whether the inflammation in the sternum has also cleared up but right now he feels great. my limbs florida.

i'm definitely enjoying life again as that's because the therapy is working. but i started noticing positive changes even while i was still at the clinic in georgia fest even during the 1st week of treatment evil in the good really strong but the so yes i'm enjoying life the no 2 lives for to start with closer and. it does seem possible to treat bacterial infections by using bio features or medicinal plants instead of out of iyonix they could provide a viable alternative as the threat of multi resistant bacteria continues to grow.

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