coughing also very so usually you cannot distinguish between covert 19 and a common cold. the new coronavirus has sparked fears worldwide and stringent protection measures are being put in place in germany a group of researches has long been working on medicines to treat coronavirus diseases we have on a minute examined a new class of drugs that have established that it's very effective against a range of dangerous viruses. dangerous viruses including a boat and sica but will it help against the new coronavirus. researches have found a possible active substance against the virus and then that surely occurring molecule sylvester will it can be extracted from the leaves of a client mahogany plants which are used in borneo in traditional medicines for a variety of diseases bio chemist arnold couldn't valor and his team 1st

investigated the effect of sylvester on the ebola virus you know come on the. phone before that sylvester old had only been known in cancer research beginning in 2000. here in marburg we were the 1st team to start using sylvestre all on cells infected with a bowler i mean. these experiments showed it to be very effective in inhibiting a bowl of viruses from reproducing and cells from your. friend. and not just about. once a virus is in the body it enters the who cell and reprograms it. it forces the cell to replicate the genetic material from the virus. that results in the release of more and more viruses into the body sylvestre all stops this mechanism by blocking an enzyme in the cell responsible for this reproduction.

there are searches are looking for an active substance for a drug rather than a vaccine that scenes often have a job back. normally the body fights a virus with antibodies produced by white blood cells they combat viral infection such as seasonal flu the immune system also produces antibodies in response to a vaccine but viral proteins can also mutate and trick the immune system that's why vaccines always have to be re adapted to the current outbreak the research is in. a different approach than method concentrates on fact. which is relatively unchanging these factors are very stable and barely changed compared to viral proteins that means there's relatively little potential for the development of resistance. but sylvester will is difficult and expensive to

obtain the tree is on the red list of threatened species it wouldn't be possible to extract sufficient quantities to help fight a viral outbreak so there was such a set out to synthesize it. they succeeded in also officially producing a molecule they call c on $31.00 b. whose chemical structure is similar to sylvester. but doesn't work as well as the natural substance in fast we've shown that c.r. 31 b. has an almost identical antiviral effect. on different viruses that we've tested. but will it be effective against the new coronavirus that 1st emerged in china. and we've been able to show that this substance has an antiviral effect against at least 2 coronaviruses the cellular factor it inhibits this one that also is needed

by the current virus so it's likely that it would be effective with this one to. demonstrate the effect with a test in. without the active substance the cells are attacked by the virus. the sample on the right is tested with the synthetic substance c r 31 b. . for almost every virus tested replication is successfully inhibited. however it will be some time before this could be approved as a new drug only a major pharmaceutical company would be in a position to invest the $1000000000.00 the development would cost but big pharma is interested hopefully it won't be long before medicine can be launched. sars coronavirus 2 is the official name for the new corona virus

a persistent move is that face masks can protect us against the virus but it's not to stand up masks don't protect against the new coronavirus they are not designed to keep the virus particles and they are not designed to fit flush with the face and even if they are the virus can see into the body through the eyes through the eyes however this mask can prevent infected persons from spreading the virus further well at least that's a very good thing but how can you protect yourself the most effective way is by washing your hands properly. that's quite enough because water and soap destroys the virus entirely you don't even need any disinfectant but this may help if you're traveling by bus or train speaking of travel is it still ok to go on a journey today or can you get infected on a bus a train or

a plane. exotic cruises and sunny beaches images from happier days travel restrictions in many countries have now brought tourism largely to a standstill as official struggle to contain the new coronavirus and even when things normalize again fears about travel especially air travel will remain but doctors say the chances of catching something on board an aircraft are low. and because it was in a plane the situation is safe because the air usually blows across the road in which we sit as is it's our air tends to be shared mainly with people in the same row here passes through hepa filter is which also remove viruses. of course the idea is to prevent infections from other pathogens to as much as always do so in an aircraft you're getting some of the cleanest air that you can breathe obviously it would become there's practically no chance of infection but getting to the aircraft by an airport is

a different matter you know there we have many people crowded together so it's more likely that someone will transmit the virus there. cruises have practically halted with up to thousands of people in close quarters the risk of a mini epidemic on board is simply too great and there's also the problem of port closures. on a cruise you're trapped in the situation if anything happens you can't avoid the problem as you can on land where you can choose to go elsewhere. the corona vaccine is still unavailable but you can get a flu shot and that's particularly important for older people and travellers with existing medical conditions and there are other vaccinations that can help too. it's also worth getting vaccinated against bacteria that might take advantage of this virus infection for example in yuma caucus that raises your protection against complications many companies have reduced business travel to a minimum

a wise move to stop their marquess under. employers have a particular judy of care towards their employees so they have to ensure business trips are well planned safely executed and that the traveler returns fit and healthy. so 1st they should be as well prepared as possible for example by getting all the possible vaccinations the sure the received a new macaco vaccine a flu shot and the like. they should take care with hygiene and they shouldn't travel to regions at risk that's not advisable that. if you are traveling make sure that you have the very latest travel and health information deal where that the situation may continue to change and remember to keep washing your hands on the road good hygiene is essential. saying it is also a good protection against infections. and try to reduce contact with other people a bit ok one more move the claim that you shouldn't accept mail packages from high

risk areas. research has shown that coronaviruses of letters and possibles do not survive for long. the best thing would be if exceeding. the most effective way to prevent specific infections is to harness the body's own immune system that scenes like those used to prevent flu are made from either a weakened version of a virus or pieces of its genetic code the vaccination puts the immune system on the alert it makes antibodies that help it respond quickly to the target virus if exposure occurs under ordinary circumstances it can take up to 5 years to develop a safe and effective vaccine but in a race against the novel coronavirus some labs have already begun testing candidates in animal models sounds promising does that mean we'll be seeing one in the next few months if everything moves as quickly as possible the soonest that it

could possibly be. a half to 2 years that still might be very optimistic in the meantime could antiviral drugs and at treating those who are already infected help the development curve for a new medicine is even steeper than for a vaccine that can easily take 10 years for a new pharmaceutical to gain regulatory approval and the industry claims it costs upwards of a 1000000000 euros around 9 out of 10 drug candidates never go into production they fail at some point during testing disease experts say repurposed drugs originally developed to fight malaria or hiv also show promise clinical trials with all these compounds are ongoing. this was our look behind the scenes of this new disease my advice to you. be careful i don't panic and be sure to stay in good shape.

to the point shaun opinions clear positions international perspectives of. more than a 100 countries around the world are in the grip of the problem of virus thousands have died and many more are infected and this by. this is struggle to stay alive great fears of a global recession signs a deal with taxes find out all to the point shortly to the point. of being 30 minutes on t w. and are. cancelled.

and closed. livelihood some under threat. the crisis is also a catalyst creativity. new directions where the arts take in response to knock downs and fear. 20 more than. 90 minutes on t.w. . passion drama competition rival marketing numbers atmosphere by that side and traditional love hate money millionaire fans friends via spam.

because women love football. come up to golf on you tube joining us. each still tells my story. of the people who come to me builds me dedicated to me. i am not cut down to come. listen closely and i will tell you about those who built me up. and i'm going to slow me down. i am. not to dumb depending. on i 60 days for centuries i'm tired of company my country to its finest hour days . until the day i mean any vanished.

i still not too dumb to publish. april and. this is d. w. news and these are our top stories the u.s. states of new york california and illinois have ordered all residents to stay harm as the country ramps up measures against the coronavirus more than 70000000 people cannot leave their horns unless they have a vital reason. britain has announced sweeping new coronavirus measures pubs restaurants teaches and gyms have been ordered to close the government says it will pay some of the wages of people who can't work because

of the virus. $627.00 new deaths from the corona virus were registered in easily on friday it's the biggest day to day increase in the country's full weight epidemic after its apos china's death toll is a lay hazard of 47000 confirmed infections. germany's largest federal state varia has imposed a lockdown amid devalue the way the entire country should do sorry 13000000 people live in this area for the next 2 weeks then movements will be severely restricted. good news from both teams all follow us on twitter at t w news all visit our website dot com. italy france spain all under a law to limit the spread of the deadly coronavirus the southern german state to

bavaria joins that list tonight by the end of the weekend it may be all with germany on the other side of the atlantic the same threat the same tactic from new york and california 60000000 people told to stay home for their own safety for their own health i'm off in berlin this is the day. we need to read a state wide order for people to stay at home we are confident that the people the state of california will abide by practicing social distancing none the less when they're out in the streets of people still getting their medicine people still going about doing the kind of essential work that is required to meet this moment the order provides for all of that confidence because i've seen it every single day we've seen it in cities large and small and people will regulate their behavior

begin to adjust and adapt as they have been quite significant it's time for all of us to recognize as individuals and as a community we need to do more to meet this. also coming up with the coronavirus and the calendar in china and the contradictions of the u.s. president. we have it totally under control it's one person coming in from china is it we came up so suddenly this is a pandemic i felt it was a pandemic long before it was going to do is look at other countries the voters. this is the new house. to our viewers on p.b.s. in the united states and around the world well we begin the day with more deaths more desperation and more lockdowns all connected with the corona virus pandemic in

the u.s. residents of california and new york 60000000 people in total are now under lockdown the governors of both states telling people to stay home to protect themselves and to protect each other with the number of confirmed cases doubling in just the last 2 days no one to be seen out under california's sun far and wide and that's how things are set to stay for a while in america's most populous state governor gavin newsome has ordered a lockdown to battle the virus this is a moment we need to make tough decisions this is a moment where we need some straight talk and we need to tell people the truth we need to bend the curve in the state of california and in order to do that we need to recognize the reality more people live here than in the whole of poland or in canada new some fears that 25000000 people will become infected in the next 2 months out of $40000000.00 californians 20 percent off civilization right it's

about $19543.00 people that would need to be hospitalized under that scenario above the existing capacity of our system california will be transformed in the coming weeks with hotels being converted into coronavirus clinics. in washington the state department has called on u.s. citizens to stay in the country and anyone of brawn to come home and president trump has canceled the g 7 conference planned for june instead of meeting at camp david world leaders will meet by video conference. for more than one i'm joined now by journalist t.j. matthews in los angeles a.j. we usually talk about hollywood how i wish this were all a bad movie but unfortunately it's not talked to me k.j. what is it like right now where you are well 3 words to describe it bad

bad and bad that's essentially what it's like here it is impossible to shop at my local grocery store to go to the big stores the small stores any place you try to drive and you go inside there's simply no food left on the shelves this morning alone i went out to try to buy pasta just pasta and i went through 4 stores and none of them had pasta they said come back tomorrow so it's day after day after day you go to the store looking for the same items and it's nothing but empty shelves so it's been very difficult to say the least here ok so you've got problems there you know buying the essential oils what about if you need to be tested for the corona virus i mean can you get a test if you if you need one if you want one. you still can't get a test you're getting a lot of conflicting information from different medical professionals you've got

your city there which tells you one thing you've got your county which tells you something else and then you've got to state that a lot of people are firing or just recommending is that you contact your main doctor your primary physician let him out in their local hospital in showing up they don't want dozens if not hundreds of thousands of people just showing up at the same time because they think they may have called in 1000 yeah you can only imagine our colleagues in the white house press corps you know they are facing a very contentious president when they ask about testing and the fears of americans this is what happened earlier today when a reporter asked president trump what he wants to say to the nation about the skyrocketing number of corona virus infections take a listen nearly 200 dead 14000 or so millions as you witness who are scared right now what to say to americans who are watching you right now who are scared i say that you're a terrible reporter that's what i say. because it works i think it's

a very nasty question and i think it's a very bad signal that you're putting out to the american people the american people are looking for answers and they're looking for hope all right so he attacks a reporter her for a very legitimate question i mean that is a legitimate question in this environment how how does that go down on the west coast where you work a j. it's tough you know that's why i think so many people have been relying on their local officials because you're getting so many conflicting comments and orders by so many different agencies that you don't your head is spinning so i think a lot of people have just gone to their local television and said look let me contact my local authorities and find out what we're doing because every day we're hearing something different as you just heard from the president he's very contentious with a lot of people in the media that are simply trying to do their job and educate people as to what to do during this pandemic yet so it's like you're saying

california's are pretty they're trust more and more in the governor and the state government but you know at the end of the day you i mean who in the world do you lean on some of the people have lost complete trust in established institutions. can you hear me now yes i just rushed there but i can hear you now i think you asked me something about who do you have been basically it's back to the local agencies every day information that we're getting is fluid it changes so often the number of people have been diagnosed with cold in 1000 goes up overnight the number of test kits that they have go up overnight you really just have to stay plugged in and dialed in to your local officials here to find out where you go for help and luckily i live in los angeles county where they've actually been calling everybody with a cell phone allowing them to call in every so many hours with their questions so

the local medical officials so they've been pretty much on top of it here i can't say that's how it is for every single city in the state of california but so far so good in l.a. county well at least there's some good news there t.j. matthews in los angeles tonight he's if we appreciate you taking the time to talk with this stay safe and stay healthy thank you. well here in europe italy spain and france are all under a lockdown germany has been the big subject but that began changing today the southern state of bavaria today told residents to stay home all public life in bavaria is now shut down. up friday dark speech it's up for writers from friday this friday beginning tonight at midnight for an initial period of 2 weeks there will be general restrictions on movement into various house guns be showing through and we're not closing the very year off but we shutting down public life in bavaria

for almost completely by 2 full 27th or. that was the bavarian state premier markets. this week and the german chancellor angela merkel will most likely declare a lockdown in some form for the entire country that as the number of coronavirus cases continues to climb 14000 people are now infected 31 people have died empty streets a sign feinberg will have to get used to after all thora t's announced a 2 week lockdown it was the 1st german city to water residents to stay at home but many are now asking themselves if the whole country could soon be stuck indoors including sarah and her friends who were out enjoying some together despite appeals not to as this pushed them best outcome of this is measurably better simple don't get infected and the hospitals are already overstretched but it's hard to imagine in a country with so many people like germany. for which they are not thrilled at absolutely

not most of those gathering in the park know they shouldn't be but they find it hard to accept. in this residential area nearby many are staying at home it's hard. to get i'm not doing well i'm going to cry. because i can't see my children. for use in something you know is this and it's a real shame that we can't see our children and especially our grandchildren i don't believe that we need but we accept it we do what we're supposed to. do to bring our distance you know keeping distance the brandenburg gate is pretty empty and those we spoke to expect a lock down it's come to 9 part it's over here in a few days that's why right now. the town of heinz berg is

a coronavirus hotspot in germany both already is there are appealing for a reason i love using high risk groups ourselves isolating they only go out to the doctor the others restrict their movement to a minimum official they drive to work for and by centrals. call for the threat of a lockdown is weighing on people's minds. before you had experience in the biggest loss of personal freedom since the 2nd world war 2 weeks ago there was soccer matches with 50000 fans it's not easy to change so radically from one day to the next the government is trying appeals if they don't work bans on going out will follow the mood when you find dog has taken that decision the lockdown goes into force on saturday or the political correspondent joins me now good evening to you hans are you also hearing that a nationwide walk down will most likely be approved or declared this weekend.

it seems pretty likely yes what we know for sure is that i'm glad machall will have a video conference with all the prime years of the 16 german federal states on sunday and in that this and that discussion they were going to in fact decide on a common common line on whether or not to impose a lockdown there was a kind of script behind this i think earlier this week on monday very severe restrictions were already imposed on public life in germany all shops that did not do not sell essential goods were closed all places of entertainment were closed concert halls gyms clubs cinemas all of that in an attempt to kind of give a disincentive to people to leave their homes there was no place to go as it were no place to go out and have fun no place to go out for

a bit of shopping as it were you could only go out to do essential things and the idea was that one would of service for about a week and the german center for disease control the robot cough in situ it was is getting today data from about phone companies which should be given indication to the extent of the extent to which people in germany are no longer moving their own so they were trying to see whether this would be effective enough and then decide on sunday whether to take the next the last possible step in the sens what happened today in fact was that there was a whole range of new measures announced by various federal states ranging from the lock up locked on in bavaria to other states to say that much smaller groups of people were only allowed to be all.