world's 100 most influential people by time magazine in 2018 and we 1st actually tested this in patients or at age i.d.'s actually because they have lost 2 of the virus many of their own t. cells. 2 years later my wife died of ovarian cancer in 2004 and so they are really in the. move from a child the to do really all cancer or have the time however he did not receive a dollar from the pharmaceutical industry because the treatment initially only worked on mice but not human it's ok what we know for sure is that the. fundin essential a was essential to make a new industry so to have their laughter be at the government's support it was millions there was millions it was probably $20000000.00 i mean. i think for sure $20000000.00 were invested between when i came to university of pennsylvania in

1900. in till novara said the alliance were made in 2012 but the riskiest part was state by the government yes all the initial research that showed this new concept of our car teams could work was. academic laboratories in 2010 and came the breakthrough in the cancer patient douglas olson however it was the news of 7 year old emily whitehead that spread around the world thank you mariah saved the young leukemia patients mind and even 7 years after the infusion she remained cancer free. the treatment is more effective in children than adults. we had hundreds of calls for a venture capitalist wanted to start new companies and fortunately had novartis call us about one of their course was just. inventing a drug is one thing says novartis but putting the research into practical use

through a market launch is costly and time consuming insiders say no far she's paid the university about 225000000 for the exclusive right to sell q mariah. and novartis is paying the university about 5 percent of the sales price for each infusion the group has no comment on this the health care industry is not transparent and it's not been designed for the benefit directly of a patient and transparency our most recent estimates. are around $55000.00 just to make the cars the cell that's our cost per patient and with no profit. so the actual cost is almost $7.00 times cheaper the university however and it only done small scale trials with camera while novartis had to fund world wide studies to attain market approval and build centers to produce the treatment will.

make a dime is still waiting for his cancer killing cells from the us when suddenly a message comes from nov artists the group will give him to mariah for free. clothes that was made of all things we were thrilled with joy i'm very relieved that made you to be. i mean you always a lot of money at stake and also of azza will start their own cult of what about other came via patients standing looking not. those i don't know novartis is a play on scene that's when ethically it's a delicate question as to whom no barges gives free treatment iana to yes of course . the 1st 2 swiss patients are being given key mariah for free because negotiations with health care insurers are taking so long no far to 6 planes. mikail moonshine

a father of 2 children will ultimately lose the race against time. to see us a informs him that his cancer killing cells have not managed to multiply well enough to produce camera. 900 days later he dies. my name is paul toys and then in the pharmaceutical industry for 30 years in the last position the law as a us president and chief executive officer of a company i am retired now and over the last 5 years i have been dealing with and

then curable cancer. so car know what it's like to show us all the medications that i have to take in a day. this being the most important long distance my anti-cancer drug. this product is to take one of these capsules for a day the cost of those a $750.00 each and entrust a millionaire if they only cost $1.00 each to manufacture what do you think about the price of 370000 swiss francs for a camera that's ridiculous car it should never happen this is a product that was developed at the expense of the us taxpayer did you have a different view when you were still a former manager than you have now on your industry. the answer is yes current and. for 2 reasons 1st i was not

a patient i've been part of the system i've been a my family's been a beneficiary of that system. i really didn't know any better at the time you know you go to work at the get a perspective which is the company perspective. what you learn as you get older is your perspective becomes much wider. than is the former c.e.o. of a company acquired by nope artists in 2002 he says no of artists are also benefited from a 50 percent discount on the cost of its trials or camera this was the us is way up in some devising research on a rare disease and it's people like myself who actually have funded the development pro at the development program or half the development program come right out and what we get in return is basically a punch in the teeth from the artist. recreated a price model for human rights based on no participants claims that it had invested

over 1000000000 euros by the time the treatment was approved. i calculated a fair price current all for $200000.00 or infusion in 2019 using the assumptions using the assumption that you know of artists who generated total of $1700.00 patients and fusions out of 14. out of 14000 potentially. goes on we can actually drop that price it can be reduced to about half of 370000 francs the fair price is calculated in such a way that no barges achieves an average operating profit of 20.7 percent the research costs averaging at 17.3 percent are also included in this calculation the health insurer. is also demanding a price of $200000.00 francs for. can write. i've looked at the document you sammy

the document is full of incorrect information thank you for the correct information i cannot give you that and i am up i cannot comment on it because it is not ardent darr data it is not our document the criticism on the farm are not just novartis but on the pharmacy in transparency is growing worldwide we hear it we age over here it with the health insurers with the public because the public is the payer. are you afraid that this will damage the image of nobodies. are not afraid of damage to the term of art is or you mention in transparency transparency is required across the system not just from one party our government is asking for transparency because we have a transparent list for prices i think it's the opposite. or it can be discussed in a broader group i think it's a bit it's a different conversation. 71

year old court ending. also has left no cancer and he says if he has the strength he goes out with his dollars because of the price dispute he has had to wait 3 months for the health insurer to decide whether to pay for camera. quite a few could you afford it if the health insurance didn't pay when he owned approach and i were 100 percent sure it would work i would sell my helsel but i can tell you that if it doesn't work my wife will be left with nothing that's out of the question in my eyes that ever it is that most of us have an excuse a company didn't pay for you or you wouldn't do it me no it's too risky stunt because the low chance of being cured. and. each year around 110 cancer patients in switzerland who have undergone all other treatments

to no avail receive camera and the 64 year old teacher anton schlosser in bun maryland is one of them. the question is what is a human life worth it is to put it bluntly you're over 60 if a young person asks how much longer do you have left is it even worth it when curing your illness is a best case scenario doesn't hurt to hear that kind of question. now you have to think of it now and it's so you know but i've also met young people in the hospital who are in greater need when you look at it that way. i've lived a decent life it's been nice so far. i almost feel ashamed even though i didn't set the price you feel very uncomfortable and so guilty but it's the only chance he has left of course you're not going to say no. do you feel

guilty sure. now i really need billy not really i was in good health for a long time and paid premiums for decades it never really needed anything that i'm a beam out of the stroke this came as a surprise that i should of course. there's health insurance is also paying for him right now. the price negotiations between the insurers and of artists took 4 months with the price being haggled up and down like at a bazaar. some insurers threw in the towel while others came to an agreement with novartis. insiders say insurers wanted a 45 percent discount on camera out for treating lymphatic cancer which was too much for novartis they instead agreed to a 20 to 30 percent discount to pending on camera a success rate meaning about 250-002-3000 extension 00 francs but no one is willing to talk about. the agreement after all is confidential in

fact it is so shrouded in secrecy that health insurers such as concordia which were not in on the deal will not even find out their discount on till they have signed the contract because for investing kits scandalous this is the 1st time i know of for us to conclude a contract where we don't even know the price that was issued that's unheard of in swiss health care with prices and contract clause as a normally transparent rolls but you can usually check what you have to pay for hospital treatment and cost transparency is very important in health care otherwise we subjugate ourselves to the big corporations. pending or has to have another cell sample taken because novartis didn't manage to produce the cancer killing cells in the us as they did for me.

in a school it's clear of course it doesn't feel good things were looking up and asked if this event that want an off cells at strain a cut. in the approval study for camera one 3rd of patients could not be treated at all either because the cancer killing cells couldn't be produced the patient's illness. had progressed too far or they had died waiting like mikail moonshine. anton schlosser receives good news from the us his cancer killing cells have been successfully produced and are on their way to switzerland the mccombs it is in one sense and then you get about these cartier man cells cells that are even stronger than normal immune cells and in the last many moons and and when immune cells get into action there are side effects last time i slice since may experience fever circulatory problems or even organ failure. in that site at best kidney failure for

instance has been observed in about 20 percent of patients once but some of them needed dialysis that just has a huge puts in. a material use as a potential most. cancer killing cells can feel patients and kill them. so those cells are the last hope for those who would otherwise die of the disease. you know michel for jerry my name is alfred scheidegger and i'm a risk capital investor we don't here in san francisco i'm attending the world's biggest health care conference. or invests in small biotech companies developing new cancer drugs. have a good day about his goal is to sell the small companies to pharmaceutical

companies for a profit. so what. you see now is very yes actually doing ok for those flavors of the star we're doing. is good but 1st there's no mr scheidegger what's going on here yeah that's a shell so it's like a marriage market it's unbelievable. but you run into all kinds of biotech companies especially own political ones that fall mafia with pharmaceutical companies aiming to take over small companies later on once they've provided proof that their cancer drug is effective in humans and the like we're doing that it's in the. 60 percent of new drugs are not developed by pharmaceutical companies but by small biotech companies they need a lot of money for studies with patients and this money comes from investors like alfred shad ika and marcus horse. trying to close

a company often invests during the early stages of research but the pharmaceutical industry pays the most when a biotech company is about to launch a new drug on the market so far this is why the u.s. property of texas the price secondly $90000000000.00 gilliatt scientists that we defy kites farm out for almost $12000000000.00 you know march as is now demanding a record price of $2100000.00 for of excess treatment is it the greasy noodles there are calculations involved that have an impact on the price and the better you have to gain back your investment and of course that's part of the market price in the event of a stealth diet of souls from bach plays with kim riaa nov artist managed to avoid dealing with the biotech companies for investors by signing a contract directly with the university saving them billions. for patient court bending or at

a hospital camera is able to be successfully produced on the 2nd try. to read a few more to 3 milliliters costs 370000 francs it. doesn't satisfy this is a discussion that i frankly do not want to get into now at a patient's bedside young i've still got a life to live. i feel like i comprehend. you have high hopes it will work. and received his infusion 2 days earlier. gets into the data base how are you doing fine so i. heard it tired right i fall asleep even if i want to watch something. maclin you tell of the camera is working

and this is very since it's too early we hope so of course but we can't tell through should. we have high expectations of course that's there it's. scuse me for a moment no government representative on the phone informs her of new problems with khumra since it is considered a hospital treatment the cantons have to cover 55 percent of the costs. maybe a stocking doesn't know we're starting that process and parallel to it day by day care who has it because it's a vicious circle because the health insurance only covers the costs if the cantonal government also agrees to give its part as i was in the south as it does allow for by you know each of them says they'll only do it if the other has already agreed to the stem cut.

make and it's we meeting with jenny lee an investment banker from hong kong where she covers china and they clean up. china conducts the most trials on cancer killing cells worldwide and market observers say if the treatment is approved there it will cost about $70000.00 to our using credit and i think the data that really that last i mean i'll get. right to that jenny lee says the chinese government is putting pressure on pharmaceutical companies. what then the have to lower their drugs so the approach to baby. marketing they said they are a bit yeah yeah yeah because you'll want new games that will be a huge volume of the plot so that it was all the oh yeah there's the lot of them if the pharmaceutical companies read my mind those high priced really the tiniest market can all afford it the tiniest patients are our insurance is going to sell you'll be all lost lost situation on the ballpark.

also use this about profit or saving lives psalm of the. sixty's existence the existential justification of a private company is to generate profits while simple feat. and that comes before life. you can't really answer that question that. anton schlosser's wife documents his treatment using a cell phone. you know you say that no. depressed no. agitated. in the 1st days he has fever and chills so only minor side effects. it's the same story out in social retard with court bending or coming down with

a fever but otherwise he feels fine. so you feel like it's doing any good it's. over i can't say that we don't know yet there. are markers for the owners and this biotech company is researching in the booming field of medicines for rare diseases referred to as orphan drugs just like a mariah when you say 3 locations. are free to quit focusing on your phone is an issue yet. it's. in the us and e.u. orphan drugs receive exclusive marketing rights with similar products from competitors excluded from approval for up to 10 years sates each as old to toss it

is a little or is built to incentivize research because once you obtain approval you enjoy a sort of exclusivity for several years a competitor can just launch on the market that's exclusivity told to lay kick the greasy excuse of the day it's. in the us the orphan drug act was enacted almost 40 years ago today the politician who initiated it was not meant that some pharmaceutical companies are exploiting their monopoly to increase their profits. the topic of orphan drugs and market exclusivity also reached switzerland a few years ago. just a. moment ladies and gentlemen pursuant to council regulations for engaging in the debate on this topic i hereby disclose my vested interests. i

am the president of into going to the swiss association of generic drug and bio similar manufacturers. in order to promote the development of medicines career diseases pharmaceutical companies should enjoy market exclusivities for 10 years for orphan drugs during this period and no other medicinal product should be approved for the same therapeutic indication unless it is proven to be safer or more effective tool. the point is the point is pharmaceutical companies are not social institutions and they only conduct research when they expect to profit from it this people have to know in order for new drugs for rare diseases to be introduced at all it takes a monopoly and this is achieved through market exclusivity will push the market exclusively to it because often. when sebastian flanery was voted into parliament he gave an access badge to novartis lobbyist at the time while the heart of us and russia donated nearly 900000 swiss francs to the middle class parties last year and

that about the missing the 1st stolen at the end of the debate it became clear to us it was not the patients who had gained anything it through this revision of the law on thursday you see a product recently out on being patient caution no but instead the main changes have been about his coffers to be filled up even though no although koeppen you dims are throughout the commission's deliberations and still here today i feel like i and perhaps others here tonight have only been aware of the fraction of all the lobbying going on here in the background lobby are right on the interests that they don't like. courts and that had consequences. but i received a reprimand from past. then the head of novartis. safe. treats and what did he say. your head he emailed me because he wanted to meet with us and discuss our stance for methadone so he claimed we were

not being pharmaceutical friendly in our law making work that hard at the bit i thought it was outrageous for him to interfere with my parliamentary work in the parliament darvish have that ever happened before because the so i never experienced that previously or again at last. the debate went on for 2 years and the national council voted in favor of market exclusivity twice but the council of states opposed it the monopoly didn't pass but instead a stripped down measure protecting orphan drugs did. one month after the infusion with camera and is thoroughly examined. did kim royal work and has the cancer disappeared. yes not much i'm 1st going to show you the old pictures there was this lump here or

that there was the main mass in the fashion compartment. and of course on your lower leg. it's called and now here's afterword with just some slight activity flower activity attack that there are still some in the fashion compartment but it's already received there's a lot. rainy go. so it's mean if i couldn't have expected things to go any better for that that's the old tumor mass has completely disappeared without a trace of inflammation can you tell if he's in remission or could the cancer come back again. we don't have a crystal ball we don't know that but it's a good start. that's come you can never rule it out but with kim treatment waits with carty cells still need more data not to quote.

meanwhile retard quote pending years cancer also disappeared immediately after the treatment. of course i'm glad i can get home and i'm darned wearing this mosque. take care and enjoy life and use the magovern group that's the group to see if a medical or his doctor doesn't want to give a prognosis according to the no watches study it takes about one year to know which patients have overcome them phatic cancer for good. more than half die. and it's not yet clear how the cancer killing cells develop in the body in the long term. but. in this brave new world of health care the cost of a chance of survival is exorbitant. jim ryan is just the beginning.

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