any points brian got the win them hurried off the pitch to catch their flights to the club world cup. you're watching news the live in bill and michael ok up next our documentary series doc still on the power pharmaceutical companies don't forget you can get all the latest news and information on our website. when using 45 minutes. imagine how many push the old loves us right now in the morning climb a tree carry it off to stores face is one place a way from just one week. can really get. you still have time to. run during. this. process.

my name is michelle and i'm a father of 2 children i was diagnosed with cancer. 3 cold 2 weeks later my life looked radically different has never been the same so it's unclear. even 2 rounds of chemotherapy couldn't treat mikhail's aggressive cancer only hong lit up. if left untreated i would die in 2 or 3 months at best. so it's incredibly serious . his my last hope is a gene therapy with cancer killing cells such as kim mariah from nova artist with a price tag of 370000 swiss francs and camera is just the beginning a new drug let's turn it was injected into the body $850000.00 sold gens

it's now the most expensive drug on earth the price tag of $1000000.00 how willing are society to bear the costs it would hold and when you let someone die to save money because their. power at these prices calculated. the coals pharmaceutical companies sound the market to determine what can make it house of it and when the limousines actually need the. wood health insurance companies pay these record prices. for the free 170000 francs is a lot of money and we can't afford it was what can you do. it's tricky it's hard to tell what the future has in store. all she want will get this cancer. out of let's hope so. make a hormone shine has a rare and aggressive form of lymph node cancer his crooked mouth also comes from

the disease. his last hope is kim riaa a completely new treatment just approved last fall. samples are taken of the patient's own immune cells and these are sent to a noble artist laboratory in the us there the cells are genetically modified and reprogrammed into cancer killing cells. after being multiplied and frozen these cells are sent back to switzerland. the patient receives the killer cells in one single infusion with a price tag of $370000.00 swiss francs according to the no watches catalogue.

it remains unclear whether the health insurance companies will pay for camera they have joined together to negotiate a discount. on melting of ice and i work for the insurer has done where i negotiate contracts with the pharmaceutical industry we're currently negotiating the price of kim rai with novartis. the price is too much she says partly because it is unclear what long term effects can royal will have and whether the cancer will return. official and it isn't quite clear to us how the price came about we didn't receive any cost breakdown and don't know why the price is so high you thought i had skin i was all who see the pharma companies provide that gonski formally and there is no formula as to how the price breaks down and i've never seen a lot of the whole i mean this and i think they try to start with as high a price as possible because in the end it always gets negotiated. the 1st price they said is just a starting place it's off it's a real problem if you ask me i couldn't tell you what we can never be cause in any

saga. they discussed whether health insurers should pay. only in the event of success but what is success when it comes to cancer there's no solution in sight and for the time being every insurer is deciding for themselves. the going on monch times low cost of sure to pre refuses to pay for. the benefits are not clear enough they say. to be honest i was furious as well because this stinks of incompetence she gets in the end it's like the wild west you're with the theater life that those who can afford treatment so the ones who get a chance to have. and for others it's not clear whether they can it's 2 tier health care yes. mchale's relatives want to fund the treatment themselves but the hospital is demanding half a 1000000 francs as security. after a camera infusion some patients reactions require transfer to the intensive care

unit to leave because he. believes kindly willing to give 850000 franc advance on her inheritance. appropriate to its credit also only 5 metres so i'm also getting an advance on an inheritance. when my brother spot their houses they've got their share and i haven't needed it so far so but soca well that now i'd like to use it for this and it's also cool. it's usually it's not me what i was exactly c.v. to get it really touched me that a lot of people i know are ready to give 10000 francs if it will help saying they know it isn't much so. there are a lot of kind people like that and it really touches down the hall who benefits because everyone realizes that in the worst case scenario the money will simply be

gone or the fall out and in the very worst case it won't even have done any good to fall. back east. according to nova artist one and a half years after treatment 40 percent of patients like me. still have cancer. that's a start but could it be better. if. those made of course it's not the drug i'm currently on had a 20 percent chance of success. in the south was good there were days when i thought that's it as he gets older. i could only hope my final hours would go quickly. i didn't want my family to have to watch forever and for me to be a never ending with a work out committee and i didn't want to lie around like a vegetable on drugs all strogatz with the. shook musique of the dog can do my league.

about a dozen cancer patients cannot be treated due to the price dispute critics might claim the health insurers are at fault with terminally ill patients running out of time and dying while negotiations my gone with no bar to see the full or there's this level of never thought of but that's not the case we all share the responsibility because we have yet to find a solution to this all around less than ideal situation fall is it not so. mikhail monch times family has scraped together half a 1000000 francs he is the 1st lymphatic cancer patient in switzerland to receive can write. good to mordor. mikhail has a muenster house taken from him that will be shipped by plane to the us where they will be converted into cancer killing cells referred to as carty cells.

will the treatment work week iles cancer is growing so every day counts. instead of the end of it takes a while for the cells to be produced in a best case scenario it will be 4 weeks but it may take a little longer since so many products are sent in put up that i'm concept of that i'm called to. go. to ensure the funds are available to go come to ny about as prepared to issue a bank guarantee that i and we are supposed to deposit everything into a special escrow account that beck fears stance will make sure it's not touched a bit but this way we can proceed with treatment by their father murphy earlier lymph nodes it. was a pro. moved through clinical trials funded by novara case.

here i can feel at least 2. experts criticize the fact that the effect of can riaa has been tested on less than 100 patients worldwide the follow a period was less than 2 years and can royal was not compared to an existing treatment so the long term effects remain unknown this criticism generally holds true for other trials on rare diseases. but naturally patients want the treatment as soon as possible and the companies present the study results as positively as they can says antonio. this is how this is the case everywhere and it's intuitive although there have also been studies with carty cells that have to be aborted because test subjects were dying and there were too many side effects up or and. because that went out isn't that crazy. as i will say yes but we're

also talking about patients who would otherwise die along with all the can comets and diseases that's. done as our world has gotten impatient and our patients have to we're not just going to say to them let's wait 5 years and all that's the problem. is those 4 being. the trial with these deaths didn't concern no artist which conducted follow up studies on safety and efficacy and a 3rd what do you say about no barkus is price as if in south sudan prices i find the prices in general to be staggering in many areas and not just those of novartis in the orne and these prices are completely nontransparent to patients and to us doctors or mr bush and also by someone enabling all. all of this to go on because there are vested interests and month so there are reasons why they want to be on

the company's good side this pushed into interestingly to whom they're stacking the 1610 film and then measure their wives stand off it because they could also produce in india or china you know. so it means jobs in basel albats that's in that it's the jobs of course and if you look at switzerland for example it doesn't have much industry but it does boast a few of the world's most important pharmaceutical companies at least if i can sell it. at no far to says plant in the town of dine in argo switzerland we meet with the head of cell and gene therapy in europe a month away the austrian e. so this will be. this will be a key site for us. they avoid talking about numbers here but cancer patients expect a price discount if the transport costs to the u.s. are eliminated. no says mr austin e.

because the production side doesn't affect the price it is the value of gene therapy that is relevant meaning a prolonged life. this is a paradigm shift because the pharmaceutical industry used to justify its prices with high research costs. the principle of value based prices is wrong health insurers say because a human life is ultimately priceless and they estimate that premiums will rise by more than 10 percent over 10 years due to the cost of medicines. and you're not afraid that the health care system could break if you continue like this. no i'm not afraid i think we can find the solutions we are open to take the resources the kinds we're open to take risks with with our

stakeholders to make sure that we can bring the therapies the patients. the pharmaceutical industry calls this risk sharing with those insured bearing part of the risk including the risk for camera which was not even invented by novara to small. these cancer killing cells trace their origins back to the university of pennsylvania and this is far from an isolated case with more than 60 percent of newly approved drugs in the us not stemming from pharmaceutical companies that are coral german army a professor of the universe there pennsylvania march aim invented. in 2465 years old but i've been working on the. 1992. coral june was named one of the world's 100 most influential

people by time magazine in 2018 the 1st actually tested this in patients or at age i.d.'s actually because they have lost 2 of the virus many of their own t. cells. 2 years later my wife died of ovarian cancer in 2001 and so there really is a move from h.i.v.'s to do really all cancer or. at the time however he did not receive a dollar from the pharmaceutical industry because the treatment initially only worked on mice but not human it's ok we're what we know for sure is that. fund in essential way was essential to make a new industry so to have philanthropy and the government support it was millions there was millions it was probably $20000000.00 i mean. i think for sure $20000000.00 were invested between when i came to university of pennsylvania in

$9099.00 until novara said the alliance were married in 2012 but the riskiest part was state but government yes all the initial research that showed this new concept of our car teams could work was. academic laboratories. in 2010 came the breakthrough in the cancer patient douglas olson however it was the news of 7 year old emily whitehead that spread around the world that. saved the young leukemia patients my life and even 7 years after the infusion she remained cancer free. the treatment is more effective in children than adults. we had hundreds of calls for a venture capitalist wanting to start new companies and fortunately had novartis call us about why their course was this. inventing a drug is one thing says novartis but putting the research into practical use

through a market launch is costly and time consuming insiders say no party has paid the university about 225000000 for the exclusive right to sell q mariah and novartis is paying the university about 5 percent of the sales price for each infusion the group has no comment on this the health care industry is not transparent and it's not been designed for the benefit directly of a patient and transparency our most recent estimates. are around $55000.00 just to make the cars the cell that's. cost per patient and with no profit. so the actual cost is almost $7.00 times cheaper the university however had only done small scale trials with camera while no heart tests had to fund world wide studies to attain market approval and build centers to produce the treatment.

is still waiting for his cancer killing cells from the us when suddenly a message comes from nova artists the group will give him q. mariah for free. as soon as mid of all things were killed with joy and very rarely has it made you have to be. i mean you always a lot of money at stake also of azza will start their own cult of what about other team i have patients in flicking a lot of. those i don't know novartis is a play on scene that's when the ethically it's a delicate question as to whom the hardest gives free treatment he ought not to use a course. the 1st 2 swiss patients are being given key mariah for free because negotiations with health care insurers are taking so long no far to 6 planes. mikail moonshine

a father of 2 children will all to lose the race against time nope artists usa informs him that his cancer killing cells have not managed to multiply well enough to produce a camera. 1000 days later he dies. my name is paul tillich and then in the pharmaceutical industry for 30 years in the last position the laws us president and chief executive officer of a company i am retired now and over the last 5 years i have been dealing with and

then curable cancer. so car know what it's like to show us all the medications that i have to take in a day. this being the most important one just as my anti-cancer drug. this product is to take one of these capsules for a day the cost of those a $750.00 each and entrust a 1000000 of they only cost $1.00 each to manufacture what do you think about the price of 370000 swiss francs for a camera that's ridiculous car it should never happen this is a product that was developed at the expense of the us taxpayer did you have a different view when you were still a former manager than you have now on your industry. the answer is. yes current and. for 2 reasons 1st i was not

a patient i've been part of the system i've been a my family's been a beneficiary of that system. i really didn't know any better at the time you know you go to work at to get a perspective which is the company perspective and what you learn as you get older is your perspective becomes much wider. than is the former c.e.o. of a company acquired by no bar to see in 2002 he says no far to say so benefited from a 50 percent discount on the cost of its trials or the camera this was the us is when you have him send devising research on a rare disease or it's people like myself who actually have funded the development program development program or half the development program of come right out and what we get in return is basically a punch in the teeth from the artist. create a price model for camera based on no participants claims that it had invested over

1000000000 euros by the time the treatment was approved. i calculated a fair price current all for $200000.00 for infusion in 2019 using the assumptions using the assumption that you know of artists who generated total of $1700.00 patient infusions out of 14. 214000 potentially. goes on we can actually drop that price it can be reduced to about half of 370000 francs the fair price is calculated in such a way that no barges achieves an average operating profit of 20.7 percent the research costs averaging at 17.3 percent are also included in this calculation the health insurer associates. there's also demanding a price of $200000.00 francs for camera. looked at the document you sammy the

document is full of incorrect information they gave me the correct information i cannot give you that and i am not i cannot comment on it because it is not ardent darr data it is not our document the criticism on the farm and not just novartis but on the pharmacy in transparency is growing worldwide we hear it we age o.b. hear it with the health insurers with the public because the public is the payer. are you afraid that this will damage the image of nobodies. are not afraid of damage to the wires or you mention in transparency transparency is required across the system not just from one party our government is asking for transparency because we have a transparent list for prices i think it's the opposite. or it can be discussed in a broader group i think it's a bit it's a different conversation. 71

year old court ending a barren also has left no cancer and he says if he has the strength he goes out with his dollars because of the price dispute he has had to wait 3 months for the health insurer to decide whether to pay for camera. quite could you afford it if the health insurance didn't pay when you owned approach and i were 100 percent sure it would work i would sell my house but i cancelled because if it doesn't work my wife will be left with nothing that's out of the question in my eyes that ever it is that must also ban it if a company didn't pay for you or you wouldn't do it may know it's too risky scone because the low chance of being cured it. each year around 110 cancer patients in switzerland who have undergone all other treatments

to no avail receive camera and the 64 year old teacher anton schlosser and burn their land is one of them. the question is what is a human life is to put it bluntly you are over 60 if a young person asks how much longer do you have left is it even worth it when curing your illness is a best case scenario and does it hurt to hear that kind of question. now you have it done can it be now and it so you know but i've also met young people in the hospital who are in greater need when you look at it that way. i've lived a decent life it's been nice so far sure it's a return to the me i almost feel ashamed even though i didn't set the price you feel very uncomfortable and so guilty but it's the only chance he has left of course you're not going to say no. do you feel guilty. now i really need

billy not really i was in good health for a long time and paid premiums for decades have never really needed anything that i'm a beam out of the stroke this came as a surprise in court. his health insurance is also paying for humor. the price negotiations between the insurers and of artists took 4 months with the price being haggled up and down like at a bazaar. some insurers threw in the towel while others came to an agreement with novartis. insiders say insurers wanted a 45 percent discount on camera out for treating lymphatic cancer which was too much for novartis they instead agreed to a 20 to 30 percent discount to pending on kevin ryan a success rate meaning about 250002300000 francs but no one is willing to talk about. the agreement after all is confidential in fact

it is so shrouded in secrecy that health insurers such as concordia which were not in on the deal will not even find out their discount on till they have signed the contract because from the think it's scandalous this is the 1st time i know of for us to conclude a contract where we don't even know the price of those usually that's unheard of in swiss health care with prices and contract clause as a normally transparent rules but you can usually check what you have to pay for hospital treatment and cost transparency is very important in health care otherwise we subjugate our selves to the big corporations. bending our has to have another cell sample taken because novartis didn't manage to produce the cancer killing cells in the us as they did for me.

in a school it's free of course it doesn't feel good things were looking up but 1st it is a vendor want an off sells it's training. in the approval study for camera one 3rd of patients could not be treated at all either because the cancer killing cells couldn't be produced the patients illness. had progressed too far or they had died waiting like mikail moonshine. anton schlosser receives good news from the us his cancer killing cells have been successfully produced and are on their way to switzerland and the cons it is in one sense and then you get about these cards here man cells cells that are even stronger than normal immune cells and in the last many moons and and when immune cells get into action there are side effects last time i say sions may experience fever circulatory problems or even organ failure organic in that site at best kidney failure for instance has been observed in about

20 percent of patients ones but some of them needed dialysis that dust had settled parts in and and material used as a potential most. cancer killing cells can feel patients and kill them. so those cells are the last hope for those who would otherwise die of the disease. you know michel for jerry my name is alfred scheidegger and i'm a risk capital investor day here in san francisco i'm attending the world's biggest health care conference. invests in small biotech companies developing new cancer drugs. have a good day about his goal is to sell me a small companies to pharmaceutical companies for

a profit. so. how are you doing here do not tell you why they don't play because if you start what we're doing. is good the truth. mr shining or what's going on here. it's like a marriage market it's unbelievable. if you run into all kinds of biotech companies especially own political ones that fall mafia with pharmaceutical companies aiming to take over small companies later on once they've provided proof that their cancer drug is effective in humans and the like we're doing that it's in the. 60 percent of new drugs are not developed by pharmaceutical companies but by small biotech companies they need a lot of money for studies with patients and this money comes from investors like alfred scheidegger and marcus horsa. trying to close company often invests during

the early stages of research but the pharmaceutical industry pays the most when a biotech company is about to launch a new drug on the market so far this is why the us for value has access the price 2nd only $90000000000.00 gilliatt science is that we defy kikes pharma for almost $12000000000.00 no rochester is now demanding a record price of $2100000.00 for of access treatment in the state the vicinity feels there are calculations involved that have an impact on the price tag and the fact you have to gain back your investment and of course that's part of the market price in the event based on the diet of souls from bach plays with kim riaa no artist managed to avoid dealing with the biotech companies for investors by signing a contract directly with the university saving them billions. for patient court bending or at

a hospital camera is able to be successfully produced on the 2nd try. 3 a few 43 milliliters costs 370000 francs. does that is this is a discussion that i frankly do not want to get into now at a patient's bedside young i've still got a life to live. i feel like that competent. you have high hopes it will work. and tom shows are received his infusion 2 days earlier. gets in really data base how are you doing fine. tired right i fall asleep even if i want to watch something. maclin you tell if the camera is working

and this is a since it's too early we hope so of course but we can't tell through food. we have high expectations of course it's it's not scuse me for a moment no government representative on the phone informs her of new problems with humira since it is considered a hospital treatment the cantons have to cover 55 percent of the costs. maybe a shocking us at no we're starting that process in parallel to buy the car because it because it's a vicious circle because the health insurance only covers the costs if the cantonal government also agrees to give its part it's either as of this act as if that's partially lawful by you each of them says they'll only do it if the other has already agreed to stay in touch.

make and it's we meeting with jenny levy an investment banker from hong kong where she covers china and they clean up. china conducts the most trials on cancer killing cells worldwide and market observers say if the treatment is approved there it will cost about $70000.00 i'd say the. president and i think they do you know that really that last i mean yes it's great that jenny lee says the chinese government is putting pressure on pharmaceutical companies that don't want them to have to lower their costs to the approach of baby. marketing they said they did it yeah yeah because you'll want new games that will be a huge volume of the plot so that was all the oh yeah is the lot of them if the pharmaceutical companies read my mind those high prize really the tiniest market can all afford the tiniest patients or that our insurance is done so you'll be our last last situation bob. i

also use this about profit or saving lives psalm of. 60 existence the existential justification of a private company is to generate profits while simple feat. and that comes before life. you can't really answer that question for. anton schlosser's wife documents his treatment using a cell phone. you know you said no. depressed no. agitated. in the 1st days he has fever and chills so only minor side effects. it's the same story out in the town with court bending or coming down with

a fever but otherwise he feels fine. so do you feel like it's doing any good. however i can say that we don't know yet there. are barkers. going i think you can write this biotech company is researching in the booming field of medicines for rare diseases referred to as orphan drugs just like a mariah when you say 3 locations or. are just a few we're focusing on. this nation yet or if it's. in the us and e.u. orphan drugs receive exclusive marketing rights with similar products from competitors excluded from approval for up to 10 years say that each is all come off

to the 6 the war is built to incentivize research because once you obtain approval you enjoy a sort of exclusivity for several years a competitor can just launch on the market that's exclusivity told to lay kick the greasy exclusive dates. in the us the orphan drug act was enacted almost 40 years ago today the politician who initiated it was not meant that some pharmaceutical companies are exploiting their monopoly to increase their profits. the topic of orphan drugs and market exclusivity also reached switzerland a few years ago. ladies and gentlemen pursuant to council regulations before engaging in the debate on this topic i hereby disclose my vested interests. i am the president of into

going to the swiss association of generic drug and biosimilars manufacturers. in order to promote the development of medicines for rare diseases pharmaceutical companies should enjoy market exclusivities for 10 years for orphan drugs during this period no other medicinal product should be approved for the same therapeutic indication unless it is proven to be safer or more effective albeit from the point is the point is pharmaceutical companies are not social institutions and they only conduct research when they expect to profit from it this people have to in order for new drugs for rare diseases to be introduced at all it takes a monopoly and this is achieved through market exclusivity we'll push the market exclusively to it because often. when sebastien trainer was voted into parliament he gave an access badge to novartis lobbyist at the time while no barters and rush donated nearly 900000 swiss francs to the middle class parties last year and the

power to mislead fest stellan at the end of the debate it became clear to us it was not the patients who had gained anything it through this revision of the law on thursday you see a product recently being measured caution no but instead the main changes have been about his coffers to be filled up even though no on the code i need i'm sorry throughout the commission's deliberations and still here today i feel like i and perhaps others here too i have only been aware of a fraction of all the lobbying going on here in the background of the op i wanted to distance the debate on life. costs and that had consequences. but i received a reprimand from past. then the head of novartis. 3 chief and what did he say. your head he emailed me because he wanted to meet with us and discuss our stance. of methadone so he claimed we were

not being pharmaceutical friendly in our law making for the supposed to be there i thought it was outrageous for him to interfere with my parliamentary work in parliament on the shelf but had that ever happened before i never experienced that previously or again at last. the debate went on for 2 years and the national council voted in favor of market exclusivity twice but the council of states opposed it the monopoly didn't pass but instead a stripped down measure protecting orphan drugs did. one month after the infusion with camera anton treuer surrey is thoroughly examined . did kim royal work and has the cancer disappeared. yes now my i'm 1st going to show you the old pictures there was this lump here or

there was the main mass in the fashion compartment. and of course on your lower leg . it's called and now here's afterword with just some slight activity flower activity attack the top there are still some in the fashion compartment but it's already received there's a lot. when you go. it's mean if i couldn't have expected things to go any better for that the old tumor mass has completely disappeared without a trace of inflammation can you tell if he's in remission or could the cancer come back again. we don't have a crystal ball we don't know this but it's a good start that's the obvious. that's come you can never rule it out but with kim treatment waits with carty cells they still need more data not to quote.

meanwhile at retard court pending his cancer also disappeared immediately after the treatment. of course i'm glad i can get home and i'm done wearing this mosque. take care and enjoy life the it's the cover group that's the group to see if. his doctor doesn't want to give a prognosis according to the no artist study it takes about one year to know which patients have overcome the emphatic cancer for good. more than half die. and it's not yet clear how the cancer cells develop in the body in the long term but. in this brave new world of health care the cost of a chance of survival is exorbitant. kim raia is just the beginning. but

. she is only 12 years old and already on the fast track. a german film award. nominee a hollywood debut. left. helen. super talented and extremely successful. she even tells us what tom hanks is like. your rolodex. 30 minutes.

it's about billions. it's about how we're. it's about the foundation of a new world order the new silk road to. china wants to expand its influence with history network. but in europe there's a morning when for accept money from the new superpower will become dependent on the commitment of the state the chinese state has a lot of money at its disposal. and that's how it's expanding and asserting its status and position in the world the 1st place china's gateway to europe. starts feb 19th.

place. blame. news to launch from berlin. cuts off internet access amid protests against the military coupe around a 1000 people take to this feature of mir and marched largest city of gone gone on saturday to denounce the army's takeover flying please block the streets using barricades and water cannon. russia expels diplomats from germany poland in sweden moscow accuses the diplomats of attending a rally for jailed kremlin.