for 65 years old but i've been working on the. 19. coral june was named one of the world's 100 most influential people by time magazine in 2018 and we 1st actually tested this in patients or at a child to get factual because they had lost through the virus many of their own t. cells. 2 years later my wife died of ovarian cancer in 2001 and so i really needed to move from the to do really all cancer work at the time however he did not receive a dollar from the pharmaceutical industry because the treatment initially only worked on mice but not human it's ok what we know for sure is that the. funday essential a was essential to make a new industry so to have philanthropy and government support it was

millions there was millions it was probably $20000000.00 i mean. i think for sure $20000000.00 were invested the tureen when i came to university of pennsylvania $999.00 until nov artist of the alliance we made it in 2012 but the riskiest part was state but government yes all the initial research that showed this new concept of our car keys could work was the academic laboratories. in 2010 came the breakthrough in the cancer patient douglas olson however it was the news of 7 year old emily whitehead that spread around the world that can save the young leukemia patients mike and even 7 years after the a fusion she remained cancer free. the treatment is more effective in children than adults. we had hundreds of calls for a venture capitalist wanting to start new companies and fortunately had no heart us

call us about wanted a commercial artist. inventing a drug is one thing says novartis but putting the research into practical use through a market launch is costly and time consuming insiders say no far she's paid the university about 225000000 for the exclusive right to sell q mariah and novartis is paying the university about 5 percent of the sales price for each infusion the group has no comment on this the health care industry is not transparent and it's not been designed for the benefit directly of a patient and transparency our most recent estimates. are around $55000.00 just to make the cars the cell that's. cost per patient and with no profit. so the actual cost is almost $7.00 times cheaper than the university however had only done small scale trials with camera

while novartis had to fund world wide studies to attain market approval and build centers to produce the treatment. make a dime is still waiting for his cancer killing cells from the us when suddenly a message comes from nova artists the group will give him to mariah for free. plus the most mid of all saints were killed with joy i'm very relieved to be. i mean you always a lot of money at stake also vaults will start their own cult of what about other teams i have patients standing looking like. those i don't know novartis is a play i'd seen that's when ethically it's a delicate question as to whom the largest gives free trade not to use of course. the 1st 2 swiss patients are being given key mariah for free because negotiations

with health care insurers are taking so long no far to 6 planes. mikail moonshine a father of 2 children will all to mentally lose the race against time nope artists usa informs him that his cancer killing cells have not managed to multiply well enough to produce camera. 1000 days later he dies. my name is paul toit can then in the pharmaceutical industry for 30 years in the

last position the laws us president and chief executive officer of a company i am retired now and over the last 5 years i have been dealing with and then cure the cancer. so car and what it's like to show you is all the medications that i have to take in a day. this being the most important one just as my anti-cancer drug. this product is to take one of these capsules per day the cost of those a $750.00 each and interesting only enough they only cost $1.00 each to manufacture what do you think about the price of 370000 swiss francs for a camera that's ridiculous car it should never happen this is a product that was developed at the expense of the us taxpayer did you have a different view when you were still

a former manager then you have now on your industry. the answer is yes current and. for 2 reasons 1st i was not a patient i've been part of the system i've been a my family's been a beneficiary of that system. i really didn't know any better at the time you know you go to work at to get a perspective which is the company perspective. what you learn as you get older is your perspective becomes much wider. cloyd can is the former c.e.o. of a company acquired by no bar to see in 2002 he says nope artists are also benefited from a 50 percent discount on the cost of its trials and camera this was the us is way up incentivizing research on a rare disease and it's people like myself who actually have funded the development program into development program or half the development program of come right out

and what we get in return is basically a punch in the teeth from the artist. created a price model for human rights based on no bar to since claims that it had invested over 1000000000 euros by the time the treatment was approved. i calculated a fair price current all for $200000.00 or infusion in 2019 using the assumptions using the assumption that no forests were generated total of $1700.00 patients fusions out of 14 out of 14000 potentially. goes on we can actually drop that price it can be reduced to about half of 370000 francs the fair price is calculated in such a way that no barges achieves an average operating profit of 20.7 percent the research costs averaging at 17.3 percent are also included in this calculation the

health insurer association. is also demanding a price of $200000.00 francs for. can write. or looked at the document of the document is full of incorrect information thank you for the correct information i cannot give you that and i am up i cannot comment on it because it is not ardent da our data is not our document the criticism on the farm are not just novartis but on the farmers in transparency it's growing worldwide we hear it we age o.b. hear it with the health insurers with the public because the public is the payer. are you afraid that this will damage the image of nobodies. are not afraid of damage to the to know why it is or you mention in transparency transparency is required across the system not just from one party our government is asking for transparency because we have a transparent list for prices i think it's the opposite. or it can be discussed in

a broader group i think it's a bit it's a different conversation. 71 year old ct fanning out there and also has left no cancer and he says if he has the strength he goes out with his dogs because of the price dispute he has had to wait 3 months for the health insurer to decide whether to pay for camera. quite a few could you afford it if the health insurance didn't pay when he owned approach i were 100 percent sure it would work i would sell my house but i can tell you that if it doesn't work my wife will be left with nothing that's out of the question in me that ever it is that must have an excuse that the company didn't pay for you or you wouldn't do it me no it's too risky scone because the low chance of being cured

. and. each year around 110 cancer patients in switzerland who have undergone all other treatments to no avail received camera and the 64 year old teacher unconscious or in bun maryland is one of them. it has the most interest in that the question is what is a human life worth it is to put it bluntly you are over 60 if a young person asks how much longer do you have left is it even worth it when curing your illness is a best case scenario and does it hurt to hear that kind of question. now you have it then can it be now and so you know but i've also met young people in the hospital who are in greater need when you look at it that way. i've lived a decent life and it's been nice so far. i almost feel ashamed even though i didn't set the price you feel very uncomfortable and so guilty but it's

the only chance he has left of course you're not going to say no. do you feel guilty sure. now i really need billing not really i was in good health for a long time and paid premiums for decades it never really needed anything that i might be matson to have to throw this came as a surprise because. there's health insurance is also paying for him right now. the price negotiations between the insurers and of artists took 4 months with the price being haggled up and down mike at a bazaar. some insurers threw in the towel while others came to an agreement with novartis. 4 insiders say insurers wanted a 45 percent discount on camera out for treating lymphatic cancer which was too much for novartis they instead agreed to a 20 to 30 percent discount to pending on camera

a success rate meaning about 250002300000 francs but no one is willing to talk about. the agreement after all is confidential in fact it is so shrouded in secrecy that health insurers such as concordia which were not in on the deal will not even find out their discount on till they have signed the contract coffin with think it's scandalous this is the 1st time i know of for us to conclude a contract where we don't even know the price of those usually that's unheard of in swiss health care where prices and contract closes a normally transparent you can usually check what you have to pay for hospital treatment and cost transparency is very important in health care otherwise we subjugate ourselves to the big corporations. pending or has to have another cell sample taken because novartis didn't manage to

produce the cancer killing cells in the us as they did for me. in this court's q of course it doesn't feel good things were looking up and asked if this event there wasn't an op sells its training. in the approval study for camera one 3rd of patients could not be treated at all either because the cancer killing cells couldn't be produced the patient's illness. had progressed too far or they had died waiting like mikail moonshine. anton schlosser receives good news from the us his cancer killing cells have been successfully produced and are on their way to switzerland and the comms it is immense and so then you get back these cards here man cells cells that are even stronger than normal immune cells and in the last many moons and and when immune cells get into action there are side effects last time i saw

a chanst may experience fever circulatory problems or even organ failure organic in that site at best kidney failure for instance has been observed in about 20 percent of patients but some of the needed dialysis that dust had settled puts in andy and mattel use it as a potential most. cancer killing cells can feel patients and kill them. so those cells are the last hope for those who would otherwise die of the disease. you know michele for jerry my name is alfred scheidegger and i'm a risk capital investor day here in san francisco i'm attending the world's biggest health care conference. alfred scheidegger invests in small biotech companies

developing new cancer drugs. have a good day about his goal is to sell the small companies to pharmaceutical companies for a profit. so. how are you doing yes they're doing ok for those fables we're doing. is good the truth. mr shining what's going on here yeah that's a shell so it's like a marriage market it's unbelievable. if you run into all kinds of biotech companies especially on. all mafia list pharmaceutical companies aiming to take over small companies later on once they've provided proof that their cancer drug is effective in humans like we do and i think it's you know. 60 percent of new drugs are not developed by pharmaceutical companies but by small biotech companies they need

a lot of money for studies with patients and this money comes from investors like alfred shah tica and marcos horsa. try to gross company often invests during the early stages of research but the pharmaceutical industry pays the most when a biotech company is about to launch a new drug on the market the pharmacist lying to us for value of access the price secondly $90000000000.00 nearly as lions as if we did like heights farm out for almost $12000000000.00 you know vargas is now demanding a record price of $2100000.00 for of excess treatment is it the greasy noodles there are calculations involved that have an impact on the price tag and the fact you have to gain back your investment and of course that's part of the market price in the event based on the diet of souls from bach plays with him riaa no artist managed to avoid dealing with the biotech companies for investors by signing

a contract directly with the university saving them billions. for patient court bending or at a hospital camera is able to be successfully produced on the 2nd try. 3 a few more 3 milliliters costs 370000 francs. does that if this is a discussion that i frankly do not want to get into now at a patient's bedside young i've still got a life to live. i feel like that company hit. you have high hopes it will work. and tom shows are received his infusion 2 days earlier. that's in the data base how are you doing fine. if. you're to tired right i fall

asleep even if i want to watch something. maclin you tell of the key roy is working in this investment it's too early we hope so of course but we can't tell through for whom we have high expectations of course their kids it was all excuse me for a moment my government representative on the phone informs her of new problems with humira since it is considered a hospital treatment the cantons have to cover 55 percent of the costs. maybe a stocking doesn't know we're starting that process and parallel to. the car because it because it's a vicious circle because the health insurance only covers the costs if the cantonal government also agrees to give its part of this act as it does properly lawful by you know each of them says they'll only do it if the other has already agreed to stay in touch.

maker that we meeting with jenny levy an investment banker from hong kong where she covers china they clean up. china conducts the most trials on cancer killing cells worldwide and market observers say if the treatment is approved there it will cost about $70000.00 i'd say they are using trend and i think the day i get really is the last i mean i'll get it right jenny lee says the chinese government is putting pressure on pharmaceutical companies that of course then the have to lower their drugs so the approach to baby. marketing they said they are a bit yeah yeah because you'll want new games that will be a huge wall that of the clock so that it was all the oh yeah is the lot of them if the pharmaceutical companies read my mind those high fives really the tiniest

market can all afford the tiniest patients are that our insurance is going to sell you'll be all lost lossage. are. also use this about profit or saving lives psalm of the. extinct existence the existing chilled justification of a private company is to generate profits will support feed. and that comes before life. you can really answer that question for. anton treasures wife documents whose treatment using a cell phone. is no use said no. depressed no. agitated. in the 1st days

he has fever and chills so only minor side effects. it's the same story out in the town with court bending or coming down with a fever but otherwise he feels fine. so do you feel like it's doing a good. cover i can't say that we don't know yet there. are heartless you know nothing you can write this biotech company is researching in the booming field of medicine is for rare diseases referred to as orphan drugs just like a mariah when you say 3 lives or 3. years to complete focusing on your family is an issue yet. it's. in the u.s. and e.u.

orphan drugs receive the exclusive marketing rights with similar products from competitors excluded from approval for up to 10 years states each has all come off to the cities a little or is built to incentivize research because once you obtain approval you enjoy a sort of exclusivity for several years a competitor can just launch on the market that's exclusivity told to locate the greasy excuse eat that. in the us the orphan drug act was enacted almost 40 years ago today the politician who initiated it meant that some pharmaceutical companies are exploiting their monopoly to increase their profits. the topic of orphan drugs and market exclusivity also reached switzerland a few years ago. just a. moment ladies and gentlemen pursuant to council regulations

before engaging in the debate on this topic i hereby disclose my vested interests. i am the president of into going to the swiss association of generic drug and bio similar manufacturers. in order to promote the development of medicines for rare diseases pharmaceutical companies should enjoy market exclusivities for 10 years for orphan drugs during this period no other medicinal product should be approved for the same therapeutic indication unless it is proven to be safer or more effective if your vehicle the point is the point is pharmaceutical companies are not social institutions and they only conduct research when they expect to profit from it this out in order for new drugs for rare diseases to be introduced at all it takes a monopoly and this is achieved through market exclusivity we'll push the market exclusively to it because often. when sebastian was voted into parliament he gave

an access badge to novartis lobbyist at the time while the artist and roche donated nearly 900000 swiss francs to the middle class parties last year and they've that the power to mislead fest stolen at the end of the debate it became clear to us it was not the patients who had gained anything it's through this revision of the law and there is you see a product recently being measured caution no instead the main changes have been about his cost has to be filled up even though no tom went out hoping he'd i'm sorry throughout the commission's deliberations and still here today i feel like i and perhaps others here too i have only been aware of a fraction of all the lobbying going on here in the background lobby are right on the interest since the 1st. calls and that had consequences. but i received a reprimand from past. then the head of novartis. creature

and what did he say. your head he emailed me because he wanted to meet with us and discuss our stance for methadone so he claimed we were not being pharmaceutical friendly in our law making it hard to be there i thought it was outrageous for him to interfere with my parliamentary work in parliament. had that ever happened before called us i never experienced that previously or again at last . the debate went on for 2 years and the national council voted in favor of market exclusivity twice but the council of states opposed it the monopoly didn't pass but instead a stripped down measure protecting orphan drugs did. one month after the infusion with camera and one schlosser is thoroughly examined. did kim royal work and has the cancer disappeared.

yes not much i'm 1st going to show you the old pictures there was this lump here or that there was the main mass in the fashion compartment. and of course on your lower leg. it's called now here's afterword with just some slight activity flower activity ted there are still some in the fashion compartment but it's already received there's a lot of boyd lish rainey go. so it's mean if i couldn't have expected things to go any better for that the old tumour mass has completely disappeared without a trace of inflammation can you tell if he's in remission or could the cancer come back again. we don't have a crystal ball we don't know that but it's a good start. this can you can never rule it out but with kim

treatment waits with carty cells still need more data not to quote. meanwhile at retard court than in years cancer also disappeared immediately after the treatment. of course i'm glad i can get home and i'm done wearing this mosque. we to take care and enjoy life and it's a matter covered with a 000 that's the group to see if a vehicle or his doctor doesn't want to give a prognosis according to the no artist study it takes about one year to know which patients have overcome emphatic cancer for good. more than half die. and it's not yet clear how the cancer killing cells develop in the body in the long term. but. in this brave new world of

health care the cost of a chance at survival is exorbitant. to mariah is just the beginning. of. everything is quiet without art and culture. but when a moment. is it possible to experience a closeness while social distancing. new social togetherness reflected by our visit. at work below is what everyone is missing right now. aren't

20. 30 minutes on t w. what secrets lie behind these walls. discover new adventures in 3 hope. and in 60 degree . and explore fascinating world heritage sites the kooky w world heritage $316.00 to clean up now. by calling me old and i'm game did you know that 17 trillion land on the east coast killed worldwide sure so that we can keep in touch but it's not just the animals little suffering it's the environment we went on a journey to find ways out of the ignition if you want to know how old one cliff to

the priest and the huntress train stopped listening to the 1st listen to our podcast on the green pants. this is do you have any news live from sunday and at least 150 people are feared dead as a guy ca hits a dam in india a huge flood cascades through the broken down carrying with it solid and debris into the areas below the search for survivors is ongoing also coming up germany is hit by treacherous weather as winter begins to find a majestic.