to the point. clear position in the international perspective. it's the ultimate cause of it catastrophe soaring infection hospitals that breaking point a death rate that kicks shattering records are missteps by the government to blame coronavirus in india out of control at our top they come to the point to point. to 16 years on the d.w.i. . maybe it's a pill. or a spray. a liquid medicine. an easy and safe treatment to target sars cover to. it would be given immediately after diagnosis ideally it's available over the counter in a pharmacy at cheaper antiviral tablet with bearable side effects we have cracked

scenes we even have drugs that help with the most serious symptoms of coke at 19 in the hunt for drugs scientists are exploring many different treatments. but where are we in the search for a pill. good question welcome to our code 19 special i want to johnsonville and good to have you with us and wouldn't it be wonderful if we could just pop a pill in covert 9000 would be nothing more than a nasty cold science is working on a variety of therapies but it's somewhat slow going. how do you switch off the coronavirus render it harmless german scientists co-write therapeutics set themselves this task a year ago 12 months later they seem to have achieved their goal. most drugs currently in development target mild cases of covert 1000 illnesses. are drug is special a designed to cure serious illnesses as well. and. their research and

initial clinical tests which have been running for a few days were primarily financed by private investors and government funding from the state of lower saxony. but now the company needs more funding. of course we want to be ready to meet market needs and our goal is to get the emergency approval by the end of the year. then we would have to produce in sufficient scale that we can supply patients with the necessary medication. currently the german government offers funding of $50000000.00 euros which is split between several companies. this compares with over 740000000 euros in funding for vaccine research. we need tens of thousands of volunteers for testing that's what costs a lot of money and where you simply need larger sums. of money that truly. when you

vaccinate healthy people you need a lot more healthy people then when you're testing a drug that is targeted at the sick. bike. recently however the federal government appears to have rethought the issue and further funds have already been announced. we lost many many months because the financial resources were simply not available for the drug developers we can no longer afford to keep wasting time and. color therapeutics says it needs 50000000 euros to reach the emergency approval stage. german government funds won't be enough for this so the biotech start up has been speaking to international investors. now antiviral treatments attack the virus and stop it multiplying but the virus doesn't fight fair using our own cells to reproduce and finding a treatment is difficult of the best of times let alone during a pandemic. so far the only antiviral drug approved for the treatment of covert 19

in germany is rendez severe studies show a 33 percent reduction in the duration of the illness. there are other treatments being developed. american pharmaceutical giant marc is working on a similar drug called mano pair of air and pfizer has also started human tests on an antiviral drug. if the immune system overreacts in a later phase of the disease steroids such as dex a method zone come into play it's the cortisone the curbs the immune system in germany to the method zone is used in severe cases that is when the patient receives additional oxygen. there are also preparations for antibody treatment which helps prevent symptomatic infection to drugs from us pharma giants were general health former us president donald trump. antibodies are also found in the blood plasma of recovered covert 1000 patients

there affected pans on the severity of the illness and how long ago it was germany's public health body the robert cock institute says deployment in severe cases is possible. you know mistaken on is a senior id physician of the department of infectious diseases and respiratory medicines at university in berlin as a very good to have you with us especially because you are now offering the use of monoclonal antibodies in short n a b or mab in the so-called cold map outpatient clinic in berlin what exactly does this therapy offer. well we offer treatment with one of the 2 a bale of mono clone antibody tried out and the mono clone a. tog a protein off the sars cough to virus and

they have a potential to prevent. the progression to a c.v. a disease and symptoms and yet limit the progress in patients with mild to moderate. disease particular the we know that in those who have not developed yet and. indeed genus antibody response we know that there is potential that these patients benefit from this kind of therapy and who are these patients that are actually illegible to benefit from it is it available to everyone. well. there are some criteria which we look at 2. and then the right patients. we look for patients who 5 have new or positive tests so we. need to. test p.c.

our reside which is not order then 72 hours. to provide. that security that we only treat patients in the early course of infection. and we look for certain risk factors in the patients. which are for example age or immuno. suppression for example are purely patients who are on to shimon therapy because of. the cancer. patients who are are going to transplant patients and therefore immunosuppression are candidates for the treat men and other patients for example who have received medication or just qadri took similar patients who suffer off aids are candida.

people with down syndrome are patients kidney. patients patients on chronic him or dilates those patients with obesity with the see the. elevated body mass index over 35 example and you probably have to probably you probably need to go to your own g.p. and basically prove that you are one of those patients who who actually can get to this kind of treatment but could this therapy also help prevent an infection. well there are some. preliminary results showing that it could prevent infection but the results from randomized controlled trials are not published yet so we do not use it as a preventive she that say as opposed to exposure prophylaxis when you assume infection so we so far only use it for patients with

a provan infection in which we use their p.c. our results are. now of course i have to remind you that we're all dreaming of a simple cure or as we said in the beginning of the program a pill a spray something like that to help us through infection how realistic is that notion. of course that's what we are dream half so we do not agree have anything read the clothes coming up closely for example just appear of course as the trials going on and we're looking for treatment options but so far there is no serious single pill for example. which we can hope to be done for future easy treatment of the stigma and from the sharia to influence thank you so much. let's get back now to the root of

our troubles and that of course is the virus and its variants time to hand over to eric. is it possible that the same variants a rose independently without travel in different places. the answer to this touches on one of my favorite evolutionary concepts called convergence it's basically the idea that when different species face similar environmental pressures in different places then nature can come up with remarkably similar solutions to cope with them a good example of convergence is for instance the the protective spines that are embedded in the skin of both porcupines and hedgehogs the trait didn't arise just once in a common ancestor and then get passed down it evolved independently in both species because a spiny outside is clearly

a good defense against predators if you're small and slow and just want to be left in peace the ija leaves and then sets viral genomes also change constantly and it happens a lot faster than with animals because by iris is replicate so quickly and abundantly the vast majority of those changes will be neutral or even harmful but a tiny number of them will give a virus an advantage for example a mutated gene might change the spike proteins on its surface in ways that allow the virus to slip into cells more easily and because the sars could be to genome is is actually pretty small the chances of specific identical mutations like that occurring in different places at different times. it's actually fairly hot so

we are seeing some of this sort of genetic convergence but because variants also collect many other highly individual mutations as they evolve genetic sequencing still allows us to tell them apart. there is williams there and he'll be back again tomorrow to answer more of your questions just post them on our covert 19 you tube channel for now that's all for this edition of out of the night in special thanks for watching. how does a virus spread. why do we parent and when we'll. just 3 of the topics from covered and i we couldn't read your blog. if you would like any more information on the chrono larysa or any other science topic we should really

check out our podcast you can get it wherever you get your podcast you can also find us at dot com. science. these places in europe for smashing all the records. to step into a trench or it's the treasure map for modern globe trotters to discover some of the record breaking sites. back to know also in book form. blank will be our fighters want to start families to become farmers or engineers every one of them as a planet. so nothing is just the children who have always been the way and you and those that will follow are part of a new kind of. they could be the future of collaboration it would be. granting opportunities global news that matters d. w. made bargains. india's coronavirus crisis. news special

we'll look at the dramatic situation and debt and the impact of the triple mutation on the country how can the rest of the well how what can be done for the people and how can india bring the situation under control as special edition of d w news on the cover oh no virus crisis in india starts april 30th at 11 u.t.c. and d.-w. . hello and greetings from the german capital where the city's already superlative museum landscape regains yet another masterpiece. after 5 years of renovations work on the nice funded or designed knowing it not to not a gallery in berlin is complete the building will open this summer and i'll be

speaking to the architect david chipperfield who oversaw the project. and to get your blood flowing in on our all of international dance day we met up with instagram sensation sunny get in. on the importance of berlin's noir nuts or not they can hardly be understated it's a veritable icon of modernist architecture designed and built by a giant of that period german american architect nice funday a hole as such it's a cultural landmark not only for the city but in the history of architecture itself and the story of its return to splendor the feat of engineering that it entails is certainly one with telly. after more than 5 years. the renovation of berlin's noir not you know gallery is finally complete and for now the famous and iconic museum designed by big meets founder can be admired in its simplest form as

a temple of lights on the surface not much seems to have changed the hull is now 2 seconds you're not often hired and sometimes of openness this hole is a unique structure no other museum in the world is like it that was one reason to preserve it of course we stuffed lots of technical equipment into the ceiling where it can't be seen the guiding principle for the renovation was as much as possible please maze was a big meet fandango out the german born american joint of modern architecture he was commissioned to design the new museum in the early 1960 s. . $1200.00 metric tons of steel were welded together on sites into one piece to form the roof hydraulic jacks lifted it into place the top 8 pillars a masterpiece of engineering that still causes jaws to drop. the last minute find

a building to be completed the crowning glory of his career released to the goods produced. the noir that's now camry opened in 1968 and became a cultural landmark 1st of west berlin and then of the reunified berlin. it hosted one spectacular exhibition after another and maintained its own mcness and collection of 20th century art but now the 50 years on it was clear the buildings technology was hopelessly obsolete comprehensive whenever they should it was. british architect david chipperfield was a fan before he took on the renovation job. on palm print. it's about pictures quite shocking very. impressive. very identifiable comprehensible you everybody can understand how the screen works the

contract for the noir next you know calories renovation wasn't immense and the taking 14000 granite plates had to be removed restored and reinstalled the entire structure was completely stripped down it was meticulously inventoried and later reassembled like a vast puzzle. cleared of unnecessary intrusions meese found a stark concept is now restored to its former minimalistic glory. david tipper field is certainly well known here in berlin for his refurbishment of the noir newseum or new museum and recent completion of the james simon gallery on the city's museum i lent his refresh of the noir nuts and i gallery is a triumph for the capital marked by a symbolic handover of the keys on thursday and earlier today i spoke to mr chipperfield and i asked him to explain in his own words just why this building is

such an icon. what its reputation is is both. as a major. cultural building in berlin. and especially as it was you know. 96 it was part of rebuilding but in especially west berlin and trying to is aware reinvented city which had lost all of its cultural. monuments to the east side so it it took on a huge responsibility within the city and within the history of architecture it's also identified as one of me says great work so the building carries leaves you know. this importance both in terms of its situation in berlin and also in that situation in the history of architecture and. i have spoken

about the structure as as being radical and i'm compromising what was it like for you as an architect to actually take on such a building and walk in the footsteps of a giant like. me from that whole. we're lucky we didn't really have to walk in his footsteps we just had to sort of. cover up something or you know deal with looking after this incredible thing which he had made. and you know our responsibility and task was pretty straightforward in it in general terms was to repair it and bring it back to what the architect intended it to be and and that it had been at some point. and of course. that is a on the face of it a simple task but michael simple tosses it was actually it's quite complicated. and that complication is to do with issues of repair which you know if things are

broken sometimes this at least for the bridge some say but to solve the initial reason as well as putting things back so there's a lot of diagnosis and there's a lot of collaboration required i mean that's why these projects are interesting because this is not. as architects we are not the genius the genius was was nice but our skill has to be in finding good solutions between the technical ones is that it wants and you know of course staying as close as we possibly can to the original project i'm just wondering if an energy efficiency of course wasn't really a topic at the time of that construction in the 1960 s. that more sustainable since the renovation well you're absolutely right the building it was a very idealistic building and nice it's work is very reduced in stripped down to very elemental components which is why it's so beautiful and quite unusual in

that in architecture that period on the other hand that whole approach did create moments such. technical weaknesses so. the window frames work but not designed to deal with some of the issues brought in. and that was a lot of the problem of the the building it was certainly the temple and we had to result that we had to result up between you know on the one hand protecting the integrity of the original resign and at the same time resolving to within within stunned boundaries were booked you know the thermal issues that you talk about ok i'd just like to ask i mean obviously no other architect has really left such a mark on historic but when i did does your relationship with this city change in

any way with each of these projects. well that's a very generous thing to say i'm not quite sure it's true i think there's quite a few other markets without a big influence to meet that. and i'm happy to be associated with burning it as my office is also going to be paid for quite a few years now and i have a very. wonderful team of partners an architect who has maybe you know taken these projects of noise museum james simon national gallery you know these are. the things that we've got to do believe we've been working on. this process since 1907 and it's it's wonderful to be part of this incredible story of this incredible city and i and that's when i got of a will open to visitors of course in august fittingly with an exhibition of

american modernist sculpture alexander called a congratulations again david to profiled on this achievement and thanks so much for speaking with me today thank you very much. and a bit of a change of pace now and dancing is so good for you that you really don't need much of an excuse a tall to do it but international dance day on april 29th is perhaps the best reason of all to let go and boogie around the kitchen gates started out as a street performer in paris and he's been called the next best thing in dance after michael jackson so check out some of these moves for your inspiration. sonny is on the show in paris his specialty is the move which was michael jackson's trademark move back in the 1980s son is gay has even done stood in the loop in paris. i still remember watching michael jackson's music

video bad when i was 3 years old it for me it was more exciting than a cartoon and i was absolutely fascinated by. michael jackson has been copied by many but never with as much success as the 24 year old frenchman with senegalese roots from a paris suburb. posted this video in october 28th and now has received more than 10000000 clicks on instagram. now so the past 2300000 followers including the american wrestling and movie star. he's also done for serbian tennis player novak djokovic. so now works as a model he even designs his own sneakers for a french fashion label by now he is well known in paris where people approach him

regularly nowadays so if kate makes good money with his various activities he even has a manager of the days when he don't for money on the streets of paris oh no. ringback i once lost my phone at the dance to buy a new one. so carbon one day there's 200 euros again and bought a new phone with the money. i paid was the one i'm going to euro coins is the salesman was really surprised what i. have been joys hanging with his friends that condones almost as well as he can but having the same success. i'm very grateful to them. spending time with him does me good in them what he gives me and howard will make me stronger with what astri is the soul of life for me no one up will the more i became an artist. the money some of it is a stall one they can see on the internet but also experience up close on the street

for free. and that kind of performance is certainly all the more appreciated in times like these when out side is of course the place to be to enjoy a bit of culture but if the weather's bad i can highly recommend getting down in your own kitchen so why not try that tonight after dinner that's all for today but i do hope to see you next time and until then all the best from us here in berlin and stay safe a few dozen. troops

. point to strong opinions clear positions international perspective such. as the ultimate covert catastrophe soaring infections are supposed at breaking point a death rate that keeps shattering records are missteps by the government to blame coronavirus in india out of control that's our topic on to the point to point. up to 30 minutes on the w. . we however important numers let's get right to the. smoking is healthy. post decides are good for the beams global warming

doesn't exist. don't believe those. not yet if just. upgraded my mind this. industry is controlling your thoughts they are tense truly seeking new science. it's not easy to spot i'm saying one thing industry is saying another. great books of the 20th century. present day hoaxes. and who's behind the. news manufacturing ignorance starts may 3rd on d w r. this

is. from berlin tonight joe biden's blue collar blueprint for america the u.s. president delivers his 1st speech before a joint session of congress and promises big spending on infrastructure and families he says america is returning to the politics of international cooperation but warns the biggest threat to the free world is china.