thing and i would never have thought that today's and can be live. so i live in europe. the 2 part documentary starts july 5th on d w. ah, ah, johns against which antibiotics has become policy are becoming a more dangerous in europe alone around $33000.00 people die from them each year. they have come to you. now a new wave is coming to our region germs that are completely resistant. and so the new treatments have to be found owned ones have to be rediscovered when drug stop working, patients feel helpless. we need to get rid of all the big germs that i have at the

moment, and there are quite a law to get the pathogens under control. scientists, in workshops and research laboratories, feverish li, looking for new solutions. can humans when the battle against john the all? johan is shy guy and he is 15 year old daughter. paulina has travelled from regarding an in germany to add to up in belgium to try to get help dangerous germs keep cropping up in pounding his lungs. she wore a face mask long before the pandemic. i need the mac so that i go to infect other people and so that i don't infect myself with any germs in belgium. lena's lungs will be treated using

a special therapy. the clinic uses viruses known as bacteria pages or pages per short, which literally means bacteria eaters. i forget because often it's for the past 3 years. we've tried in vain to remove the germs from pauline, his lungs with antibiotics. and so far we've not been able to get them out completely when it was hopefully in the spring friends told us about age therapy and after a long wait, we're finally here today. i hope the pages will bring us success in the next few weeks in the fog. these viruses destroy bacteria. paulina suffers from cystic fibrosis, a metabolic disease that makes a long secretion thicker. this is why gems are always returning to her lungs. among them are antibiotic resistant bacteria. the doctors in belgium, hope to be able to destroy these gems using pages,

they tell paulina to breed them in therapy has not yet been approved in germany. bacteria pages are organisms that can multiply on their own. they are found everywhere in our environment. they feel most at home wherever there are also many bacteria like in sewage. it's hoped the pages that paulina is inhaling will reach the dangerous bacteria in her lungs. each type of phage only ever attacks. one specific type of bacteria and reproduces within it. if an age is grow, they destroy the bacterium and look for a new one. if none of the host bacteria are left in the body, the features die. when eventually, of course, we'd like this to happen in germany to act on, but then when this is approve, there, it'll be a very big step for all patients who have an infection with period up can no longer be treated with antibiotics punishment rather than con. really, the doctors use viruses to treat bacteria infection over 100 years ago. but with

the discovery of antibiotics, really pages were forgotten in the western world. in parts of eastern europe, they are still use successfully to day. and they are currently experiencing the renee songs in belgium, the benefits we are hoping that they will be able to help us combat those infections. who are inter bill takes aren't enough anymore. we'll face therapy be able to help paulina detected m r. s a once before, and now it's back to the non emma essay stands for methods still in resistance stuff. you know, congress already is something many patients fear because it's a constant threat for hospital treatments or surgery bent inc. and young and medical hygienist, ron hendrix, have a patient with dangerous germs in his sinuses, but the hospital and the german dodge border region has a very special prescription for dealing with the patient. used to be a farmer and belongs to a high risk group. because the germs are widespread in cattle stalls. when are you

still live on the farm? do you have pigs or horses or what is on our farm? hasn't had any pigs for a year. unfortunately, that doesn't help much. it takes a lot of time before the germs are gone, to notify you know that in 2017 you had a positive nasal m r. s a test result when you went in for another operations. and we've now detected m r. s a. again, the homes and that's why we're very much in favor of trying to remove this year from your nose and scan and so that you can get through the operation with as little risk of infection as possible. your 100 showed to boeing has the multi resistant jam in his sinuses and on his skin, it's completely harmless in these locations. but if it gets into a wound, it can lead to a life threatening infection. and operation therefore presents a risk for the retire farmer. but he needs a new need join to the hospital is performing more swamp tests than most other clinics. it tests about heart patient. if there are multi resistant germs, present,

doctors combat then before the operation, this can distant. i'm a bit scared, but i've been in a phase like this for 5 years now. where i've noticed that when i run, things are getting worse from one day to the next. and now something has to be done on its most, most doctors have significantly come back on the use of antibiotics. that's the me can be an organ again. and the 5th is what the micro biologists and hygienists fear is that we will keep going with antibiotics. always trying to support or treat every disease with them without restraint. and that makes the germ stronger and stronger even image image data. the fear is that ultimately the germs will make all our antibiotics and effective feelings. hendricks wants to further improve the use of antibiotics. old anti biotech should be used for pathogens that are not resistant to the while. new ones should be said for problem germs,

and then for no longer than necessary. to do this, hendricks, there's also expanded the capacity of the hospital laboratory on a bore without a laboratory. it's almost impossible to practice good hygiene and good antibiotic stewardship. well, every german hospital with over 400 beds needs its own laboratory to gain better control over the processes. and in house laboratory means more jump test, faster diagnoses. and a more targeted used to antibiotics. in many german hospitals, the laboratories were shot down decades ago. the reason of cost, but today if more tests have to be pre owned the cost of the clinics, increase its money, many hospitals lack, but the needs to be spent near and kind of if you don't test anyone, you don't see any germs. if you don't see any germ nation, you don't take any extra hygenic measures and then the patient is not always treated in good time or with the right out of order. no hygiene means the germs

will spread further from high. that's just a few years ago. it was thought that the medical profession had infectious diseases under control thanks to antibiotics. in 1928. alexander fleming from scotland discovered a mould that killed pathogens. he called it penicillin. it came into its own during world war 2, due to the large number of wounded, the u. s. put it into mass production. fleming recognised early on that bacteria could become resistant to penicillin. when he received the nobel prize in 1945, he urged caution, but in vain. look at the time. multi resistant germs are not hospital term house here. one horse in our hospital and others, we found that over 95 percent of the people who are infected with these germs, bring them from outside and that you can catch them in our hospital. does the dark it doesn't, that means that there is much to be done. and if we don't do anything,

the problems will get worse and worse than the next mom know for hospitals. it is an important problem going on import the problem. antibiotic resistant gems thrive wherever a lot of antibiotics that are administered, such as an agriculture. the drugs can only killed bacteria that are not resistant. the others multiply due to the widespread use of antibiotic can meet production. they also spread in animal, stoles, and manila. the retard farmers gems also came from agriculture disinfectants to use to help reduce the dangerous bacteria on his skin and nose. before his operation. i found that i was amazed because we hadn't had any pigs for a year that the germs were still there and i would have preferred if they hadn't noticed. and your interest question, will he be able to reduce the number of gems? and now that he's surgery can go, well, yeah,

work focuses on ensuring that the dangerous jobs patients bring in to not spread further in hospitals or researchers in the danish city of order and are aiming to revolutionize the killing of pathogens and hospital rooms with molten technology. autonomous cleaning robots and coming to show the robot brings together to technologies, mobile navigation and u. b. c, like you should be getting are important because the ultraviolet light that is installed here hills, the bacteria in the room that is being disinfected. woman is the important thing about you be like, is that it can go where it is needed, your hand. column company parts class reader pushed the development of the robot

for your friends of his head, lost family members to resistant jobs. in the future, he hopes robots, like these can help to better disinfect hospital rooms. the model in the company, cargo is a dummy without uv radiation. they had a sudden they're hanging now a days around 8 to 10 percent of all people treated in hospital pick up and faction the government reported by assisting the cleaning staff with the robot. infection rates are reduced failure, so it saves human lives and then save massive hennings. in a testing room engineer, pair your nielsen applies test strips to you v c radiation. the higher the exposure, the darker they become, the stake and by the robot can be programmed precisely, room by room accounting for the furniture and floor plan. uv radiation would be fatal to humans, says the robot has to work alone in the room. most importantly,

it must disinfect the places where the germans build up, known as high touch since it is heavy. if the game for here we can clearly demonstrate that the maximum radiation outward reached the high touch surfaces when we disinfected them. if we say and the u. v. c. radiation here and on all the services in the room with high enough to kill 99.99 percent of all the bacteria for physical housing and her father. johan is waiting for the next round of page therapy at the antwerp university hospital. dr. tina boy uses bacteria ages to kill the germs in germany and many other european countries. these pharmacies have not yet been approved. as a medical treatment, the prostate would make the most sense to approve the entire bacterial stage

manufacturing process the focus. but to do this, you would have to relax some of the existing approval procedures in many countries, there is no legal framework to make exceptions. but here in belgium, we have now done jeff, who told us we were looking for a way to allow fades treatments while ensuring patient safety. i believe that is why this has failed in other countries to dina studies think digital communicating . i'm going coins prepares the pages for paulina in the hospital pharmacy for every pathogen. medical professionals have to find and breed suitable bacteria pages. the dosing takes place here in the clinic area, phage solution. that's how it comes from a military hospital in brussels. and we only use it for infections with very specific multi resistant germs. we prepared here in our pharmacy. we only do this every few months. we've had another patient before,

but it's all pretty new to us. the high security at the laboratory is purely a precautionary measure, because the side effects of the pages are not yet known. so doctors determined the dose individually for each patient. the so far power lena has tolerated the pages well. she's supposed to inhale the viruses one last time in the clinic, then she can continue the therapy at home. so i just feel like feel that my lungs have already become are applied from a cause and my voice sounds a bit strange now, but they're letting me go home today longer. second, paulina is supposed to inhale the pages several times a day for 3 weeks. if the virus therapy does not bring the desired results, she faces a 2nd round this time intravenously, with

a needle. and she would have to go to antwerp for 4 weeks. not something her father and the doctors would like to avoid treatment. so let's hope that the areas of the loan will be enough and that you don't have to come back for the 2nd part of the treatment that will follow up. in the next weeks, we will be checking her sputum sample every week and we'll have to see whether or not and at what point we won't be able to culture the bacteria that are in our lunch right now. so i can't predict it. if it's in the 1st week, then we'll throw a party, i think that very soon. but it's also possible that from the 2nd or the 3rd week or, or not at all, we don't know how to find all the jobs and to dissolve the secretion in her lungs. paulina has to inhale several times a day, both with pages and antibiotics. i think it's a good combination thus unto the antibiotics does not harm the ages because their virus pages don't harm the antibiotic conditions. there aren't

a lot of studies on this studio and intensive research is needed if, because it's obvious, multi resistant germs will cause more and more problems for us. this is out in the my goals will only know in 3 weeks whether the therapy has worked not any pages and better hygiene, promise solutions. new drugs are also being developed in akins book, molecular biologist martinez. so is looking for ways out of the anti biotech crisis for the biotech company lose. and he has developed a process with which he can specifically find any type of bacteria using artificially produced protein. enzymes are shine a coma for our basic building blocks come from nature. any key how we optimize enzymes that are used by phases primarily to emerge from the bacterial cell at the

end of that reproduction cycle, from the old community to the basic idea is to make the bacteria burst from the outside, almost like a balloon. i mean, i'm a phantom once the ages have found a suitable bacterium, they multiply within it. during this phase, they produce enzymes. if enough enzymes are present, they cause the host bacterium to burst. and so grease still produces these enzymes artificially optimizing them to attack bacteria in the human body. he calls his invention r t license. the 1st volunteers like l can i get you have already been tested with them down. the geriatric nurse suffers from neuro dermatitis again and again. stuff . hello, chi causes inflation on her skin. it's getting so bad that she might have to give up her work. success been off top yet. my doctor said he tried every fish. there

was nothing left. so he didn't know what to do with me anymore, but then he read about this and said we could ask for a sample of my and, and then within 2 or 3 days of trying it, you could see how everything went away. you see, i just took it, had healed this to high skin, stop ditching came out. it was a miracle of you and one of my team agrees, so did a lot of tests and no resistance ever developed license. so delta biotech company have a solution to the fight against jones does matter. and then let's the on the, i believe that in recent years, and we've seen that the problem of multi resistant germs has come more and more into focus. and our technology in particular offers many advantages over classic antibiotics is tiny, that this tends resistance, does not develop and we can kill a large number of germs in a very specific way to the effect of crystals. artie license is

visible under the microscope. they destroy the target bacteria in a fraction of the 2nd. but there is a long way to go before the enzymes can be turned into medicine. the small company need support from the pharmaceutical industry. and that's what martine grease of found in the western german city of upa. i told him a man wants to bring art license to market. pharmaceutical company, i curious is one of the few worldwide that are researching new antibiotics. and that present gleeful with a great opportunity for service the for us, it's very important because it's the 1st step toward youth and human pharmaceuticals. that's a big milestones or a biotechnology company. my inch time, the potential of the new development is impressive. even a small dose is enough to read

a highly concentrated germ solution of pathogens within minutes strapped to conquer are responsible for the milky cloudiness, particularly if just made this strapped to caucuses, germ solutions. i'm about to add a controlled substance, and are already licensed. to compare them, you will see that within 5 to 6 minutes, the cloudiness will be different. so the germs burst and are destroyed. and as a result of the solution loses, that's allowed in, it isn't even time lapse shows how the anti license destroyed that cloudy jumps, city model to see what else vision of the human medicine. this would be a huge step because you have a completely different class of ingredient on a completely different mechanism and model of action, you know, where you can work against existing resistances. this is a new weapon against resist in germany, into climate. for many pharmaceutical companies to search for new antibiotics is not worthwhile. because new drugs have to be kept back, can reserve antibiotics, and only used in imagine says use levels would probably be low. and developing

costs would be high. level tension is when we talk about resistance, it's like an arms race because the bacteria will always mutate and build resistance with you constantly have to keep up with them because they never stop trying to defend themselves against the drugs where developing the it's an endurance phrase all that love employees regularly analyze the global resistance situation. dangerous intestinal germs are gaining ground, that antibiotics can do little stop. 5 percent of hospital germs are resistant, even in the netherlands. a country with exemplary public hygiene in dodge london via by in revenue that i now 12.2 percent. and you can see it increasing. and it's a similar story in poland, austria, and spain you do as kind of, i don't know if there is no country under 5 percent anymore. and i think that's pretty dramatic with the germs on. a new approach like that provided by artificial

enzymes is not without challenges when he gets him at all. if i come up with innovative approaches that have never been tested and humans, and there's of course, a certain risk because they 1st have to prove their effectiveness and human. and it takes time to develop them from scratch. the movie i was the movie we have to say and believe there will be a solution must be a solution because the problem is so syria, unless i have on the news on the, in the problem is the goal. it may take another 5 to 10 years before author license ready for the market as drugs paulinus. phage therapy in belgium has now ended at home gene hales, a harmless, say line solution. look a, move your upper body so the vapors can get deep into your lungs. incomes. ah, the pages worked

out, lena finds it much easier to breathe. she finally feels like working out again. and exercise is good for her lungs. shot and how much is $122.00? wow. wow. not bad, better than last time. cool. when you look, if i do the pulmonary function test, the results are good. it also influences my mood. i usually feel better immediately, which was to have more motivation and i'm somehow happier to show a feel better because i feel like i can do more on the cost of illness. paulina have to catch up with a lot of schoolwork at home. it's much easier for her to study when her lungs are clear. she is doing much better, but doctors can still detect dangerous gems in her lungs in point. so she is considering going to antwerp again with her father for another round of age therapy

. doctors here at saint agnes hospital in buckles have already made great strides in the fight against the germans and by applying hygiene. concepts from the netherlands. standards have increased, and antibiotic consumption has decreased. regular training and self monitoring are important factors for ron hendricks. this is what it is incredibly interesting that in the last 20 to 25 years and microbiology, the approach to hygiene has changed 100 times more than in almost any other discipline markets that makes it very interesting. and also means that we always need to be on the ball and to be able to explain to people what is going on with us . some 113 hospital. so taking part in across the board network, more and more german clinics are adopting dutch standards in bulk out before doctors don't rated on your billing. the treatment significantly reduced the number

of interest jobs, while the wound was open during the operation, he was given a one time reserve antibiotic that was all that was needed later on. i'm so really not unless it's such a weight off me. when i'm about to try to take some steps with crutches, and that's really good that this was listed in the move to land clinic. the doctors have the gems under control. but for ron hendricks, that's no reason for complacency, yet it's forgetting how we proceed now. will help us to keep these germs under control and the long term we need to restrict prescription of antibiotics, preferably using the oldest drug with hunger and we need good hygiene, taking swab so we know who is infected with which germs. so we can act accordingly, and no matter what we can think of the germs already have an answer. the fight against the killer germs can never be entirely one. but we might be able to keep them under control with better hygiene, new drugs, and only using antibiotics as

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