has warned of a protracted war in ukraine. he says there is no indication to the russian leader vladimir putin will give up his ambition to control you, right? that is your news update at this hour. don't forget you can always get more news and analysis around the clock on our website. that's d w dot com. or you check us out on social media at gate of units. i'm clear. richardson in berlin for me in the team. you so much watching take your time for the experiment about time. it can be measured precisely. and yet each person experiences it differently as if there are different forms of time. but dimension and illusion about time starts april 14th on d w. ah,

ah, that's pretty much the courtesy. it's like the plug spin pulled. the switch has just been turned off. so therefore, the stomach, imagine being at the amusement park and suddenly there's just noise again, or all the lights go out to clean on the carousel stops that music disappears or your disoriented in your fall and you can't do anything about it. just be close to begging, cold comes soon . the sweetest congregations at austin. i felt deathly ill for 8 years to certain. i know my body has changed and this condition is now irreversible. he did not

in the evenings, i often said in despair, telling my boyfriend that i can't understand why nobody can find any language. let us finish. interesting chem, communist mothers, americans is rice. why when it's bart, my can't even get out of bed was kind of movement from i'm on my leg should react and there is no paralysis. it's ashley. but i can't find the energy to swing my legs out of the bed. and so i'm short of breath, the cut i have the strength to use my lungs as to mom. so bases mishma in that complex can't even complete a sentence without taking a breath bill just unfold french,

natalie, financial and foolish, directly. and of course, there's a piece of life missing them, especially when you see what others my age are doing. i wish it hasn't affected me as badly yet. but i still have bad days where i can hardly move on. my whole body hurts is schmidt, and it makes me afraid that it will become a permanent condition. ah, just look, i'm sure it swift. $2.00 and eileen brown, i'll flip girl and sonya co. 3 of over 100 patients who answered our request for interviews with the german m e. c. f. s. society. they were all willing to tell us that personal stories. the strong response makes it clear just how much suffering and despair the disease has caused them. ah,

we begin our investigation at the shallow tie hospital in berlin, common shop, and bogan has been researching emmy cfs for years to come master on cookie. dalton for immediate fancy, fancy hits, bookish to my background, isn't on college. it does. and in 2020 technology has now allowed us to get a detailed understanding of so many disease mechanisms that we can use them for specific treatments for, for the know this also applies to neurology and the accountant to, to november. but with this disease, we know about it as much as we did others 30 or 40 years ago. for christiane von, the overall number of scientists working on this disease will drive is very small in relation to the disease as frequency and kind of a lot to enter the hutch. try to conquer. 17 to 24000000 people suffer from emmys. cfs around the world in germany, an estimated 300000 in france,

around 250000 women are more frequently affected than men. scientists assume that at most, only half of those affected have been diagnosed. christie, that she was, the child is impartial. mostly i'm disappointed and just i'd never imagined that i could be left so alone with this illness and address of those animal. there's not only a lack of interest, but a lack of understanding mudding mom like when you speak to politicians, they think you're just an isolated case that you're not awesome. and the worst thing is that you gradually disappear in 2018. 0 my neighbors thought i had moved away on google chrome, golf club. mm . 1626. so tuba

surveys the 26th of october and i had been getting progressively worse since last night and i couldn't do much to day and spent most of the day lying down even the slightest exertion was too much in good. so fear for me. emmy cfs stands for my allergic and stuff. hello my a light us chronic fatigue syndrome. a complicated name for a complicated illness. deb, because i'll go show to the 10 mile, jake refers to muscle and in sofa. my litres of is an inflammation of the brain and spinal cold marks. as is all kinds of guns em group, the term is unfortunate because in most patients there is no evidence of inflammation in the classical sense. now, why isn't? let's endless. m gobbled flight olden phones to normal. it was an attempt to give it a more appropriate name in 2015 on a desert systemic exertion, intolerance, disease, blessings, intolerance. a candle is naturally also as cumbersome,

but it better describes the call problem. and this problem ambition than does this, the, those who suffer from this illness have very low energy reserves and can no longer tolerate exertion and bluster mishma to love. yet history or a completely inexplicable physical reaction. your bones hurt so much that you can't get up in the morning. like the flu. 3 feel weak. you're feverish, your muscles ike. your teeth or our teeth are used to be active, very active listings, and not just as a police officer on the street making arrest, even when things got rough order. my private life was also very actors were done. little that's just disappears. does, would uncompleted common eileen

got mano, nucleus is 2 years ago. and she hasn't been the same since. she can only occasionally go to school. her parents am mystified by what's happened to their daughter that she wasn't murdered. he always used to go out with her friends, boys had seen that she just exercised all the time. she used to work out here at home to work out go, she can't dance anymore of a gun. it's really bad. i told them this month was i don't hers as a parent you are helpless if you don't know what's causing it was and what you can do to help an aunt. what have you tried to be encouraging and say come on, let's go outside ski. let's take the dog out. well, come with us again. love or no, i can't. i don't want to do that. he can be a bit much and before every time and then missed if i had to describe what the

illness feels like, i compare it to a battery and the system and a healthy person gets up in the morning with 100 percent and uses it up over the day in the evening they go to bed and it recharges overnight, so they can start the next day with a full battery. and he doesn't work like that for us. we only have a few percent to get through the day. in addition, i took overnight or during rest periods, that our batteries don't really recharge at all. any health issues, we always have to work with only a few percent in our batteries. our bodies are under supplied. we just don't have enough energy. i saw nicole, a former communications designer also caught mano, nucleus is even though she recovered, she caught

a number of viral infections in 2012 and hasn't been healthy since long in person interviews are too strenuous. so we do the in depth interviews later over the internet. could you briefly describe your symptoms? what are the disease, the symptoms? him lot more and more, a symptoms emerged over the years. launch fighter, i kept getting salah, very gland infections. and dear infections, i'm out in 2015. i was in the hospital 3 times with really serious bell problems and, and run kindest of burning in the lungs. wouldn't go away. and i went from one doctor to the next. no, i saw neurologist in 2016 or 2017 therefore that he just took one look at my medical file, saw how thick it was and said, i don't even need to see it. i can tell it's like a some lat, angel, marsh, or most doctors are unaware of the disease. even though it was included in

the international classification of neurological diseases by the world health organization. in 1969. even today, those affected a wrongly diagnosed as suffering from depression or mental illness, this fellow venomous. as sin. i went to see my doctor describe my symptoms and told him how i was feeling. but he didn't know what it was either. and eventually said, my stomach was the problem. sure. i've been to various alternative medical practitioners, but they couldn't help me either. we've tried a lot, but no one could tell us what's wrong. that was fabulous. since no doctors could help, eileen searched on the internet herself and came across a research project at the technical university of munich and the helm. hold center . who to ballons, conducted abroad study at the center on mano nuclear doses. she met young people

who did not fully recover after the infection and went on to develop emmy cfs. very few scientists around the world are researching emmy cfs in children and adolescence. in germany. she's the 1st then beth concoct alysia to us lisa. it trigger we can characterize best is indeed infection unit or infections with various pathogens. and if i vacant, these are mainly viral pathogens. for example, the epstein barr virus all the sars virus sigh but also inter a viruses. and she bucked area and it's a cheerier as well in isolated cases in ironing, finn and i'm accidents and surgery have also been described as a trigger on however, these cases are not as well understood as cases triggered by infections and healthy people. he got and found out was best take his own title out,

then they appear as excessive and noon reactions to one says manifest in more than 90 percent of humans catch, the epstein ball virus or e b v during their lifetime, usually in early childhood. the virus often develops without symptoms, and most have no additional consequences. but an infection can reappear as mano, nucleus is, especially in adolescence and young adults. common symptoms are a high temperature, fatigue, sore throat and swollen lymph nodes most fully recover. some however, such a life threatening complications including respiratory disease, spleen damage, low blood cell counts or long term conditions like emmy, c, f. s. an estimated 40000 children and adolescents in

germany suffer from emmy c. f. s. a diagnosis is complicated. the disease has no biological characteristics that can be used to objectively diagnose an infection. other conditions have to 1st be eliminated as the cause of eileen's permanent exhaustion and pain. the internationally established canadian consensus criteria for emmy c fs helps doctors reach a diagnosis, neurological and cognitive symptoms, immune disorders, muscle and joint pain, headaches, and sleeping dysfunction. the best symptom for distinguishing emmy c. f. s from other cfs conditions is post exertions malays, or p e. m. the symptoms worse and after patients exert themselves physically or mentally leading to a crash glue than

9 months after getting mano nucleus is. eileen was finally diagnosed with emmys. cfs by professor water barons in munich. but what then? no medicines or therapists have been developed to battled the disease standard treatments, tackle the symptoms instead of name their guns and who am i and besides the entire symptom oriented treatment, including cardiovascular support. it is, it's important to give patients good advice to recommend relaxation techniques and how to manage their very low energy reserves with all they shouldn't over exert themselves, but also get limited exercised da, how short daily walks if possible. so they don't lose what's left of their fitness, ms. d. i lynette the quantity of alien. ah,

eileen is now taking part in one of utter baton studies. the professor and her team are looking at the course of the disease in emmys. cfs patience. eileen's pulse on blood pressure are taken regularly and her blonde is tested. cardiovascular changes are measured during a standing test. i okay straight legs and lean your head back with you. are you nauseous? i feel dizzy with you, but would you rather lie down? yeah. this cause a problem by design conklin is desmond inputting the worst thing about this illness is that patients don't actually look ill lot home to and which is also a problem for research because you stigmatization gets in the way of both treatment and scientific attention of random ashby, at aren't a methodology yet st. english end,

but at the moment we are thankful for support from the us national institute of health without him the n i h of teeth, her daughter was getting and valuable. thank god. now a little more research is being advanced by the wave from that on off. it's of a nick on, but it's too little with too little public funding and thought our home or if with food in germany, most of the patients are left battle the disease on their own. they're dependent on private care from relatives and friends. health insurance companies don't yet recognize, emmy c. f. s, and refused to take over. most of the costs. patients are reduced to trial and error in hopes of getting their lives back up i. i lost all school yet. i tried everything yet really everything college also i was so desperate shopped on . i then happened to try and off label drug calls on medical medication. that meant

for different illness. and i experienced what i now know as a crash. what of ice crush on the so i researched the medication and kept coming across an illness. i never heard of dog. i'm a concrete go store, cindy, my allergic and stuff. hello. my allied us, follow me really. and i thought yet that's it. still all my initiative nettles collision that she read it and said you look these people feel like i do on and she sends it to me. and then also i remember that well the size is not an that text. the article was very scary. if reckoned aunt i saw passage and i kept wanting to leave as i read it, also be and i had to get out of my office and somebody was sorry for the call. i didn't think this would happen is, was because we take

a break if you want. i yes, a short break. i know that spike light up as on the one hand i was relieved when i read it and totally recognized myself. although, but on the other, i realized that i had been fighting it for 6 years and would be fighting it for a long time before i could get better again, because it doesn't. and it's not even clear whether i ever will get better again guys of this one is on the bottom or it's it's, it's still, it's one more in your process that began 9 years ago with pneumonia. oh, i didn't. the weeks and years sort of followed towson. i haven't been able to get myself back to where i was towards was on beach does. we're bo,

was to diminish. i start like a 90 year old with a walker, who can only go so far, and no further damage. no hassle. it went from doctor to a doctor for 2 and a half years. no one was able to find anything. then his cardiologist pointed him to common shaban bergen's outpatient clinic at the chart. a hospital she diagnosed him with emmy cfs in 2016 and her lips the glitter, the hello. hello, good morning. come with me please. for the consistency, take a seat and we haven't seen each other for a while. how are you permanent getting worse all the time but slowly mr. okay.

okay, still working? no, i'm on sick leave. okay. on. okay. and before then for her come before that i gradually moved from being in the field to desk work and then working from home. and eventually even that didn't work anymore harder even with breaks 8 hour days or too much them and you've brought me these results. yes, all to am you neurotransmitters on smith are no ninty back in. they are really very high. when i saw you 1st, they were elevated. i live at the values you have now are extremely high via in different houses. we think these antibodies also regulate the body and you to see a face. the function is disrupted era function. and this may mean that exertion can lead your muscles not being properly supplied with blood. your quickly and pain can't concentrate circle and ultimately energy production is also controlled by the

system that is a sustainable that it could be a major factor for explaining all the complaints of this illness angle. misprint. damage, harden line is still only have an incomplete creature of how this disease functions that's from what is relatively clear, is that it's an illness where the immune system plays a significant role. it is only because the disease usually begins after an infection. mention 9, i infect chillin, begin the infection ramps up the immune system and it doesn't return to its original state via indifferent hours death. we assume that this overactive or mr. late to deny in response then takes over the function of the autonomic nervous system. in the autonomic nervous system controls all the bodies, involuntary functions, our heart beat, breathing, digestion, and centrally, the dilation of blood vessels. if during exertion, plant cannot flow freely through the vessels,

muscle pain and pour concentration are the result. not enough oxygen is available to produce energy. the b to to receptor is vital for blood flow regulation and is located on the blood vessels in muscles. it's controlled by adrenalin, which is released during physical exertion as well as antibodies in healthy people . blood vessels dilate to increase oxygen supply to muscles. 2 but the charity team found indications that antibodies don't function correctly in m e c. f s. patience muscles don't get enough oxygen. half lipp curs antibodies are being exempt. they listen, they're packed and had anti cutting back. i thought we know the patient has antibodies against the b to, to receptor. what we want to know is which part of the b to, to receptor in we've divided up the b to 2 receptor into 15 small pieces and stuck each piece onto a different little bait with can be light nice. be so glow in

a slightly different color epicenter and then we can see i'm tired. this patient reacts more to the front part. if i got another to the middle part or 4th, we can pay this with the reaction pattern of healthy people. this would help us understand disrupted receptor mechanism better, and ideally we would see such a clear different sign that we could use it as a diagnostic test. and you have not pushing tests, not the blood taken from my lean is to be used for further research. the munich researches send it with other samples to the julius maxine millions, university in birth, bog microbiologist, and their ologist doctor, boop, hash prostate and his team are awaiting the samples. i personally am very fascinated to search for the infectious causes behind the disease. if at all, there is a vital infection being associated in this disease. and if we can find out this virus association, can be rufe at the molecular level,

how the virus causes the disease. this will be really a big, big breakthrough in this field. and if we can prove that really, viruses are responsible for the disease, then in a long done definitely we can find a cure to eat or a way to interfere in the process of disease. and the scientist has been studying the role of viruses in the human body for many years. he was the 1st to discover the link between the epstein barr virus and m e. c f. s. what we have found out that hope is viruses, particularly human hope, is 5 step 6 and epstein, barbados. they are the most interesting candidate which can contribute to the development of the disease. we have found as that 80 to be 6 produces a small irony. and the small army can directly target mitochondria to fragment. and

this is already known that in v infection also, mitochondria fragmented. so we believe that these virus induced mitochondria recommendation is one of the most important steps in the development of m. cfs. physical and mental performance is determined by tiny little power generators. the mitochondria ah, healthy mitochondria have a long mash like structure which is important for producing 80 p. r. bodies universal energy sauce. when mitochondria fragment and lose their mash like structure, they can no longer function properly and produce energy. ah, in his experiments he adds antibodies from the blood of emmy cfs patience to healthy cell conscious. he has grown water will then happen to the healthy

mitochondria. if there is a factor in the system of m as if a spaces which causes medical dysfunction, we expect that this factor will affect the healthy cells and the mitochondria will be fragmented of 2 different degree. the 1st results appear after between 24 and 48 hours. he's right. the mitochondria from the healthy cell culture have fragmented. this is severely affected. mitochondria can see that they are on pieces . now they're not interconnected to each other. if you look into a healthy cell, you can see that the mitochondria of it's like interconnected with each other. now and this matter is, 1st of all, we can immune response. they cannot fight in any infection. and they produce less energy than metabolism is completely flown. this is how,

what happens in some of the senior spaces who pash, prostate research is groundbreaking, and a possible explanation of why m cfs patients have low energy levels. but this process could also be used in diagnosis, which would be an enormous advance. we had the very beginning stage of testing. you're still not using as a diagnostic, but we are trying to develop this technique. so at this stage, it's very preliminary we, we can get nice results with cv, let me see if a spaces almost 100 percent of his books are with mild, moderate embassy of his patients. it still goes sometimes wrong. so you still have to work on it. but he needs funding to his work and there are not any public funds available for emmy c. f. s. research in germany. donations are all he

has low self, emmy c, f, as research is insufficiently funded. around the world in the united states, for example, it ranks very low. u. s. health authorities spend about $14000000.00 on the $2500000.00 emmy cfs sufferers. however, for $1000000.00 multiple sclerosis patients, the same authorities spend $100000000.00. and for the 1200000 people with h i v. 3000000000 the international hash tag emmy action movement is fighting the more research funding recognition of the illness and adequate treatment. they want to draw attention to the precarious situation of those afflicted in her documentary unrest,

jennifer bria shows hundreds of empty pads of men's and women's shoes, less symbolic for the millions of people who have disappeared from public life. i just came galena published most of what the done as soon as i saw the film, i thought i have to do something like that. i have to do something. what so we have to attack this, that the route 100 all with a handful or perhaps 10 people we launched millions missing germany named and then planned and carried out. our 1st events. landon dory d for dog treatment in germany for emmy cfs patients is catastrophic. and they have no access to treatment on after fi, legal battles for every small step like getting a wheelchair and sometimes even subjected to consider all stigmatization and discriminate. shipment is coming off as us ah, ah,

with specials al, called bonham. patricia. it was a very exciting time. it really felt like you could make a difference, could change something and didn't have to resign yourself to your family. chicago, mom in norway. there are at least 15000 people with m e. c f. s. a norwegian research team led by aston praga and olaf miller from bergen university, has long been searching for a drunk that could help them. they came across, retook c mob a few years ago by chance. they had wanted to use it to treat it cancer patient who was also suffering from emmy cfs after observing at least 8

patients telling us independently of each other about this effect on me and missy of us him. this is her than we decided to try to do some research and our hypothesis from the start has been that them is the of us can perhaps be a very and dylan what them indices and with a role for what the antibodies under the lymphocytes. and that's why we decided to pursue the nab surveillance. be sounds are important immune sounds in our body that produce antibodies that destroy viruses and bacteria. unfortunately, this process sometimes goes awry and the p cells produce antibodies that don't work properly or actually attack the body itself. this occurs in many auto immune diseases like lupus or mice dina gravis.

scientists believe that emmy c. f. s. is one such auto immune disease. retook the map is a medication which temporarily destroys be cells preventing them from producing antibodies to attack a person's own body. in 3 smaller scale trials, they succeed in treating emmy c. f. s. patients with retook c. ma'am. scientists then initiated double blind randomised phase 3 trials with 152 patients patients and their families around the world. a hoping it will be the medication that can save them. ah,

it's more of a doll shem store. i think the worst thing is the loss of control arms or ma'am, and the more you struggle and hide it, the more the more your health deteriorates. like being and quick samsung ah, the anti bodies in the blood of emmy c. f. as patients seem to play a significant role, who to balance and her team also want to discover whether they can diagnose the disease based on these antibodies. and whether a marker can be found in the blood though could simplify the diagnosis. yeah, i'm ready. 5 interested. we asked whether the see if this patient had been infected with the epstein bob iris at some point as into theater. then if so they should have a few green johnson to her and they do that. this is a green dog. the we also seen some standard diagnostic test done, not yog gnostic testing, and whether the unique signature, which we see he is related to cfs. if we can only say once we've examined

a lot of patients after our vendor gone through the content on t, as in tom during our research reports of the new saws, covey to virus began to appear exponentially. world wide, over 100000000 people have been infected with a new virus, weeks and months after an initial infection. many a still suffering with very similar symptoms to emy cfs relics, mon felt a neuro psychologist and musician contracted corona in march 2020. he still hasn't recovered, suffers from permanent pain cognitive lapses, sleep disorders and extreme exhaustion. they bought a nozzle switched excellent on the weekend when it began going down hill. i just thought i had severe fatigue in the fatigue. did i know the turn?

and i know that its post viral devices because of your father's i just googled post viral fatigued without knowing that it's used as a synonym for m e. c fs. as $400.00 foot, i saw that it was precisely these seemingly unrelated symptoms that i had until now . i couldn't have imagined an illness that so blake close the smells or leave the muzzles there. it's as though you just don't exist anymore. yeah. mishma as of offers x till after the 1st wave of the corona virus, it gradually starts to become clear what an infection with the virus really means. professor, common shy, been bogan, is war it via didn't notice it like in the site. what's in there? i think that around one or 2 percent of those who had a mild case of coven 19 could develop cfs and vehicle adelante of when we see how

dynamic the spread of this virus actually is that there is great concern that we will have a significantly increasing number of chronically ill m e. c. f. s. patients in germany because of covered maintain in our trend and farther from cover. come in. international researchers including boop, ash, prestige or rushing to investigate the long term effects of coven 19. he doesn't think the size covey to is directly responsible for the long term effects. he believes that latent herpes viruses in the human body are reactivated after a corona infection. and weeks later lead to long cove. it prostheses a comparable pattern with m e c, f, as which also develops after a viral infection. if the signature of the ceiling that we are looking at the embassy of his presence are the same in these places. at this moment, we are talking that symptoms of hemisphere for spaces are similar to these patients

who harped is long coverage. but we don't know it, it just simply an association. these no proven her own data to say that okay, a long covert basin is now an embassy for spacing offense will actually love, i love, can i live, i left school and decided to do remote learning to finish schooling. so i can do it from home. my school just wasn't giving me enough support as many i would have had to continue to go to school normally, which just isn't possible. and if you will please. but since i've been doing everything from home, i definitely feel much better for you. yes, now, fumed pedro garza to most most families. leave he with a new slack of hope. after talking with us and have known the vincent griffin to patton, we wish we could make patience much earlier i had we wished the illness that clinical picture was more widely known. and that any patients who haven't recovered 3 months

after infection and show the symptoms for me would be referred to a specialist and begin treatment, which it's a list and also tartan on the innocent. remind her to be handled to begin and we would then see fewer patients in such a poor condition. pushed on clifton after our millions of patients around the world, a hoping for salvation from norway. the results of the 2 year re took them out. trial are eagerly awaited but then disappointment. the trial is negative. retook the map doesn't have the expected effect level when it was a bit unexpected. it could have had a negative trial. that is all saw that that that can happen. even if you have an active drug, but her not seeing a tendency in the right direction was a bigger surprise for us. especially as i said, based on our previous experience. on the other hand,

we did the changes in the reduction of double bond study. for example, lower doses in maintenance, treatment which may have had an influence on this. the scientists had to have the dose because they received no funding from the pharmaceutical industry. but the research continues the hunt for other drugs that could help patients. me, they can use their research, bio bank with 3000 plant samples, or donated by participants in the re took him out trial with if you are what we're looking for in the future. one thing we're looking for is a bio marker because a lot of patients do not have the m e t s at diagnosis because the practitioner general practitioner or the specialist has problems and putting the diagnosis of the patient response for research and about the court is that the disease and

possible drugs, scientists everywhere need money. at least 40000000 euros in germany alone. the federal government recently set aside 3700000 euros for research into patient care. a drop in the ocean. in my personal opinion, the only way we can find a solution to this disease is to bring patients, the clinicians and the basic sciences, such as to one umbrella. and our political system can play a very important role in bringing together bes, 3 pillars. if this happens, i guess in the next 5 to 6 years, we can help solution to this problem. it also had phases with suicidal forms. first, of course i have right here, would you want to live like this with my prospect of getting any better?

gibson portion, even if the massive research was launched mountain, it wouldn't help me as well. but until then, i'll try anything. i'm not going to let this drag me down. if the disease once a fight didn't come from, i'll give it one comes on. we keep looking at the bench nicholson. there are so few people out there who are able to fight for us void or who want to fight for us after you talk of to, to attend. that puts a lot of pressure on our shoulders. thanks. look at, look, you put yourself under pressure, you know it's misty because you really want to get out of here again. we all know exactly what we want to do tomorrow. if we get well again.

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about family face, masculinity. fathers and sons starts april 16th on dw ah, this is dw news, and these are our top stories. officials in ukraine are urging people to leave eastern areas a fear a renewed assault on the don bass region as the prevalent pulls russian forces from around the capital. keith, all the world condemned. the killings of civilians in towns including butcher, president volota mirror. zalinski has compared them to nazi war crimes. u. s. president joe biden has accused russia of brutality and in.