soon i can help secretary sergeant javin say the government under johnson's leadership is no longer competent or acting in the national interest. and russia stepping up, it's a tax on ukraine's eastern genetic region. after seizing all neighboring lu heights, the city of civilians came under relentless shelling on tuesday. chances governor is urging the remaining 350000 residents to flee his update at this hour. i'm clay richardson in at berlin for me and the team here working behind the scenes. thanks for watching a we're interested in the global economy. our portfolio d w. business beyond. here's a closer look out the project. our mission to analyze the flight for market

dominance. good stood with d. w. business beyond lou with swagger shocked. i'd say i was shocked when i found out i had diabetes. suddenly i had to give myself an insulin shot in the stomach. ever since i was diagnosed, it is a fact in my life. i'm 29. there's no foreseeable future for children for us because of the finances and because of my health, we are currently estimating something over 400000000 people with diabetes today in the world. we like to describe this as a global catastrophe. slow motion. so you put together b productivity losses to put together and health care costs medical course. it's

awesome. um, i mean we know that the pharmaceutical industries relating to diabetes and making a lot of money. it's a wonderful with ah, good for the daughter she now me. so i was born in 1963 really in february, 1975. i went to a concert job. when i got home i felt tired and very weak and it's i think i spent the night drinking water and peeing. wow. the next day i did blood tests now and was told i had type one diabetes. good to go. type one diabetes at strikes without warning. musician, bad handbook,

and that's pancreas stopped producing insulin 45 years ago. medical science has yet to explain fully why for to find the cure for the disease. diabetes is insidious and people's lives are often severely disrupted. she's doing it again. when i get over, it showed point 81. so you don't see there's always a delay through thick. if i'm not thinking about the show your emotion, i'm wondering what i'll do. if i have too much sugar machine. cool, i'll be exhausted and not having enough is also a problem with that will take something to eat on stage. with that a yeah, she did visit him on you a debit for a type one diabetic guy. the injection is a relatively minor hassle in the list of inconveniences. info and it is some things

are much worse. you only have 10 jobs a day to feel ok is fine if trees what's exhausting is constantly calculating whether you have too much sugar or insulated food to do constantly thinking about all those constrains you don't to trying to think ahead. also the insulin you inject acts a lot more slowly than a insulin, the pancreas produces, don't you have to anticipate. there's lots of things every day that are much more of an inconvenience than shots. guarantees will be approved and present before. ah. the body needs a certain amount of sugar to function at different levels of exertion. even the smallest activity requires energy. the metabolic system gets the sugar it needs from reserves in the blood. if blood sugar levels become too

low, the result is hypoglycemia. but too much sugar and the blood can trigger hyperglycemia. the pancreas regulates sugar in the blood of healthy people. the oregon produces insulin of vital hormone. if this process is disrupted, the result is what is known as type one diabetes. ah, without insulin blood sugar levels rise causing oregon's to fail, patients fall into a coma and will eventually die if not treated several synthetic insulin injections a day help patients regulate the blood sugar levels. ah

ah. as the consumer society emerged in the 1960s, a 2nd kind of diabetes type 2 started to become more common lifestyles and eating habits were changing. go on, take it. all right, ma'am. people started consuming more fats and sugars and exercising less repair. and korea's had to start to creating more and more insulin to offset the high levels of glucose or sugar in the blood. and sometimes it would stop working properly. the amount of sugar in food continually increase during the 20th century . processed meals, soft drinks and foods rich and carbohydrates were consumed and large amounts.

ah, the number of diabetes patients climbed rapidly within just a few decades from 50000000 to 430000000 worldwide. 90 percent suffer from type 2 diabetes for the cases were initially concentrated in western countries in europe and the u. s. then they spread around the world 30 years ago, diabetes was where in china to day one in 10 adults has it. the chronic disease has also spread in africa. a 150 percent increase in cases is expected by 2050. 1.

it slightly of it is as a nick us as a fox, a conical type 2 diabetes and is a classic common disease or cultural disease. and beyond in the 1960 often had less than one percent of the population in germany was diabetic. and today did often we estimate between 9 and 11 percent before cold and diabetes hub. the disease creeps up on its victims, unannounced until suddenly serious health problems appear. law had dr. below dr. boseman. good morning. let's take a blood sample. come with me. ah . it looks like

a better hum and it is a quote for conflict. the elevated blood sugar levels carry the threat of complications, but many diseases can develop awful. micro vascular problems are the main concern to do and can occur in the eyes and kidneys by the nerves as well, because they could possibly be damaged by narrowed blood vessels. who does the major blood vessels in the neck and heart are also at risk musical? that means people with diabetes face as statistically higher risk of heart attack than people who've actually already had wanted. and who don't have diabetes for thought. i need to refer to the a one of the most beer complications is diabetic foot and it happens when the nurse no longer function correctly. but the kind of by the feet made then no longer feel many sensations when people step on things as all, and they get wounds on their feet and leg sign. but don't notice them recently, the ice then become infected illness. and that's when the real problems that can

lead to amputation began be seen to, i'm put as one foot. good to dorothy. does that hurt? diabetes is one of the leading causes of amputation in europe in the us. the disease can also attack the kidneys. and as a result is a main cause of dialysis and kidney transplants that she will spend with dorsey silly me. the pharmaceutical industry reacted quickly to the rapid rise in type 2 diabetes of 3. want to reach glass. i can check with lakedale to receive me. don't nice so more lead. in the 1980s, a wide range of tree mintz were introduced as advertising campaigns that promised a happy and carefree life. witnessing of guessing that energetic, liberal equals with mr. thomas c o. david k, i one 0,

a whole range of pills became available to help patients lower their blood sugar oral anti diabetics. ah, the drugs could control the disease but not cure it. patients had to take them for life and their price kept rising. diabetes had become too expensive. communities around the world sounded the alarm. the disease caused health care systems about $760000000000.00 a year. worldwide. there is a un declaration on di visas in 2006 because of its potential to cripple any health care system. ah, because of its costs. ah,

and to actually up the potential to effect the productivity of the country with the number of people with diabetes. ah, that need treatment. but those are also invalids because of diabetes and on able to work because of their diabetic complications. it is the only other condition apart from h i. v aids that has a un declaration in 1921 canadian doctors, frederick panting, and charles h best discovered insulin and made industrial production possible. the revolutionary innovation saved thousands of lives. children who were facing certain death were treated with spectacular success.

the canadian researchers sold their patent for a symbolic dollar to lily, an american pharmaceutical company for commercial production. could you tell me anything about him chillin what he gave, or how it made was not made? it had come from animal bank with the plant work day and night to supply the demand potentially and uses, manage all the pack that each week. most of the bag that comes from abroad and arrive at the factory deep throat. it is reduced to a paste and mixed with alcohol which dissolved the instrument. then followed along complex processes which gradually remove all the impurity. the manufacturing process was continually refined to day 3. companies compete for

new patents, lily, the danish company, noble nor disc, and sanofi of france. human insulin based on the human gene for insulin, eventually emerged and led to an increase in price. in some countries, human insulin can be 10 times more expensive than insulin derived from animals. it became possible to take the human infant you should be cut out from the chromosome of humans. put the gene into a little microorganism. we use a yeast like a baker, yeast or bill yeast that we put the dream in there, and then the ye, so starts making entering. so best court genetically engineered engine, and that means we can deliver insulin to the whole world because we have no capacity problem. if we need, we'll just build a new frederick french pharmaceutical company,

sanofi then announced the development of a new improved and even revolutionary insulin in 2000 lantus noon as an analog insulin. it was similar to human insulins but with a modified gene. so no fees innovation prolonged its effect, but came at a hefty price in france, a dose of lantus then cost $46.00 euros, a dose of human insulin sold for 18. ah, the analog insulin reduced the number of times a diabetic would have to inject themselves to just once every 24 hours. pierre shall say over saw the lantus launch and thinks it was a major advance level disco lotus come soon assured us united to as an insulin

solution. lantus was a real revolution. only both children did changed the lives of diabetic patients that especially type one diabetic who had their last injection at 10 pm. for example, middle land then had to set the alarm for 5 am for another injection to hypoglycemia . striking in the night had always been a threat with fatal consequences at the city of pacific union marketing. the marketing was brilliant. it convincing people, it was much slower than the others, so it really didn't slow. insulin existed in 1975, it was one i only did one job a day of security. this is assuming no sanofi also wanted to type 2 diabetes patients to profit from what they called their wonder drug. these diabetics had traditionally only been prescribed injections, if anti diabetic pills no longer worked. o sip

a cylinder to do healthily basil and should in 20 minutes at the la, down near her, down there it up for its hype to patients who were moved on to injections. it was the last stage of the last year they were on death row digit buddhism, as the simplicity of lantus lowered the fear of insulin injections man. and they began using it earlier who to? oh, so these patients were then also able to benefit from the drug flexibility of a shilling of the more judicial issued inches he'll, ah, glucose levels in the blood or blood sugar results are too complex for non medical people to understand that's why sanofi introduced a user friendly marker, with the gleich aided haemoglobin or long term blood sugar test, h b, a one see mm

hm. the company started a major prevention campaign with a simple message that anyone could understand. long term blood sugar levels below 7 percent are okay. above 7 are problematic. a stroke of marketing genius within just a few years, lantus became a pharmaceutical blockbuster in 2015 the year of its greatest sales. and just before the patent expired, lantus accounted for 20 percent of sanofi sales. more than 6000000000 euros. ah.

but a doctor from germany through cold water on lantus is victory lap. peters davinsky was head of equate. germany is independent institute for quality and efficiency in health care. your 30000 fear hutch with in 2000 war vendors, all the joint committees to the highest body overseeing health care in germany over our commissioned eg, big to evaluate this insolent gorgine lantern with respect to possible additional benefits on face sister. up for the objective was to determine if the greater cost of the drug was reflected in greater benefits. where this is, if it costs the health care system a lot at reason when they wanted to know if it was justified a mere course. and you know, because ultimately every one was paying for it or not health insurers. the result

was that there was no significant difference. she didn't, and that lantus was not superior to finished. medically speaking, the analog insulin was no more effective than other drugs. pharmaceutical representatives disagreed expressway and loss of osgood. c. i'm explaining it badly . the lee of hope was if you ask a patient taking insulin to abandon their analog insulin and go back to the old insulin i dug and tell them not to worry. there's no disadvantages and it was like, you did not many would agree yet, but my mom, so he's spending a whole new when you tell me about bell friendship as she was able to lou, the statement is unjustified, but mas reply think it's rather strange to procure you, as the lighter funds on north georgia for the head of senovia, germany invited me to visit the company in frankfort to discuss the results for you that i was happy to go welcome. but at the start of the visit started me. he showed

me apartment buildings where lots of people depended on sanofi for me and said how many of their existences would be at risk if we stood by our institutes assessment for. because then also no, be workers would lose their jobs about you, robert, for you. they put pressure on you. i tried, i don't want people to lose their jobs this me, but i still need an object of the valuation of drugs or not just of insolent be, but of all of them. and we don't have that one, not in any european country. kaiden, rural patient. the german authorities stood firm. patients with type 2 diabetes, using lantus would only be reimbursed for the cost of a corresponding dose of human insulin. but so no fees, drug kept selling, well, sales remain tie and patients grew accustomed to paying more

other countries, including france, have also questioned the superior efficacy of lantus. but nothing has changed. so no fees. block buster remains the world's best selling insulin since 2015. so no thes competitors novo nor disk, and lily have also marketed long lasting analog insulin and they to justify the high price with attractive promises the company say that higher production costs contribute to analog insulin being comparatively more expensive than human insulin. but researchers at the university of geneva disagree they looked at the question of why one of 2 diabetes patients worldwide has no access to insulin. mm

hm. it is its rule, ollie's austrian and their actual book conflicts affably. ticket is austrian, you men. we were told that analog insulin is much harder to produce than human or could probably, and we wanted to know a little more about the cost of manufacture of a we got together with him colleagues to determine the manufacturing cost us by looking at each section of the production line such and the public destro an appeal could be much help um yeah, totally madell from your key volkoff of retail flipping that we send the cost of all the raw materials required for a vial of insulin. makisia then added regulatory costs, which are significant or i'm them. regulatory costs are the expense of licensing a product to submit clinical trials are required to demonstrate the drugs effectiveness here in mouse. we also included a profit margin and the investment costs for infrastructure up love plus virtual. the manufacturing costs for human insulin is between $2.50 and $3.50

a vile health record for most analog insulin products. and it's about the same. honda. c o. godly plead. wrong or false. val, he's on a flock when done sooner. men on viola, looking at the selling price in france, a vile of human insulin costs around $13.00 euros high school. whereas an analog insulin such as lantus, costs almost double in 25 euros a vile he sion cooler. there are 3 conclusions. first, the final price for the patient or for the health care system is not justified by the manufacturing costs. the exec industrial. all the difference in manufacturing costs between human and analog. insulin does not justify the price difference involved, which and, and 3rd, he plus him, the profit margins for the pharmaceutical industry on these insulin products are enormous in the local context. it to know when

the pharmaceutical giants dominance has tragic consequences in the u. s. within a decade, the price of insulin has risen tenfold. even though a 10th of the population suffers from diabetes. many can no longer afford the vital hormone despite costly health insurance policies. yeah, a lot of people know, like maybe i pay a $260.00 premium a month. that's just to have the right to say i have insurance. and my deductible is $14000.00, which means i would have to pay for my insulin. and for my doctors visits and my other medical supplies out of pocket anti reach that 14000 dollar mark before they'll help me pay for my insulin. and not many people can afford to pay an

extra $14000.00 out of their income every year. it's almost impossible for my husband and right now my insulin comes from my doctor and it comes from my friends. my mom has friends that are also like maybe type 2 diabetic and they have an excess of insulin that they don't use. so they've been kind enough to give that insulin to me in my doctor when he has patients that pass away, which is unfortunately, happened recently. he gave me over a year supply of insulin. so thankfully, i won't be paying that money right now because it would have been catastrophic for me if i would have had to pay the money for then swan rima ah huffmans,

where you can manage to abuse. i really don't know. i'm sorry. i really can heal, that's best thing. i've been fortunate, not apt experience yet, but it, us sit in the back of one point. ah, my name is elizabeth, and i'm the founder of to you on international. we're a diabetes advocacy organization that takes no funding from pharmaceutical companies. and we advocate for everybody with type one diabetes, specifically access to the things that we need to survive. this company right behind me has raised the price of their insulin over 1000 percent. ah, and we believe that access to insulin is a human right. this is a global problem. people are dying in every corner of the world. people are dying here in the united states of america. what's supposed to be the wealthiest country

in the world was supposedly the best health care system in the world. this is not the way that it should be. this company is putting profits over people. and we're here to say that that is not okay and that something needs to be done about it. medicines for people. 0, one more time. medicines for people. oh, it truly is a crisis. people are rationing their insulin, so they're taking less than they should take or trying to not take any. they're trying to adjust their, their diet and their insulin intake. and mrs. so so dangerous people are dying because of that. and they're cutting years off their life. because they just simply can't afford it. my husband, i don't, in our future, we won't be able to buy a home. we can't afford that right now. we won't be able to have children. that's an expense that we wouldn't be able to afford. so i,

i would say the biggest things we sacrificed is just the traditional family life. that's something that we're not sure if we'll ever get to experience. we've lived a very international married life for 8 years. and although, you know, i'm very, you know, have loved our time together and it's been very hard. we've had a lot of challenges. we, we don't get to experience the things people are age, are getting to experience. the next step here is to deliver some of these insulin vials that we have created. so this is a vile of humalog with the label taken off and a message inside. what we've done is we've said these are the things that we sacrifice for the cost of insulin. um, nicole has brought some of alex ashes that are in one of these vials to show the sacrifice the ultimate sacrifice that they made. because he couldn't afford the insulin. alec was feasting accost at

$1300.00 a month for insulin and diabetic supplies. alec work full time as a restaurant manager for a small family owned company who did not provide health insurance for its employees . alec made decent money and because of this, he did not qualify for assistance of any kind, not from the insulin makers, not from the state, and not from the federal government. without anyone knowing alec began to ration his remaining insulin, because at the time he went to the pharmacy, he did not have enough in his bank account to spend the 1300 required. elac began to adjust his diet, take less insulin than his body required to make it to payday. alex body was found 3 days prior to payday. alec died from diabetic ketoacidosis due to a lack of insulin in his body. ah,

at the start of 2019 the u. s. congress demanded pharmaceutical companies justify the enormous rises and price. the 3 big insulin producers blamed the us health care system. and the large number of distributors stay the subcommittee on oversight and investigations is holding a hearing entitled, quote, priced out of a life saving drug, getting answers on the rising cost of insulin. so mr. mason from eli lilly who is making a profit from these increases in insulin prices. you know, i, i think you, 1st of all, we don't want any one not bill for der insulin who is making a profit with his increases in insulin prices that patients have to pay for our net prices. the parts that we receive are going down, are you, are you making a profit or the ceo of your company's making? these profits are, are net prices. the prices we receive has gone down to 2000 to not well, somebody is making a profit,

somebody's getting richer on the backs of our patients. a mr. lambda from nova, nor disk. what entity in this supply chain is prioritizing affordability and access of insulin for patients? or we like to think we are, i mean we, we participated as many formulators as we can, as i've mentioned, that is critically, most important. we have patient system assistance programs as well as co pay system, provo who is making a profit. they well our nets are going down as well. but there is a small profit that your nets, but your overall, your overall profits for the company and ceo's have been going up, haven't day. no, our our profit take home pay ensemble and relatively stable from c e o pay hasn't gone up in the past several years. his pay has increased yet. okay. after the hearing, the 3 company is pledged to reduce prices for the poorest to patients. but it was no more than a p r. stunt. patients in the u. s. unlike their european counterparts,

are not supported by generous reimbursement systems. for most american diabetics. insulin remains a luxury item. the price of the synthetically made hormone is just one problem facing diabetics. another can have fatal consequences, her patients kick to keep their blood sugar levels below the famed 7 percent limit. many type 2 diabetics take many drugs and by doing so, put their lives in danger of falling. hobbies just wanted da madigan house at cindy in an air, you have boxes hotter. i found out from our physician, she had an office near here. she did an annual check done and said that my blood sugar level could the long term average age be

a one sea level was too high and that i had to take medicine days 2 whole do you miss and don me to come in to name the owner and i lived with that for many years, but then during that time my blood sugar levels shot up to about 11 percent of the whole. it would be your base of is what's in. and my weight was at its highest and out about one 114115 kilos. it's a 100 foot of think hero is well and i need him on the tablet. and for by the way, it was actually only just bells and variable. although i gradually took more and more of them in saline, and then i injected insulin for about 7 years. the hobby shadow, not him ear snares. i am not him, isn't leibniz, who voiced unmounted. that was after the 1st time when i noticed that my body was shaking and my blood pressure wasn't quite right. when i measured my blood sugar, my device that i was below 60 does the sea and it was blinking red and saying it

was no longer measurable, but under 60 buyers. and then it came to the incident at the end of august and beyond where i nearly ended up in a coma. and oh, ghost always don't get locked up. who will she in 1st come on for a year to severe hypoglycemia, could have caused the patient his life. it was a result of an obsessive attempt to keep his blood sugar level below 7 percent in 2008. a study shook what had been established treatment protocols. it showed that the higher the level of drug consumption to keep blood sugar low, the greater the risk for patients regularly taking medicine to reduce h b a. one. c levels increased the risk of hypoglycemia and heart disease. left is a phys all it is a studio becomes fear media commencement whitfield of medical men can by 100 people

in the study were treated with lots of medications or fashion up to 5 as fabric on the study showed that it was probably the wrong approach. the intensive decreases in glycemic at all, could reduce complications in the nurse and eyes house in fact, but what we really wanted was to reduce the risk of heart attacks and strokes, but that didn't happen lawyer. and so that's why the correct approach is not to focus on blood sugar levels in the short, but rather on the study of diabetes. so now you need an overall picture of the cardio metabolic syndrome is um, with all the risk factors. and that's how we succeeded. cool, fucked. all bundled it when done, cynthia, for could it be any sinister took? she, angel puzzle is still stuck. approves of its cyclone. so hyperglycemia is toxic. the evidence is incontestable. the more sugar you have in your blood, the greater the vascular toxicity schools have you, but it doesn't follow that if you have hyperglycemia, lowering the level will reduce the risk to see if you have a risk marker and look,

the higher it is, the greater the risk cascoo, a linear or automatic reduction, does not necessarily reduce risk b. major studies have shown that trying to hard to lower glass, same yet increases risk loser quantities. don't the hard looks, alamo, less the multi, cuz he really made it so. paradoxically, it's been shown that if you use intensive treatments to reduce glycemic bye too much, or reach a bigger as close as possible to that of a non diabetic weapon, said, you might think you're as healthy as a non diabetic person. he but you're worse off than if you had left the glycemic. hi, is it? not only do patients have more complications than non diabetic systems you, but they have more than people with higher blood sugar. it is in you. they end up in the hospital with serious hypoglycemia. it's due to medication and can be severe . mortality has been increased previously separated. humble, see,

there was no permission when i'm not anti hunter yet. i had this near coma experience and said, i don't ever want to have that again. mr. stronger, come with me. of the, with, like mid day featuring are no longer takes drugs. and the blood tests show that after 3 decades with tied to diabetes, a kind of remission, a retreat of the illness has sat in his doctors suggested a radical approach developed by a british team of researchers. it involved a strict diet he quit eating carbohydrates sugars for 3 weeks and instead drink a low calorie, so a base drink. strong weight loss is generally needed to get type 2 diabetes into

remission. believed that if you had type 2 diabetes of yeah. then once a diabetic, always a diabetic, and then an english research team published a sensational studying. they went and found subjects that had been suffering from diabetes for some years and had them radically lose weight or she cleanest. they were able to show that this could cause remission in almost half to 80 percent of the subjects. so depending on how much weight a person had lost hosea and that without a serious operation to you, just by radically losing weight by should lose it is if, if they've learned from very in depth m r, i exams that if there's too much fat on the pancreas and then insulin production falls with the pulse, but that doesn't mean that it's broken the just that the cells are no longer able to produce insulin. i guess mia, including if the fat is removed from the pancreas, then the insulin producing cells are again able to produce more of the hormone in

response to stimulation. yes. and then blood sugar levels fall yamisha. the zone for that. we've done similar experiment and had comparable experiences here in dusseldorf, come into comp, we've managed to allow people who were on insulin to only rely on pills for from pills into a complete remission. and i think that's where we're headed for the future. if a patient loses weight, they can stop taking diabetes, drugs and blood pressure medication upsets and i may be able to prevent ne opperation scan locally. he'll visit about that soon. for can equaling phase. we've discovered a universal remedy in lifestyle here. i and it works and very different areas, dance sheet and if you were to take all these sicknesses together and is a good luck, then you'd save lots and lots of money and food that could then be invested in this area far. hm. osmond done. it isn't, but the general opinion is that won't work. the i so we don't have to do it and yeah, gone and that's a problem for politicians. and then there are the associations that represent the

pharmaceutical industries, interests, an attorney, cindy, and different one from university holland. you have no interest in this at all, and that always makes me suspicious us and sat one day thus mark. mm hm. um, it was still teaching college a few 1000 patients in europe in the us have already tried this method. it demands strict discipline, lots of motivation. and only a 3rd of tied to diabetics can hope to be healed by it. the majority will have to continue taking medication with tr boss, get them, and again you is looking ahead. i think we will when see the problem is knowing when says hodges is what we're saying will become incontrovertible evidence

within a few years. it printed the teachers in the meantime with many diabetics will die unnecessarily with them. some will have had poor medical treatment and national july, and too much will have been spent pointlessly on overpriced treatments. each study showed it, but the diabetic industrial complex will be swept away. rec, sir, deputy, going to see eddie, somebody diabetes is more than just a question of blood sugar. the illness has revealed evils within the food and pharmaceutical industries. and if governments don't react, diabetes will continue to spread. mm ah.

ah, the thread illegal dumping destruction of livelihoods and indigenous tribe in brazil fighting for the right to exist. the land of cody bona is legally protected. but the state does little to curtail illegal loggers and trespassers. now the carry puna are suing the government, global 3000. in 30 minutes on d,

w. a can inspire big changes, meet the people making a possible. you go africa. joined them as they set out to save the environment, learn from one another and to work together for a better future. ah many thoughts do you all for choosing it for go eat 90 minutes on d w. o . did in wide wing extremist, i suggested again world mommy and coping wait and burned in south africa, people with disabilities more likely to lose their jobs. in the pandemic black lives matter. po, shine a spotlight on racially motivated police violence, same sex marriage is being legalized in more and more countries,

discrimination and inequality, or part of everyday life. for many, we ask why? because life is diversity. to make up your own mind. d. w. lead for mines. ah, this is dw news and these are our top stories to senior ministers have resigned from the british government, putting further pressure on prime minister boris johnson to resign the health secretary sagging job it and the find.