24 year old spanish topped the time sheets at the beautiful philip island to secure his 3rd hold position of the seats. he's a quick reminder at the top story with been following for you. the 1st russian troops have been arriving and bella burst as part of what's being described as a regional military worked there. a fee is that the new joint force could be deployed across the border into you credit at all for now. coming up next is doc film with a look at the efforts of an international research firm to decode the secrets of aging, realized the dream of immortality. that's after she'll break a vibrant habitat ended glistening place of longing. the mediterranean sea scene of l muster. and to far of dual career drift along with exploring modern lifestyles and the mediterranean,

he's ready to lead journey this week on d. w. ah, what is aging? is it possible for us to affect it? how much more can we do? these are big questions. they're going to take us to answers that are going to be illuminating to mankind as a whole engine has become a hot topic. we are right now at the point where we can already develop strategies with ongoing injections, simulation stimulation, methods, personal programs, pills, or we're in the midst of a seismic shift. it will open up possibilities for more healthy aging. and it helps with a something in the air and we can feed it. and plenty of people who already show you gold nuggets and on fe best gold here. you know. right now we're

seeing a huge gold rush. was the proof of concept is established on longevity, will go viral. ah, what was your name and date left? i saw the person who lived to 150. it's probably already been born. it's highly likely isn't his with ah

. 2 2 i'm 15 right now. how and i think i only, i think that, you know, i do wanna live a full and happy life. so i think whatever number i can live into at that time, that guarantees need to have a very healthy life. i love the number i go about earlier wake up early just because it's important for my house to do this . so i do it. that's really going to be consistent in your sleep schedule. it's easy for me to be consistent with waking up at 5 the sort of nice, quiet time and yeah, i mean it's, it's, it's, so i do, it's that i'd have consistency because that's really important. think future katie or them?

nina tara 1st became interested in longevity, research when she was 12. now the teenager is one of the scenes rising stars. nina stands for a generation that takes a new view of aging that wants to see aging eradicated when she's not in school. nino holds talks around the world. she's launched a small start up with a couple of friends. the group searches for scientific clues on how to crack the aging code. yeah. yeah, and one of our proteins is probably involved in that process in some way. so we could weigh how much that protein is involved in that process and try to give an

estimate even if we're not adding a whole new protein involved with that process. yeah, i think that definitely something that we could that's useful to measure my grandfather did have a form in my check. that was not a problem and i wanted seasoning with that one in 6 women get dementia after the 65 and i'm one in 10 man which is a lot of people when you think about it, right. it's these diseases that you previously thought were inevitable. so we thought maybe we'd have drugs to alleviate the pain or to sub one particular type of disease from occurring, but never sort of to, you know, look at the root cause of these diseases and haggard from there. each animal species has in certain ways an expiration date in a mouse. it's less than 5 years in the boy had whale. it's 211 years in human sex, a $120.00 to each species has a time that's kind of allocated to it. and the question is,

why is that in nature? death is a normal part of life. but can we humans push this biological age limit? human life expectancy has risen steadily and recent history back in ancient rome, it was to 25 years by the middle ages. it was still only $35.00. now we live in to our seventy's on average medical advances and better living conditions are enabling us to get older and older. but can we extend our lifespan indefinitely and what we really want to as even leverage vision to the lots of people want to live forever. and when they

wonder if we can reverse or slow down the aging process and unkind in exist, he tells us so much about violence which steph and dying. but it also touches on reincarnation and live live. it's a hugely popular fema niga. immortality is a topic double, never die is or stablish. in germany, there is a famous painting the fountain of youth, and on the painting you see all the old men and women, particularly taking their clothes off and getting into the fountain of youth and swimming across to the other side and emerging young and healthy on the other side then going off to the tents and dressing and then having a wonderful dinner together with plenty of wine. ah, and it's, it's man's age. all dream to be able to reverse aging his room, wouldn't it? this fountain of youth has become an allegory in biomedical research and that's no

longer just about eating a healthy diet and leading a balance lifestyle. and we want to make more serious adjustments if you and we can take pills or get injections and so on. and well, end up living longer when you come into the idea, the fountain of youth that's outside ma'am, and that i can jump into as it was shifted to a fountain that's put inside the main one injected into my anger plan. i'm good, i'm good bastard. we're closer to finding the fountain of youth than ever before. but what if aging were kind of program a program we could hack into an initial clue as to how humans might be reprogrammed, leads to an unassuming setting in central america. ah,

i've lived in costa rica since 1972 and just completely fell in love with costa rica peninsula. natoya is a place where people age very well and long. i think about it all the time. i think about it all the time because it's really mysterious and they themselves cannot give you any clue as to why you ask them. and they say, i have no idea. it just is what it is. but yet we are more curious and we want to know more honor gail. glen takes care of some of the regions, centenarians, the residence of costa rica, natoya peninsula. not only live longer, but stay healthy for longer to

go and die. i will hang on to my leg. okay. and the way, oh navy, the koto is 90. 1 people here often live to be over 90. many thing to over a 100, dana, florida. to put it in both of these are herbs. you've used to heal diseases. corner, fussy at a bas ha! that's right. what's your hampton and lots of people all around the world, want to know how to live a long and healthy life. what's your advice to have a component? i live for many years. ha, guam bed. eat a healthy diet, herbs thought a better and lead a peaceful stress relief to young or what else? oh i so vitamins in a ha ha she it. so when a person eats lots of chines their heart won't stop today or not. i have to

go about vill this area was very, very distantly removed from the mainland, so to speak. it's a peninsula, it's still connected, but our roads were bad. communication didn't exist. people survived here on what they planted on, what their parents taught them, how to survive. there was no pharmacy to go to say yes, let's now. so good luck. when this armed treat had a fever and all kinds of things. in the fact that people in natoya live to be older than average went largely unnoticed until one scientist stumbled onto some unusual data some years ago. for most young professional initiative, i was initially an economist, but it never really felt like the weight field for me. eventually i found my knees

and demographics up to much more precise with clear cut rules. it's black and white . oh it, and they got them on it, a casual, not by sheer coincidence, we discovered that mortality rates in the region were much lower than the rest of the country. you know, let him which important help initially i didn't pay much attention to deal with martha. i'll knock on when i presented my findings at a conference and there was a lot of skepticism. we asked about whether it was really so public and costa rica element that less causality then on will not persona, but one person from the audience approach me afterwards. and said, lucy, it's because it's a blue zone. you cannot guess if, where's mom? and at that moment, i realized that nicola really was a special place this young no korea, nicole. yeah. fike, so called blue zones, had been identified so far on our planet. these are locations where an unusually

high percentage of the population lives very long. men in nagoya, have the world's highest life expectancy. an 80 year old male here is likely to outlive his contemporaries elsewhere by an average 8.2 years ago. but why this is alan vick, is it the diet rich and fruit in acoya all or does religious faith explain it? laugh, everly. she ought. there wasn't any real data center government in avia. that's my normal guy. romeo loved hampton. the question is, is, is it genetics or is it lifestyle any ambien? ah, people in costa rica say put of either good. i mean they

can, you're still, you're casey. most of it campus. we carried out a study to see what happens when people leave mccoy. and what happens on people from other parts of the country, the more to nagoya, as part of the price? i'll be reading makalya the most get we found out that neither of these groups achieved the scene. one job, it is those who are born in spend their whole lives. here are new revealed. tar, tim quantity in blue zones, eating seems to proceed more slowly than compete coming up for the environment and the lifestyle appear to positively impact human biology for matthew. but how exactly, and will this help us crack the aging code?

with the molecular biologist biochemist. i'm interested in understanding the origin of diseases. the majority of diseases are those associated to the aging process. so i'm interested in understanding why we h molecular liver. i wanted to have all my life to on this found the origins of cancer and 89 i thought to long as could be the keep the human body consists of around 30 so and trillion, sells some last few days, others live for years. we constantly produce new cells to replace the old ones. it's a process that involves duplication. before cell division can take place, the chromosomes in the cell nucleus have to be duplicated the dna double helix they

consist of is unwound and separated into strands. each strand then becomes a template for a new one. the ends of the chromosomes, which are especially prone to replication errors, are protected by telomeres, which are sequences of non coding dna. but with every cell division, these safety caps become shorter. charged. i feel charged was that the shoe on it tillman. i imagine this, so

a shoelace is our chromosome. so the spark of a shoe lace is the dna where the genetic information is. and this little planet we have for dominates, the says half to want to blight over janae. the damage on these sharpens the dilemma. they're the cell division of the some communication. so at the end, the damage began so short by we don't have any more a t t m. so now our dnas, i'm protected and this is leading to asia as listen to the seas. and ultimately, we'll be moving to this cell division and the rate of telomeres shortening may be influenced by our lifestyle. smoking, stress, environmental pollutants, and poor nutrition are all negative factors. some researchers believe living in harmony with the natural world has a positive effect. and con thomas k, less persona than eco. yeah. generally people from the koya have longer telomeres, significantly longer telomeres than people in the rest of the country just on ice.

scientists like maria glasgow, are exploring ways of artificially lengthening telomeres in order to slow the aging process. but this does come at a risk digger fata by is stuff keeps the danger, is it cancer can develop it because cancer cells are immortal? and is alina, we're walking a fine line here yet? do we tell the cells to resist their pre program, cell death and risk that it will result in cancer flight in or do we leave things to run their natural course and let the cells die when their time is either stooped, vanished, then there is no proliferation and we just accepted or final destination. it was around 120 and to 125 year. no transfers will not from it's wanted liam's. yeah. but of course, what can we all know the answer? humans wanted to test the boundaries and see if they can really live to 150, or 300 and ah, how far can we go?

how much should science interfere in nature is blueprint we don't have to necessarily accept current biological limitation because that's what we do as a species. we're problem solvers. we don't just sit around and get rained on, we build houses. so we may want to transcend normal biology at some point and set goals for ourselves beyond just normal concepts of health. ah. when you wonder what the, what is aging, you end up asking how tissue repair. this is the process that these his feet poorly understood. says progressively accumulate

damage. they age that when they re to something threshold, they undergo speech, they become kinessa. i like to describe them as zombies, because you know, they're like in a middle stay between alive and dead. deny either, but they're at the same time they're really damaging higher than this and says produce an alarm signal so that they will, this has him to body, realize that there is a damage or a big go and they repaired. the problem is that as we get old, these repair says they are also old and they don't go and they don't repair. and we accumulate the says that are constantly producing these alarm. this is a phenomenon that is called inflammation. all people have in amatory signifies innovative, caused by their own senescence says that are not eliminated. we

are trying to crack the code of the son s s. i was trying to understand the need these how to kill them without killing the non finance and set in some initial experiments. manuel serrano and his team were able to show that mice lived longer. once their senescence or zombie fells were eliminated, but that does not guarantee eternal youth. it's a double edged thought. finesse themself, play also a very good and important role with, for example in wound you doing if you ever want. if you don't have senescence, the wound will never hear. so you could have a treatment that removes all sin s themselves, and suddenly you have terrible side effects. it just means we need more research and research into telomeres and saw the cells are only 2 approaches

in the race for longevity. and one thing is certain cracks, the code is set to earn millions. all right. so guys, how do i look guy? i look old. so you've seen what we did. we've announced that $255000000.00 res is the largest rays in our industry so that the hong kong has the highest life expectancy on the planet today, which is no surprise because it's very often correlated with well. and i hear people are filthy,

rich welfare is increasing dramatically in the region in china and mainland people who are present just 35 years ago. they are now multi 1000000 years. people demand ones. you have any news on the heel for biotech company. i tried to collaborate with a lot of people and they try to contribute to as many projects as possible. life clinic is a very fun concept where the founder is decided to bridge the starbucks concept with preventative medical care. you choose a cocktail of all kinds of nutrients that will be going into your blood while you're sipping on a juice may offer ivy drips and all kinds of other interventions.

i cannot vouch for some of them. yeah, i'd be in hong kong or anything geared at increasing life expectancy already promises megabucks dubious wonder drugs and id trips are readily available. the region is also attracting biotech companies from around the world. money from wealthy investors has created a much higher startup longevity research in hong kong. new dot com boom and brooklyn noise and new development is that the research is being carried out with business started methods with massive capital. you got cut, we're investing, we're pumping funds into it, and we're throwing cash out and you're from them that will invariably result in a product. it's an infallible economic model about which will always work in 5 from

noon market. there's a huge market for these new companies. one really is to have treatments for, for the faces. so that's where the big box out. i'm willing to experiment on myself because there is a lot of data on me. and one of the most well studies humans in applied and i try to optimize for high performance at this point in time. i tried to perform at my p . i've tried to call my son in the past. it's very often referred to as magic drug in longevity, not in the same line, those mit foreman, but likely to be stronger than the form and it's not with outside of things. so there is a chance that you're going to see me beside us and a few others. so we decided to try to ourselves in a very controlled mode. and he's not at all my 0

was that decided to in the hotel. i got some serious ones on i think i feel good. all right. yeah, thank you. thank you so much. i assume like literally like a rather my sin metformin m e d boosters. do any of these substances really help? how can their effectiveness be tested?

i was interested in anti aging science since i was a teenager growing up in frankfurt, germany. i had a group of friends who were very interested in science. and at some point we realised the most important challenge of our generation is to prolong life. we had very lofty goals, i need to tell you in our we have crazy goals. we wanted to study physics, math, biology, chemistry, also we wanted to do space travel, and then the minute you finkel space travel, you realize that you will need decades in order to travel at oregon centuries. and so we felt we really need to solve this problem for us to extend our lifespan before we can even think about space travel one day by accident. really,

because i did somebody a favor, i analyzed these methylation data. i immediately recognized that epigenetics or methylation is really the data source that has a tremendous signal for aging. he was able to find clusters of genes whose methylation state could tell you how old you were a particular time. the amazing thing about this is that it works from the day you're created as a fertilized egg cell, all the way until the day that you die. there are more than 200 distinct cell types and the human body. although they all contain the same dna, there was a mechanism that tells the cell whether it is the skin cell or a liver cell, for example, called epigenetics. this involves information that sits on the dna,

resulting and genes being switched on or off. perhaps the best known type of epigenetic change is methylation. the addition or removal of methyl groups on the d n a strand. these changes continue to take place throughout our lives. the dna contains for left us a c, t, g methylation, sometimes attaches to the letter c and modifies it similar to an onslaught by keeping track very carefully. which parts of the dna gain methylation on news methylation we can measure aging methylation can be thought of like the rust that accumulates by measuring the amount of thrust we can determine h. so if we have some hours glass, the passage of time is measured by how the sand,

how much sand accumulates at the bottom. the dna molecules though, has 28000000 different our glasses because we have 28000000. let us see an hour dna. so by averaging the measurements of 28000000, our glasses, you arrive at a very accurate measure of age. this is one of the most insightful discoveries in the history of mankind does read it. and what the invention of the we ought is that that was a turning point meeting. i think that was to severe a very, very important point over like, hey, we can measure aging. now the epa genetic clock has revolutionized research into aging with a simple dna sample. any one's biological age can be determined. however, that can produce some nasty surprises.

my name is mark a toy i've out, and i am steve's identical twin brother. he's my older twin brother, 5 minutes older than me. and however, only at 1st he measured epigenetic clock a couple of years ago. then according to one of the clocks, i was actually 4 years older than him. which is not necessarily the those technologies are enabling us to accelerate aging research dramatically by not waiting until he died. we can now measure where you are in life and measure how different interventions affect that prediction. we pick this up

and applied a i to the same problem and developed many, many asian clocks above all the quest for eternal life requires personal biological data. the digital devices we use every day can provide mountains of it. big data is currently one of the most promising approaches to cracking the agent code. unlike conventional medicine, artificial intelligence can scour the data for hidden patterns to help prevent diseases from developing in the 1st place. this situation looks very similar to soft on the subway. so when you pull your wallet and you don't know who every human on the train looks the same, they move, they move a different patterns to observe many, many of those scenarios in many subways, globally,

to develop really precise address or catching a fee for the subway and your tray and a technologies to recognize those thieves and predict human behavior. and i think nowadays, and advanced countries like mainland china, there are video monitoring techniques that allow you automatically to recognize the fact on movement. so it's very similar to recognizing those proteins that misbehaved during aging and cause trouble at the touch of a button, startups can run through thousands of possible outcomes and quickly discover new medication. we recently receive $255000000.00 is from a group of ultra elite investors. so it turns out that we are on the right place

and the right time with the right technology. i think that very soon we will see guys like amazon. i'm waiting for those guys to react. guys like facebook. i guys the produce video games, netflix, those people who, he'll your time. they will come back and try to figure out how to make more time. so you can waste it on their product. ah, silicone valley is already on board. in 2013, google founded a secret of biotech venture called calico longevity research has carried out behind closed doors with nearly unlimited resources. a group, backed by amazon founder jeff bezos, has also burst onto the anti aging scene, with hundreds of millions and funding altos labs is recruiting top scientists from

around the globe to join the project. they include steve horvath and manual serrano . there's even a longevity clinic in the pipeline before steve horvath embarks on that new task, he's focusing on another promising project. it's the so called trend trial, designed by his colleague greg fi to reverse immune system aging. hardly any other study in the field has prompted as much interest in recent times. the flow of immune cells plays a central role in fighting illness in our bodies. but there is a limited supply of these essential cells or bodies. thymus gland produces t cells. the superstars of the adaptive immune system. however, once we reach puberty, the time it begins to shrink. it is replaced by fatty tissue and eventually stops

producing new t cells. once we've used them up, our bodies become more susceptible to pathogens and to age related diseases like cancer, stroke and dementia. ah, when i saw that you could use growth hormone to regrow the thymus and take immune system function that was down to about 20 percent of the young immune system function all the way back up to a 100 percent of youthful function. i just thought we have to do something about this, but nobody took any action. so i did an experiment on myself and i re grew my own thymus. he published a scientific paper that described one person and that was himself. in 2016, the trial was repeated. this time a total of 9 test subjects renewed their thymus. v suspected the treatment

was having a positive effect on the whole body. but how could he prove it? this person came to me and said to him, to help me to analyze a treatment, and the minute he set the word thymus rejuvenation i already said yes him a ha. steve horvath compared blood samples from the test subjects before and after treatment. and he was just as amazed if not more amazed as we were about the results. if they are confirmed, it will be a sensation. the original intention was get rid of the fact of the thymus. this treatment had a side effect and unexpected side effect. it really rejuvenated the methylation the epigenetic clock. all 9 test subjects turned their epigenetic clocks back by around 18 months in

a year of treatment. that means they had essentially reversed their biological age by 2 and a half years. we began to get reports from some of the people in the trial that i feel gray, you know, i feel so energetic. now i feel my mind is working faster than it's worked before before the trial was over. this volunteer says, you know, my, my wife has been telling me that my hairs growing and dark again. and i said, really i, that's interesting. let's have a look. so we looked at his hair, and boy, it was a big, very strong difference. and his hair was darkening all over the place. i need to say we're all very excited about it. but we are also very sober scientists and therefore we always felt we desperately need a 2nd validation study. and that's really why i continue to work with greg. why

become a study participant, a 3rd study with more test subjects, aims to corroborate the original results arrive. so if successful, find the 3 generation could be the 1st scientifically proven anti aging treatment for human beings. but the scientists need more data. steve horvath and his brother have volunteered to take part in the trial. as identical twins, they are ideal candidates. steve will get the rejuvenation treatment, and marcus will join the control group. we're now ready for your baseline testing, and this is the, the testing that you do before entering the trim ex trial. and i'll give you a countdown on your mark. yes. go

live in my in my now that we have your blood pumping. we're going to looking at your epigenetic clock. the the news which 80 women and men of different ages are taking part in the latest time of study. and the treatment inventor also hopes to rejuvenate himself once again. i can't wait any longer, right? i'm getting older. i don't want to age. i'm 71. i don't know how old i will be. that's an open question. i hope but longer than usual, that's all i can say at this point. the main component of the treatment is

a growth hormone. to counteract certain side effects, the steroid hormone d h. e a, and the diabetes drug metformin are also added down the hatch. i think about this future of biotechnology in changing the composition of our bodies, worries me, my dream is that there will be an intervention against aging free, lucky and 5 years and 10 years. and then people go to the annual checkup. the doctor says, you know what, you're aging a little bit too fast. why don't you take this pill? that's the dream. so we are now building the toolkit, many enabling technologies that need to converge. and we need several more technologies to come to life in order for us to make a major leap in terms of agility for everyone. i think we are 25 years away

with the development of an anti aging wonder drug raises issues that threaten the foundations of our natural and social order. what will our planet look like if we live to the ever older wood? overpopulation make our ecosystems and social systems collapse. how can longevity be in harmony with the natural world and human civilization? our lifestyle is expensive, it consumes resources, it creates over population. this is true. ah, we would live in very short life didn't have such a value. and also not care so much for nature for anything. so maybe it's not bad that we live longer because we would care more about our planet on our vitamins on the life of the rest of this planet.

ah ah, i'm run a sawyer. what come to the mountain, kinda mumbled soto, i'm going to take you to my real city, missouri. here's what to expect. marina, on a journey of nature's majesty, and shows you the things that were really matter to him. a free max to go off in 30 minutes. d, w a.

we've got some hot tips for your bucket list. romantic corner track hotspot for food. chair and some great cultural memorials to boot w travel off. we go ah, let us see when i arrived here, i slept with 6 people in a room, 9th and it was hard. i wish fear i even got white hair. is that with fleming the german language head? yeah. a lot this kids to me and create opportunity to interact with you want to know their story, my grants verifying and reliable information for my grants. ah

ah ah, this is dw news live from berlin, a huge blaze breaks out and gunshots, a heard at a taber on prison with antique government protesters and political prisoners. a help for 5 comes amid the most intense protests across iran in he's also coming up delivers welcomes the 1st russian soldiers taking part.