yes, it's breaking sport news now, and christiana rinaldo is to lead manchester united with immediate effect. the english premier league club has tweeted, the news comes after the 37 year old attack a gave an explosive interview on the eve of the world cup in which he criticized coach erington hog and manchester united owners. the club said the portuguese star was leaving by mutual agreement and thanked him for his contribution across 2 spills in manchester. ha, that's all for now. next, a documentary on the business side of diving. he stayed with us for that. the call for like is in the changed imagine how many portion of lunch are thrown out in the world. climate change division off the stores. this is my plan, the way from just one week. how much wealth can really get we still have time to go. i'm going on with

my 5th lou with chicago shocked. i'd say i was shocked when i found out i had diabetes. suddenly i had to give myself an insulin shot in the stomach. ever since i was diagnosed, it is affected my eyes. i'm 29. there's no foreseeable future for children for us in the finances and because of my health, their cars, estimating something over 400000000 people with diabetes to stay in the world. we like to describe this as a global catastrophe in slow motion. as i've, you put together the productivity losses and put together the health care costs

medical costs. it's astronomical. i mean, we know that the pharmaceutical industry is relating to diabetes and making a wonderful with ah, ah, good for the doors and she, naomi of. so i was born in 1963 really in february, 1975. i went to a concert job. when i got home i felt tired and very weak and it's i think i spent the night drinking water and peeing. wow. the next day i did blood tests now and was told i had type one diabetes, give it to beauty, go type one diabetes at strikes without

warning musician batt handbook and that's pancreas stopped producing insulin 45 years ago. medical science has yet to explain fully why for to find the cure for the disease. diabetes is insidious and people's lives are often severely disrupted . she's doing it again when i get her, it showed point 81. so there's always a delay through 2nd issue. i'm not thinking about the show your emotion. i'm wondering what i'll do. if i have too much sugar. she could pull, i'll be exhausted, and not having enough is also a problem with take something to eat on stage. with that, yeah, he did his exam on you a debit for a type one diabetic guy. the injection is a relatively minor hassle in the list of inconveniences and it is some things are

much worse. you only 10 jobs a day to feel ok is fine. a priest, what's exhausting is constantly calculating whether you have too much sugar or insulated food to do well. constantly thinking about all those constraints you don't to trying to think ahead. the insulin you inject acts a lot more slowly than a insulin, the pancreas produces, don't you have to anticipate. there's lots of things every day that are much more of an inconvenience than shots. guarantees will be approved, you presume, photographer? ah, the body needs a certain amount of sugar to function at different levels of exertion. even the smallest activity requires energy. the metabolic system gets the sugar it needs from reserves in the blood. if blood sugar levels become too

low, the result is hypoglycemia. but too much sugar in the blood can trigger hyperglycemia. the pancreas regulates sugar in the blood of healthy people. the oregon produces insulin of vital hormone. if this process is disrupted, the result is what is known as type one diabetes. ah, without insulin blood sugar levels rise causing organs to fail, patients fall into a coma and will eventually die if not treated. several synthetic insulin injections a day help patients regulate their blood sugar levels. ah,

as the consumer society emerged in the 19 sixty's, a 2nd kind of diabetes type 2 started to become more common lifestyles and eating habits were changing. go on, take it. all right, ma'am. people started consuming more fats and sugars and exercising less repair. and korea's had to start to creating more and more insulin to offset the high levels of glucose or sugar in the blood. and sometimes it would stop working properly. the amount of sugar in food continually increased during the 20th century . processed meals, soft drinks and foods rich and carbohydrates were consumed in large amounts.

ah, the number of diabetes patients climbed rapidly within just a few decades from 50000000 to 430000000 worldwide. 90 percent suffer from type 2 diabetes. the cases were initially concentrated in western countries in europe and the u. s. then they spread around the world. 30 years ago, dia, these was where in china to day one in 10 adults has it. the chronic disease has also spread in africa. a 150 percent increase in cases is expected by 2050

b y d of it is isn't it just as a fox, a topical type 2 diabetes and it's a classical common disease or cultural disease and be out in the 1960 often had less than one percent of the population in germany was diabetic, went on to day to day from we estimate between 9 and 11 percent before cold and diabetes hub. the disease creeps up on its victims unannounced until suddenly serious health problems appear law. her doctor bellow dr. boost mont. good morning. let's take a blood sample. come with me. ah. the hood looks look, i the at

a hum and physical for conflict. the elevated blood sugar levels carry the threat of complications, but many diseases can develop. opal micro vascular problems are the main concerns do, and can occur in the eyes and kidneys by the nerves as well because they could possibly be damaged by narrowed blood vessels with just the major blood vessels in the neck and heart are also at risk musical that means people with diabetes face as statistically higher risk of heart attack than people who have actually already had wandered and who don't have diabetes for thought and a dig fruit it. and one of the most beer complications is diabetic foot and it happens when the nurse no longer function correctly. but the kind of for the feet made then no longer feel many sensations when people step on thanks i soon, and they get wounds on their feet and leg sign. but don't notice them crucial. the ice then become infected illness. and that's when the real problems that can lead

to amputation began be seen to, i'm put, that's one foot good to dorothy. does that hurt? diabetes is one of the leading causes of amputation in europe in the us. the disease can also attack the kidneys. and as a result is a main cause of dialysis and kidney transplants that she will spend with dorsey see me. the pharmaceutical industry reacted quickly to the rapid rise in type 2 diabetes of 3. want to be cause i can check with blue link builder missy me to tell nice song let. in the 1980s, a wide range of treatments were introduced with advertising campaigns that promised a happy and care free life. deseeno bethany, that energetic little dick was able to me sometime if you've heard of it. i haven't

. oh, a whole range of pills became available to help patients lower their blood sugar oral anti diabetics. ah, the drugs could control the disease but not cure it. patients had to take them for life, and their price kept rising. diabetes had become too expensive. communities around the world sound at the alarm, the disease cost health care systems, about $760000000000.00 a year. worldwide. there is a un declaration on di visas in 2006 because of its potential to cripple any health care system. ah, because of its costs. ah,

and to actually up the potential to affect the productivity of the country with the number of people with diabetes ah, that need treatment. but those are also invalids because of diabetes and on able to work because of their diabetic obligations. it is the only other condition apart from h i v h that has the un declaration in 1921 canadian dr. is frederick benting and charles h best discovered insulin and made industrial production possible. the revolutionary innovation saved thousands of lives. children who were facing certain death were treated with spectacular success.

the canadian researchers have sold their patent for a symbolic dollar to lily, an american pharmaceutical company for commercial production. could you tell me anything about him to learn what it is and how it's made? well, it's not made it, it come from animal bagley at the plant work day and night to supply the demand for the city and use is manage on the bank that each week. most of the bank that comes from abroad and arrive at the factory deep throat. it is reduced to a paste and mixed with alcohol which dissolved the instrument, then follows a long and complex physical processes which gradually remove all the impurity. the manufacturing process was continually refined to day 3. companies compete for

new patents, lily, the danish company, noble nor disc, and sanofi of france. human insulin based on the human gene for insulin, eventually emerged and led to an increase in price. in some countries, human insulin can be 10 times more expensive than insulin derived from animals. it became possible to take the human interest and you said, be cut out from the chromosome of humans. put the gene into little microorganism. we use a yeast like a baker, yeast or beer, yeast that we put dream in there. and then the ye cell starts making insulin. so that's called genetically engineered engine, and that means we can deliver engine to the whole world because we have no capacity problem. if we need, we just built a new factory french pharmaceutical company,

sanofi then announced the development of a new improved and even revolutionary insulin in 2000 lantus noon as an analog insulin. it was similar to human insulins but with a modified gene. so no fees innovation prolonged its effect, but came at a hefty price in france, a dose of lantus then cost $46.00 euros, a dose of human insulin sold for 18. ah, the analog insulin reduced the number of times a diabetic would have to inject themselves to just once every 24 hours. pierre shall say over saw the lancers launch and thinks it was a major advance level nika,

lotus come soon assured us unite in as an insulin solution. lantus was a real revolution. leave us shall get it changed the lives of diabetic patients. the chief especially type one diabetic who had their last injection at 10 p. m. for example, middle land then had to set the alarm for 5 am for another injection eric to the hypo glycemic striking in the night, always been a threat to with fatal consequences at those city of leslie. in marketing, the marketing was brilliant. it convincing people, it was much slower than the others, so it really didn't slow insulin existed in 1975 because when i only did one job a day look secure, additional business, you know, sanofi also wanted to type 2 diabetes patients to profit from what they called their wonder drug. these diabetics had traditionally only been prescribed injections. if anti diabetic pills no longer worked

go sip a cylinder to do healthily basil. incidentally, you miss it. they lay down the hill. they'll never get up on her type to patients who were moved on to injections. it was the last stage of ministry they were on death row. did you buddhism, as the simplicity of lantus lowered the fear of insulin injections man, and they began using it earlier who to host these patients were then also able to benefit from the drug flexibility of us showing that the more judicial issued inches hill ah glucose levels in the blood or blood sugar results are too complex for non medical people to understand that's why sanofi introduced a user friendly marker with the gleich aided haemoglobin or a long term blood sugar test. h b, a one, see mm

hm. the company started a major prevention campaign with a simple message that anyone could understand long term blood sugar levels below 7 percent are okay above 7 are problematic. a stroke of marketing genius within just a few years, lantus became a pharmaceutical block buster. in 2015 the year of its greatest sales. and just before the patent expired, lantus accounted for 20 percent of sanofi sales, more than 6000000000 euros.

but a doctor from germany through cold water on lantus this victory lap. peters davinsky was head of equate germany is independent institute for quality and efficiency in health care. martha jones and fear hutch with in 2000 more blunders. all the joint committees to the highest body overseeing health care in germany of tar commissioned eg, big to evaluate this insolent gorgine lantern with respect to possible additional benefits on face sister or the objective was to determine if the greater cost of the drug was reflected in greater benefits, where this is, if it costs the health care system a lot or to reason when they wanted to know if it was justified, a mere corston dealer because ultimately every one was paying for it or not health

insurers. the result was that there was no significant difference. she given that lantus was not superior to finished. but medically speaking, the analog insulin was no more effective than other drugs. pharmaceutical representatives disagreed expressway and most of us could see i'm explaining it badly, lee of hope was if you ask a patient taking insulin to abandon their analog insulin and go back to the old insulin rogue and tell them not to worry. there's no disadvantages. and there was like 2 people, not many would agree yet, but my mom, so he's been to kill all new when you philippa belford. sure, but she was able to lou, the statement is unjustified. but marshall too, i think it's rather strange to procure you. as the dea, lighter funds on north georgia for the head of san oakley, germany invited me to visit the company in frankfort to discuss the results for you that i was happy to go welcome, but at the start of the visit. certainly,

he showed me apartment buildings where lots of people depended on sanofi for me and said how many of their existences would be at risk if we stood by our institutes assessment for. because then also, nope, you workers would lose their jobs, which are by thought you, robert, for you. they put pressure on you. i'm trying. i don't want people to lose their jobs. this me, but i still need an object of the valuation of drugs or not just of insolent be, but of all of them. and we don't have that when not in any european country. kaiden, rural patient. the german authorities stood firm patients with type 2 diabetes, using lantus would only be reimbursed for the cost of a corresponding dose of human insulin, but no fees. drug kept selling well. sales remained high and patients grew accustomed to paying more other

countries, including france, have also questioned the superior efficacy of lantus. but nothing has changed. so no fees, block buster remains the world's best selling insulin since 2015. so no fees, competitors novo, nor disk, and really have also marketed long lasting analog insulin. and they to justify the high price with attractive promises the company say that higher production costs contributed to analog insulin being comparatively more expensive than human insulin. but researchers at the university of geneva disagree they looked at the question of why one of 2 diabetes patients worldwide has no access to insulin.

and it is, it's all ali's as seen on that. ok, so book. okay. flexibly. tickled is austrian, you men. we were told that analog insulin is much harder to produce than human could probably, and we wanted to know a little more about the cost of manufacture. i, we got to get with and colleagues to determine the manufacturing cost us by looking at each section of the production line such and the public destro an appeal could the materiel quickly madell, premier key volkoff of retail, flipping that we took the cost of all the raw materials required for a vile of insulin makisia, then added regulatory costs, which are significant or i'm them. regulatory costs are the expense of licensing a product to submit clinical trials are required to demonstrate the drugs effectiveness here in mouse. we also included a profit margin and the investment costs for infrastructure up love plus virtual. the manufacturing costs for human insulin is between $2.50 and $3.50 a vile health,

flexible for most analog insulin products. and it's about the same. honda c o godly, pre roll. false val, he's all are flexible, thus junior men, they've been viola looking at the selling price in france, a vile of human insulin costs around $13.00 euros high school. whereas an analog insulin, such as lantus, costs almost double $25.00 euros a vial, a bunch and pull it. there are 3 conclusions. first, the final price for the patient or for the health care system is not justified by the manufacturing costs exec in this room, all the difference in manufacturing costs between human and analog. insulin does not justify the price difference involved, which and, and 3rd, he tells him the profit margins for the pharmaceutical industry on these insulin products are enormous in the local context. it to know when

the pharmaceutical giants dominance has tragic consequences. in the us, within a decade the price of insulin has risen tenfold. even though a 10th of the population suffers from diabetes. many can no longer afford the vital hormone despite costly health insurance policies. yeah. people know, like maybe i pay a $260.00 premium a month. that's just to have the right to say i have insurance. and my deductible is $14000.00, which means i would have to pay for my insulin. and for my doctors visits and my other medical supplies out of pocket until i reach that 14000 dollar mark before they'll help me pay for my insulin. and not many people can afford to pay an

extra $14000.00 out of their income every year. it's almost impossible for my husband and right now my insulin comes from my doctor and it comes from my friends. my mom has friends that are also like maybe type 2 diabetic and they have an excess of insulin that they don't use. so they've been kind enough to give that insulin to me in my doctor when he has patients that pass away, which is unfortunately, happened recently. he gave me over a year supply of insulin. so thankfully, i won't be paying that money right now because it would have been catastrophic for me if i would have had to pay the money for then swan every month ah huffmans where you can manage to

abuse. i really don't know. i'm sorry. i really can heal, that's best thing. i've been fortunate, not apt experience yet, but it, us sit in the back of one point. ah, my name is elizabeth, and i'm the founder of to you on international. we're a diabetes advocacy organization that takes no funding from pharmaceutical companies. and we advocate for everybody with type one diabetes, specifically access to the things that we need to survive. this company right behind me has raised the price of their insulin over 1000 percent. ah, and we believe that access to insulin is a human right. this is a global problem. people are dying in every corner of the world. people are dying here in the united states of america. what supposed to be the wealthiest country in

the world was supposedly the best health care system in the world. this is not the way that it should be. this company is putting profits over people and we're here to say that that is not okay and that something needs to be done about it. medicines for people. 0, one more time. medicines for people. oh, it truly is a crisis. people are rationing their insulin, so they're taking less than they should take or trying to not take any. they're trying to adjust their, their diet and their insolent intake. and this is so, so dangerous people are dying because of that. and they're cutting years off for life because they just simply can't afford it. my eyes and i don't in our future, we won't be able to buy a home. we can't afford that right now. we won't be able to have children. that's an expense that we wouldn't be able to afford. so i would say the biggest things we

sacrificed is just the traditional family life. that's something that we're not sure full, ever get to experience. we've lived a very international married life for 8 years. and although, you know, i'm very, you know, have loved our time together and it's been very hard. we've had a lot of challenges. we, we don't get to experience the things people are age, are getting to experience for the next step here is to deliver some of these insulin vials that we have created. so this is a vile of humalog with the label taken off and a message inside. what we've done is we've said these are the things that we sacrifice for the cost of insulin. i'm nicole has brought some of alex ashes that are in one of these vials to show the sacrifice the ultimate sacrifice that they made. because he couldn't afford the insulin.

alec was facing a cost at $1300.00 a month for insulin and diabetic supplies. alec work full time as a restaurant manager for a small family owned company who did not provide health insurance for its employees . alec made decent money and because of this, he did not qualify for assistance of any kind, not from the insulin makers, not from the state, and not from the federal government. without anyone knowing alec began to ration his remaining insulin, because at the time he went to the pharmacy, he did not have enough in his bank account to spend the 1300 required. alec began to adjust his diet, take less insulin than his body required to make it to payday alex body was found 3 days prior to payday. alec died from diabetic ketoacidosis due to a lack of insulin in his body. ah,

at the start of 2019 the us congress demanded pharmaceutical companies justify the enormous rises in price. the 3 big insulin producers blamed the us health care system, and the large number of distributors stay the subcommittee on oversight and investigations is holding a hearing entitled, quote, priced out of a life saving drug, getting answers on the rising cost of insulin. so mr. mason from eli lilly who is making a profit from these increases in insulin prices. you know, i, i think you, 1st of all, we don't want any one, not bill for dur insulin who is making a profit with his increases in insulin prices that patients have to pay for our net prices. the parts that we receive are going down, are you, are you making a profit or the ceos of your company's making, these profits are our net prices. the prices we receive has gone down to 2000 to not. well, somebody is making a profit,

somebody's getting richer on the backs of our patients. a mr. lang from nova nor disk. what entity in this supply chain is prioritizing affordability and access of insulin for patients. or we like to think we are, i mean we, we participated as many formulas as we can, as i've mentioned that is critically most important. we have patient systems, assistant programs as well as co pay system, provo who is making a profit thing. well our nets are going down as well, but there is a small profit that your nets but your overall, your overall profits for the company and ceo's have been going up, haven't day. no our, our profit take home pay ensemble and relatively stable from c, e o. pay hasn't gone up in the past several years. his pay has increased your okay . after the hearing the 3 company is pledged to reduce prices for the poorest patients, but it was no more than a p r. stunt. patience in the us, unlike their european counterparts,

are not supported by generous reimbursement systems. for most american diabetics. insulin remains a luxury item. the price of the synthetically made hormone is just one problem facing diabetics. another can have fatal consequences for patients kick to keep their blood sugar levels below the famed 7 percent limit. many type to diabetics take many drugs and by doing so, put their lives in danger of fallen. harvey stokes from the da madigan house at stint a year and an air yoga pucks is what i found out from our physician. and she had an office near here. she did an annual check done and said that my blood sugar level

because the long term average h, b, a one sea level was too high and that i had to take medicine days to whole the miss and maybe come in to name the owner. and i lived with that for many years, and then during that time my blood sugar levels shot out to about 11 percent. it all would be your best of is what's in when my weight was at its highest and out about one 114115 kilos. it's a 100 foot of think of as well. and i need him on the tablet and for by the it was actually only just bells and variable, although i gradually took more and more of them in saline. and then i injected insulin for about 7 years. the hobby shadow, not him ear snares. i am not him, isn't leibniz, who voiced unmounted? that was after the 1st time when i noticed that my body was shaking, and my blood pressure wasn't quite right. when i measured my blood sugar, my device that i was below 60,

does it. and it was blinking red and saying it was no longer measurable, but under 60 buyers. and then it came to the incident at the end of august and beyond where i nearly ended up in a coma. and oh, ghost always done because i worked up her or she has gone for a year too. severe hypoglycemia could have caused the patient, his life. it was a result of an obsessive attempt to keep his blood sugar level below 7 percent in 2008, a study shook what had been established treatment protocols. it showed that the higher the level of drug consumption to keep blood sugar low. the greater the risk for patients regularly taking medicine to reduce h. b, a one. sea levels increased the risk of hypoglycemia and heart disease. left is a phys all it is a studio becomes fear me to commend from it fearful for me to come in from behind

or the people in the study were treated with lots of medications or fashion up to 5 . as i recall, the study showed that it was probably the wrong approach. the intensive decreases in glycine me at all, could reduce complications in the nurse and eyes how to suck. but what we really wanted was to reduce the risk of heart attacks and strokes. but that didn't happen, lawyer, and so that's why the correct approach is not to focus on blood sugar levels an issue, but rather on the study of diabetes. so now you need an overall picture of the cardio metabolic syndrome isn't with all the risk factors. and that's how we succeeded co factor, all unbundled it was done. cynthia focused won't be any sinister cookie. angel puzzle is still stuck, approves of its cyclone. so hyperglycemia is toxic. the evidence is incontestable. the more sugar you have in your blood, the greater the vascular toxicity schools have you, but it doesn't follow that if you have hyperglycemia, lowering the level will reduce the risk to see if you have a risk marker. i look,

the higher it is, the greater the risk cascoo, a linear or automatic reduction does not necessarily reduce risk. if the major studies have shown that trying to hard to lower glycemic increases risk loser quantities. don't the ha looks, alamo lesson, the multi cuz he really amid the so paradoxically, it's been shown that if you use intensive treatments to reduce glycemic by too much or reach a bigger as close as possible to that of a non diabetic weapon said, you might think you're as healthy as a non diabetic person. he but you're worse off than if you had left the glycemic. hi, is it not only do patients have more complications than non diabetic situations, but they have more than people with higher blood sugar is in you. they end up in the hospital with serious hypoglycemia. it's due to medication and can be severe. mortality has been increased, dissipated almost there was uniform measurement. i'm not anti

he hunter yet. i had this near coma experience and said, i don't ever want to have that again. mr. stronger, come with me, with like mid day featuring are no longer takes drugs and the blood tests show that after 3 decades with tied to diabetes, a kind of remission. a retreat of the illness has sat in, his doctors suggested a radical approach developed by a british team of researchers. it involved a strict diet he quit eating carbohydrates sugars for 3 weeks, and instead drink a low calorie soy based drink. strong weight loss is generally needed to get tied

to diabetes into remission. and to find the of it us and that the la gloved i my diabetes in my diabetes because i know english are what's copa then that's when it was long believed that if you had time to diabetes of yeah. then once a diabetic, always a diabetic, and then an english research team published a sensational studying. they went and found subjects that had been suffering from diabetes for some years. and had them radically lose weight or she cleaning, they were able to show that this could cause remission in almost half to 80 percent of the subjects. so depending on how much weight a person had lost hosea and that without a serious operation, t just by radically losing weight, by sure to lose it is if, if they've learned from very in depth m r, i exams that if there's too much fat on the pancreas and then insulin production falls with the pulse, but that doesn't mean that it's broken just that the cells are no longer able to

produce insulin target. mia in the dean, if the bad is removed from the pancreas than the insulin producing cells are again able to produce more of the hormone in response to stimulation. yes. and then blood sugar levels fall the i'm squash off the zone for that. we've done similar experiment and had comparable experiences here in dusseldorf, come into comp, we've managed to allow people who were on insulin to only rely on pills for from pills into a complete remission. and i think that's where we're headed for the future. if a patient loses weight, but he can stop taking diabetes, drugs and blood pressure medication upsets and i may be able to prevent ne opperation scan locally here. melissa, about soon from konica lincoln fe, we've discovered a universal remedy in lifestyle here. i and it works and very different areas, dunphy sheet. and if you were to take all these sicknesses together and is a good luck, then you'd save lots and lots of money and good let could then be invested in this

area far. hm. osmond done. it isn't, but as a general opinion is that won't work. he, i, so we don't have to do it in gigantic. and that is a problem for politicians. and then there are the associations that represent the pharmaceutical industries interests and i truly cindy and different one from university holland who have no interest in this at all. and that always makes me suspicious us and sat and it does mock me. some of it was a short fishing call with a few 1000 patients in europe in the us have already tried this method. it demands strict discipline, lots of meditation, and only a 3rd of tied to diabetics can hope to be healed by it. the majority will have to continue taking medication to post them. and again, you are looking ahead. i think we will win. so the problem is knowing

when says hi, this is what we're saying will become incontrovertible evidence within a few years. yet printed the teachers in the mean time with many diabetics will die unnecessarily. some of them with them. some will have had poor medical treatment and national july, and too much will have been spent pointlessly on overpriced treatments. huge studies showed it, but the diabetic industrial complex will be swept away rec, sir, debit going to see it is how body ah diabetes is more than just a question of blood sugar. the illness has revealed evils within the food and pharmaceutical industries. and if governments don't react, diabetes will continue to spread. mm

ah. ah, a beginning of a story that moves us and takes us along for the ride. it's all about perspective. culture

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ah ah ah, ah, this is daily news live from berlin. germany's government decides to withdraw its troops from molly. berlin says it will begin bringing its forces home by mid 2023. more than a 1000 soldiers will leave the un peacekeeping mission and follow similar moves by britain and france also coming out.