the, the, this is dw news line from the rationalist, as it has driven the group of attackers, as if it's cabinetry and backed into ukraine. so keith denies any involvement. we look at the potential consequences if it's something that's crossed for the incident, both so on the program science the break through in the decades long conflict oven

and pull. no camera back clean up in my media may now give up its claim to the contests in regions. groundbreaking vaccine techniques used against coffee 19 is health as a potential game changer in the fight against cancer. and the police in portugal launch a new search for modeling the captain, especially toddler, who disappeared 16 years ago, one on holiday with the info. going to welcome to the program. the russian defense minister says it's false as of kale, goldman 70 cross border attack as and driven the rest back into ukraine. moscow are to use these keys of launching what they call the sabotage attack on russian territory. however, ukrainian officials denied any involvement, insisting that these are the actions of antique kremlin russians. suassa state

media says that these photos shows the off them off of fighting, and the belgrade region officials claimed the into separate attacks, houses, and administer the buildings were damaged in the town. the furs of guests and gray bore on they've named do crating on forces and said 10 people had been injured in the fighting with many others leaving the area. the city of belgrade remain calm, but it's government claimed that ukrainian drones had launched attacks on the border on monday and tuesday. that's the situation remain for the tile of it. so this is the minister of defense is together with law enforcement agencies. continue clearing out the territory so far you shouldn't return home with i'm addressing the residents of graver once the district which we have temporarily. and thanks so that to the left, their homes used to me. the fighting broke out about 5 kilometers from rushes, bought it with you, crane. while ukraine has been preparing for counter offensive for months. keith

denied any connection to the attack. videos posted by dressing opposition groups. the liberty of russia legion and the russian to the typical indicated they may be responsible legit stuff to do it in time to put an end to the remnant dictatorship spicy. but send you to all those who support us, who send us donations on not face the board and that's amazing. explosives last year support reminds us every day of our final goal, the red square. and they seem to be brave and don't be afraid because we are coming back home voices. russia will be free. and so the more or see if we get starboard from that to try to the crime and said thing crash and, and to distract attention from box mode, which russian forces claim to have captured often more than 9 months of fighting while in ukraine itself. the armies making its final preparations for a long awaited counter offensive against the occupation. so what will it take to

break through the russian lines? the w, william blue cross customer for months now the front line in russia's war and ukraine has barely bunched. let's have a closer look. now, while russia has consolidated positions in the eastern part of the country, ukraine has been able to hold them there. the cost of doing that in human and material terms has been immense. intelligence estimates suggest tens of thousands of debt on both sides, if not more. and the front runs more than 650 kilometers and ukraine's east and south. now, the no man's land between russian and ukrainian forces is littered with fortifications . but keep each side at bay preventing the ukrainians from breaking through. well, let's have a look. first. we have a mine field behind them. rows of paint traps and other barriers. the more mine feels and trenches the likes of which we haven't seen since world war one more than a century ago. behind that we have trenches big enough for tanks and other vehicles

to get trapped in. and all that is hundreds of meters of deadly terrain. so what to do? well, clear them out. military analysts say that ukraine could use a combination of artillery air, power and specialized mind clearing explosives that would clear a path for ukrainian armour and infantry to pass through. but it would be dangerous by squeezing, advancing forces into a corridor that makes speed and fire power decisive. any lit up could give russian troops to chance to regroup and push back the counter offensive. and that would be devastating for ukrainian forces who have less before i went to despite than russia does. now there's also a psychological element. there is already evidence that russian chronic conscripts are poorly trained, equipped, and motivated. a concentrated ukrainian attack could cause a ripple effect of fear, sparking a chaotic withdrawal. we saw that happened to some degree last year when you crean

made its 1st major grab a territory at last. but many of the cranes best fighters have been killed. and that makes a successful counter offensive, far from certain, and unclear how much it will actually help reach the broader goal of ending this war was with him blue cross now with liam collins is a retired special force. he's kind of sucked in the us army for nearly 50 years, with deployments including iraq, afghanistan and bosnia is not finding director of the modern war institute at west point in new york. so welcome to dw tunnel. can we start with belgrade, or the status of a swell rushed us at any attack on its territory, would cause a major escalation. i do expect must go to respond to this. suppose a do cranium sabotaged attack? yeah, the 1st of all were actually just spent 10 months giving everything it had just to take back moved. so russia is not a position to escalate anything that's. that's really just russian rhetoric. they just don't have the capability to escalate it. and so with this,

this isolated attack of what appears to be nice way to attack isn't going to make a significant change, right? so that's time then, so this expected ukrainian counter offensive. what do you find in military pon, has been looking for this to signal the beginning of the end of this will only look to shift russian positions back in the east. yeah, i mean, this is going to be a long war. you know, it's gonna take many successful kind of offensive to push russia out of the country and making so painful that will rush eventually. but dr. so this is not the beginning of the end. this is just a continuing part of a long war. and so it will be coming probably fairly soon, but it's definitely not the beginning of the end. and so would that as administrative part of yourself as advisor to the ukrainians from time to time, what, what are you looking for, and where as a sign that this counter offensive has begun? yet me, 1st of all, ukraine's done a good job of a really confusing everybody about when or where it's going to be. and that's by

design, right? so why she doesn't know where it is, what can't concentrate its troops at that point a tax would have to disperse, which will make it easier for them to gain that foothold as your, as your previous reporter set, right? they, you know, breeching these mind deals and obstacles is going to be difficult, but something that they're more than capable of doing that with the leadership, the training and the weapon systems that they have. so, but you don't, it doesn't, there's nothing you particularly that video going to look at and say ok, okay, now it started. yeah. i mean really, you're just going to see an increase it right in the, in the attack. i mean, it might be gradual or all, or, or it may be like, hey, it's pretty obvious of the attack started, but really you're trying to see the concentration of the crew, the troops, and really that artillery fire that's really going out there are the engineers. it start to breach the significant obstacles. that's really what you're looking for is, is we're of the cranium scattering this fire power problem. we starting with an artillery rocket attack,

right. and then breaching those mind deals and those efforts to get through the obstacles. is that how would you describe the current shape of the ukrainian on the 15 months into this war? yeah, i mean, without a doubt, they've taken some significant losses and lost probably, you know, tens of thousands of really good soldiers. but in other ways, you could argue there they are in a better shape than they were at the beginning. the conflict morale remains high, right? the designated, you know, russians throughout the conflict, right at the beginning of the war. look, look at the beginning, right? probably 50 percent of the missiles and rockets that were fired into ukraine went through and now that's probably $80.00 to $90.00. percent of them were more getting shut down with improved air defense systems that they have. right. they have the time are rocket systems that can penetrate deep hit rushing command and control nodes and, and supply positions. and that was those were instrumental in the that kind of offensive and hers on, in, in our key. so in some ways, the discontinued aid has, has made them more capable than they were at the beginning of the war. and what about basketball? it's about the longest and blood is battle of a,

a war costing anywhere between $20.30 russian troops. with a ukrainian loss is estimated at around the 5th of that. why is this bottle for this region? what so many lives to either side? yeah, i mean it's not worth that many lives to either side. i mean that, but unfortunately that's how worried is right. it just happens to be there, but wasn't back moved, it would be somewhere else. that's just where the finding happen to be. that movie doesn't offer any kind of a tactical or operational or strategic. real value is just where the finding happen to take place in, in russia will try to sell this as a strategic success. but any, it's anything but that it's an unmitigated failure for the russians. i mean, as you said they, they last tens of thousands of soldiers, they do everything they had at it, and it took them 10 months to take a territory. what's left of revel, buildings. it offers little tactical value, a really great cost. and so this is anything but a complete, tactical and strategic failure for us. you can so can you thank you so much for

joining us. kinda liam collins, founding director of the model. more institute at west point in give you thank you. so take a look now as of all stores making headlines around, well, 7 people, including 4 children, were killed when a school roof collapse during a stormy time on people's were inside of what outside on the sports field. when heavy rain and strong winds brought the roof down, highlands entering it set monsoon season and his prime ministers received a rupture as welcoming australia. thousands of engine ex pats of packed into a, bringing it in sydney here and there and promoting, joined on stage finance training, prime minister, described as the boss and a reference to bruce springs. police in germany, already investigated to be suspected poisoning of 2 russian. john. this a here in, by then we may be treated as a shot, it's

a hospital and they were awesome events organized by the problem. and it's a kremlin critic at me file for the cost of the media and maybe as prime minister is offering to recognize they bring as a by john sovereignty of a disputed region is nikoto cadillac. the 2 former soviet republics have been locked in conflicts of the area for decades. but the fraud jobs ceasefire has not passed away for peace talks. it's a territory that's been plague, but i'm classes for over to 2 years, punctuated by 2 deadly conflicts. but the long dispute over no core, no care about could be coming to an end which, which has a meaning. you recognize this as a by john's terry tree. 8 to 6600 square kilometers. lots so long as, as a by sean is willing to recognize a territory with integrity of our meaning is trying to 9800 square kilometers as far as the by john's tablets right. includes and going to cover about the k number

of junction which on ritual personnel and made the commitment on condition that our servers, young guarantees, the safety of ethnic armenians living there. the region was established by the soviets, after world war one is predominantly populated by ethnic armenians. it was never the less included within the soviet socialist republic of a stuart version. since the collapse of the soviet union, armenia and a sub a john have both made claims to the territory. some 7000 soldiers were killed in the last war and 2020. the foreign ministers from both countries met in moscow last week for a trilateral talks with russia star gay life rough leaders from both armenia and to serve a. john met you council chief charles michelle and brussels 10 days ago. they are expected to meet russian president vladimir putin on 1st day. he's still seen as a key broker by the posts. so you have neighbors. let's talk about this method to

get a go see on who runs the regional studies. sense of, that's a think tank in the armenian capital a yet about welcome to the w. and this is region to go on are kind of back that's been force over for decades. why is on media a ready to give it up now? well, it's clearly not, in other words, the army named government has become very good at being very bad at strategic communications. and i do think that there's a disagreement, but also a misunderstanding. the argument and government has on officially once again reiterated the recognition of the territorial integrity of mazda john. but that is based on the premise that newborn oak horrible the art meeting populated enclave. we'll have it to security and rights protected by international mechanisms. in other words, it's much less giving up, we're giving in and much more approaching diplomacy from

a negotiating point of view looking more of this. right? so this, this isn't this, this isn't the media. putting a proposal on the table that it presumes will be rejected. this is, i mean, you say yes, you can have that. if we can have these guarantees will generally yes, fail. and that's a good question because we don't know much about the logic behind the arminian diplomatic position. and in fact the lack of information promotes dangerous. this information, but i do think our media is in a very weak position after a devastating war of 2020 and has little leverage. the security today of the art mediums of newborn a car law is both under threat by algebra. john's seizure, the enclave warner. also because of the weakness and incapacity of the russian peacekeepers and other station, there are the 2 points that i want us to pick up. but start with the ethnic

albanians and they're going to at cairo. bad news. vague news as you, as you say, of this deal is now out there, i would say, reacting to this welcome page to buy it. we feel betrayed and ignored. in other words, the art meetings of newborn a car law are now increasingly looking to russia and no longer to armenia for their security. which in the aftermath of rushes, failed invasion of ukraine is perhaps a dangerous ploy. but at the same time, they are pretty much stranded at the mercy of the algebra, johnnies who have both for digital with the reserve board and much greater capability than our media. so let's talk about russia then as you say, got his hands full with ukraine at the moment. how active has it been at dealing with this dispute uh, on its doorstep because of a, i believe a media is very upset about, but the lack of support is received from russia as well. yes. and 2 observations

regarding russia. the 1st is also over, john is openly defying the russian ceasefire and challenging the russian peacekeepers. it's an embarrassment the humiliation for proved in russia, but secondly, rushed up because of ukraine has lost the diplomatic initiative. it's the west, the european union, and the americans that are now taken over the diplomatic negotiations and momentum between our video and also been drawn sort of clear. thank you so much for joining some outlining not for so richard got to go see and from the regional study center and yet tax. now, not only did the cobit 19 pandemic traumatized people and societies, but it also spread some innovative medical advances. groundbreaking, a new platform based on molecules called messenger r n. a saved millions of lives when it was incorporated into new vaccines. now that

technology has been utilized in other areas, for example, as a potential treatment for another can pancreatic cancer. the pancreas plays an important role in digestion and metabolism, a tumor, there is bad news. mortality rates and people who develop pancreatic cancer are very high. bank of the cancer, so deadly because it starts to metastasized early on, which means to massages, move out of the human micro my. i'm in the primary to minute location and start to migrate your other places in the body. and this is extremely difficult to contain. and means that the chances even of the removal of the primary tumor that you have or turns and become disease a pretty soon i a demo. and a cancer vaccine works by making the body aware of cancer cells which are able to grow and detected by the immune system. a dose of vaccine contains many copies of

a short stretch of precise genetic information. the messenger r n. a. it induces the body to start making specific protein, slight ones found only on the surface of the cancer cell. after being trained by the vaccine to recognize the cancer cells, the alerted immune system, defense cells attack them wherever they are. the big hurdle is that because every patients, cancer is different, their cancer specific proteins are also highly individual. so every m r n a vaccine has to be specifically produced for a particular patient. the, this is and you know, makes, and in being able to, i enter my potentially highly mid atlantic androgens that are quite unique to the patients themselves. giving it a personalized focus is, is also a huge, huge advance in a small scale study recently published in the journal nature,

researchers use custom made messenger r n a vaccines as part of the pancreatic cancer treatment plan. in around half the patients, the individualized vaccine candidates, based on technology, developed by german firm biotech, appeared to prevent a relapse of the disease for at least 18 months. a larger trial is now slated to start this year. of the trial was a combination of 3 things of chemotherapy, a check point inhibitor and the vaccine and comparing it historically to just check point and and chemo therapy. the results were much better, but we need to see a larger trial, more patients, and double blind. so compared to the, to versus plus vaccine, to know that it, it's, it, it's truly a factor this, the new m r n a vaccine therapy does prove effective in larger advocacy trials. it

would be a huge step forward and combating one of the deadliest forms of cancer out there. let's go on this promising development on a cod house from dw sites. welcome to add a service. looks promising is a site what is left to overcome? well, so you're right, it is exciting news and it might be a turnaround and pancreatic cancer treatment, which is a cancer that is known to be incredibly that lee and has just the limited amount of treatment options. that's it is 30 days. so 1st we're looking at a very, very small study here with only 16 participants. so the results need to be confirmed and larger and randomized trials. second, patients to not only receive the vaccine but also the standard treatments like chemotherapy and check point inhibitors and surgery. so it's hard to attribute this effect to the vaccine only. and finally, by now it's not yet clear at all. like half of the patients that not moaned and

then your response, and these were the patients. they actually also showed a relapse after a couple of months. and as everyone got an individualized, maxine that's actually the 2nd part of the revolution here. we want to make that exceed better. so in order that everyone can benefit from it. okay, so still lots to do, how likely, but then a we are we going to get is this going to end in a successful treatment by the end of this trial after 18 months, which for pancreatic cancer is actually a very, very long time. half of the patients had not relapsed, one can say that's only 50 percent, but for pancreatic cancer that's actually a huge success, right. so still, we're only talking about patients here and which the cancer could be removed and for pen for the cancer. that's definitely not the case for every patient. so the question is, can also patient's benefit from the treatment with an approval situation or in advance setting? because there might be much harder to get this in, you know, therapy into the big, bulky pat, credits,

pancreatic cancer tumor. and so i appreciate that that i'm sort of extrapolating now, but is it possible that be salt? so instead of you to give vaccines could be used for other kansas as well. this is the big cope here and research as have been trying to to produce m r n a vaccines for, for decades. now, that has been some positive results just earlier this year. for higher risk melanoma. but what's special and striking in this pancreatic cancer situation is that's research as cold calls cancer. so a cancer that usually hides from the immune system and a vaccine, of course, wants to boost the immune system. so people would not expect that it works so it would work so well in this particular setting. and this is part of the surprise. people say if it works here, it's very likely that it might work for other kansas as well. okay, so a brief what then about cost, cuz that's what it always comes down to. this treatment is expensive. um, it was like or shy in the founder file text that's it was able to redo,

they were able to reduce from $350000.00 to $100000.00 for treatment. but it stays an expensive treatment with need which needs a lot of logistics and highly specialized centers and to perform it right. so but this that at least this hope. thank you for that. and i caught house from dw science. thank you. not to portugal where police are counting on it's a new search for modeling the kind of british child who disappeared in the southern alga region a 16 years ago. this is the full search for its being 16 years since madeline. mccann disappeared but not portuguese investigators are looking for clues at this remote reservoir. it's located around 50 kilometers from the resort where mccann went to missing. madeline was 3 when she vanished while on holidays with her family and prior the loose. despite and international search,

she's never been find this location was allegedly frequented by the main suspect. he's been named as christian b and is behind bars in germany for raping a woman in the same area of the al gore of region from where the british toddler went amazing. christian b is also under investigation on suspicion of murder in the mecan case, but hasn't been charged. he's denied any involvement, but at the behest of german hard, he's. a search is being carried out at the location in portugal, up to the advisor, the icons give any concrete information on the clues on which the search operation is faced by the people. they're not the tips that come from the accused, but as you can imagine, we don't start a search in portugal on the off chance on doesn't that there has to be a good reason. and we have one bill. i ask for your understanding though because i can't disclose it here for technical reasons. the police come to side months after mccann's disappearance. but divers only find animal remains. they're hoping they

some new search results in a breakthrough. in the case. when we spoke to a journalist, antonio martin snacks, so in lisbon, and he told us why police are focusing on this location. well, generally, although it isn't police the find the, the national computer of the increase in the block is the voltage. in some cases, some, some of themselves, in this case, some pictures and the videos from does lake, they use it to, to visit this space. because this, this is, it is more fire guys. and the, the police, i think they can find them with a trace of clues from the victims, not, not just modeling, but for the victims from does the washing dw are coming up next in news. asia in the late on their end,

remotely addresses thousands from the diaspora in sydney and the duffel governor of a famous doctor in hong kong times up here in band or spanish. they will have those stories and it just looks 1st of a reminder of our top story, specialist defense ministry says that security forces have killed 70 cross for the attack, has driven the rest of back into ukraine. chief, has denied and connection to the incursion and insisted that russians partisans respond back to this of the out better strategy has news agent in just the

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