the. 2 2 2 2 2 2 2 2 2 2 in meeting cultures around the world, people learn to classify small handful of animals with edible and all the rest of the classify. as we're discussing the w series about our complex relationship with animals. the debate watch now on youtube. d. w documentary, the talks in trouble and false thing can all home all parties as can support and fullness, if you ever do it within the right. so this is the same sofas that stress can actually be ups boost also. but learning how to cope with challenges, help sell body become more resilient the the good, the bad,

and much more this week on tomorrow. today, detailed the new science program. the nicholas gwen blog, is a molecular biologist and best selling populace science. all of his work led into a very big question. what are the positives of something that isn't itself, but for us if you have something that we humans created like a building or a call and watch, the more you use it, the more one down it gets and then the less functionality. so you can say that the cost ages as you use it, but you know, biological organisms are different because when we stress ourselves, when we use our bodies, we do get this damage. but then we can also repair or so. so that means the damage then get turned into becoming stronger in the, in the scientific term is derived from the ancient greek full to excite,

the leases basically how mesa is, is string through adversity getting stronger from stress and becoming more resilient as you actually damage yourself. on home is this a company's us throughout our entire lives beginning with the immune system in early childhood. these hospital incubators, a temporary home through extremely vulnerable babies. the technicians are checking the ventilation is nothing in only a minimal amount of particles to the premature baby bored. at the same time, this is not supposed to be a gym, free environment. shooting infants, some old like tyria is counter productive and cleaning them down to st. louis team, and these are basically in this phase the immune system learns how to fight infectious agents from outside when,

and that is the reason why we don't get sick. so often in our teens and in adulthood, approximately i've had no clock on how does that look? the a nate immune system with bowman has a built in response protocol. it targets anything that identifies is a danger and only knows one way to fight. in contrast to the adoptive, i mean systems relate to require individually this custom trained, developing sophisticated defense mechanisms of the facing challenges in the shape of viruses. all bacteria, the whole nice effect stress leading to great to resilience and excessively clean environment presents the risk of the immune system. basically, having nothing better to do. instead it's science on our own body. among the potential consequences or allergies, the children play

outside and get dirty on the other hand makes them tough and strengthens their meaning. defenses. thoughts? according to the hygiene hypothesis, at least traditionally a popular premise among he'll meet his researches these days. the theory is considered too simplistic, but the principle has not been refused. it makes less painful, dug around and a range of studies on the subject side of the positive factors. things 8 experiments was toxic comp, towels that taking the motor ration. hudson, the astonishing effects when you restart is, for instance, taking whims and then feeding them. we've kilo another pricing, and then you'll see that if you keep it at a low dose, these ones where they tend to live longer than the ones that have not been placed on that or a or that's examples with radioactive radiation. while you take, for instance, mice and then you, you ready aids them. and of course, if you have really, really and height, i radiation, they didn't kanza and die. but if you have

a low level of activity live longer than the mice that has just been left alone on, how does this work? high doses of radiation, obviously by saying coach the generation of free radicals through oxidation, they destroy cells and cause what's called oxidative stress. but in smaller doses, radiation can reverse that process. in this case, for a radical service and a look for the body to toughen up from that is home basis. and effect of this kind do appear to occur in humans. studies show the nicholas simmering shipyard workers hod longer than average life spends with some of the findings among radiologists in britain. while the results of the subject a considerable debate. these are those effects do exist. the exact doses of

yet to be determined. so don't try this at home, kids said vent blog. what he would like to see is adding a little home uses to our everyday lives. peer to exercises good view. it might mean a bit of damage to the body due to oxidative stress. but again, in the right dosage it makes a stronger plus, according to bind blog, the vegetarian diet can also have a home meat. this effect. a lot of edible plants, in fact, have a slightly toxic effect for us due to water soluble molecules. they contain cold police deals, they stimulate the gene, the directs defense mechanisms at the cellular level, consumed in the right dosage that helps to train our immune system. the

this on the works, however, if the city of the process is in our body all functioning properly, nicholas principal could like is the situation to a waste removal service. once defective molecules have been detected by the cell, they're enclosed in a bubble. and al, scenario a garbage truck, which then heads off to a kind of recycling yard inside the cell. the molecular waste is then taken apart with many of the constituent elements being reused. this process a pre requisite for nice this effect is called on top of g funding. the right dosage, however, is far from straightforward. we can, the 1st thing we can learn from home is just that biology is extremely complex. it's not just as straightforward as if you're trying to fix the car,

something like that. when you're trying to do something on your body, that's always all of these feedback loops. so if you try to move your body in this direction, it will push back into the other direction. then you can see even if damage yourself, well then you get stronger. but sometimes also when we then try somebody else so stronger, we end up in making ourselves, we go in the end because of the systems as well. so we just learned that the body and just even the symbol when is really, really complex. the, the bottom line, an unhealthy lifestyle is good for you. but now and again, a lot of us do like to, let's all head down and muscle cells go, despite knowing that it can reduce our life expectancy. and around half of us have an additional contributing factor that they can do little about

that global life expectancy, cement is several years. joseph and so women and i, a cya, and his team in frankfort are among various researches he's been suspecting a certain culprit for many years. now. the y chromosome is the one that genetically makes a man a mine, and struggles i love to start to show us. it is relatively clear from large scale studies that the y chromosome is indeed involved in the slightly lower life expectancy and the man, the mental chromosomes store genetic information in our body cells. we have $23.00 pairs with one of them determining on gender. while women have 2 x chromosomes, men have an x and y that's suppose one was in fact the y chromosome is the smallest of all of our chromosomes and contains need just over 50 genes x chromosome of 800 or less. so it really is atanya chrome is i'm or was

assume that it's sold purposes to determine gender, to determine near on that were such as have now come to conclude that the y chromosome plays a major role in male health. the problem is not the chromosome itself, but it's low. over the years and decades, someone's y chromosome stops to deplete connection with errors and cell division. this effect for the cold, the blood stem cells in the bone marrow that filled in new blood cells. some of them then no longer have a y chromosome. m either. so from the age of $45.00 or so around 5 percent of man have suffered y chromosome law. so it's a slight 60, that figures between 20 and 25 percent and fish on animal men, age 70 plus 40 percent and cut y chromosome loves and photo specifics on

chromosomes over a lifetime. the last of the why chromosomes can lead to what scientists cool music jews, the patchwork of cells with different genetic compositions. this can have serious consequences. and then let's since fi um, studies over the last 2 or 3 years have shown that menus lost this y chromosome and have a high likelihood of cardiovascular disease outside those diabetes. if it's under classic geriatric disease, macular degeneration to get on, which is a gradual loss of vision based on some stuff that mount on south hall. so the question them was, how is this possible to become the assign the team and frank for us, examine blood samples from patients with heart issues and found cells with no y chromosomes fall more frequently. this is, this is a healthy group, and this is the group with cardiac in sufficiency. and you can clearly see how

chromosome loss is far more common in the group with cardiac and sufficiency. another aspect is the patients lacking the y chromosomes on average die sooner from the heart condition. this is blown out and the survival statistics to patients with an artificial hospital. a research group in the us discover the following. among life, blood cells with alpha y chromosome can trigger a sickening or scarring in the hot, cold fibrosis. this stiffens up the hot and compromises its capacity to pump. it's not yet clear whether these results can be applied to humans. the frankfurt team are observing a similar process and all cells, but there is still plenty of areas that have yet to be examined, including house account to the loss of the y chromosome. dead

side give just the only really 2 recommendations at the moment. we know that smoking accelerates the loss of the y chromosome london man, so we recommend that men quits indicate answers to the 2nd thing that seems to be emerging. how is that a physical activity on a regular basis? how's that protective affects the ssl from protecting? the preventative action definitely always help. which is why the research is aim is to gain a more precise understanding of the home full effects of y chromosome. last, although even then it will be many years until effective medication has been developed. so for the time being, the gap in life expectancy between men and women is set to stay. on the other hand, men often get a better deal in life. they don't go through child o to go on the hills. this is only ever been available for women

that, that might change in the near future. the, at the university of minnesota, a research team headed by going to guild of discovered a compound that would be suitable for making a non hormonal contraceptive pill ferment in micro, we're really targeting um, a multitude of proteins. so i would say probably about 6, and of course the, it's very in stages of development. and the one that is the furthest along is the project on richard in the wake assets receptor alpha. and so i guess we are at the stage where we have um, i guess the clinic. ok, i mean it's not candidate is called y c t 5. tonight i'm was

tested on my own mind. this compound is reducing sperm counts and the thoughts from montezuma and excite coal and the most is 35. that is true. and so that is the amount of times that you have with men just as the walk to see the effect. 99 percent of the mice rented, instead of tile 6 weeks after being taken off the drug they were able to reproduce again. plus the side effects with minimal contraceptive has since been tested on other animals. the company that license the compound, they also did a similar amazing studies with rats. and they also found that it was equally effective. and also they did not see any side effects. and then they actually also administer the talk to non human prime. it's basically it's a monkey is and again,

it was effective and also totally reversible. following those promising developments, the compound is now being tested in human clinical trials. researches in germany are also working on alternative contraceptive solutions biochemist, claim, and steve, born on his team at the university of 5 wait, i've been conducting tests on mice and collaboration with american colleagues. the compound in this case is t d i 11861. it looks by inhibiting the enzyme soluble honda little side place s a c plays an important role in activating spence and making them mo tile or able to swim. that means that and then that's this is prevents and swimming rapidly, isn't that in an effect from moving forward?

it also stops and maturing process. it isn't necessary for this from the fumes with an egg. so he's midnights, and if estimates the new compounds advantage is that it can take effect within just 30 minutes. and as a 100 percent, success rate preventing fertilize ation for around 2 and a half hours. 24 hours after the injection. the much is spent, vitality was restored before the by white researches move on to clinical studies. they want to make detailed improvements to t. d. i 11861 and produce optimize derivatives of the compound in the other compounds of more bio available absorbed effectively or digesting more slowly in work longer here. while our objective before starting clinical trials is to combine the features and also coming in and the results from the animal trials i

confirmed in clinical studies with human subjects, non homeowner contraceptive pills, cause mock another milestone in gender equality way perhaps soon we'll finally see a fish of responsibility between men and women. for all potential consequences of romantic and couch. let us read, why do you have this science question, then send it to us as a video, text or voice mail? if we answer it on the, i will send you a little surprise as that. thank you. this week's question comes from bosnia herzegovina specialist says, why is it that our teeth don't grow back? many people lease that teeth as they reach old age road route. slight tempest isn't squirrels. have teeth that never stop growing. whereas over the course of their

lives, chunks produce ups of 40000 teeth whenever they lose one eye replacement shift fluid from behind, the case only on nails in hand keeps on growing. the only replacement for loss teeth are sufficient. want to understand why we have to look at our tooth formation process or owed on to genesis, which begins in week 6 of pregnancy, a milk p stone to form. at this point, the fetus is just 8 millimeters loan. starting in the 3rd or 4th month, the buds of what will be all permanent teeth, appear in a secondary dental lamina. and once with milk teeth and dropped an average 8 months off to buff before floating else again, between the ages of $6.00 and $9.00. the june now has sufficient space for the

permanent teeth to break through. the imagines about wisdom, teeth and adulthood, is the final stage of ode unto genesis. looking at all, even nation humans have no need to adjust the set of teeth. but with people living to an increasingly higher age, are change, need to last longer to, and on dietary habits caused them to fall out prematurely. tooth decay, for example, is one of the most common health problems in the world today. so if that set of teeth would make a lot of sense for searches around the globe have spent years on the development of regenerative chief at violins, technical university, scientists managed to produce funds that couldn't ferry spend new teams. so the meantime, those will have to make do with oh, school solutions. the

people with alzheimer's disease become increasingly forgetful and experience problems with orientation and speaking the most patients and their families. the conditions progression is a painful and distressing ordeal. many patients require support with otherwise routine tasks out time is, is the most common form of dementia and remains and incurable brain disorder, the medication available to date, to know me and the v 8 the symptoms, but not put in into them. you compounds all. however, in development, in may 2023, an american pharmaceuticals company published a provisional findings from a study on its outside the antibody to non them up. the 47 percent of page in streets of with

a new compound remain stable on 40 percent. so let's decline in their ability to carry out today the tasks the cabinet soon. there was an improvement in cognition. and that's one of the crucial differences between the anti bodies used in the past . and we're going to have access to the drug research a 100. so it was, they didn't move out of hand in the development of a similar auntie party therapy many years ago. but the compounds deployed to data had only a limited effect. the windows sheets folks who do not know the difference is that the minimum oper moves in essentials super toxic peptide applied on this book to a course source of crystallization and plaque formation. so crystal is up to an on so plaque food and field of existing antibody medication likely kind of does break down the flux and the brain, but does not deliver an improvement to patients mental well being. today,

scientists know that the truck deposits are not the only factor in the onset of outside. this is a force to them. what we sometimes call the milk made idea. it's been that flex damage the neuron. somebody moves to, to a degree to pop, to one is perfect. what device month today or do we know that the link them up peptides? these are gonna clumps of toxic peptides that are free christmas to the plaque deposits. play a very big part in disrupting the nervous system from the staff is the students are from a study in the us launched in the 1980s provided early indications that not only plucks with the blind and examined around 600 nuns age between 76 and a 107 at that time of day one conspicuous finding was that the intellectual faculties had evidently not been compromised. despite the out summer plucks even nuns with the launch number of plucks and their brains was still able to perform

mentally challenging tasks right up until they're passing didn't understood in who's on the we were fascinated by the non study back then thought this was it prompted a lot of scientists to ask themselves with the blacks where the central element in the triggering of the disease. ready meant to us is on whether it was parts of the plaques that were playing a decisive role. the, the provision control dispute drugs developed to date things to support patients memory capacity. but the results were of limited effect until the development of an antibody treatment, touching particular components of the flux might to none of them off. now, mean a breakthrough into teen point is scientific direct to add a german assignment to research association cheese wherever you have premature celebrations to the patient after 9 am i but it's still not a game changer. a cons actually still the disease or symptoms. i'll give them

a tool in the shop and come is a kind of best delay the progression of the disease. now whether this will be tangible to patients is questionable in the dark, the even that would be cause for hope for a lot of patients and their loved ones. even given the side effects in the brain swimming was detected in 24 percent of cases. and so she wanted to send in both micro hemorrhaging point and the vast majority of cases, the side effects, what asymptomatic. but 1.6 percent of cases involved severe side effects. and that would even 3 depths related to side effects. phillips or one from even, even though it's hard to say was it, the new anti party will lead to a to a some research as belief just as the disease itself progresses very gradually, the new anti back remind me quite some time for its healing effect to fully develop,

so use of clinical trials will be required before a fair assessment can be made that for from this edition of tomorrow today dw science show. thanks for watching and see you next time the, [000:00:00;00]

the shift your guides to life and it did to to explore the latest online trend, navigate your way through the digital jungle, get a global perspective. we'll be your guide and show you what's possible.

really match it to you see if in 15 minutes on the w. e co, africa, they are hot to commodities. beach and pansies are being illegally treated as pets and kidney ranger oper. now international parks are set up. they want to raise awareness of the issue with a wide range of projects to protect, to co advocate in 30 minutes on the w, the . she's got issues with a lot say,

well crazy. the words people have to say is too much. that's why we listen to every weekend on d w. how many platforms can you help me to single attain usually without having the feeling that is just too much you might see me. how much can we do simultaneously? multitasking diesel, modern meds? because if we do too much, we paid it all wrong. we messed things up, risking brain damage. so let's stop this self sabotage,

humans and multitasking watch. now on youtube, v. w documentary. the, this is the w news live from berlin, at least 13 people audit of, to a fire rips through 3 spanish nightclubs. they're off is the desk told, could rise for the as risk you with is search the ruins also on the program. off of the code is separate, says p k. k claims. it carried out a suicide funding and i'm correct to t responds with s price on suspects. it's code is talk is in iraq.