country you're all up to date, but stay with us. shift is up next with bio printed donor heart from 3 d printers. i am one of whom well, in berlin, thanks so much for watching state your and, and take care the g w. this is the, is available to them and it has never been since the germans count about why does that mean? i think it's like now i'm leave them on the new host. join us for an exciting exploration and everything in between.

this is a video and audio production 5 d w. i hope video will tune in the right now hundreds of thousands of people around the world. a waiting for organ transplants like 4 year old, a v green who's been waiting for a new hoc for a year will smart technology revolutionize organ transplants. and all 3 d printed organs anywhere close to becoming the norm. find out on shift. it's a hot may from human cells using ice 3 d printer scientists, intel of they've already made this breakthrough back in 2019. the printed hot couldn't be yet, but it was assigned the researches were on the right path. the key here is printing using living cells, circled by printing id printing. well, the other 3 d printing, also known as additive manufacturing. laughter has been in use an industry for

a number of years of yet it basically means building complex objects layer by layer hiding young and a few years ago. and this trend also made its way into the field of biomedicine filled us in all we've been naked up in the enables those to print the layers of living materials. and that's my logical material. teeth which are very complex material properties in all fixed lives. and for the world all phone cutting, the ones that we now have new possibilities and file medicine complaint can hopefully print complex oregon structures in the future using 3 d bio printing of the key to all the file printing that's for the bottom printing had submitted. so scientists can actually print organs using living cells. that's pretty incredible. in 2022, the 1st 3 d printed it was transplanted into a volunteer in the united states. but that was the last we heard. we reached out to the company 3 day by a therapeutics several times for an update on the current clinical trial without

any luck, but this much is clear. the race to manufacturer functioning organs using 3 d printers has been going on for years. first attempts to fly printing artificial organs were made over 2 decades ago. one of the trail blazes is us surgeon, dr. anthony atalla, in 2011 a 3 day printed accuse me. thus the organ is measured using m r. i scanned the data is then used to create a 3 day model which has been sent to the printer. the printer manufacturer has the model layout by layout, from living cells, all as shown here from plus a race such as noting. and trent university develop basically using a 3 d printer in 2021. it looks deceptively real, but it's actually made of synthetic materials. it's supposed to help train doctors to recognize live it cancer. in 2020 to 3 day systems and united therapeutics presented a 3 day printed long structure. this synthetic creation should help regulate gas

exchange the way healthy lungs do. animal testing, shoot off an insight into how it functions it will probably still take some time before 3 day printed organs will actually be able to replace traditional organ donations. but this technology is already proving to be very useful in medical research today. like this 3 d printed bought a cop made from synthetic material. race such as at the massachusetts institute of technology in the united states have developed a road, bought a car using a 3 d printer. the replica is supposed to emulate the functions of a patient's individual heart researches 1st create a 3 dimensional computer model using data from the patients hot. it's made up of soft, flexible, synthetic materials. the artificial heart is wrapped in slaves that mimic a hot date. h one is controlled separately to ensure that it pumps realistically,

this way the rug bought a car and mirror a hot date of the patient. researches one to hone in on how the patients thought is contracting. the robotic is not meant to be transplanted. instead, it's supposed to help doctors better understand the hot conditions of individual patients. and therefore i pinpoint the best treatment very helpful for treating people with hot conditions, but not a solution for patients waiting for an actual hot transplant. still 3 day by printing can be deployed in other ways. lots of patients who need a bypass due to block vessels, researches in northern germany, a testing out this idea of vascular surgeon, dr. riven bands and his team of developing a new procedure. speaking and fees isn't in artificial vessels, are in a georgia dream and surgery from the actual content of the cardiovascular surgeon,

you and have typically end up in a situation where you're caring for a patient, but don't have any suitable material to use for to bypass and for example, i must, i'm for a heart bypass or a bypass and the leg researchers have been working for many decades now. i'm creating bio artificial vessels and a lot. yep. so standing in level view, it would enable us to help perform a bypassing patients that don't have the necessary bodily material. i expect them to bypass on beating the research teams idea. a print, a single tenuously presses to liquids to create a flexible, to made of bio materials that's roughly 30 centimeters long. one of these liquids is so called by a when it's a type of organic think that's enriched with even investigative cells. it's guys, this is an elgin, a material made from brown out what is a normal and back to the cell generates that cell is country bind well to it. that's why we have peptides which are small pieces of proteins that can be found in

the human body like college and you need to pay the sounds good. now bind to these peptides cubic even the peptides can also send signals to the sales so that they feel comfortable then can survive and reproduce and bianca after and initial phase using standard straight printers. the team is now switching to a robot with a specially developed printed one chain. the in the print head contains the boiling . while the other contains calcium, fluoride stabilizes the bypass graft. let's look at selective i'm. this may look relatively simple, but it actually requires fine shooting a lot of different parameters and power allows the also to 11 challenges the bio into it does not have no technic properties. so here's what's missing. in other words, it behaves differently from typical liquids. becomes more solid under pressure eva um, but just means we need to equip the printed resistors here to ensure a uniform flow of the by a wink forgiveness and who move in flows to few instead of allies. it's all

incredibly delicate and precise work, so it's no surprise that the researches have carried out countless test prints. one challenge, the entire structure needs to have a consistent thickness to take a look at this bypass and you can see how much it sends out within the site as long as of yes. and on the other 2 sides, you can see that it's quite sick on the wrong side, right? so it won't hold up on those are the more symmetric, the structure, the stronger the circular structure, the more stable it will ultimately be. what was, was the some stuff the artificial bypass cross supposed to be as uniform as possible so that they can function inside the patient the decades of the printing. the new structures must mature in a nutrients solution that's $37.00 degrees for a few days. we usually print at room temperature, that's where it is the same,

but keeping the cells at room temperature for a long time can be detrimental to the cells even selling nothing. so we print using this substance, we on the bike and then we place them in san to bio reactive where the culture is kept up. 37 degrees theme is for as many cells to survive the printing process as possible. if everything is going smoothly, numerous grain cells become visible under the microscope. in the next lab test phase bypass graft a being tested in animals. clearly a controversial ethical issue, but the scientists say it's necessary. and on that topic, 3 d printing with living cells could sleep even help to replace animal testing. for example, when developing new drugs, pharmaceutical labs could use so called organ on a chip models. these devices can emulate how human organs function thanks to bio chips. the need for animal testing could soon be reduced the cells on the so called organ on a chip systems by logically mimic human organs. when they come into contact with

active agents, instead of animal testing, researches are increasingly using these kinds of many labs. it helps them to sun, if substances toxic to the human body or whether they could work as medications. the system basically consists of a microscope slide, at least one cell culture and micro channels. the membrane works as a carrier for the cell culture, while the micro channels supplied with f, nutrients and active agent pot live. uh, excuse me, cells can be grown onto the chip or printed on the slide using biling. sensors allowed to sign system monitor the condition of the cells home. the chip. many of the bar trees have also started using coaches from multiple organs on the same chip, reducing the number of tests. today, there are even chips with complex 3 dimensional cell structures, which allows for more precise testing. 3 d printing using living cells,

certainly books, very promising. of course, it would be even better if we could print cells and organs exactly where they needed inside the human body. and scientists are already making big strides. check it out. this is an experimental meaning 3 d bias to could directly print by material until opens and one day it could be deployed inside the human body. we can directly deliver multiple in the way on the table, inside the big body and quite the coloring melvin lizzy. they have to make more material and outside of the body. and then it'll go to the lady, the material, to have to be quiet. when says re a bunch and ready to quiet last infection and look last similar to an endo scope. the soft and flexible robeteck is inserted into the body by the through the mouth and a small, a small skin incision using bio ink. the device can print by material onto the

organs and tissues, for example, to tell them after an injury. so this is a larger version of our 3 default printer. we have. this is basically used to, to, to live up on materials to the ended side or off of the surgery to facilitate to the healing process. we have a camera located at the tip for the visualization, as we can see right here. and we have one channel at the top, 2 for the delivery of the materials. and of the fact we have the control us to control the bending of the printer. and it doesn't lead print. it can also make incisions and spray water to clean the wounds after an operation. in the future, this medical tool could be used for different types of surgeries, including the removal of cancer risk. janice, especially did the fi,

can be utilized on one set of co device that can before them the, and course a big safeco for seizure. and therefore they can do more to sit and tie up the kinds of timble inside the bodies. i think actually on the call on comes up. there is so much of groundbreaking research going on right now. but what people who are waiting for an organ transplant need the most is more open donors. would you're doing night your organs or do you say 3 day printed organs as the way of the future? let us know and so you next on. the adventure is serious coverage. definitely no 0. the dog

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