it was the plague of as you just say that it has been always, there is, this is really affecting or warm blooded animals including us. so it spread everywhere in the words. and there are to be some way to get things to infection by screen receiver, sorry, and in the gulf, and that'll be infection cause of system making the blog. and then it's really, really difficult to be treated as instructs infection via the respiratory system is particularly deadly. so deadly. in fact, the seats inspired biological weapons projects in the 2nd world war. it's nearly 2 weeks since the 1st and track of tax in the united states. the circumstantial evidence is low. american is leading the authorities to investigate possible links between the anthrax and a solid been loven's network. 5 people in the us actually died from left to is laced with on strikes in 2001. so how can we protect ourselves? so this is let us to class security by law.

and what design instructors even look like. how this for me. and then i'm gonna send them in again she was interested in one specific characteristic of the bacteria. this is positive or some charges. it's our long save bus a lie, it's makes change, made of the center data. they are covered by anonymous that it's made of little pieces that are trophies, it's work so i can make those kind of them. and if you remove the item or the bacteria are getting a signal at austic and there are no sticks any more. and i came up with the idea that, well, what if i can destroy these are the thoughts turned to the nano bodies

discovered by how university colleagues might they be able to use them in a school size to infiltrate the bacteria is alma, like tiny missiles that code for a nama, the protein that makes up the bacteria is um, uh, was injected into the beast. and after a few months, the nama had created nano bodies, specifically targeting this protein. fyodor of anti then introduced, and then their bodies to the answer. i expect tyria the results were astonishing. those of the known cheese themselves, you see they have these uh, as most shape. but when you treat them, we do not know bodies. they start to read to wrinkle and then they collapse. they were able to stop the proteins to make the armor and without the support of its exoskeleton, the bacterium fills the pops. so it's really like the non about as are the key of

the story going between the on were and these assembled just and that nobody was possible because of the size, the that success come to, to test and no bodies in the lab. in other words, on living mice, the, my swear infected would on trucks and then giving the nano bodies twice a day for 6 days. well, i really, so the, we're going to die on a sleeve, me and my colleague of sleep fluids doing experiments. and then the my subject to, to get better, get better, but getting better. and on sunday morning i get this cold from sleep like so. why is that, why, why the control? we got old dad. i remember really i started jumping. i was like, maybe my ph, i'm having remco and i expected something likely to is because, oh my god, we say it sounds saying this, this, this isn't, this is huge. the zip,

it's worse. so this is the best phase of my life. this opens up really low on the line over stairs, and also the opening of new foss with treatment for under my kids that have such a higher. this is huge versus in the belgian city of kent when not able to use have enjoyed the most spectacular success. this is the headquarters of ab links, a stone top founded in 2001 to develop applications for college, not a bodies assigned to fix success story. the discovery of a special type of small anti bodies and candidates, sparked decades of innovation. and it led to the foundation of abilene in 2001 about the time the small antibody was 3 names amount of body.

and the start of the company at 10 at police 15 is blink 6 fluid potential applications to various types of diseases. investors . gretchen, we began seeing the advantages of using calculating non abilities and in 2018 they hit the jackpot. the goal process, i know 6 evaluate both. it was a good investment it out the well full cost of the 3900000000 years and amount equivalent to the promise held in the timing on a bodies. the 1st actual use was a drug center feed began selling in 2019 caps. assume. ready a drug tobacco for an auto immune blood disorder that's very red, but faithful in 90 percent of cases. if left untreated, a t t p. the

assembly suffers from the disease. a quiet storm both takes from the site to peanut poor poor. today thanks to capt decision map. she's in the class. she's returning to the hospital for a checkup with professor a couple. an a t t piece specialist gets a treatment work in the summer. yes. very well overall. ok on it on us. everything's really back to normal. now we just need to check every 3 months and probably for the rest of your life a lot faster. it is solely on the good multi, it was a real prostitute, the edges and all that stuff to get bruised is of my body disappeared for no reason for the they stuff is on my legs and then gradually all his all you too bye.

literally stuff is moving up, is see this one, which is up to some of it. i suppose i bashed into something and so not realize it because i'm very active. i'm a primary school teacher. so, so do go, go to my children and very young is off. i'm always moving around to her. it's happened over a couple of weeks. it's an eyesore since if it smells like, hey, something's wrong and is because the bruises started to appeal in my arms. i have and i had a huge one on my hand and i'll see if i thought to myself is on. this is something wrong. tricity a christmas to them for having to talk to matter the key. it's a disease that's linked to the formation of small clots in the vessels of emotion organs, typically the brain and the heart, but also the digestive tract and the kidneys. and if we do nothing, the organs fail, then the patient dies all gun a mushroom on. as soon as the hot opportunity might not the nano body see

count the blood proteins involved in the disorder detached themselves. they replace the platelets that cause the blood clubs and prevent them from company. the cumberland nano bodies make it possible to attacks that diseases and know what kings are supposed to do get this is you might, since we added campuses a map to plasma exchange and other immune suppressive treatments, patient responses not just in the past or it's also long last angle, that's what's new to the 2nd month. no, on the out of it this off, thanks to this, we can now stop plasma exchange much sooner than before. currently, we estimate that with the addition of capital susan that we can cut treatment time in half lashawn with this function, some of the, the nano bodies. and now such an integral parts of medical research that,

that origin in the calculated immune system is often overlooked. the well gave camels, these unique superpowers, the native vienna, austria permanent book studies, the genetics of the very ancient camella di family choose a specialist on the origins of the cumberlands which have undergone surprising changes during that evolution. the camel originated in the northern america and it was about maybe like 40 to 45000000 years ago at the very beginning. do the very small, like a goat and um, over the millions of years developed into different campbell types lie to a smaller. so to iraq,

50000000 use it go. they split into the tool on images, name least a new roof, camels into all the cavities. and then you will, kimberly, they migrated around for the southern america, which i represent that now by the nama. i talked to the, we're not going to be calling you, and the old book campbell stay migrated various via the bearing land preach to asia and from the i didn't to africa. the illusion of the nano bodies. it's it also very, very old development must have been older even than 15000000 years ago because both kimberly niches have it. so the system does not have bodies must have developed before display of these totally ditches. they have developed over the millions of years, very successful mechanisms to fight against diseases. then

no need for lucian has left it small come the species. but white cabinets in particular, i would say is by chance. a lot of it will. lucian thing happened by chance trial and error. so something which has been successful survived and evolved. and if it was too much of a cost to keep, then it would have been abandoned again by the species. but why other mammals would not have developed the same strategy? i don't know. the, the cumberlands may still have the other secrets, but for now the, showing the benefits of their immune system with humans. these i'll pack us for the king near paris, belong to the us, the cheapest. they play an active role in some major research. the

immuno logistics site is to ship it to this small research, heard the clickable c. uh, adults interested in cumberland antibodies about 20 years ago because of professor how much work in brussels this week said all the people 1st thought it was funny that we were working with our package. so as of now it's become so important that everybody understands remote. i'm facts and i seen them against various proteins, really against outside was in particular, how did you get home to pull you up? once the facts and nights it would take a blood samples of continual work in the line of credit you sold to please continue to use them. we leave the animals alone for a couple of years. so you'll notice from key to phone, don't presume, is that okay? with them now, if you 2 years of peace and quiet the next step,

extracting from those few sentences of blood, the anti bodies, the animal has produced in response to the protein characteristics the outside this disease. fewer than a dozen house of several 1000000 antibodies. louie passed developed the rabies vaccine in these buildings in the 18 eighties and the institute continues to work on promising treatments, thanks to itself, packed as many anti bodies affinities on to call a 4 call. we can make antibodies against cause a to see again see kind of an recently against monkey pox so we can make the make and stuff. and brain cells flattening containment for service on the ship to include my research focuses on now. so i'm just a big, we're trying to extract the anti bodies specific to outside the school, the diagnostic heat, and eventually for treatment will call for the digging. let's take a look for that to help with the nano bodies that could

recognize some of the diseases degenerative characteristics. and in this case, no bodies specifically produced by elpac. cuz the, the 1st stage is to extract the dna from all the nano bodies in the blood. sample and then introduce it to the bacteria, the dual credit. oh yeah. i mean, yeah, direct can we have 1000000000 bacteria containing the dna encoding for about 100000000 nano antibodies. we call the phil is we selection method so that we gradually isolate the 10 best amount of what easy to put key, the email, and then on to call the long keys and do the the, the selection is ruthless. they 1st use a virus that can eliminate 99 percent of them suitable not able to use

the remaining 1000 candidates to attend as a, to a robots which one by one test their ability to identify the outside that protein. the entire process takes around 3 months, just to if the original $100000000.00. none of the bodies remain standing chosen and unable to use it, then taken to the us, the to do several, the power sprain institute to help conduct research and outside this p a p. a lot size antibodies are always eagerly await it, especially by adults have been one of the lead to who is exploring new methods of diagnosing the disease. the

outside mis directly affects the brains, neural communication network, the, the formation of protein deposits, known as i'm annoyed. tax blocks the flow of information, but the disease also causes the new runs themselves to degenerate and die. the outside is initially effects memory. before closing and reversible damage in the other areas of the brain for treatment to be effective outside this must be diagnosed as early as possible. the goal is to detach the amyloid packs that build up in the patient, sprains from the stops the into the nano bodies. but that responsiveness must 1st be tested

to die. so that is what you call mush clear premium is quite interesting to include the 2 anti bodies really work very well. this one recognizes the family plaques, and so i've done some tagging on a transgenic mouse that's full of amyloid legs and that you can see they're all tactic to. this really resembles what we see in the brains of alzheimer's patients . i don't go into the anti body is very precise and we recognize there's only one thing. there's no background noise so told to go through it really as perfect as you. and the other anti body recognizes the 2nd classic lesion of alzheimer's disease. ero 5 blurry tangles locker opening is useful. you can see that all the legions have been carefully detected. and most of the naval campus people go, which is the memory center for humans and animals. and you can also see all the time you are on is recognized by the anti body. or when you follow the logical the 1st experiment was conducted on brain tissue extracted from mice. it will now

be repeated on living animals. delete the most there under the microscope on the aim is to see if the nano bodies can cross the blood brain barrier. speaking body, i'll keep them in assets. name, suggestions. this a barriers isolates the brain from the plot through fi on. so if it's the blood carries pathogens, talks that molecules that mustn't enter the brain, they're inside of this battery, or is that important molecules like antibodies count the process to go, except maybe cml it onto body is and click on the small size is the key. trouble sourcing claim you can see for now it's very flag inside. you can just start to make some shapes appearing and real time it can, you can see the attic for the exit. the vessel is crossing the blood brain barrier and it will gradually spread and gather at the sight of the amyloid flax. and it's a community where they back in and enjoy the yacht. that's cool. and you can see

the prox crazy, low some old attacking is done by the anti bodies. but this time, since we're in vehicles, we're not a slice unimaginable just a few years ago. the technology opens up new opportunities for treating outside this disease. since just the sea level to call these nano anti bodies or nano bodies, but clearly have a feature by combining them with elements that can be picked up on an m r. i will be able to carry out early, high resolution diagnoses on patients through the city bus here, as well as monitor of various therapies on the regression of these lesions. no, i think it is going to say these are these are high hopes in the fight against a disease that afflicts hundreds of thousands each year in europe and an estimate to $10000000.00 worldwide. but none of my buddies can go even further and highlight all the processes that occurred deep inside the human body.

the literally schwartzbar wants to use the nano bodies, tiny size to infiltrate living cells and monitor what goes on inside them. a joke that requires a slight upgrade to the number of bodies, the nano bodies are invisible. since we can see them, we must make them visible. we link the nano bodies with a small source and protein to make a chroma body histidine coma from the rest. and it's not a body that makes it possible to navigate within cells and ups of some of the biological processes live. since these are dynamic process is taking place inside sales, and that's where the chromium body has the additional advantage of functioning in

living cells. the cells processes can be displayed and the dynamic modifications with them can be visualized in real time. and when does it tell it which side is what is the inside the cell, the crime a body binds itself to a its target. it traces the targets come tools and reveals that some movements must be. you'll see that we can see the chroma body, the signal of a chroma body that has bound itself to the h i. v virus. we can observe and find detail how the h i. p virus attaches itself to a sales plasma membrane and it's been discharged to infect, to neighboring cells. i'm not able to send it to you from my bodies are already used today to study the effect of 2nd drugs on cells. in particular for cancer treatments. you see for an hour are sleeping, all right,

and you can also see a criminal body in the living cancer cell. the chroma body collides with the nuclear membrane. so we can observe the division of this cancer cell. it's an important process the most, for example, if we want to now develop a drugs that prevents cancer cells from dividing, we can test them in the cell line. we will know immediately at what moment and then what quantities of drug stops this cancer cell minute. and we can see it in real time on this kind of monster tongue lice, mitchell flu. so this is what this helps us choose medicines at a very early stage and saves money and the development of new active ingredients and expulsion none the abilities of the greatest hope in kansas, the treatment of 18000000 new counts the cases, the diagnosed every year of nearly 10000000 people die from the disease.

most current cancer treatment, slack precision, the chemotherapy attacks no certainty, cancer cells, but healthy ones too, were such as they're looking for more targeted cetera. pace. and none of the bodies have become a new precision weapon in the fight against cancer. the, the number of potential applications is growing. so i'm a designed to inhibit to cim as gross, while others destroy the cancer cells. a strategy adopted by belgian stop per site rex. it relies on unable the special ability to bind on to other molecules to form a bond with a radioactive isotopes. the treatment is still in the test face,

but some potential uses already being assessed in clinical trials. here in a 1st stage, the no body is being added to a trace of the tooth, very slightly radioactive, its mission to seek out disease cells and attach itself to them. here, we say an excellent random floats with a high uptake and hair. as we can see, the rest lesion also very good uptake. on the tracer, the nobody's target is approaching cold have to that's a characteristic of certain types of cancer. for us, it's very important to know if there is a higher her to expression in the tumor and in the best assist of the tumor. and then with a start the new flows. because we know in that way,

if this patient will respond to therapy. another advantage as it to now is the treatment to be tailored to the nature of the cancer. however, there was such as long term goal is to equip the nano bodies but the phone more powerful radioactive payload. so the nano will be east present into 2 more but the few to couple the same nano beat me to. so if you to create your eyes a to so you will, you read the aids to, to more. and so the cancer cells, so specifically targeting to, to more cells while spreading to the healthy tissue. what you want the small size is very beneficial for this approach. once you administer it to a patient, if use a screw too much to, to hurry fast. on the other hand, of course you're working with the very potent radio as it took for to if you take use. and you don't want the friction that he's not bound on the to mark to stay along in the body. and because of the small size you to clear out very fast from

the body, which is perfect for the safety. now the young style top must complete the extensive series of required tests to guess its treatments approved to the clinical studies to prove that their drug is safe. and if he gets from all the way from the cameras, if you want all to the patients and the adults are need to take more than 10 years . i'm not able to use have potential to revolutionize therapies and diagnostic procedures now and in the future. the growing number of companies offering custom made nano bodies is proof in itself the along with physical and chemical benefits. the single domain anti bodies are also especially lights and inexpensive to produce these practical and economic

advantages make them affordable. so many research labs stimulating innovation. the candidates may look very unassuming, but them must as a minute to rising antibodies, which has made them into the kings of biotech. something. no one could have predicted. the fact that should cheer campbell's unplug, as unlike the

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i'm still gonna keep close that even local credit vehicle. we've got a response to this transfer and unexpected sides of the each tells my story of the people who planned me build dedicated van lines to me. i am not too dumb. depending on the online made in the centuries they billed me, they created something and had to watch. as i wrote the story. i have month, my cities, days for centuries and accompanied my country. until the

day i nearly vanished stuff, july 18th on d. w, the, the, the, this is the w news and these are out top stories. the french file rights, national riley, is on close to we in the 1st round of parliamentary elections. we the send to lift coalition in 2nd place. and emanuel microns centrist can looks it to lucy's. he called the vote off to his potties poor showing and recent european elections. if the national riley wins in absolute majority, in the 2nd round, the crone may have to see if how with the found right government for the 1st time taliban officials are attending are you in conference on the future of.