hello i'm arthel neville. time now for "sunday house call." >> i'm eric shawn. welcome as always. joining us dr. david tomadi. >> and dr. marc siegel professor of medicine at the nyu's langone medical center. also author of unlocking the secret code of sickness and health. good to see you. >> we start today with a really important message. a new hollywood movie that reveals what it is really like to live with the early onset of alzheimer's. >> i've always been so defined

by my intellect, my language, my articulation, and now sometimes i can see the words hanging in front of me and i can't reach them and i don't know who i am. and i don't know what i'm going to lose next. >> that was actress julianne moore giving an emotional performance as the title character in the new film "still alice." the story of a linguistics professor who learned that she is suffering from early onset alzheimer's and it comes at a time that research is revealing a potentially promising new treatment for the disease in the form of a nasal spray. you know the film and that performance and the message is so heartbreaking, and so important. >> also at the same time a very strong message. and i think julianne moore did an amazing job in this, bringing alzheimer's problems to the surface. everyone knows alzheimer as an aging process over the age of 65 we have 5 million americans that

suffer from alzheimer's. but that's not what she's talking about. this professor of linguistics, we're talking about people in the age of 40s and 50s, early onset alzheimer's which is a totally different disease. about 200,000 american suffer from this disease and it's only 5% of the population in this category. what happens exactly, the dark side of alzheimer's, the sentences are fumbled. the words are there to grab but it doesn't come out. lack of judgment. things that are familiar to you that you do all the time. playing games, spending time with family, becomes a huge problem. and so it's not just a memory loss but it's a whole neural/spatial type of disease. that we're finding out. now -- >> what -- >> what does this nasal spray do, dr. siegel? >> by the way, in addition to what david was just saying you lost, you don't know how to get back home. you park your car somewhere, you don't know where it is. your personality changes. you get very irritable. people notice you're not acting

the same. >> sometimes they say i'm forgetful, it's not really -- how do you know when it gets to that concentrated point that it is early onset? >> because it's sustained. it's not just reaching for one word, eric. it's constantly reaching for words. it's not just forgetting where you are one time. it's forgetting it many, many times. that's what julianne moore portrays in the film. i wrote for six years a column where i analyze tv and movies for medical accuracy. she is about the best i've seen. she really brings home the idea of somebody who is 50 years old, that suddenly has a change. and it's not just alzheimer's. it's the idea of facing death, facing mortality. facing disease at a very young age. >> i think what is happening here is that we're talking about different stage of alzheimer's. you may have mild problems to moderate to severe. that's important for people to know. what i want people to know is that there are basic things that we are capable of doing. certain things we cannot control which is the progress of the disease. so for example, we know lack of

sleep certainly insomnia can affect us. stress plays a role. that's when you start forgetting one or two words here and there or where you left your keys. but this is a real entity. i want people to really check their vitamin "d" levels. studies show that low vitamin "d," low vitamin b-12 can mimic signs and symptoms of alzheimer's. check your home cyst even level, because it has neurotoxic effect and can cause some symptoms of alzheimer's. by changing your diet, adding nuts or omega-3 fatsy acids we can slow down the process. now we're getting better imaging, so there are ways to diagnose the gray and white matter with cognitive function tests and with neurologic tests. we can diagnose this early on. try to prevent it. what happens in this particular movie is very interesting. because she went on and she does about four months of deep research and found out not just

the memory loss of where you left your car but some of the teachers were writing backwards and they were not aware of this. so the whole brain all of a sudden the connections change, and i congratulate here for bringing such tremendous job and awareness to alzheimer's disease. >> it's interesting. at 50 should you get an mri? >> not an mri, eric. but when someone comes to my office at 50 one of the things i check is a b-12 level. on everyone. because b-12 level if you're low in vitamin b-12 you can have the same memory loss. if you start to see somebody fumbling like this the p.e.t. scan has the ability to diagnose this much earlier. >> what's a p.e.t. scan? >> a study that looks at the amount of chemical energy or heat. it's not just an imaging study. it tells you how much metabolism, how much energy is going on. if we find it early we want to do that because of all of the money that's involved. millions and millions of dollars. billions of dollars taking care

of alzheimer's patients it affects entire families. now treatments, what treatments do we have? right now all we have so far is basically a drug called aricept. but we're look nothing new ideas. you can prevent the onset of alzheimer's by exercising, by eating fruit and vegetables, by playing board games, and keeping your mind active. one more thing the study we're looking at, if you have it, we actually have a study coming out of north carolina that inhaling insulin, now it's a small study, but inhaling insulin, of course insulin is very involved with brain function, may improve alzheimer's. >> you mentioned the nasal spray? >> i'm not sure about this study. i think it's a very small step forward but we have genetic testing. i can't you to know about this. apoe genetic testing if you have family history and you're at high risk you should get this genetic test. also i want you to know that you're not alone.

alzconnect.org. there's a whole community out there. alzconnect.org is a whole group and website -- >> can you tell us now -- >> alzconnect.org. so you can learn about this disease. don't ignore it. early intervention is the way to go. but this movie brings it up all on the surface on the type of alzheimer's that we didn't know much about, which is early onset alzheimer's, there's a lot of research going on in institutions here. at mount sinai a lot of great scientists over there. >> there's two basic proteins in the brain that are abnormal in alzheimer's, and where we've made all these great advances over the last few years is knowing by being able to follow beta amyloid when somebody is going to develop that. the future, and as david mentioned the issue of genetics is involved. who's prone to it? but if you have alzheimer's in your family, we have to watch your family because it is

genetically based. >> the good thing about this nasal spray that mark just talked about is actually work in 25% on even ish paents that have this gene so there's a step forward, we have a long way to go but we want people not to ignore the symptoms, and jump in if you see things are not the way to go. >> the nasal spray is not available. >> it's not. but this also affects the families, so it really affects everyone. go for it and get tested. >> very good. it is one of the deadliest cancers for women in the united states. we'll talk about some of the most common risk factors for cervical cancer and the huge debate surrounding possible prevention, as well as diagnosis. ght, so this tylenol arthritis lasts 8 hours but aleve can last 12 hours. and aleve is proven to work better on pain than tylenol arthritis. so why am i still thinking about this? how are ya? good. aleve. proven better on pain.

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the most effective way to guard against cervical cancer. it's one of the deadliest cancers for women in the united states. but also, one of the most treatable if detected early enough. dr. siegel and most women out there watching that go and get these pap smear tests. is this enough? >> i'm going to weigh in on this debate right away and take a position that's contrary to the united states preventive services task force which says women should only be screened over the age of 30. i think women should be screened from the time they're sexually active. which, you know, usually in their teens. why? because human papilloma virus is epidemic in the united states right now. about 80% of people acquire it after they turn sexually active. and you got to follow it with two tests, not one arthel. when you do that routine pap test you look for abnormal cells in the cervix. and the cervix everybody knows is at the bottom of the womb, the bottom of the uterus. you're looking for abnormal cells. we have a new test that you can do at the same time to find the

hpv virus and identify what type it is. you know why that's important? because two of the types of hpv cause 70% of the cervical cancer, we're talking 14,000 new cases every year still. so if i identify those two types with the hpv test then i go ahead and i might want to do a biopsy right away. otherwise with the pap test i follow the abnormal cells if i'm a gynecologist over time. at one point david and i made on this show repeatedly is knowledge is power. screening is power. >> if i may just jump in i want to be clear i'm going to you if you're my gynecologist do i ask for the pap smear as well as the pap smear and the hpv test? >> i believe that both should be done simultaneously. and then they should be followed over time. how often they're done after the initial one depends on what is found. if they're completely normal, an argument can be made for every two or three years. if they're abnormal they've got to be followed more frequently.

>> the last time i asked him about thyroid exam, he did a thyroid exam. i'm glad he's not giving us a cervical exam today. i think this is a serious problem. we see the number of hpv human papilloma virus is on the rise among younger sexually active women and teenagers and that's why catching this early on is important. one of the risk fatters with cervical cancers is hpv but there are other risk factors. smoking is another one. oral contraceptive pills are one, and multiple partners et cetera. all of these are risk factors. but early on the answer to your question, it seems based on the recommendation hpv tests could be very effective, because we can find that as opposed to real cancer of precancerous lesions that you can find more after the age of 30 so you can combine pap and hpv tests after 30 but at a younger age get hpv test. >> do you have to request that? because it's just one exam? >> look it's always -- this is

what comes down the pipeline from the guidelines that we have. so gynecologist to gynecologist may practice differently but you can talk to them. ask them, and also, it's prevented. >> how about a vaccine? the kids -- boys getting a shot? >> that's a very good point. so there are two vaccines available. a lot of people may or may not know this but at the age of 11 or 12, you can get the vaccine that can prevent you from getting this hpv. if you have it, it's not as effective. this is a safe vaccine, it's effective, and usually it's not recommended after the age of 26. so early on, you can ask for this vaccine and it's fairly cheap. >> i want to add to that boys as well as girls. this should be both because that's how we decrease the amount of hpv that's circulating. one other point, if you have it, what are we going to do about it because eric always asks that question? you have early cervical cancer or you have a tendency towards it, the good news is the earlier we find it the better, same as with prostate cancer the earlier

we find cervical cancer the better. if you have cervical cancer we probably can spare your uterus and just take it out through a colposcopypy, through a scope and actually cut the part out that's cancerous. >> basically get the shot, >> get the shot. get tested. it could save your life. >> we've also heard of female menopause. have you heard about male menopause? it's actually a serious condition they say affects millions of men. coming up we'll take a look at that. how it can impact your life and what you can do about it when the doctors stay with us.

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now for our segment should i worry. our weekly segment about everything that worries us. one viewer writes i am an active male in my early 40s. recently i've noticed i don't have as much muscle strength as

i used to. should i worry? i think it's called aging. >> no, it's called male menopause and it's a very strange term that we use because we know menopause in women. and i'm not as active as i used to be. should i worry? >> it's called active menopause, kind of like menopause in women. think of the ovaries and testicles as a bank. every time you ask for money, the ovaries make it. all of a sudden you wake up at the age of 51 and the bank says no more. that's female menopause. for men, every year you ask for money from the bank they say less and less. so the testicles produce less and less testosterone. because it's such a gradual process, you don't realize you're in trouble until you get to mid-50s and your testosterone starts to go down. how do we know about this? testosterone so you are drive, that's the mojo, so you have less interest in libido, sex

drive, concentration goes down. you're fatigued all the time and all you want to do is sit behind the tv and flip channels. that's the signs and symptoms of male menopause. unfortunately, this has become a huge business. billions of dollars, all the ads on tv, the shots. that's what we want to bring up. that's a knee jerk reaction, that's bad medicine and there could be some side effects. >> what shots are you talking about? >> we're talking about the testosterone shots that are being advertised. check your testosterone in the morning before 9:00 because in the afternoon it can go down, and there are many things we can do to boost testosterone. >> should people get those shots? >> i think, first of all, any male or female individual, if you're having a problem like that, should you worry? you should see your doctor and be checked. check your testosterone. that's one of the things on the list. it's not the only thing on the

list. clearly at 40, aging is not an issue and you shouldn't have that so early. you may have a problem. get that checked, see if you need a replacement. but there are other things that can cause this. low thyroid is very common and can cause this. a problem with a tiny england called the hyperthoric thyroid can cause this. and if you've been taking steroids for a long period of time, you can get something that wears down your mufrscles. that's extremely common and you have to know that history. if you're obese, you weigh too much, we talk about how bad obesity is for you. diabetes can cause a muscle wasting. >> we talked about whether size matters or not. in this particular case, size does matter. the size of the belly. the belly fat sucks the testosterone, converts it to

estrogen and that's when your libido goes down, man boobs, et cetera. the best thing? lose weight, guys. vitamin d is essential to boosting your testosterone, having shellfish, egg yolk, meat, all those things will boost your testosterone. lack of sleep affects it, so make sure you sleep well. as i've always said az newer s neurologist, size does matter. that's a very good point. >> there is sometimes you want more testosterone. >> if you're still doing all this and you're still not making testosterone, get it treated. but people are getting shots without needing it and that's bad medicine. >> i'm going to check what's in the bank, that's what i'm going to do. >> garcelle neville has a great idea of how to lose weight. >> every man's testosterone

helps others so it's going to work. you exercise, you eat healthy, but according to a new study, that may still not be enough. we're going to talk about it after the break. ght, so this tyl arthritis lasts 8 hours

but aleve can last 12 hours. and aleve is proven to work better on pain than tylenol arthritis. so why am i still thinking about this? how are ya? good. aleve. proven better on pain.

an eye-opening new article showing no matter how much time you spend at the gym, it still may not be enough to undo all the damage you could be doing just sitting down all the time. dr. segal, why is sitting down too long bad for you? >> i really love this study because it's really important not to do at least 30 to 60 minutes at the gym. all day long it decreases your risk of depression, it decreases your risk of infections, stroke, heart disease and certain kinds of cancer like colon. so get moving all day long. >> if you're sitting for an hour, you want to make sure you get up at least two to three minutes. the rest of the show will be standing like this, and the way this would work is when you stand and you're moving around, you help your circulation, but when you're actually sitting, your insulin may not work. those receptors that work on the

muscle, they're not going to work. the atrophy is an issue and that's why moving around for just two or three minutes is absolutely the key. we know that if you sit for a prolon prolonged period, risk of heart disease, certain kind of cancers. just because you work out doesn't mean you can sit for a long period of time. even for three minutes, you can reduce the risk of death. >> it will get rid of that belly fat for you, it complements the amount of regular exercise in your diet. >> some people have desks that stand. >> those are coming in. >> sitting is also a very important key. you're sitting straight, you always have your arms in a 90-degree angle, flat feet, which is very important, and always the back support. if you want to sit, that's the way you support your spine and your back. >> walk at least once an hour.

>> and do more housework. vacuum a little more. >> housework? >> yeah, vacuum. >> stand every hour. if you do that, you'll be healthier. >> i'm marcella neville. thank you for watching. we'll see you next week. president obama pushes back saying the political vacuum will not stall u.s. counterterrorism operations there. potential 2016 gop contenders at the key state of iowa, including businessman and reality tv star donald trump. my one-on-one interview with the mogul on his presidential aspirations are, will he run in 2016? >> i'm totally serious about it and i'm looking at it so seriously. to the extent that a lot of my time up here is spent thinking about that.