this is "nightline" -- >> tonight the little pink pill. it is being called viagra for women. >> getting a little flutter not a heart rate flutter. a little further south. >> some say it is a revolutionary solution to a bedroom epidemic. so why won't the fda approve it? plus -- >> well, well. >> queen angelina. hollywood royalty angelina jolie is back. >> how quaint. >> with her first film role in years. she is opening up tonight line. >> when i was little i didn't relate to princesses. >> the star of "maleficient" getting personal about her film,

health and surprising wedding plan. >> and the most expensive divorce ever. the tycoon who was just told by a court that he has to give his ex-wife half of his fortune, wait until you hear how much. but first, the "nightline" 5. >> wait. prilocec isn't made for relief. zantac, rushes relief in 30 minutes. prilo prilocec can take 24 hours.

good evening. they sell it as the little pill that can help you have a happy marriage and ensure a thriving love life. unfortunately it is only for men. drugs like viagra are all over the place, but women suffer from sexual dysfunction too. so why no pill for them? turns out there is one, but you can't get it. so we sent abc's maria schiavocampo to find out why. >> reporter: it's known as viagra for women. >> the little pink pill. >> reporter: a tiny tablet that could have hey huge impact in the bedroom. >> i think this is an evolution in the female sexual revolution. >> reporter: but you won't be able to get the pink pill just yet. the drug is locked in a heated battle for fda approval, raising controversial questions about why there are so many sexual enhancement drugs out there for men. >> why would you let's wreck

ti -- let erectile dysfunction get in your way? >> a great big zero for the most common form of female sexual dysfunction. >> we are having spaghetti for dinner. >> i realized something was wrong. i didn't feel like myself. >> reporter: amanda parish says she used to have a smoldering sex life with her husband. over time, things cooled off big time. she says the problem wasn't with him, but with her. >> i felt like even though we were close and having a great relationship there was something just not there. >> reporter: amanda parish took the pink pill as part of the clinical trials. >> i can remember the very first time driving down the road at lunchtime in the middle of the day thinking about my husband and all of a sudden getting a little flutter. when i say flutter not talking about a heart rate flutter. a little further south. that was the first time literally probably mine life that had ever happened to me. >> reporter: amanda found herself buying sexy lingerie and

initiating things in the bedroom. >> whether it was because my inhibitions loosened up or desire returned, i became an initiator and in turn we became much closer. >> reporter: amanda never discussed the issue with her friend but had a sneaking suspicion she wasn't alone. >> if you really asked ten ladies on the street, i think probably, seven or eight of those would fess up that their sex life was not what they had wanted it to be. that's exactly what we did. >> with "nightline." >> we're with "nightline." we have a famous doctor. >> accompanied by sexual health crusader, we hit the streets of new york sit yo to tacity to ta taboo. >> for women? viagra? >> there you go. >> if you did have a low sex drive at some point in your life? >> even without it i would take it. >> something you would consider taking? >> absolutely.

>> i'd take it. >> because it is such a taboo topic. women don't know that other women have these, use. they feel very isolated. >> how common is this? >> very common. >> but the little pink pill is about more than curing waning libido, it is for treating hypo sexual active disorder. >> if you are married have no sexual desire and channing tatum walks through the door do you have the condition? >> you do not. that's important. >> how do you gaj that if channing isn't in your house? >> a diagnostic questionnaire that physicians go through. they really can pretty quickly get to whether or not this is a relationship dynamic, or something that is happening biologically. >> reporter: estimates say as many as one in ten women suffer from hsdd. while many doctors agree it is a problem. >> there are no medical treatment options at all for hsdd. >> reporter: cindy whitehead is out to change that.

>> four in ten women report sexual dysfunction. the woman behind the little pink pill whose working name is the less than sexy. she quit her job to buy the rights and founded sprout pharmaceuticals, fighting for fda approval for three years. this has been called female viagra, is it accurate? >> it is not. contextually, i get why people call it that. in truth it works very differently than viagra. viagra is a blood flow, mechanical issue, and this drug works on key chemicals in the brain. >> reporter: scientists have known for years that a woman's biggest sexual organ is actually her brain. and that's what the pharmaceutical targets. taken every day it is not hormonal, but rather works on brain chemistry. 1,000 women participated in the trials. according to sprout's results, on average the women taking the medication doubled their number of so-called satisfying sexual events and reported a 50% increase in sexual desire. >> how would you characterize

that? you are with a girlfriend at a cocktail party, how did it go, what would you say? >> i would say if you talk to any one of the patients nay would fell you that is a significant impact. >> reporter: about 15% of those in the clinical trials dropped out because of side effects. including dizziness and sleepiness. ♪ ♪ which pink pill proponents point out compared to those in the viagra commercials >> to avoid long term injury seek medical help for an erection lasting more than four hours. >> what did you hear from the fda? >> we heard from the fda in simplest terms, no. what they basically said to us, in the risk/benefit evaluation they felt the ben fit was modest and didn't give us an approval. >> reporter: the rejection ignited a storm of controversy with many crying sexism. the agency barraged with letters in support of the drug from prominent women's groups and even a handful of congresswomen. when you look at how many options there are for male

sexual dysfunction, talking medical options, more than 20. and that we have zero fda approved for women's use. what do you think is going on there? >> first of all i think there is sexism at play. no one is making this up. not a hallmark holiday that someone decided to invent something to solve more of something. >> reporter: the fda denied our request to be interviewed about the drug or comments about the drug, but they are committed to advancing treatments for female sexual dysfunction and denied any allegations of gender bias. >> it is not sexist for the fda not to approve a drug that it doesn't believe is effective or safe. >> reporter: some doctors say that the drug was reject ford a very simple reason. an ineve f an ineffective drug for a problem. >> a marketing technique, create the problem and sell the solution. that's what is going on here. sexual destir varies by person and phase of life. that doesn't make it a disease.

>> cindy whitehead and sprout pharmaceuticals are appealing. if sprout wins the appeal, the drug could be available as early as next year. of a ruling women like amanda parish are eagerly waiting for. >> i will be the first one waiting for my prescription. i believe that strongly in how it works and i believe that strongly that women deserve an equal opportunity to enjoy and become active members in their sex life. >> what would that mean to you to be first to market with this? >> it is much more than getting a drug approved. this is an important moment in women's health care. and in i think a societal moment around women's sexuality. >> reporter: for "nightline," maria schiavocampo in north carolina. >> you think sexism was a factor in the fda rejection? let us know. tweet us @"nightline." >> angelina jolie is back and her first movie in years. and talking to us about her health and a crazy wedding plan for her and brad floated by

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there are few women more powerful and prominent in hollywood and in american culture than angelina jolie. we hear about her health and her family life so often it is surprising to think that she hasn't been in a movie for years. tonight, she opens up about her new role and a wild wedding idea proposed by her kids. here's abc's george stephanopoulos. >> before the sun sets on her 16th birthday she will fall into a sleep like death! >> reporter: a fairy tale old as time with a new twist. disney's remake of "sleeping beauty" seen through the eyes of maleficent. >> well, well. >> reporter: an iconic villain played by one of our biggest stars. >> what an awkward situation. >> reporter: angelina jolie says she was drawn to maleficent as a young girl. >> when i was little i didn't

relate to the princesses. i saw maleficent and i thought she was so elegant. it really is a study in humanity and how you lose your humanity how could you ever get it back and what is it that makes us all feel bad or different and what can change somebody. >> reporter: you seem to be having a great time. you had to play around with the voice a little bit. >> i did. >> i really felt quite distressed in not receiving an invitation. >> i didn't know what to do with the voice. i would tell my kids stories in different voices. when i did this voice they couldn't stop laughing. the bigger i got, the more they laughed. >> ril toyalty. nobility. gentry. and, how quaint. >> reporter: i brought my own little focus group to the movie. four girls. two of my own. two of their friend. they had a couple of big questions. the first you must have heard a lot. they were fascinated by it.

how did you get into the costume? how hard was it? >> i did have to take it slowly. the first time i got into it. high did -- i had two different sets of horns. horns i could pop off. because i kept banging them into things. almost knocked myself out. when they were wrapped in leather i couldn't. so i was this 7 1/2 foot tall thing with my staff and my, i kept getting my staff caught in my cloak. it all went terribly wrong in the beginning. but then, but then you just have off to own it like any little girl with the first pair of heels. >> reporter: her daughter vivian appears as a young aurora. did she know she was acting? >> she did. >> she knows what mommy and dad do for a living. we talked about what it was, maleficent, and aurora. like playing a game. she had a great time. >> reporter: you said you don't want your children to be actors. do you think you can stop it? >> no, you can't stop your kids from anything. if they want to be actors, i think we will encourage that. we just want them also to be

other things. crete yea ti creative side is wonderful. the very public side is not something that we wish for them. >> reporter: surprisingly this is jolie's first film role in four years. but she certainly has not been out of the spotlight. last may she candidly shared her desilcision to undergo preventae double mastectomy, making headlines and changing lives. >> the cover of "time" magazine and the angelina effect and the effect around the country. what effect did that have on you? >> i didn't know if there would be a strange silly reaction? >> you were worried? >> i didn't expect so much support. i was moved. it has connected me to other families and other women. and now when i meet people we don't talk as much about films we talk about their children or women's choices or their wives. so it's been a really beautiful journey. >> reporter: her frankness on this issue is yet another example of jolie using flame of

her stardom to cast a light on global problems something she has been doing for more than a decade through her humanitarian work. i first asked about it on "nightline" in 2005. >> i feel just better about nigh self as a person that i have some use in my life. that i could die tomorrow knowing that high have done something that's of value to other people. >> reporter: ask you then if you would ever think of going into politics. no, no, i have way too many skeletons. >> i wonder if now my skeletons are out. they're probably all out. i don't have any left. >> almost ten years later can you reconsider now? >> you know if i thought i would be effective. i would. but i'm not sure if i would ever be taken seriously that in way and be able to be effective. >> reporter: she is speaking out about the mass kidnapping of the nigerian school girls. >> this is human trafficking, sexual violence against women against girls' education, this is one very horrible example of something that is happening on a grand scale. >> reporter: but we couldn't end without the question on

everyone's mind. wedding plans with partner brad pitt. if it happens it will be a family affair involving their six kids. i was surprised to see, talking about your kids talking about a possible wedding. what is a paint ball wedding? >> i love that. i don't have to do this now. we don't have a wait. we are not hiding anything. we talk to the kids every once in a while. they ask us. once of them suggested paint ball. we thought, well -- it's different. so, who knows? you know i think the important thing whenever we do it that the kids do have a great time and we all take seriously the love and connection between all of us but we also just get silly and do something memorable. we will at some point. if we do it, let them be part of the planning. >> reporter: for "nightline," george stephanopoulos in new york. >> our thanks to george and angelina, and "maleficient" from our parent company disney opens in theaters may 30th. up next on "nightline," brave heart star, mel gibson had one

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"nightline" continues with feed frenzy. >> here is one for the books. a swiss court ordered a russian man to split his estimated $8.8 billion fortune with his now ex-wife elena in what is looking like the most expensive divorce ever. the 47-year-old fertilizer tycoon and mother of his two kids are nearing the end of of a five year battle over their assets. here in the u.s. their lavish lifestyle included the purchase of donald trump's $95 million palm beach mansion and a $20 million hawaiian estate once owned by will smith. the court in switzerland is

ordering him to hand over $4.5 billion to his ex. this beats the previous recordholder for divorce by $3 billion. rupert murdoch shelled out $1.7 billion to his second wife anna. even hollywood stars can feel the pain of the payout. braveheart actor mel gibson, reportedly forked over $425 million to his ex-wife robin in 2011. arnold schwarzenegger expected to part with more than $250 million in his divorce from maria shriver. while tom cruise and katie holmes didn't set a record for the amount of their settlement they may have taken the cake when it comes to speed. all over, just 11 days after the couple filed for separation in 2012. moral of the story, marry carefully. thank you for watching abc news. world news now is coming up soon

with overnight breaking news. as always tune in to "good morning america" first thing in the morning. we are online at abc news.com. 24/7. good night.

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