the man go ♪ ♪ move up and let the man go let the man go through ♪ ♪ move aside and let the man go through let the man go through ♪ ♪ ♪ move aside and let the man go through let the man go through ♪ ♪ ♪ move aside and let the man go through let the man go through ♪ ♪ ♪ move aside and let the man go through let the man go through ♪ [ cheers and applause ] this is nightline. >> tonight. what happened to matthew perry? the beloved actor and friend. star. >> i'm chandler. i make jokes when i'm uncomfortable. >> found dead in his hot tub last october. the dark hollywood

underbelly of doctors and dealers, authorities say, charged the star $60,000 for ketamine in the last month of his life. >> they write, quote, i wonder how much this moron will pay. >> do you feel responsible for matthew perry's death? >> what we're learning about those charged, including the so-called ketamine queen and the additional victim discovered during the investigation, plus oprah on i. >> people are going to end up falling in love with and wanting to marry and have really intimate relationships with their. >> i robots. the multi-hyphenate media mogul sitting down with eyes power players. >> this sounds basically exactly like a recording of my voice. yeah. and even to the trained ear, it's pretty convincing. >> the excitement and warnings about new frontiers this technology will be misused like every other technology before it. >> and we need to be clear eyed about that. >> and space history. stunning images of the first civilian

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at kaiser permanente, all of us work together for all that is you. sure, i'm a paid actor, and this is not a real company, but there is no way to fake how upwork can help your business. search talent all over the world with over 10,000 skills you may not have in house. more than 30% of the fortune 500 use upwork because this is how we work now. >> good evening. thank you for joining us tonight. what happened to matthew perry? the inquest into his death leading investigators to a dark hollywood underground where they

say doctors and dealers worked hand in hand to exploit the beloved actor's decades long battle with substance abuse. here's abc's matt gutman >> it is very odd to live in a world where if you died, it would shock people. but surprise no one requesting two additional units and a supervisor respond to lucille drive. >> a mystery unravels after a beloved actor, matthew perry, was found dead. >> we're learning more about perry's final hours, known around the world as chandler bing on friends. >> i'm chandler. i make jokes when i'm uncomfortable. >> but in one of his last interviews ever, he told diane sawyer about the substance abuse disorder that would hold him in its grasp until the very end. >> how will we know when you're in trouble and you're not okay? >> if i say, i'm just going to chill alone at home tonight? >> struggling with drugs,

alcohol and ultimately in his final moments, ketamine. a powerful drug sometimes legally prescribed for mental health treatments. perry's death igniting a sweeping, multi-agency investigation into two separate drug rings. matthew perry sought treatment for depression and anxiety and went to a local clinic, where he became addicted to intravenous ketamine. >> when clinic doctors refused to increase his dosage, he turned to unscrupulous doctors who saw perry as a way to make quick money. do you feel responsible for matthew perry's death now? >> less than a month later? disturbing details continue to come to light about what happened in perry's final days. another alleged victim, and who will be brought to justice. >> we're here today with our law enforcement partners to announce federal criminal charges related to the death of the actor matthew perry. >> his demise ultimately exposing an elaborate web of death. doctors and dealers allegedly distributing at least

70 vials of ketamine, which cost perry more than $60,000 in the final month of his life. >> five people, including two doctors and matthew perry's personal assistant, all arrested. >> those involved now facing multiple charges in connection with the actor's ketamine death, and face ten years to life in prison if convicted. >> we charged five defendants in this matter. these defendants took advantage of mr. perry's addiction issues to enrich themselves. >> the defendants include 54 year old doctor mark chavez from san diego. >> do you have any remorse about what's been going on? >> 59 year old kenneth iwamasa perry's live in personal assistant and eric fleming, a former movie producer turned drug middlemen. >> three of the five immediately decided they were pleading guilty. they were working with investigators, flipping on the other two. >> the alleged ringleaders are 42 year old doctor salvador plasencia, doctor p. the

indictment alleges plasencia himself sold iwamasa vial after vial. >> prosecutors say that iwamasa was getting the ketamine initially from doctor plasencia, but iwamasa has no medical training, so he had to figure out and learn how to inject this ketamine into matthew perry and that it was allegedly doctor plasencia who said, i will show you. >> over two months from september to october 2023, they distributed approximately 20 vials of ketamine to mr. perry in exchange for $55,000 in cash defendant plasencia saw this as an opportunity to profit off of mr. perry. >> also indicted jasmine song, whose customers allegedly dubbed her the ketamine queen. the 41 year old, posting photos on social media depicting her high end lifestyle. do you know why she was given the name ketamine

queen? >> one can infer, based on the fact that she sold 50 vials in two weeks to mr. perry. very large amount. >> song and plasencia both pleaded not guilty. what the indictment seems to show is that he was really a charlatan. administering ketamine to matthew perry, who was clearly in the throes of addiction. >> that's what the government is alleging, whether or not that's what actually happened. we'll have to see if it plays out. >> jasmine song has attorney mark geragos spoke to newsweek defending his client? >> i think all of these so-called urban legends that somehow my client knew matthew perry are demonstrably false. >> after the feds raided sanjay's apartment, they also say they learned of a second victim who died years earlier. >> that other victim was a person named cody mclaurin >> how would you describe your brother? >> you know, growing up, he was

very sweet. he had lots of close friendships. and, you know, he also liked to have a good time. >> the autopsy report listed his cause of death as acute ketamine, along with heroin, methamphetamine and cocaine toxicity. when you heard that ketamine was one of the causes of death from the autopsy, were you surprised? >> well, yes, because you know, it's tough to think that something that you've never heard really being a cause of death or just not common, was a factor for him. addiction was not something that was a part of cody's life. >> months after he died, the police mailed kimberly her brother's belongings, including his cell phone, which kimberly says revealed a disturbing discovery. cody's text messages with singha. you do find something that is very, very suspicious. what do you see?

yeah. >> so i see messages back and forth between the two of them talking about ketamine and how much she has available, how much it costs. >> kimberly decided to text singha herself, stating the ketamine you sold my brother killed him. it's listed as the cause of death. is it possible that cody mcclory's death would never have been investigated had it not been for matthew perry's death? >> it's certainly possible, but i will say that we investigate the deaths of many people who are not celebrities. i think there's a shift in terms of how we look at these deaths. we don't blame the victim. we want to vindicate the victim. we want to hold drug dealers accountable for the deaths they cause when prescribed and administered legally, many doctors and their patients say the results can be groundbreaking. >> the research is favorable when you're looking at ketamine

as a treatment for depression, particularly individuals with resistant depression who don't respond to traditional therapies. >> doctors recommend that ketamine and traditional psychotherapy be done in tandem, and patients should be under medical supervision. would you prescribe ketamine to someone who has known addiction issues? >> what we do know is that there is a body of evidence suggesting that ketamine treatment, if done properly, can be helpful for folks with substance abuse disorder. it is very dangerous to use ketamine in someone who's actively using substances. it can become a drug of abuse psychologically, strapping you rock and roll. >> this is kind of. >> sebastian is one of the many believers in ketamine therapy. he's come to bespoke treatment run by doctor nima bahamian. today he's getting help with his

treatment resistant depression. >> take a deep breath. >> i've been using the same antidepressant for 12 years, and it kind of stopped working at some point. it was really hard to do anything. i would say my depression symptoms have probably reduced by 50% by now. which is which is good. >> our thanks to matt watching that piece reminded me of my own therapist wisdom. we're all having a hard time with something, he says and has been said. the opposite of addiction is not sobriety, it's community. each of us find and cherish our own community. if you or someone you care about is struggling with thoughts of suicide, substance use or mental health crisis, text or call the crisis lifeline at 988. free help is available 24 seven. for much more on matt's report, watch what happened to matthew perry on impact! by nightline, now streaming on hulu. it is worth

the watch. when we come back, oprah sits down with the power players of the artificial intelligence industry. their intelligence industry. their dire warnings about ai's future a prescription medicine used to reduce the risk of hiv without daily prep pills. with one shot every other month, just 6 times a year. in studies, apretude was proven superior to a daily prep pill in reducing the risk of hiv. you must be hiv negative, to receive apretude and get tested before each injection. if you think you were exposed to hiv or have flu-like symptoms, tell your doctor right away. apretude does not prevent other sexually transmitted infections. practice safer sex to reduce your risk. don't take apretude if you're allergic to it or taking certain medicines, as they may interact. tell your doctor if you've had liver or kidney problems or mental health concerns. if you have a rash or other allergic reactions, stop apretude and get medical help right away. serious side effects include allergic reactions, liver problems, and depression. some of the most common side effects include

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where there was only one pediatrician to serve more than 10,000 children. daniel lurie said, i'm going to help. we opened a clinic for our most vulnerable children. i have worked shoulder to shoulder with him as we have brought solutions where people thought the problem was unsolvable. daniel doesn't take excuses. he holds himself accountable. and i know that he can do it for the city of san francisco. .

>> welcome back. oprah is a deep thinker, a straight shooter, and really good at getting people to open up. but when she sat down with the superstars of a.i, oprah says what they share left her with two words of advice for the world buckle up. here's abc's rebecca jarvis in your seven decades here on earth,

where do you put a.i? >> rebecca, we are in for the ride of our lives. >> oprah, known for her deep dives into cutting edge topics, is now taking on artificial intelligence in an all new abc primetime special. ai and the future of us. >> life for all of us is about to be very different. >> i know if i am curious about this, the other millions of people who are watching are feeling the same. >> the interview queen, who is in america's living rooms for 25 years, known for her ability to get to the heart of a story. >> i think that this is going to be so interesting today. >> now, using her talents to give viewers a crash course in artificial intelligence with the help of experts like openai ceo sam altman, microsoft co-founder bill gates, and youtube creator and technologist mark brownlee. let's see if we can do it. >> okay. generate speech. to the

untrained ear, this sounds basically exactly like a recording of my voice. yeah. and even to the trained ear, it's pretty convincing. >> for me, this is like a.i. 101 ai. in the future of us is having people to think about it in a more profound way, in terms of what we need to do for regulations before it's too lat, because already it's out there, it's out there, it's everywhere. >> it's everywhere. >> what was your first encounter with ai? >> well, i have to say, i had no encounter with ai until my first conversation with sam altman. >> just take me to 2035. >> i hope that in ten years, we are all of us. we are limited by what we can imagine. we have this ai that can help us figure out anything. if you want to go build like a beautiful house, you can dream with the ai. you can figure out, oh, i want it to look like this. or do you have any other ideas and architect this amazing thing? and then can

you invent some robots that can that can actually build this, this house that we just imagined together? >> and after he was telling me about all the things it could do, i was saying, okay, don't be scared. >> go. >> don't be scared. you can get the chatgpt app. and my first experience was asking ai for airbnb listings. it was miraculous to me that before you can practically finish the request, the answer has come back to you. >> when you use chatgpt do you say please? >> yesterday i was asking a question and i said, could you please? and i realized you don't have to say please to ai, but i said, could you please and then would you mind finding. i mean, what what? yeah, i've already started that. >> yeah, well, the good news is, when the robots take over, they will remember. you were very gracious. >> no, this is the thing. >> i said this to bill gates. people are going to end up falling in love with and wanting to marry their ai robots.

>> or how do we feel about that, oprah? >> i think that the evolving of humanity is just going to take another big leap that none of us had ever expected. >> while many embrace ai, 52% of americans are more concerned than excited about it in their daily lives. as with all technology, bad actors see new opportunities for more sophisticated crimes, from deepfake scams to sextortion to cyber intrusions and more. fbi director christopher wray issuing a stark warning all americans should try to be more discerning consumers of information. >> it is incumbent on everyone in america to bring an intensified sense of focus and caution to the use of ai, and how ai can be used by bad guys against all of us. but not to panic, i don't think this is a

time for panic. >> what was your biggest question going into these conversations? >> what is the possibility and what's the peril? and so what i'm thinking is we need to get ahead and not wait until so many lives are impacted negatively. and i think because it's here and here to stay, we need to develop a new sense of muscle for discerning what is real and what is not. >> there are a lot of people watching right now who are probably scared and have never actually used it in a knowing way. >> i don't think we should be scared. i think we should be disciplined and have a reverence for what is to come, because i think it's going to change in ways that are unimaginable for the good. and just as there is for the good, there's the yin and yang of everything. and so we need to do whatever we can so that we are not in the same position that we are now with social media. now is the time

oprah, using the opportunity to ask ai leaders like altman about guardrails and safety regulations. what kinds of restrictions do you believe should be put in place? >> a partnership between the companies developing this technology and governments is really important. one of the first things to do, and this is now happening, is to get the governments to start figuring out how to do safety testing of these systems. >> what surprised me about the conversation with bill gates and with sam altman, is that they are surprised at how rapidly things are moving, and they also know that there needs to be some regulations. my thing is, who's going to do that? yeah. you're expecting the guys in congress, those guys who have trouble figuring out how to use their phones. so i think that one of the reasons for doing this special is to create a sense of awareness and alerting people to

what is to come so that we all can start thinking about what we want in terms of controls for ai. >> we're here in the u.s. and developing this. people all over the world are working to develop ai, and some of those people are not really our friends. >> well, yes. >> and i think that the race to be first and the race to stay ahead as we are right now is also fueling the speed at which things are happening. and, you know, one of the reasons for providing this information is to get people to thinking about, you know, what that race means for us as individuals. and do we need to slow it down and how we even would slow it down if we could even slow it down? i'm telling you, we need to buckle up for this ride. it's coming. >> our thanks to rebecca for more on the possibilities of ai, the good, the bad, and what might keep you awake at night. watch ai in the future of us, an oprah winfrey special available tomorrow on hulu. when we come

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>> and finally, tonight, spacex dragon making history. >> the hatch is open on dragon. >> the crew of polaris dawn are not professional astronauts. these are the first civilians to ever perform a spacewalk. tech billionaire jared isaacman was the first out mission control back home, cheering as he gazes toward earth. >> back at home, we all have a lot of work to do, but from here, earth sure looks like a