wanting to intervene in the trans mr. region, a mid, a looming energy crisis. us after our russian intelligence report disclosed president maya sanders alleged intentions to implement a military operation and established control over eastern territory. supplies the entire country with electricity and outlines how ukraine's unwillingness to extend a deal ensuring the transit of russian gas has provoked the prices. according to sound do. if moscow does not find a way to bring gas here cation now will take revenge on the pro russian trends and easter orders for criminal cases. against trans nister's leaders, for separatism were issued in ordinary trans needs to residents were to be subjected to thorough searches. when crossing the regions borders, the meeting ended with sand new saying that it is necessary to develop a plan for a military operation to establish control over transit east or any eliminate the russian peacekeeping presence in the region. most of us energy problem is increased one k of announced that does not intend to extend the trends that agreement,

which expires at the end of this month. president sand who has claimed moscow is responsible for finding alternative supply routes. well, that's for cation, i was trying to avoid a key contractual point with russian guys prom payment of more than $700000000.00 of past that. and the primary russian gas consumer is the disputed territory of transitory store, which is look into the state from odessa, but provides electricity to the entire country and box cooperation with moscow. a former motive and politician told us russia is under no obligation to transport gas directly to the territory. a piece of what to do is that they moved it to the security now wants to avoid an energy crisis, which it finds itself due to its rejection of negotiations with kias, primarily regarding gas trends. i do, but i think the kitchen now still has a desire to put some pressure on trans denise to in order to fulfill its main goal of, namely the guy from agree to deliver a gas to the board. is the cation now argues that this is provided for in the

contract, but now not through ukraine, but by some other road. it is possible that cation now may go for this kind of pressure. but i think that it has no intention for a military invasion or an attack on them will do on hydro electric power station. whereby acendo is lying by putting all the blame on russia. because the contract between us and gas from states that russia is obliged to deliver a gas to the points that are on the territory of ukraine. russia has no other obligations in the contract. at the same time, official cation now says that they do not want to negotiate with kids, because it would mean stopping the apartments in ukraine in the back. which case, you know, kind of do. we see the example of slovakia when prime minister fits so he's ready to argue with care about gas transit because slow back citizens need it very much. i think that this very hard pro western position of the mold open government does not find understanding in the multiplan society. people are very concerned about getting cheap fuel cheap electricity. and i think they are less concerned about the problem of ukraine. but so far the mold open government has other priorities.

ukraine 1st and the mold, open people. second, a few people are missing out for our russian cargo ship sank in the mediterranean between the shores of spain and algeria versus foreign ministry says the vessel went down following an explosion in the engine room. of the explosions caused hasn't been discovered yet, the vessel called her some major was traveling from st. petersburg to a lot of us doc and russia's far east. there were 16 crew members, 14 of whom had been evacuated to the spanish port of cards. i cannot to all right, well just stay with us here on our to international up an extra one customer on this exclusive interview with the director of the gamma la institute about russia's new, groundbreaking cancer vaccine. the average under laney, they say, i remember steve, mr. ginsburg,

let's begin with the most important question for something we recently heard from you. you mentioned that as a result of the new vaccine or medication, melanomas can dissolve and disappear. could you explain in simple terms for those of us who aren't doctors, how this is possible? i suppose i'll try melanomas dissolve because the medication you're asking about and which will be discussing today. cancer vaccines based on m r n, a technology act as a therapeutic treatment. these vaccines train the patients immune system to actively destroy malignant cells, meaning the tumor itself, the immune system achieves this by producing side or toxic lymphocytes in the body of the vaccinated patient. these lymphocytes, a type of white blood cell identify for and proteins, specifically known as anti gents or on the surface of tumor cells. the attached to the tumor cells or 2 or tissue and release. the series of active enzymes contained

in small vessels include, some of these enzymes, create holes in the tumor cell membranes. these enzymes are called preference, hence the name which relates to preparation, or other group of enzymes enters the holes in the tumor cell and begins to break down its proteins affecting the tearing them apart. this process leads to a phenomena known in scientific literature as apple. toast is during apple. tusa is the in sematic, if to video of these enzymes causes the cell to essentially digest itself, breaking down into water c o 2 and you re up. why is this important insurance? the destruction of 2 more cells does not trigger an inflammatory reaction. as a result, the tumor cell is eliminated without causing inflammation. this mechanism allows us to protect the body from form proteins, whether they come from infectious agents or appear in tumor tissue. right, since our body contains many sided, toxic lymphocytes and this specific vaccine stimulates them to multiply further,

they can destroy not only the primary tumor which to be fair, a surgeon can remove with the scalpel. but more importantly, the matter of static cells as well, or these are tumor cells that spread throughout the body and can settle in any oregon. surgeon, of course, cannot remove every micro tumor with the scalpel. however, site are toxic lymphocytes which travel through the lymphatic system and bloodstream to reach any part of the body can accomplish this. not only can they, they are biologically program to do so. their role is to identify and destroy for and met a static cells throughout the body. and our institute over the past 3 to 5 months, we developed an animal model using mice to study melanoma highly malignant tumor. this model has shown that the vaccine created with this new technology can destroy not only the primary tumor, but it's metastasis. we're continuing to refine this model and we're developing additional models for other types of tumors by around september of next year,

we planned to transfer this work to real patients and collaboration with our 2 leading oncology centers, the hertz and center, and the blind center. the centers will use therapy to crack seeds develop at our institute to treat uncle logical diseases, and specifically tumor targeting vaccines, designed for treatment purposes, sent me out. so i will confess, quickly that i'm the speaking of timelines. how long have you been working on this new vaccine? and of course we all want to know when will the word cancer no longer feel like a death sentence for people. you mentioned that it will soon be tested on humans. when will that happen? and how long have you been working on this adventure that up with a single group? as we all know, this is a multi stage process. we began the 1st stage around the middle of 2022, when we realized that the technology underlying the development of these vaccines held great promise. why 2022. because it was only in 2020 the technologies emerged, allowing for an ant engines to be introduced into the body of his proteins or adage

ins. but as nucleotide sequences in the form of genes, this breakthrough was made possible by the rapid development of new cobit 19 vaccination methods. at the time to very similar, yet fundamentally new technologies were introduced. as i mentioned, the key difference is that the vaccine contains genes that encode these proteins rather than the proteins or antecedents themselves. it was quickly show that this method enables the creation of highly effected vaccines in a very short amount of time for vaccination in a preventive context. the q requirement is the ability to develop vaccines against infectious diseases where the specific infectious agent or protein target is clearly identified. the most effective approach has been the technology used to create the splitting the vaccine. this method results in minimal side effects, and when the vaccine is administered, intern easily side effects are virtually non existent, m r n a base technology used to develop the pfizer and where they're in the vaccines is also effective, but has

a relatively high number of side effects and healthy individuals. however, when this technology is applied to create treatments for patients, such as those with cancer, the side effects it may cause are generally already present in cancer patients on fortune. see. this technology also offer significant advantage. it enables the production of a very high concentration of the target protein required to activate the immune system even exceeding the levels needed to train the mean system to distinguish between self and form proteins. this includes differentiating self proteins from viral or material proteins, which is crucial for developing preventive vaccines. in contrast, when therapy duct vaccines are developed, the immune system must learn to differentiate between self proteins and proteins that are almost identical found and transformed, malignant or simply tumor cells. in such cases, the differences can be as small as a single amino acids or deluxe. over the past 10 to 12 years, as methods for determining nucleotide sequences and humans have become widely

available, it was discovered. the tumor cells differ from normal tissue of the same individual by a large number of small mutations. these mutations present in tumor cells are now being used as new engines, new engines that can be introduced into the body of a cancer patient in the form of m, r n. a. as we discussed earlier, this process stimulates to patients immune system, particularly side of toxic lymphocytes to target and destroy tumor tissue. this is how the drug works. the 1st stage of developing domestic technology for synthesizing and designing m r n. a base treatments began in 2022 and partly because the same team that created the sputnik dfacs and at the emily instituted began working on this project once they became available during this time 6 patients were obtained. and as of today, they're already 7, making this technology, fully domestic and sovereign. we implemented numerous fundamental changes that enabled us to secure patients in the russian federation using this technology. as i

mentioned earlier, we created an animal model of melanoma and demonstrated its effectiveness and treating mice. currently we're developing models for all their own collage equal diseases as well for such a serious own co, logical disease. and they are all serious of course. there is a particularly common one non small cell lung cancer and as i now understand though, i am not an call just, it is the most frequently diagnose cancer with the highest mortality rate. this type of cancer does not respond well to the existing treatment methods in on call gene, such as surgery, radiation or chemotherapy. yes, that's why we're now creating such a model. other models, wrong causal diseases will also be developed including for the pancreatic cancer, which is also different to treat surgically and certain types of kidney cancer. unfortunately, the business can go on it includes cancer is for which there are currently no effective methods of treatment. these are the cancer types for which the immuno

biological method we're developing is likely to be effective. ask for this specific timeline for transitioning from animal models to patients. according to the roadmap, currently being approved by the ministry of health, which was actually developed by the ministry of health under whose guidance, all of the studies are being conducted by around september next year, work will begin at the hertz and institute and at the blend center led by a could emissions kaplan or city to introduce these treatments to actual patients in the initial stages, the technology will be tested and its effectiveness will be demonstrated on unlimited group of patients. once this technology is registered by the ministry of health, i hope it will expand rapidly and be implemented in other medical treatment centers across our country. because if it goes, but i don't know, teacher it's ability to tear, i'd like to make a remark for our viewers, that unlike traditional vaccines such as the flu vaccine, sputnik that can be used universally on any person. this cancer vaccine must be

individually tailored for each patient, or am i right in this? why is it so so shouldn't in addition, so shifting them, i mean, absolutely right. this is a very important point that is essential to the completeness of the story that we're telling you today about the creation of these vaccines. this is a truly personalized product with the customized vaccine created for each patient. it is because of the fact that no 2 tumors are ever similar. as of today i'm call just know about. i repeat that, i'm not, i'm gonna call just myself. but as far as i know, there are about 300 types of tumors that differ. so, you know, typically if we take several tumors at the genetic level, that is sequence them to determine the nucleotide sequences and they're genomes. we will find out that no 2 tumors are actually the same. and this difference, which is the characteristic of each tumor, is an excellent target to force the immune system, figuratively speaking, to find attack and destroy this tumor. but for this purpose, 1st of all,

we need to identify these point mutations in each tumor for each patient. based on this, the medicine can be called personalized. then from these point mutations, we put together a construct called m r n a. the one you and i have talked about, synthesize it, and then package it in a little bit shell, which let's not go into detail also represents some technical innovations and then injected into the body of the patient from home. this personalized data was obtained, at 1st glance is going to be very expensive at 1st and it is indeed on. however, at the r and d stage, which we're now talking about, all the costs are borne by the state. when this goes into mass production, it will be the result, not only of the technologies i just mentioned, but of new technologies related to the calculation of the nucleotide sequence that is part of the m r n a on co vaccine. for this purpose, we're now working with a leading institute capable of doing this, the vondik of mathematical institute academician, ever d. c on academician battelle and degree to fundamentally new mathematic framework

for this project. we want to all the calculations which now take 3 weeks or a month for each patient to be done in an hour and a half, maybe even less not to mention the far greater accuracy of these calculations, which will also surely increase the effectiveness of the vaccine product at the moment about 30 specific orientations of a patient are included in one vaccine system. this is done in order to guarantee that the immune system will recognize at least one or 2 or 3 mutations. as for the new mathematical framework will greatly increase the probability that a given mutation will activate the immune system, and the size of that m r n a can be reduced. thus reducing the time it takes to create the vaccine, a layer on the schedule with them, i'm going to say probably the biggest, the most word for 2024 artificial intelligence. surely that's something you have been using your center in some way and surely artificial intelligence will have some effect on speeding up certain processes. can you tell me, please,

how did you involve in the creation of this vaccine? can we talk about that? especially was that the to a procedure disputes and refer to the radio and thank you for that question. indeed, when i was talking about our relationship with the vondik of institute, it was about them creating a neural network enables model that would not just do calculations, but would also enter the results of those calculations into a database of cancer patients being created at the same time so that this software can train itself in terms of speed of action and accuracy of its predictions and calculations. it's the tech spoke definition of artificial intelligence as far as i understand it again. i'm not a professional mathematician mathematically speaking. when can we say that a particular development is being made using hard to visual intelligence? we can say so because the program that under pins, the creation of a certain medical service or product is based on software that is powered by big data. and the results of the worth and the rendering of the service are entered back into this database, thereby increasing the efficiency of the software. my mathematician colleagues have

taught me to say not a model, but a mathematical environment. yes, we hold joint seminars and we learn a great deal from them. i hope that we in turn offer them something new to some new information. right now. the creation of a mathematical environment for this work is being spearheaded by a highly respected colleagues at the vondik of institute. insurance of those spoken yesterday is when he cotton is mr. ginsberg. let me repeat that, because each case of cancer is unique, every patient will get individual treatment and a customized vaccine. we've mentioned that let's talk about the rest of the world. is there similar research going on anywhere? the yum scrub open in the technology, and that's the yes, when i talked about the m r n a base technology, i believe i said that it was originally created by pfizer. and whether or not they initially meant to use it for treating cancer, but it became widely known indeed wide spread use. and it cooled with 19 vaccine,

even though large quantities of it were manufactured and administered the advantages of the technology based on g modified and n o viruses. which underpinned this putting the vaccine are obvious. in terms of the number of side effects. not only to us, but to all the countries that have been using the vaccine. however, because pfizer and my dear and i have had that proprietary technology for a while. they had an early start. i said that we were going to roll on our cancer vaccine around september, pfizer and, but they're not. however, having completed animal testing recently started administering their maxine to cancer patients and have seen very positive results. even though we have orders of magnitude less financing. we're competing at almost the same technological level, and i hope that our know how will allow us not only to catch up with them, but get into the lead in terms of treating difficult cancer cases. with the help of this technology. clear office in philadelphia you, i'll post office for give this. now you've dreamers question,

but will cancer at some point to be consigned to the dustbin of history, like plague or typhus? man to the board and show here, i am certain that the concept of cancer will evolve. let me explain why. yes, we will prevail over what we call cancer. now, unfortunately, however, or rather fortunately, the antibiotics and vaccines have helped us extend our active lives significantly over what people could hold for 200 years ago in the pre vaccine, iraq, and before antibiotics or more correctly antimicrobial drugs. we've extended our active lives by 30 to 40 years. i'm sure that within 10 to 15 years, humanity will figure out a way to get rid of the conditions. we now call cancer. yep. longer lives, mean new diseases. cancer is mostly a disease of old age. when you get older, the risk of developing cancer grows exponentially. that is why i'm certain that unfortunately, our definition of cancer will evolve as a live span keeps getting longer. when someone brings up evolutionary processes,

i like to say that only god and charles darwin know which way they'll go. but we can ask them a question. so we need to be prepared for everything at all times. and the research component for the fight for active longevity must always be at the forefront politically and economically let alone scientifically. right. i know which initial the mug when he was put in the solution. this being here, i simply must ask you about what else your institute is working on, what other drugs and vaccines will you offer? russia and the rest of the world is only like spicy bizarre process on this uh no with the states and then i will thank you for your question. we do have quite a few things in the pipeline. some have been officially released or are pending release this year. i'd like to mention our rotor virus vaccine, which was not included in the national vaccination schedule before. a team led by that sound like you to be and you call them the corresponding member of the russian academy of sciences developed this vaccine on our institute. we've also created

a new anti bacterial medicine called store to design on which has already been registered and is available at pharmacies which is effective against old multi drug resistant bacteria. that is because the action of ford design on is based on a fundamentally different principle compared to other antibiotics. what's more, bacteria did not develop resistance to it. it 1st helps the mean system, turn off certain proteins called berlins factors does disarming all pathogenic bacteria. and then the immune system use a cycle, toxic t cells, which we talked about today, a lot or very similar lymphocytes as well as target sides to consume and digest. these does are invite syria. the drug is very effective against many vectors of hospital acquired infections. chronic confection suppressed the tightest and many other conditions. it was developed by a team led by professor and i. e. a z going to gear about the head of the medical micro biology department of the galilee institute. over the past 14 years, we will soon release a conceptually new tv vaccine,

the tv vaccines that we all know, the b, c, g vaccine, which is produced bar institute protects small children against severe cases of tv, but does not prevent adults are children from getting infected with tv, the new vaccine however, will prevents tv infection. this will dramatically change the epidemiology of the disease. we can now hope that it's factor which humanity encountered in its infancy as it were. when people started domesticating cattle and other animals, that's when it most likely happens. so we can hope that this vaccine will succeed, analysing this vector from the human population. so i think is, i hope that this vaccine will be officially released finally to 2025 or early 2026 . so to this and i see it for jessica, let it for all you just mentioned animals which reminded me of monkey box you're doing some research on it as well, aren't you? i began communicating about the early successes in the monkey pox research achieve virus scientist who attempted to create a gene engineered vaccine. it is based on the same platform that we use for split

thing cream, which means we know it well and it's completely safe. this vaccine is great because it doesn't just protect people from different strains of monkey pox for what makes monkey pox so dangerous is that it's genom is almost identical to that of smallpox, which was considered to be eliminated in 1980. apparently, it would only take a few mutations to make the vector of monkey boss called the same severe epidemiological and clinical consequences as smallpox, to our gene. engineered vaccine doesn't cause the severe side effects that are produced by all the other vaccines created with live viruses weren't in activated viruses of cal box or basine, a virus. their side effects are very significant, especially given wide spread immuno deficiencies in the human population. a gene engineered vaccine, however, it doesn't cause these effects and can be administered to patients with immunodeficiency and children. i believe having reserves of this vaccine are a must for our country. the r and d on this vaccine is done. we're now waiting for the start of the new year because

the ministry of health care as a government body operates on the basis of the calendar, not the vaccination schedule. so we're hoping to get new financing after january 1st. even though it would be helpful to have emergency funds that could be made available sooner when we're talking about the threat of new dangerous pathogens, it would be great to have more flexible mechanisms to support the research that can protect the population against emergency infections. to give you a more general answer, while it would be great to have something like this on the international scale, the situation is such that at least on the country level, we need a system that would allow the creation of vaccine prototypes against pathogens with academic potential something we call can't vaccines. the world health organization published a list of 30 such pathogens. given our country's geography and climate, the list could be sure to, to a dozen of such pathogens. we believe russia needs a program that would allow us to have prototypes of all these vaccines based on the same technology as can vaccines that could be kept in the same fridge. and when the

likelihood of an epidemic emerges, if you have the production capacity, you can roll out a vaccine within weeks. you won't need to develop it from scratch. you can just pick the right prototype, introduce it in quantity rush. it should have set up a program like that. as a lesson from the ongoing cobit 19 and the demick they may do to minutes describing your suspect for see what my room. i see what you're saying that you thank you for the interview, mr. ginsberg, i hope to be able to talk to you and your patients soon, especially if i need to. thank you for the interesting conversation. the the, [000:00:00;00]

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a special military operation mold. in 13000 far less than the race of joining the ukrainian miller trade we williams lot of things are good enough to stop growing up and we need, i need for 2 of us doing to the the what if any of them surely because it was trustworthy william wills, give you my friend, build for the fine you is fine. yeah. the, the point on it that the surgeon at the end of what it is, i didn't know that you know for your state of mental breakdown skills to talk to. so as a minus, let me read a couple of dining. come see from sues. the sean. yeah. and media con soon the vs. the back of the fiscal on top of the filter, which i mean, so there's a slight because you are calling is that us a beautiful supervisor? federal assurance for you, my florida. she knew i was like,

you strong. so then the whistle instead of the physical not so the washington is, is africa as a testing ground for its military biological projects. the russian defense ministry's accusation reveals the link between depended on and big pharma is really defense minister officially admits. for the 1st time to killing the most chief into ron, was also wanting others. they would strike a severe blow post ways of the south still remain under level bodies are now being recovered as ice cream operations on the way. but it just shows how the town c 5 is the fragile peace between israel and hezbollah is put to the test again as