positive engine sharma has somebody to re key situation for new delhi as bundle dish and indiana. they have an extradition treaty. now it's on to in get whether to comply with that sweetie or no on to. but of course, that we do also is going to be up for a lot of negroes to me now. she casino, remember she came to a new daddy on the 5th of august, she flee a dog dog off door. you know, separate protests. they will protect those food bonds, didn't har rob her residents? and also we che, cuz he now has been living in india. this is somewhere in a central or farm you daddy. and what we've been given to understand is that it's not that she, because he now has just been living in india after feeding from bundled the she also has some sort of support from you that e, she's a guest of india in that sense that, oh, sort of member, she could see now she has about 150 is a 150 all the cases, one hard. all of these cases, all obviously these did with all still a rod june,

july was still using the to test. remember that 1st started is to do to test against the a jewel pulled a reservation soon they turned into anti government protests. so using those products. so some would say that the sheet cuz you know, did use extra force on the desktop. but the, the kind of cases that are being slapped on heart genocide, bryan's against humanity. also, that is what they would need to see the 3 d, whether this is a political request or otherwise. so that's something that needs to be considered or associated because he knows so on said you wanted. he reacted the judges and prosecutors appointed by the elected eunice lead regime to conduct a farcical trial process through the international crimes tribunal makes it a political witch hunt that for 6 justice and marks another ongoing onslaught to persecute a want me league leadership the on the line your that in the us for the secretary,

mr. ms. 3, he will is in long beach. oh and yeah, this month and he did speak to the bundle these government a way we did it, but he did mention that was she cuz he now continues to be new, daddy, you daddy will wants to walk with the present the government in taca. i would want a good relationship. he also spoke about concerns that india has a regarding minorities in the country that have some under a dock ever since she could see. not just remember there have been several reports about minorities, particularly you 9 origins that have gone under it. that fast as well under our nose, happens to be the into my a cheese, the chief of the engine government. and don to these, the us, which was largely b, lead a full year off of causing that the gene change in dr. the have continuously supported off the new regime despite overlooking in fact, all of the attacks. so against minorities in, in, not in the country, but remember,

we not just talking about speculations about the us being enrolled in that region change. but also remember, you know, some, that clinton foundation event, you know, basically himself admitted that this did not happen automatically. this did not happen or yeah, and if you need that it was open the street and in fact, you also need the mastermind behind the whole regime. change still to see the us still continues to support of the news into government combined. the both leaders express their commitment to respecting and protecting the human rights of all people, regardless of religion. mister sullivan reiterated the united states a support for a prosperous, stable, and democratic bangladesh and offered the united states has continued support in meeting the challenges, bangladesh, faces. so very sticky, somebody to me please situation for india and i see that because hey christina,

so yours, she shared a very a song by lots of relationship with you, that it's not just a strong bilateral relationship. also trade relationship, people to people relationship, not just with the moody governments, the part you don't have a box you to be gp. what, what successive governments, she cuz you know, has had a very good relationship in, in depth. so it's a tough choice for india, a dis, extradition request from bonds or beach. because on one hand, if the india does suck onto that request, it's almost like the beach string of van. it's almost like between cheery cuz you know who india. uh, in that sense regards. uh, but also india does not send shape because he now back it is again, not a very easy situation because india does want to have a good relationship with its neighboring a bundle dish, but no easy choices here for him to have any of that is albany sent the ssl will be back up the top. uh, in the meantime though, we did speak to the head of russia's renowned camilla institute on what 2025 holds

as a temp this offers. it might just be a lifeline to type the . it needs to come to the rushing state never as tight as i'm one of the most sense community best ingles, all sense and up the in the 6595 and speed. what else calls question about this? even though we will then in the european union, the kremlin machine, the state on the russians cruising and split the r t smooth net keeping our video agency, roughly all the band on youtube,

the services. for what question did you say even closer to the reseller, lady they say, oh my gosh, do mr. ginsburg, let's begin with the most important question for something we recently heard from you. you mentioned that as a result of the new vaccine or medication, melanomas can dissolve and disappear. could you explain in simple terms for those of us who aren't doctors, how this is possible? i suppose i'll try melanomas dissolve because the medication you're asking about and which will be discussing today. cancer vaccines based on m r n a technology act

as a therapeutic treatment. these vaccines train the patients immune system to actively destroy malignant cells, meaning the tumor itself, the immune system achieves this by producing side or toxic lymphocytes in the body of the vaccinated patient. these lymphocytes, a top of white blood cell, identify foreign proteins, specifically known as anti gents or on the surface of tumor cells. the attached to the tumor cells or 2 or tissue and release a series of active enzymes contained in small bicycles. there's some of these enzymes create holes in the tumor cell membranes. these enzymes are called preference and the name which relates to preparation or other group of enzymes enters the holes in the tumor cell and begins to break down its proteins affecting the tearing them apart. this process leads to a phenomena known in scientific literature as apple ptosis during apple. toasts is

the enzymatic activity of these enzymes causes the cell to essentially digest itself, breaking down into water, c o 2 and you re, uh, why is this important insurance that the destruction of tumor cells does not trigger an inflammatory reaction. as a result, the tumor cell is eliminated without causing inflammation. this mechanism allows us to protect the body from form proteins, whether they come from infectious agents or appear in tumor tissue. right, since our body contains many sided, toxic lymphocytes and this specific vaccine stimulates them to multiply further, they can destroy not only the primary tumor which to be fair, a surgeon can remove with the scalpel. but more importantly, the matter of static cells as well, or these are tumor cells that spread throughout the body and can settle in any oregon. surgeon, of course, can not remove every micro tumor with the scalpel. however, sight are toxic lymphocytes which travel through the lymphatic system and bloodstream to reach any part of the body can accomplish this. not only can they,

they are biologically programmed to do so. their role is to identify and destroy for and met a static cells throughout the body. at our institute over the past 3 to 5 months, we developed an animal model using mice to study melanoma highly malignant tumor. this model has shown that the vaccine created with this new technology can destroy not only the primary to or what it's natasha sees. we're continuing to refine this model and we're developing additional models for other types of tumors by around september of next year, we planned to transfer this work to real patients in collaboration with our 2 leading oncology centers, the hertz and center and the blind center. the centers will use therapeutic vaccines develop at our institute to treat uncle logical diseases, specifically to more targeting vaccines designed for treatment purposes. so let's go to our focus 1st quickly that about the speaking of timelines. how long have you been working on this new vaccine life? so, and then of course, we all want to know when will the word cancer no longer feel like

a death sentence for people you mention that it will soon be tested on humans. when will that happen? and how long have you been working on this adventure that are both a single group? as we all know, this is a multi stage process. we begin the 1st stage around the middle of 2022. when we realize that the technology underlying the development of these vaccines held great promise. why 2022. because it was only in 2020 the technologies emerged allowing for an anti jeans to be introduced into the body of his proteins or ads engines. but as nucleotide sequences in the form of genes, this breakthrough was made possible by the rapid development of new cobit 19 vaccination methods. at the time to very similar, yet fundamentally new technologies were introduced. as i mentioned, the key difference is that the vaccine contains genes that encode these proteins rather than the proteins or antecedents themselves. it was quickly shown that this method enables the creation of highly effective vaccines in

a very short amount of time for vaccination unit preventive context. the q requirement is the ability to develop vaccines against infectious diseases where the specific infectious agent or protein target is clearly identified. the most effective approach has been the technology used to create the splitting the vaccine . this method results in minimal side effects and when the vaccine is administered internationally, side effects are virtually non existent. m r n a base technology used to develop the pfizer and what they're in a vaccines is also effective, but has a relatively high number of side effects and healthy individuals. however, when this technology is applied to create treatments for patients such as those with cancer, the side effects it may cause are generally already present in cancer patients. unfortunately, this technology also offers a significant advantage. it enables the production of a very high concentration of the target protein required to activate the immune system, been exceeding the levels needed to train the mean system to distinguish between

self and form proteins. this includes differentiating self proteins from viral or booked serial proteins, which is crucial for developing preventive vaccines. in contrast, when therapeutic vaccines are developed, the immune system must learn to differentiate between self proteins and proteins that are almost identical found and transformed, malignant or simply tumor cells. in such cases, the differences can be as small as a single amino acids or the over the past 10 to 12 years. as methods for determining nucleotide sequences and humans have become widely available, it was discovered the tumor cells differ from normal tissue of the same individual by large number of small mutations. these mutations present in tumor cells are now being used as new androgens, new engines that can be introduced into the body of a cancer patient in the form of m r n. a. as we discussed earlier, this process stimulates the patient's immune system, particularly silo toxic lymphocytes to target and destroy tumor tissue. this is how

the drug works. the 1st stage of developing domestic technology for synthesizing and designing m r n. a base treatments began in 2022 and partly because the same team that created the splitting the vaccine at the emily institute began working on this project once they became available. during this time 6 patients were obtained . and as of today, they're already 7, making this technology, fully domestic and sovereign. we implemented numerous fundamental changes that enabled us to secure patients in the russian federation using this technology. as i mentioned earlier, we created an animal model of melanoma and demonstrated its effectiveness and treating mice. currently we're developing models for all their own ca, logical diseases, as well, for such a serious on co, logical disease. and they are all serious of course. there is a particularly common one non small cell lung cancer and as i now understand though i am not at i'm calling just it is the most frequently diagnosed cancer with the

highest mortality rate. this type of cancer does not respond well to the existing treatment methods in, on causing such a surgery, radiation or chemotherapy. yes, that's why we're now creating such a model. other models, wrong causal diseases will also be developed including for the pancreatic cancer, which is also different to treat surgically and certain types of kidney cancer. unfortunately, the business can go on it includes cancer is for which there are currently no effective methods of treatment. these are the cancer types for which the immuno biological method we're developing is likely to be effective. ask for this specific timeline for transitioning from animal models to patients. according to the roadmap code, the being approved by the ministry of health, which was actually developed by the ministry of health under whose guidance all of the studies are being conducted by around september next year, work will begin at the hertz and institute, and at the blind center led by it could emissions kaplan or cd to introduce these

treatments to actual patients. in the initial stages, the technology will be tested and its effectiveness will be demonstrated on a limited group of patients. once this technology is registered by the ministry of health, i hope it will expand rapidly and be implemented in other medical treatment centers across our country. so if the deal is going to go to a teacher, it's uh, ability to here, i'd like to make a remark for our viewers, that unlike traditional vaccines such as the flu vaccine, sputnik that can be used universally on any person. this cancer vaccine must be individually tailored for each patient, or am i right in this? why is it so so it shouldn't come in addition. so shifting them, i mean, absolutely right. this is a very important point that is essential to the completeness of the story that we're telling you today about the creation of these vaccines. this is a truly personalized product with a customized vaccine created for each patient. it is because of the fact that note, tumors are ever similar to us. as of today i'm calling just know about. i repeat

that, i'm not on the call just myself. but as far as i know, there are about 300 types of tumors that differ. you know, typically if we take several tumors at the genetic level, that is sequence them to determine the nucleotide sequences in their genomes. we will find out that no 2 tumors are actually the same. and this difference, which is the characteristic of each tumor, is an excellent target to force the immune system figure to be speaking, to find attack and destroy this tumor. but for this purpose, 1st of all, we need to identify these point mutations in each tumor for each patient. based on this, the medicine can be called personalized. then from these point mutations, we put together a construct called m r n a. the one you and i have talked about, synthesize it, and then package it in a little bit shell, which let's not go into detail also represents some technical innovations and then injected into the body of the patient from home. this personalized data was obtained,

at 1st glance is going to be very expensive at 1st and it is indeed. however, at the r and d stage, which we're now talking about, all the costs are borne by the state. when this goes into mass production, it will be the result, not only of the technologies i just mentioned, but of new technologies related to the calculation of the nucleotide sequence that is part of the m r n a on co vaccine. for this purpose, we're now working with the leading institute capable of doing this, the vondik of mathematical institute academician, ever d. c on academician battelle and degree to fundamentally new mathematic framework for this project. we want to all the calculations which now take 3 weeks or a month for each patient to be done in an hour and a half, maybe even less not to mention the far greater accuracy of these calculations, which will also surely increase the effectiveness of the vaccine product at the moment about 30 specific orientations of a patient are included in one vaccine system. this is done in order to guarantee that the immune system will recognize at least one or 2 or 3 mutations as for and

that is, the new mathematical framework will greatly increase the probability that a given mutation will activate the immune system. and the size of that m r renee can be reduced, thus reducing the time it takes to create the vaccine a layer on the schedule with them. i'm going to say probably the biggest, the most word for 2024 artificial intelligence. surely that's something you have been using your center in some way and surely artificial intelligence will have some effect on speeding up certain processes. can you tell me, please, how did you involved a guy in the creation of this vaccine? can we talk about that? especially it was at the to approve the disputes and refer to the radio and thank you for that question. indeed, when i was talking about our relationship with the vondik of institute, it was about them creating a neural network enabled model that would not just do calculations, but would also enter the results of those calculations into a database of cancer patients being created at the same time so that this software can train itself in terms of speed of action and accuracy of its predictions and

calculations. is the textbook definition of artificial intelligence as far as i understand it again, i'm not a professional mathematician mathematically speaking. when can we say that a particular development is being made using artificial intelligence? we can say so because the program that under pins, the creation of a certain medical service, our product is based on software that is powered by big data. and the results of the work and the rendering of the service are entered back into this database, thereby increasing the efficiency of the software. my mathematician colleagues have taught me to say not a model, but a mathematical environment. yes, we hold join seminars and we learned a great deal from them. i hope that we enter and offer them something new to some new information. right now, the creation of a mathematical environment for this work is being spearheaded by a highly respected colleagues at the vondik of institute insurance before we spoke on yesterday is the cotton is mr. ginsberg. let me repeat that,

because each case of cancer is unique, every patient will get individual treatment and a customized vaccine. we've mentioned that let's talk about the rest of the world. is there similar research going on anywhere? the yum described opening the technology and that's the yes, when i talked about the m r n a base technology, i believe i said that it was originally created by pfizer. and whether or not they initially meant to use it for treating cancer, but it became widely known and gate wide spread use. and it co, with 19 vaccine, even though large quantities of it were manufactured and administered the advantages of the technology based on g modified additional viruses, which underpinned this putting the pre vaccine are obvious in terms of the number of side effects. not only to us, but to all the countries that have been using the vaccine. however, because pfizer and my dear and i have had that proprietary technology for a while. they had an early start. i said that we were going to roll out our cancer

vaccine around september, pfizer and, but they're not. however, having completed animal testing have recently started administering their vaccine to cancer patients and have seen very positive results. even though we have orders of magnitude less financing. we're competing at almost the same technological level, and i hope that our know how will allow us not only to catch up with them, but get into the lead in terms of treating difficult cancer cases. with the help of this technology, toyota office in philadelphia, you oppose. hope us forgive this. now you've dreamers question, but will cancer at some point to be consigned to the dustbin of history like plague or typhus man to the airport and show here. so i'm certain that the concept of cancer will evolve. let me explain why. yes, we will prevail over what we call cancer. now, unfortunately, however, or rather fortunately, the antibiotics and vaccines have helped us extend our active life significant beats over what people could hold for 200 years ago in the pre vaccine, iraq,

and before antibiotics or more correctly antimicrobial drugs. we've extended our active live is by 30 to 40 years. i'm sure that within 10 to 15 years, humanity will figure out a way to get rid of the conditions. we now call cancer, you have longer lives, mean new diseases. cancer is most of the disease of old age when you get older, the risk of developing cancer grows exponentially. that is why i'm certain that unfortunately, our definition of cancer will evolve as a life span keeps getting longer. when someone brings up evolutionary processes, i like to say that only god and charles darwin know which way they'll go. but we can ask them a question. so we need to be prepared for everything at all times. and the research component for the fight for active longevity must always be at the forefront politically and economically let alone scientifically. right. and which initial the post and when you have to put towards the solution. if i did this being here, i simply must ask you about what else your institute is working on,

what other drugs and vaccines will you offer russia and the rest of the world spice . your bizarre process on this uh, no, be the states. and then i will thank you for your question. we do have quite a few things in the pipeline. some have been officially released or are pending release this year. i'd like to mention our roser virus vaccine, which was not included in the national vaccination schedule before a team led by tatiana going to be and you call them the corresponding member of the russian academy of sciences developed this vaccine on our institute. we've also created a new anti bacterial medicine called store to as zine on, which has already been registered and is available as pharmacies which is effective against all multi drug resistant bacteria. that is because the action of ford design on is based on a fundamentally different principle compared to other antibiotics. what's more, bacteria did not develop resistance to it. it 1st helps the mean system, turn off certain proteins called berlin's factors as does disarming all pathogenic

bacteria. and then the immune system use a site don't toxic t cells, which we talked about today, a lot or very similar lymphocytes as well as target sides to consume and digest. these, this are invite syria. the drug is very effective against manufacturers of hospital acquired infections. chronic infections across the titus and many other conditions . it was developed by a team led by professor and i. e. a z going to gear about the head of the medical micro biology department of the family institute. over the past 14 years, we will soon release a conceptually new tv vaccine, the tv vaccine that we all know the b c, g vaccine, which is produced by institute protect small children against severe cases of tv, but does not prevent adults, our children from getting infected with tv, the new vaccine, however, will prevents tv infection. this will dramatically change the epidemiology of the disease. we can now hope that its factor, which humanity encountered in its infancy as it were, when people started domesticating cattle and other animals,

that's when it most likely happens. so we can hope that this vaccine will succeed, analysing this vector from the human population. so i hope that this vaccine will be officially released by late 2025 or early 2026 circus. and let's see it's jessica, later for all you just mentioned animals, which reminded me of monkey pox. you're doing some research on it as well, aren't you? i began communicating about that early successes in the monkey pox research a cheap bar scientist who attempted to create a gene engineered vaccine. it is based on the same platform that we use for a split thing creed, which means we know it well and it's completely sakes. this vaccine is great because it doesn't just protect people from different strains of monkey box. what makes monkey pox so dangerous is that as jenna is almost identical to that of smallpox, which was considered to be eliminated in 1980, apparently it would only take a few mutations to make the vector of monkey boss called the same severe epidemiological and clinical consequences as smallpox to our gene,

engineered vaccine doesn't cause the severe side effects that are produced by all the other vaccines created with live viruses weren't inactivated. viruses of cal box or by cd a virus. their side effects are very significant, especially given wide spread immuno deficiencies in the human population. a gene engineered vaccine. however, it doesn't cause these effects and can be administered to patients with immunodeficiency and children. i believe having reserves of this vaccine are a must for our country. the r and d on this vaccine is done. we're now waiting for the start of the new year because the ministry of health care as a government body operates on the basis of the calendar, not the vaccination schedule. so we're hoping to get new financing after january 1st. even though it would be helpful to have emergency funds that could be made available sooner when we're talking about the threat of new dangerous pathogens, it would be great to have more flexible mechanisms to support the research that can protect the population against emergency infections. to give you a more general answer, while it would be great to have something like this on the international scale,

the situation is such that at least on the country level, we need a system that would allow the creation of vaccine prototypes against pathogens with academic potential something we call tend vaccines. the world health organization published a list of 30 such passages, given art countries, geography and climate. the list could be sorted to a dozen of such pathogens. we believe russia needs a program that would allow us to have prototypes of all these vaccines based on the same technology as can to vaccines that could be kept in the same fridge. and when the likelihood of an epidemic emerges, if you have the production capacity, you can roll out a vaccine within weeks. you won't need to develop it from scratch. you can just pick the right prototype, introduce it in quantity rush. it should have set up a program like that as a less than from the ongoing cobit 19 epidemic. the good news minutes is put in your suspect for us. you will remember almost what those are instead of you. thank you for the interview, mr. ginsberg, i hope to be able to talk to you and your patients soon,

especially if we're going to thank you for the interesting conversation. the take a fresh look around his life kaleidoscopic isn't just a shifted reality distortion by tell us to vision with no real opinions. fixtures designed to simplify will confuse really one say better wills, and is it just as a chosen few fractured images presented as 1st? can you see through their illusion going underground? can the

stuff for the machine for the opportunity such as you're done with the machine code the should that should do this vehicle? is it the economic go to model, have us for this next time and see if it's doesn't figured that's about it. so we can, even though is the new month. so i was unable to deal with the company and some village goes up. developing bio, chemical weapons inside of the guns got to watch the news move. i'm assuming she's, you know, we're, since you've agreed to support the white glove service cost, but he's because of the same issue because

the tell good thing that team the premium parliament is reportedly set to approve controversial times to dropped 18 year olds. positive forces continue to suffer losses on the task. one thing to it is using africa as a testing ground for military biological project. that's the warning from the russian defense ministry, which also lays out the link between the big pharma and the head class. and that sort of gas prices of all pets in the or upsets out here refuses to allow russia that keep on saying it's fuel to west and consumers through ukrainians . the.