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in this vivara of the institute of molecular biology of wounds special mice are bred, their immune system is made, as scientists say, identical to the human, so that they can conduct research, the result of which will help to treat people, we lit. they made a lot of unique mice that are made for some kind of scientific problem, they allow you to understand how the body works. if it doesn’t have a particular screw, if you know how the mechanism works, then you, in case the mechanism works poorly, you have a much better chance that you can fix it molecular immunologist sergey nedospasov is studying the mechanisms of the immune response,

including to viral infections, for example, eco species, his group of scientists actually disassembles by molecules, how the immune system reacts to vaccination , and genetically modified mice are needed for this. you can infect them with the ukrainian states of the delta, and micron is there alpha beta there and all the others are now some kind of cerberus. appeared. you can look at which immunization schemes protect or do not protect against some new strain, this is the most, as it were, the simplest and you can say that such vaccination, although it was not original, the vaccine was not against amicron. it is nevertheless a micron. even if it protects weaker, and it protects, firstly, from mortality for sure, but it still protects. here are such, as it were, bad symptoms that are well, some indicators of this disease. it's a step towards looking personalized. copper using the so -called animal model, first of all, research in the field, scientists are ready to breed a mouse with a mutation that leads to a disease

exactly like a patient, so that on this micro for example, try different therapeutic approaches to select drugs that will be most effective for a particular person, relatively speaking, when it is, uh, available, then people will come to us, say, from a metallological center from an nk center, who need such preclinical models there and nine. what that here you have a patient. this patient is alive and it is necessary to understand which of the available drugs is quickly understood. which of the drugs can act on his tumor there are examples, when you, well, not with us yet, when you can you zoom in on a specific person? the scientific group of yulia gorbunova can be said to be building bridges between nature and synthetic chemistry, studying porphyrins. these substances are analogues of natural chlorophyll, which colors the plant green , and they are also porphyrins in our hemoglobin molecule at the institute of physical chemistry and

electrochemistry, porphyrins should be combined and antibacterial substances are being developed , which may play a role in solving the problem of antibiotic resistance, that is, reducing the effectiveness of antibiotics, bacteria have learned to adapt to them to create protective biofilms, and on the basis of our compounds we make photosensitizer substances that can absorb light, uh, having received this light energy during the formation, the oxygen that is in our cells, the so-called active form of flight, oxygen is the strongest oxidizing agent in nature. it actually oxidizes any cells. here in this case. bacteria are the object that this 7 years for oxygen can destroy to determine generates, the substances created by scientists, this singlet oxygen or does not generate help? this installation was also assembled here at the moscow institute. as for the substances themselves, it remains to be studied how different types

of chemical compounds interact with various bacteria, but it is already clear that destroyer substances will be needed primarily for the sanitation of hospitals, dental hospitals, to cover, for example, bed linen. you can soak bed linen with a solution of this compound, yes, and in fact, it irradiates there a couple of times a day, you kind of kill bacteria from nosocomial infections inside hospital bacteria, which are very difficult to get rid of even synthetic chemists, as they call themselves, create new substances for photodynamic therapy of oncology, the idea is that the patient make an injection. the substance accumulates in the affected cells, it luminesces, that is, it glows in such a way that experts can draw the contour of a tumor. experiments are carried out on laboratory animals in order to understand exactly what properties should possess substances for phototherapy, firstly, they must be water-soluble so that they

enter the body. secondly, they must be selectively accumulated. here in these or those tumors to diagnose. where is the e, cancer cell and more importantly, how to kill them, a certain compound of porphyrins can be used to create solar cells. academics say this substance absorbs light well, if solar cells are based on organic elements, they can be made flexible and expand the temperature range, for example, from minus forty to plus 40 °, at which they will work , also a kind of immunity evgeny petrukhin. ivan kuznetsov stanislav petrov all

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black friday works on wildberries the main sale of the year more goods more discounts do not miss payment by phone returns to your world map in the sberbank application online and pay for purchases with one touch. enjoy, bewitching design, pay and win up to 5 million bonuses. tire fitting and so on once a month, a commission of 14% was requested for mediation. no, they didn't say it wasn't legal. they just convinced that everything was legal, there were no risks, that this was the usual scheme, according to which a

lot of people work there for various retail chains, especially then the cost. uh, 14% of this cash, what they left at that time. uh, when you sit on a miscalculation you pay 15%. these are income minus expenses andrey gryaznov refused to participate in fraud. he believes that for a restaurant with small incomes, participation in gray schemes is too big a risk, for the sake of one percent of the profit it will be possible to part with the business of a lifetime if an audit comes in the middle of the month of the central bank , the tax and the federal financial monitoring service announced that they had jointly disclosed a large exit scheme from taxes in the restaurant business, the scheme consisted in the use of replacement caucasus and payment terminals, which made it possible to transfer the proceeds of catering to other sectors of the economy, which then returned back to these enterprises through the cash flow in the future. on the one

hand, this allowed their enterprises to manage their revenues, and on the other hand, to receive cash, which is used to save production in envelopes. in order for the market to become more transparent and white, the chairman of the coordinating council of the federation of restaurateurs and ateliers sergey mironov proposed several initiatives, one of them adopted since january of this year, firstly, restaurants received zero vat, that is, yes, revenue of 2 billion a year, you can not pay vat, is that a lot? why i am happy to support the topic of business separation, because at the moment when everyone completely goes into it and stops using schemes, and the market will be absolutely competitive for us, that is, there will be normal fair competition. just at the moment when someone uses the scheme, and, unfortunately, at this moment he receives other conditions. and more moreover, i'll say it again. now we can understand the situation. who participated in this agency scheme. many of those who participated in the agency scheme in the

twenty-second year had already abandoned it then, which forced others to hold on to the scheme to the last. perhaps faith in her ideal. the concept of gray terminals and a substitution of the cash desk were supposed to hide the restaurant from the tax eye, the money passed through several chains, and then returned in cash to the owners of the establishments. it would seem impossible to trace, but it's only at first glance it come to a restaurant order food. after that, they bring you a check. that is, this is a paper on which it is written that you ate how much it costs. what is the discount and what is the final result? you pay for it, and not always. ask for cash receipts directly. and if you ask for it, because the restaurant is obliged to give it to you. you can see that they are very different here, that is, in contrast to the cashier's checks . a

legal entity can be specified directly, which provides a service so that tax officials were able to determine that the money was transferred not to a restaurant, but to other companies to the accounts of travel agencies or car dealerships, and then, as experts suggest, another illegal scheme entered into action to cash out the amounts here, but there could be a scheme with one-day farms when before the sale directly to the customer. this car was sold to the farm, 1. then the sale went from the client to the one-day company. all this was reflected, of course, in the tcp and so on, but i deposited the cash into my account, but simply withdrew it for turnovers and when a critical mass accumulated. these are the payments. she simply tried to televise any tax,

until they disclose the name of the company that participated in the verification scheme going to several catering establishments at once. the investigation into the tax evasion case is kept almost secret . little is known, for example, that the organizers of the scheme opened a showroom in moscow near the prospekt mira station. there are restaurateurs. could get acquainted with a list of services and, if agreed, to sign an agreement according to the restaurateurs, the organizers, with whom tax evasion came to them in various ways at some kind of restaurant exhibitions. exhibition we did not communicate. i just saw it, of course, working in black is much more profitable than working in white, so

these schemes are implied, but i have been working for 30 years. russia is engaged all the time in the development of the restaurant business. and these businesses have grown to become successful large scale. yes, precisely, because they have become and always have been white today restaurant a business can choose a simplified taxation system at a base rate of 6% of income if the company's revenue does not exceed 164 million rubles. per year, and refuse to pay vat how much taxes the company pays in the end and how much they save on gray schemes, we asked an expert to calculate the amount of 120 million rubles as a basis. we have. two options, or we have 6% of income, right? or 15%, the so-called income minus expenses

accordingly, let's calculate if we have 120 million a year at six percent, it will be 7.2 mln rub. tax per year. if we are talking about income minus expenses, expenses of 100 million, it turns out that we have 20 million rubles. we have to calculate at the rate of 15%. so that's just three. million rubles per year, but you can pay taxes of only 1,200,000, that is, six times less. if there is practically no income, restaurants serving chemists try to hide the turnover, but you can save even more on salaries. envelope, officially, in addition to personal income tax, 13% of the company pays 30% social tax, and 2/10%

injury tax, that is, roughly speaking. payment fund labor is equal to 20 percent. in our case, 24 million per year, 24 million rubles. a year, either a third of this is taxes, that is, 8 million, or, if we say that it is paid directly without taxes, that is another plus. 12 million in taxes 30.6 million becomes what we pay for taxes on our staff. not only to evade taxes, but also for purchases, for example, exclusive products that refuse to sell, for example, crayfish for non-cash. it is very difficult to buy

crayfish officially now in winter, it is very difficult, because they don’t catch crayfish. now normal documents, as a rule, this is some kind of possible, poached goods need to be worked on, that is, the restaurant is ready to pay officially, but there are simply no good goods. the same problem, that is, restaurants need money for some purchases that cannot be made in belaya or refuse this product completely, that is, again, i think that the restaurant should refuse this product, but not all colleagues think so. preliminarily, it is the participants in the scheme that will become known after the transfer of the case to the court. this scheme was created in order to get away from vat in the first place in order to support a

tax-free regime, possibly simplified investment taxation, respectively, if it is revealed, and it has already been revealed that this scheme was used to avoid taxes of those who used this scheme they will be charged 20% vat. income tax 20%. and a fine of 40% of the unpaid tax, and that's it. this is for the last three years, in addition to a fine all participants may face criminal penalties of up to 6 years for non-payment of taxes on an especially large scale and up to 20 years for organizing a criminal community. in addition, as reported in the central bank, work was carried out with credit institutions that participated in the chain of money transfers, according to the central bank, accounted for 21% of all shadow transactions, including cashing out.

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the newest nuclear-powered icebreaker ural has reached the port of murmansk, the crew will have to work, here is the yenisei region of the kara sea, when the exit to the first flight of the rights and freedoms of our citizens are guaranteed by the constitution, they are unshakable. we must never forget this vladimir putin congratulated the workers of the russian judicial system, the head of state noted that no circumstances should serve as an excuse for superficial legal proceedings, and the president instructed the supreme court to form judicial systems in the new russian territories as soon as possible.

artillery is hitting the enemy in the donetsk direction, shots of combat work directly with the position as tasks the mobilized manage to hear the opinion of their commander, and in lugansk they met fellow countrymen rescued from captivity. the rocket with three chinese triconauts successfully launched from the spaceport. this mission should be the final one in the construction program of the chinese orbital station tengong, which the crew will be busy with in the next six months. arrived in murmansk, he left the baltic shipyard on november 23 after the ceremony of raising the national flag. the transition took six days with details.