you. [applause] >> world champions. we will do it again, baby. san francisco, i love you. thank you very much! [applause] >> ladies and gentlemen, congratulations to the giants of 2010, and to you, i have the sound that you made at at&t park in the world series echoing in

my head. we need it another few times as we face the winter ahead of next season. let's hear it again. let's go, giants. let's go, giants. >> let's go, giants. let's go, giants. let's go, giants. let's go, giants. let's go, giants. [applause]

>> one more word from andres torres. >> i want to wish my wife happy birthday. i love you. many more. >> thank you all for coming to andres torres' wife's birthday party. i cannot wait to have another party next year. ladies and gentlemen, three and half months, pitchers and catchers report to scottsdale. and the giants will try to do it again. we will see you at the yard. the giants are the champions of the world. congratulations and thank you. [applause]

♪ ♪ i left my heart in san francisco high on a hill

it calls to me it calls to me to be where little cable ♪ from coast to coast, cops are cracking down... on seat belt violations. buckle up, dand night, or expect a ticket.

it doesn't matter who you are or where you live, they'll be on the lookout. cops write tickets to save lives. ( seat belt clicks ) click it or ticket. >> the public wants to access particular information about your house or neighborhood we point them to gis. gis is a combination of maps and data. not a graphic you see on a screen. you get the traffic for the streets the number of crimes for a police district in a period of time. if the idea of combining the different layerce of information and stacking them on top of each other to present to the public. >> other types of gis are web

based mapping systems. like google earth, yahoo maps. microsoft. those are examples of on line mapping systems that can be used to find businesses or get driving directions or check on traffic conditions. all digital maps. >> gis is used in the city of san francisco to better support what departments do. >> you imagine all the various elements of a city including parcels and the critical infrastructure where the storm drains are. the city access like the traffic lights and fire hydrants. anything you is represent in a geo graphic space with be stored for retrieval and analysis. >> the department of public

works they maintain what goes on in the right-of-way, looking to dig up the streets to put in a pipe. with the permit. with mapping you click on the map, click on the street and up will come up the nchgz that will help them make a decision. currently available is sf parcel the assessor's application. you can go to the assessor's website and bring up a map of san francisco you can search by address and get information about any place in san francisco. you can search by address and find incidents of crime in san francisco in the last 90 days. we have [inaudible] which allows you to click on a map and get

nchldz like your supervisor or who your supervisor is. the nearest public facility. and through the sf applications we support from the mayor's office of neighborhood services. you can drill down in the neighborhood and get where the newest hospital or police or fire station. >> we are positive about gis not only people access it in the office but from home because we use the internet. what we used to do was carry the large maps and it took a long time to find the information. >> it saves the city time and money. you are not taking up the time of a particular employee at the assessor's office. you might be doing things more

efficient. >> they have it ready to go and say, this is what i want. >> they are finding the same things happening on the phone where people call in and ask, how do i find this information? we say, go to this website and they go and get the information easily. >> a picture tells a thousand stories. some say a map >> i'm chancellor here at ucsf, and i wanted to welcome all of you. mayor lee, president, the distinguished guests and friends, and members of the ucsf community. welcome to the official opening of the extraordinary stem cell building that rises above us. today signifies a major milestone in the history of our system cell research program. it is also a great day for the citizens of california who

supported proposition 71 in 2004 and helped make this moment possible for the field of stem cell research and more importantly, for the human race. i want to extend a special welcome to the chairman of the california -- [applause] -- robert klein, the chairman of the california institute of preventive medicine, whose personal efforts mobilized the voters of california in support of the stem cell research initiative, and whose agency awarded ucsf a major brand towards construction of this building. i want to particularly express a very special welcome to four individuals. [applause]

the vision and generosity of these couples, in support of this building and stem cell research throughout california have been a remarkable contribution to the field. all of us have ucsf and beyond thank you. when i came here just under two years ago, progress on the building was not all that evidence. some 200 construction workers had to spend a full year preparing a detailed sites and laying the foundation. working on what was in some areas 60-degree slopes -- take a look behind you. it is amazing. they drilled concrete pillars 60 to 90 feet into the bedrock, and added compression and tension isolated. a patentable engineering feat to absorber the shock of seismic activity. that is earthquakes. [laughter] because construction of the foundation began on the far western edge, after two rows to

bring in drilling equipment were established, people started wondering when we would see a building. the director of the human embryonic stem cell program reportedly grew worried. from her vantage point, there was no evidence that the serpentine-like structure was rising at all. i think it is fair to say that the end product is a feat of human ingenuity and is a testament to the architectural genius of rafael dinoli. the leadership of the ucsf architectural and construction teams with smith group and dpr construction. so thank you to all these folks. [applause] in 1981, ucsf's gail martin codiscoverer cells in mouse embryos that were capable of giving life to all the tissues in the body.

she named them embryonic stem cells. little did she know that this momentous revelation would ultimately sent a tremor through both society and national politics. just under two decades later, when ucsf's roger peterson and university of wisconsin's jane townsend began exploring every adding some so research, the political climate had changed, but this did not stop their work. 10 years ago this month, ucsf scientists develop two of the first embryonic stem cell lines in a modest lab. to look up now and see entire building dedicated to stem cell research created with state and private funds is truly gratifying. it is also gratifying to have our program led by arnold krickstein. as a neurologist, he has spent much of his career treating patients with devastating disease from childhood development of disorders like several palsy, to parkinson's, stroke, alzheimer's disease, lou gehrig's disease, and brain

cancer. he is also a world-renown brain stem cell scientist exploring with a number of colleagues a novel approach for using stem cells to treat epilepsy, parkinson's, and some of the consequences of brain and spinal cord injury. in his role as director of the center, he has built one of the strongest programs in the nation, recruiting some of the premiers themselves scientists to our campus. this afternoon, dr. krickstein will be hosting an exceptional scientific symposium. it is fitting that japanese scientists who now holds an appointment here at the ucsf affiliated gladstone institute will be a keynote speaker. in 2006, he stunned the field when he reported that ordinary skin cells could be turned back to an embryonic-like state. this discovery has given hope that someday these cells might be used in regenerative medicine

and has given scientists a potential way to reprogram the skin cells of patients to see how their diseases develop. the excitement generated by the finding and all of our researchers'commitment to advancing the science is probable. while advancing the sites in the field, ucsf scientists are beginning to move their work towards human clinical trials. a team of ucsf pediatric specialists and neurosurgeons are carrying out the nation's second stem cell clinical trial ever conducted in the brain, trying to treat a rare, fatal disease that occurs in boys. four teams of ucsf scientists supported by grants are working to develop clinical trials to treat diabetes, brain tumors, epilepsy, and liver disease. today is a day filled with promise and hope. we celebrate a feat in design and engineering, a building created to inspire a vital new field of exploration.

it is the regeneration medical building, and it is the headquarters of the rhodes center of regenerative medicine and stem cell research, a program that extends across the university. i know all of you join me in looking forward to watching the progress that emerges from this building and beyond in the years to come. on behalf of all my colleagues at ucsf, i thank all of you for being here and helping us celebrate today the beginning of something really special. with this, i'm going to turn over the program to a distinguished pediatric scientist, who dedicated years to setting respiratory disease in newborns and the dean of ucsf school of medicine. [applause] >> thank you.

it is truly wonderful to be here today. i think stem cell biology with its hope of replacement, repair, regeneration, has captured the imagination of the public, of scientists, of physicians alike. this vision rebuilding, i think, will capture the imagination of architects and engineers as well as their scientists around the world. it is particularly a huge pleasure for me to thank the dolbys and rhodes to allow this building on our campus. faculties across the school are engaging in disciplines ranging from basic science to clinical studies and beyond to bioethics and health policy. the pace of this activity is truly remarkable. when the building was just being conceived and our stem cell program was ramping up, we had no potential therapies in the pipeline. now, as the chancellor reference, we are enrolling

children in a groundbreaking clinical trial currently with stem cell, and we have four different disease areas that we -- that are actively working to investigational new drug status. the progress here at ucsf and throughout the state of california is truly remarkable. the opening of the regeneration medical building will serve to accelerate this pace of discovery. it is now my honor to welcome and introduce the roster of speakers that we have here today. our first speaker we have this morning is san francisco's new mayor and when -- edwin lee. he was the city administrator for six years before being appointed mayor in january by the board of supervisors. mayor lee, we are delighted to have you with us today. i believe your first official visit to ucsf as the mayor of

our great city. mayor lee. [applause] >> thank you, sam. let me begin by thanking, on behalf of all san franciscans, and congratulating our uc president, chancellor, and the entire uc san francisco family on the opening of this major facility. it is a stunning testament to the inspiring and critical work that will go on within these walls. but i also want to thank and acknowledge the dolbys and rhodes for their generosity, without whom the building would not have been possible. their investment is beyond the physical existence of the building and will pay dividends in the form of ground-breaking research to improve our research

and disease preventive medicine approach. of course, i want to thank bob klein and the california institute of regenerative medicine for the significant investment in this facility and also as a reminder that it was day in 2005 that shows san francisco for its headquarters and helping and making san francisco the global center of stem cell research. uc san francisco has been a trailblazer in stem cell research for more than a decade. the opening of san francisco's regenerative madison building affirmed san francisco's place as a leading location for life science research and advanced regenerative medicine. the road center of regenerative medicine and stem cell research will drive innovations that will

spin out new companies, creating new jobs and economic activity here in san francisco, in the region, and in the state. we have already seen the important role that ucsf has played in mission bay. as you will all recall, simply seven years ago, we only had two biotech and life science companies in the city. today, there are 74 of those companies located in our city. that is a great testament to this leadership role. [applause] what i want to say is that only a few years ago, when all of us were struggling with some very restrictive regulations that were imposed upon us and that did not allow science to really do its part, we lost a lot of valuable time. it is great to see that we have

got a renewed interest because in that lost time, there was the creation of the sense of urgency, especially when we are talking about disease prevention, when we are talking about the freedom to really innovate, to have cross disciplines working together, as will happen in this new building. i'm thrilled to celebrate the grand opening. i look forward to the groundbreaking research and therapies that will revolutionize how we treat diseases. i'm looking forward to those breakthroughs that will cause this whole world to know the san francisco wants to be and will be the forefront with this kind of research. thank you very much for this day. [applause] >> thank you, mayor lee. our next speaker is the president of the university of california. he is responsible for a university system that spans 10

campuses across the state and includes five medical centers and three affiliated national laboratories. since taking office in 2008, he has been a great champion for innovation in science and health, and we're very pleased to have him join us here this morning. [applause] >> dean, thank you very much. i want to welcome everyone to this great event today. we have so many distinguished guests today, and it really is an honor to be here. as i look out through the roof of our tent here, it is absolutely stunning engineering and architectural achievements. i'm a lawyer. i'm not sure why it stays up, but it does. [laughter] what is really important is what goes on inside, and i predict that the innovations and scientific brilliance that will go on inside the building will match the architectural and engineering achievements.

with all the hand-wringing brought on by california's budget woes, it is sometimes very easy to get -- to forget that california is still a magical place, a place where people can come together to dream and dare and do big things. the stem cell building where we gather today is a monument to ucsf's pioneering research to stem cell sites, investigation with the potential to literally write the book on human well- being. but it is also a monument to california, a monument to a state that has over hundreds of years been an innovator. it is a monument also to the voters of california who supported this great enterprise. obviously, it is a monument to the university of california that has played such a leading role, and to all of you who supported it in all sorts of ways the innovation on this

great campus. such potent collaboration's, as we see evidence here, are a landmark of our history, and if you want an example, i would point to the founding of the university of california nearly 150 years ago. began, like this building, with an outside stream and a few californians willing to give it a shot. i would say with 10 campuses and five medical centers and all the steps this great public university system has achieved, that it has really turned out very well. in conclusion, i would like to extend my sincere gratitude to the dolbys and rhodes. the legend on the state capital says, "bring the men to match my mountain." you certainly are those men, and before i get into trouble --

sue -- and women. [laughter] although we cannot know exactly what the future is going to bring, we know it will bring innovative scientific pursuit, and it seems all but certain that many generations ahead will go -- owe them a gift of gratitude. thank you. [applause] >> thank you, marc. i would now like to introduce ely, known both in the world of art and in the world of science as a great philanthropist and generous supporter of visionary endeavors. he and his wife were early supporters of stem cell research in the state of california and here at ucsf. we are proud that our sense of program, the center of regenerative medicine and stem cell research -- >> [inaudible] [laughter] >> at ucsf --

[laughter] recognizes their remarkable vision. please welcome eli bros. [applause] >> we are most pleased to share today's celebration. this is a celebration in which we want to thank the bilbies for their generous support of this remarkable building, so let's give them a generous hand. [applause] it really feels good to give, doesn't it? it was over two years ago that we announced our support to both ucsf's stem cell center. this is actually the third stem cell research center in

california that we helped to build. the first two were at usc and ucla. when we met dr. krickstein, and heard about his vision for research at ucsf, and then, we saw the plans for this architecturally unique building, we knew we wanted to help. i did not know a whole lot about science and medicine, but we do know that stem cell research and general looks hold the greatest promise to improve the human condition. with regard to stem cell research, there is no question that california is a center of stem cell research in the world today. when the voters approve proposition 71, they made a commitment that californians would push the bounds of scientific research because it was the right thing to do. since then, under the visionary

leadership of bob klein, the of awarded almost $1.2 billion to some 65 different institutions. the result today as the publication of more than 650 discoveries with many clinical trials under way. uc san francisco has been the highest recipient of those funds. that tells you something remarkable is going on here. researchers have made advances to develop therapies for lots of areas, including parkinson's, leukemia, neurological diseases, liver failure, and others. it is also fair to commend raw fail for doing what seemed