>> jim: for those of you expecting to see "60 minutes" you are watching the nfl. a wild game between the indianapolis colts and the pittsburgh steelers. "60 minutes" will be seen in its entirety seen in its entirety followed following -- following this game except on the west coast. 2nd and 9 for pittsburgh. roethlisberger. almost intercepted! going in the direction again of brown and off the hands of mike adams. >> phil: a little off target. coming across the field, 84, brown, gets a hand to it. that's what makes it stay in the air. he just gets a hand on it. sometimes when a hand is hitting the football over the middle, it's always bad news.

whoever is playing back gets the interception. >> jim: like you said, the colts have to hold them to mow more than a field goal, a critical play for the defense, 3rd and 9. and they mark him just shy of the first. >> phil: boy, theady h the blitz on. they had what they wanted. but they don't bring brount down quick enough -- oh, he throws it back shoulder. where's the spot? oh, that's a good one, right on it. right there by the -- almost to the inch. they get it right. >> jim: it'll be 4th down. 4th and about a yard to go. you could bring out suisham and try to make it a 13-point game. >> phil: i think they are gonna go for it. >> jim: go for the knock-out. >> phil: go for the knock out first. >> jim: the measurement first.

>> phil: many things in play. the quarterback can get under the center and read the defensive front and figure out where to run the quarterback sneak. they read where everybody's lined up and is that tells you where to go. they have been winning the line of scrimmage all day long. a pair of 500-yard games. >> jim: 511. >> phil: you know what is good about this? nothing cheap. one good throw after another. >> jim: they're going with their big package here with an extra tight end, spaeth and the fullback, johnson. and blount is in the huddle, as well. >> phil: well, a lot of things, run with power, run the quarterback sneak or try to draw

them offsides, use a time-out and see the defensive front and maybe make a decision from there. they are looking for the inside run. the quarterback sneak. >> jim: robert holcombe still has -- roethlisberger still has it, touchdown number 6! (cheers and applause) >> jim: ben's greatest day as reached another whole new level, his first ever 6-touchdown game. >> phil: mike tomlin can smile now but i guarantee you, he was holding on. here comes the fake and watch the throw and catch. >> jim: how about throwing it on fourth and inches? >> phil: oh! >> jim: and miller is the recipient of that team record

sixth touchdown pass. and the lead is 17 off the extra point by suisham. >> phil: what a game! this is sean. we saw him holding a bud light, which means he's up for whatever happens... ...in this case, jimmy johnson. i, jimmy johnson, challenge you to a little football game. don't get nervous. are we ready?! yeeaaah! i'm ready. jimmy johnson has dominated the electric football circuit. yeah! look at the little jimmy run! he's hurt! he's pushing through, he's pushing through. oh, wait a minute, wait a minute! bud light. the perfect beer for whatever happens.

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>> jim: certainly todd haley's finestr hou as the coordinator here at pittsburgh. >> phil: i think really now -- well, after this touchdown, you had to be nervous throwing it on 4th and short. but it's a big relief to know you probably have won the football game. >> jim: we would like to welcome the audience that was watching the browns defeat the raiders. jim nantz, phil simms and tracy wolfson here on an amazing day, ben roethlisberger has set the franchise record with six touchdown passes and 522 yards. . went to the auction. won a storage locker. found an old guitar.

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yards in one game in the history of the league. andrew luck. incomplete. 5:22, actual tied for 4 with boomer esiason for the all-time record,that was 63 years ago. september 28, nine 51 with the -- 1951 with the l.a. rams. >> phil: you can barely see the lines. >> jim: was that thursday night football? >> phil: it might have been. a great moment for roethlisberger and for todd haley, as well. >> jim: second and 10. luck in trouble. and just throws it into the browned to avoid -- to the ground to avoid the sack as he had cameron heyward all over

him. and another flag down. >> phil: probably defensive holding, illegal contact -- or they just looked at him wrong. that could be a call, too, you can't give mean looks. >> referee: illegal contact, defense, 5-yard penalty, automatic 1st down, indiolanapis. >> phil: when you play the great quarterbacks or the -- the group of five or 10, whatever you want to say in the league, jim -- that's a little hit to the face, too. by james harrison. but if you don't have a pass rusher or two on your front four that can get to the quarterback, you are just at the mercy of what goes on because so many good receivers. the defensive backs can do very little against them and they are gonna throw and catch. >> jim: the pittsburgh offense over 600 yards total for the

day. and luck cuts his losses. a flag comes out. >> phil: it'll be against the defense. >> referee: there is no foul for internal grounding -- intensional grounding because the back was being held. holding, automatic 1st down. >> phil: a good job by andrew luck.

ahmad bradshaw, the back and james harrison grabbed him. >> jim: a new set of downs for luck. a perfect pass to whalen, his old stanford teammate for a gain of 18. >> phil: there's no "oh, let's just run out of clock and let this game end." they are gonna keep trying to get this thing down the field and score. pep hamilton, the offensive coordinator. >> jim: bradshaw. and thrown down by vince williams. >> phil: kind of a good illustration, jim, when the steelers just play normal, they rush and play zone, i be it's late and the game and they are softer but all day long they

were hitting andrew luck because they were blitzing and giving lots of of pressure looks. >> jim: with four minutes, luck finds whalen with a flag on the field. whalen's second catch in a 3-play consequence. it might be a holding. >> referee: holding, offense, for 74. 10-yard penalty. replay down. >> phil: anthony castonzo, looked he was beat. look at 74. pretty tough call. >> jim: they said he had a hold of moats. >> phil: and moats was going so low and they will go down if you put pressure on him and that's what it looked like that time. >> jim: here's the lineup tonight on cbs, all new, "60 minutes" and the new hit drama "madam secretary" "the good

wife" and "csi" all tonight. bradshaw breaks a tackle and he's got 11 back. (crowd yelling) >> jim: third. we'll call it 2. and that's whalen for the 1st down. >> phil: good call that time, just pick up the 1st down. top of your screen, what do you do? that's how you play it. william gay way off of the receiver. why? short plays don't hurt you. quick scores do. the steelers here in a situation like this, don't take a chance.

they are not gonna blitz. >> jim: 1st down. (crowd yelling) >> jim: luck, the ball wobbling with the contact on the quarterback. >> phil: the steelers there n,agai a cross-blitz inside. so i was a little wrong there, for sure. but he hesitates. the pressure. his arm hit as he is throwing it. it looks like, you remember well -- well, thursday night, we did philip rivers. kind of like andrew luck, they look down the field and they just feel the rush. they know how to move and feel the people around them. over 1,000 yards here in today's game. >> jim: 2nd and 10.

diving across to make sure he has the 1st down. hilton with his sixth catch for 156 and a touchdown. and by the way, luck just went over 400 with that throw. >> phil: if they don't win the game, they are getting great practice. more repetitions. and looked left and came to his right to get the completion. (crowd yelling) >> jim: here's luck heading to the end zone. and it is -- intercepted! (cheers and applause) >> jim: antwon blake comes away with it as luck was trying to find hilton in the end zone. >> phil: he was trying to get the quick score. still thinking his team could win the game so he stepped up and fired it outside.

but blake, goodposition. he's doing just what we talked about, playing d., don't let the receiver get behind you. >> jim: quite a play by blake. >> phil: it was. how about that. >> jim: not a guy that gets a lot of action. you talk british corners with mccain and allen and they had to go deep because ike taylor has been out. so blake steps in and makes the play and all about seals it now. the second interception in the game. first run back by william gay for a touchdown. the play by bell for 2. an update, james brown in new

york. glnchlth talk about a game in arizona. >> bart: the hook up with john brown on the double move for a 75-yard touchdown that ended up being the game winner. it's a final, arizona 24 and philadelphia, 20. >> james: back to jim nantz. >> jim: how about the job that bruce arians continues to do in arizona. the eagles lose. andrew luck, a 400 yard performance and three touchdowns. >> phil: and the pass that carson palmer threw, one of the favorite moves for the coach. >> jim: bell for the necessary 1st down yardage at the 2-minute warning.

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>> jim: watch this last run by le'veon bell. and you see the coaching from the sideline. avoid the contact at this point. phil simms and jim nantz and trailfs tracy wolfson on this --

thovls on this historic day for ben roethlisberger. and again, showing credentials that will one day land him in the hall of fame. >> phil: no question. and he never -- we talked early in the game, hes hanever gotten -- has never gotten credit for houthed he throws the football, with ease and power. and if he plays to 40, which i think he will, he will still be throwing the football well enough to get it done in the league. with no effort. so it doesn't wear him out. it's not hard. i wonder if he has had ever had a sore arm with that throwing motion because it's so good. >> jim: what a great day to establish all these mark on a day where he will get his 100th win. and his 150th start.

bell is just adding to his numbers. another 100-plus day for bell. 85 on the ground. and a time-out called by the colts. we'll show you what ben's day looks like. the touchdown by touchdown. first wheaton and then the rookie, bryant. and the one handed grab by brown and then brown again in the 28-point second quarter explosion by the steelers. and then to bryant. and that was the team record setting six to heath miller. >> phil: well, what do you think? you think how is the relationship between todd haley and ben roethlisberger? of course i am being sarcastic. i think they are gonna get along pretty well when you do these kind of things for your quarterback. and the players will listen, you teach them and give them a

chance. >> jim: bell waiting. >> phil: it all went well for the steelers on the offensive side but i like what they did. it had everything. it had power running. they blocked it up, gave roethlisberger time to throe it down the field. these are things that i haven't seen enough of and i'm sure this is what todd haley envisions the offense turning into. >> jim: we send our wishes to the broadcast family here at heinz field, the man who has worked for us for years and years and he is under the weather. and we hope to see him back here at a steelers game soon. 3rd and 2. and roethlisberger keeps it. you don't need to get knocked around like that. you got to be looking good for the post game press conference when you stand and up smile about where you are best day. >> phil: and you don't want this kind of a hit. that was a big hit.

and not illegal because he is a runner. >> jim: jonathan newsome, who hit him. >> phil: i think you would like to take le'veon bell to kneel on the football but the colts used the time-out and kind of force you to go ahead and run the ball. >> jim: you take the time-outs down three scores, i'm not exactly sure why you are doing that in the first place. >> phil: you are right and maybe they wouldn't have taken a time-out if the steelers had just kneeled on it. it's like boxing. protect yourself at all times. >> jim: one thing to remember, you are both gonna walk off the field at 5-3. indianapolis will still have the division lead in the south. houston's at four and four and they have already beaten them

once with a second match-up to come. and at 5-3 and 5-3, if they both end up division winners, remember, the tie breaker if they end up with the same record would be this head-to-head match-up. >> phil: yeah, sure. you always -- we seven say it sometimes and i think people think it's ridiculous to say it's a big game in week five because of a match-up. it's amazing how it comes true so many times. >> jim: wing. punted away with seconds to go. just look at this. you can barely separate anyone here. >> phil: no. >> jim: look at cleveland, a half game out of first at the bottom of the four teams listed. >> phil: what's great, you are

gonna have a lot of good match-ups down the road. >> jim: the steelers will have a special requirement ceremony for joe greene's number 75. >> phil: oh, that's great. >> jim: and baltimore coming to town. for that occasion. this game is final. what an afternoon it was to sit back and watch magnificent performances. (cheers and applause) >> jim: second most net pass yards in league history in a game, 907 yards but the day belonged to ben, leading his steelers to victory. for phil and jim and tracy, so long. you have been watching the nfl on cbs. it's a bit l ...'scus it's a bit l ...or a ...'scus

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>> i was very frightened. i was. and i just dried my tears, rolled down my sleeves, so to speak, and went on about my night. >> pelley: sidia rose is one of the nurses who treated the first ebola patient diagnosed in america. you've never heard what actually happened in the dallas hospital from the people who fought to save the life of eric duncan at the risk of their own lives from the time he came into the emergency room through days of intensive care to the moment that he died. >> o'donnell: muscular dispi? >> yes. >> sickle-cell anemia? >> yes. hemophilia? >> yes. >> o'donnell: they're all diseases that can be identified by advanced genetic screenings. >> huntington's disease? >> yes. >> breast cancer? >> we do it regularly.

>> o'donnell: but as you'll hear tonight, genetic science has moved further into the future. this woman believes the technology she used will stop the disease from stalking her family. you have said, the breast cancer stops with me. >> yes. it's not just my children, it's my children and their children and my great grandchildren forever and all time. ♪ i am a one-way runaway >> cooper: the foo fighters may be america's best rock 'n' roll band, but that's not the only reason they're on "60 minutes" tonight. they're also in the midst of one of the most interesting music projects we've ever seen. ♪ you know i'm not in the clear ♪ >> cooper: dave grohl, the band's leader, invited us to watch as they traveled to eight american cities, interviewed some of the most influential musicians to record all that's great about american music.

>> i'm steve kroft. >> i'm lesley stahl. >> i'm bob simon. >> i'm anderson cooper. >> i'm bill whittaker. >> i'm norah o'donnell. >> i'm scott pelley. those stories tonight on "60 minutes." bipolar depression, ling with there are treatment options. ask your doctor if once-a-day latuda, lurasidone hcl, may help you. in clinical studies, latuda has been shown to be effective for many people struggling with bipolar depression. latuda is not for everyone. call your doctor about unusual mood changes, behaviors, or suicidal thoughts. antidepressants can increase these in children, teens, and young adults. elderly dementia patients on latuda have an increased risk of death or stroke.

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>> pelley: you've heard a lot about the dallas hospital that treated thomas eric duncan, the first ebola patient diagnosed in america. but you've never heard what actually happened from the people who fought for his life at the risk of their own. you're about to meet four nurses who treated duncan from the time he came into the emergency room to the moment that he died. the staff had been blindsided by a biomedical emergency that burst into their e.r. like a wildfire. contrary to reports that the hospital bungled the response, the story the nurses tell sounds more like a heroic effort to stop an outbreak. on september 28, duncan was rushed by ambulance to texas health presbyterian hospital. he was isolated in a separate section of the e.r., and nurse

sidia rose, starting the night shift, was briefed on the special precautions required for what they now suspected was a case of ebola. >> sidia rose: i went over and met with a nurse who gave me report. she also went over the protective wear that we would be wearing that night. she gave... you know, finished briefing me on what was going to happen, and i literally burst out in tears. >> pelley: why? >> rose: it's very scary. i know about ebola, and the only reason i do, it's because i've been just researching it on my own. since january, i kept hearing the word popping up in the news, and i just wanted to find out about it. >> richard townsend: when our supervisor said that we had a potential ebola case, i don't want to call it calamitous but there was a lot of concern. people became very vocal,

understandably. it's the boogie man virus. >> pelley: emergency room nurses richard townsend and krista schaefer made sure that rose was suited up properly. as per the hospital's protocol, she worked with duncan alone, with townsend watching over her. when you went to approach mr. duncan for the first time, what did you do? how did you prepare for that? >> rose: i gathered myself together. i put on my protective wear, and i went in and introduced myself to him and, you know, just let him know that i would be the nurse helping him tonight. >> pelley: what were you telling yourself? >> rose: i was very frightened. i was. but and i just dried my tears, rolled down my sleeves, so to speak, and went on about my night. >> pelley: but why do you go in there? why don't you say, "you know,

this one's not for me"? >> rose: as a nurse, i understand the risk that i take every day i come to work, and he's no different than any other patient that i've provided care for. so, i wasn't going to say, "no, i'm not going to care for him." >> pelley: but you were risking your life to take care of this patient. >> rose: oh, i know that. and that's why i... as frightened as i was, i didn't allow fear to paralyze me. i got myself together. i'd done what i needed to get myself prepared mentally, emotionally, and physically, and went in there and did what i was supposed to. >> pelley: though duncan's test results wouldn't be known for two days, she was certain she was witnessing ebola. >> rose: the first time when i went in and he vomited, i was standing in front of him, he was sitting on the commode, and there was just so much, it went over the bag, it was on the walls, on the floors.

i had two pairs of gloves on and shoe covers. and i had my face shield on. i didn't have two masks on at the time, i had just one. no, we didn't have any head covers. but i wiped down the walls, wiped down the floor with some bleach wipes. >> townsend: he was having so much diarrhea and vomiting that he... you know, she was constantly having to give him the little bags that we have for... for people to vomit into. all of that was hazardous waste, and it had to be bagged and then double-bagged, and then put into a separate container that could then be disposed of later. because anything that has any of his bodily fluids on it has the potential to... to be lethal to somebody else. >> pelley: eric duncan was 42 years old, from liberia, which is ground zero for this outbreak. half of all the cases in the world are in liberia. he flew to dallas to visit family, became sick a few days

later, and then made his first visit to the dallas hospital. it was the night of september 25 when duncan first came into this emergency room. according to the hospital records, he had a temperature of 100.1. over the course of the four hours or so that he was here, his temperature spiked to 103, but then it dropped back down-- again, according to the hospital records. he told the staff that he had come from africa, but did not specify west africa or liberia. about 3:00 in the morning, with his symptoms not very severe, the staff decided to send him home with antibiotics. but three days later, he was back in the e.r., gravely ill and about as contagious as he would ever be. the virus is not transmitted though the air, but physical contact with a single viral particle can cause infection. the hospital notified state health authorities immediately, and they wanted sidia rose to ask several urgent questions of

duncan. >> rose: i explained to him, "we are under the impression that you may have been exposed to ebola. and i said, "where are you from?" and he told me liberia. and i asked, "have you been in contact with anyone who's been sick?" >> pelley: he said? >> rose: no. he said no. >> pelley: state and federal health officials wanted to know if duncan had been with anyone who had died in liberia. >> rose: and that's when he said to me his family had suffered a loss, that he had buried his daughter who had died in childbirth. >> pelley: but nurse rose says duncan told her it wasn't ebola that killed his daughter. rose told us that she reported this to the texas department of health, but then duncan denied his own story when he spoke to those officials. what information was it that he denied to the health officials? >> rose: about his travels,

about his... him burying his pregnant daughter who had died in childbirth. he denied that. he said that's not true. >> pelley: so he wasn't honest with them. >> rose: yeah. >> pelley: this is nurse richard townsend, who dressed in the protective gear that was recommended by the c.d.c. at the time, just as sidia rose did. was any of your skin exposed? >> rose: at that time, it was just a gown that i was wearing, so yeah-- not my hands, not my legs, my face. i had my face shield on, the mask with the face shield. >> pelley: so your neck was exposed? >> rose: yes. >> pelley: so the c.d.c. protocols that you would've looked up the day he came into the emergency department were, in your estimation, deficient? >> yes. >> pelley: on september 29, duncan was carried from the emergency department to intensive care. nurse nina pham, who was involved in the transfer, would become the first person to catch

the virus in the united states. it took 48 hours to get duncan's positive test results. and by then, the hospital, on its own, had equipped the staff with suits that allowed no skin to be exposed. it would be another three weeks before the c.d.c. made this its new standard. then, the hospital moved out all of the patients in medical intensive care and reconfigured the 24-bed unit for just one patient. it was a strange scene for icu nurse john mulligan. >> john mulligan: by the time i came in, they had already received the tyveks, the papers, so we had the full hazmat gear that people are used to seeing. >> pelley: is this the full suit? >> mulligan: this is the full suit, yes. there were always two of us in the room at all times, and we were designated two people to be in there. i've been in health care for nearly 20 years, and i've never emptied as much trash as just from the waste of his constant diarrhea that he was having was

remarkable. and we had these longer surgical type gloves on. they were taped to the tyvek suit, full headgear with a circulator with a hepa filter that would plug into the back. and the first time i got out of that suit, it literally looked like someone had pushed me into a swimming pool. i was drenched. >> pelley: they were working 16- to 18-hour days, spending two hours at a time in duncan's room. >> mulligan: and we held his hand and talked to him and comforted him, because his family couldn't be there. >> pelley: you held his hand through the spacesuit? >> mulligan: i did. he was glad someone wasn't afraid to take care of him, and we weren't. >> townsend: i have nothing but respect and admiration for everyone that was involved in his... in his care, you know. everyone has someone in their lives that they love and they care about. i have a five-year-old and a

three-year-old, and my wife is pregnant. and the mortality rate for pregnant women with ebola is... it's essentially 100%. >> pelley: but richard, why don't you go to the administration and say, "you know, i'm sorry, but my wife is pregnant." >> townsend: people were allowed to request not to be tasked with his care. >> krista schaefer: we asked for volunteers. everyone volunteered. >> pelley: everyone was a volunteer, everyone that was there wanted to be there? >> schaefer: every person-- housekeeping, respiratory, physicians, nurses. >> pelley: but despite all the volunteers, duncan grew worse. an experimental drug wasn't helping. >> mulligan: early saturday morning, he had become very critically ill and was placed on a respirator. >> pelley: he was intubated... >> mulligan: he was intubated. >> pelley: ...tube down his throat? >> mulligan: tube down his throat. he had a dialysis catheter placed, because his... he was not making any urine, but he needed to. he was heavily sedated and he had tears running down his eyes, rolling down his face, not just normal watering from a sedated person.

they... this was in the form of tears. and i grabbed a tissue and i wiped his eyes and i said, "you're going to be okay. you just get the rest that you need. let us do the rest for you." and it wasn't 15 minutes later, i couldn't find a pulse. and i lost him. and it was the worst day of my life. this man that we cared for, that fought just as hard with us, lost his fight. and his family couldn't be there. and we were the last three people to see him alive. and i was the last one to leave the room. and i held him in my arms.

he was alone. >> pelley: sidia, you spent perhaps the most time talking with mr. duncan, and i wonder what you think people should know about him. >> rose: he was very kind and very appreciative. even something as simple as me just giving him a cold washcloth to cool his face down, because his fever wasn't breaking-- even that he was grateful for. he told me thanks. >> pelley: within days of duncan's death, nurse nina pham was admitted to the hospital with ebola. when nina became sick, that must've sent a lightning bolt through the staff because, now, it's one of you. >> mulligan: i thought someone was playing a cruel joke until i finally looked at my phone, and saw the missed text messages and the voicemails and turned the news on and went, "oh my goodness." >> pelley: then four days later, nurse amber vinson fell ill.

both nurses have since recovered. this is nina pham leaving a hospital on friday. but many on the staff still wonder whether they could be next. are any of you, all of you, still self-monitoring for signs of infection? >> rose: i am. >> pelley: you are? you're still within the 21-dy window? >> rose: for mr. duncan, i'm passed my 21-day period. but for nina pham, i'm still being monitored. i've been asymptomatic. my temperature has been rock solid. >> pelley: those who contract the virus are not infectious until they actually become sick. members of the medical staff must take their temperature now twice a day and show the reading to a state health official. but, in at least one other way, the effect of fighting this virus could linger. >> mulligan: i would have nightmares, and still do, of my

co-workers being infected and not being able to get to a hospital and treatment and dying. and so its like any traumatic event-- this too shall pass; it's just going to take a little time. >> subs must be wach update sponsored by: >> good evening, 13 euro zone banks have failed their latest stress test. parties favoring closer economic ties to the west have claimed victory in ukraine's election. and 772 americans gave up their citizenship last quarter to avoid tougher international tax rules. i'm jeff glor, cbs news. [ male announcer ] if you had a dollar for every dollar

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>> o'donnell: there are few fields of medicine that are having a bigger impact on how we treat disease than genetics. the science of genetics has gotten so sophisticated so quickly that it can be used to not only treat serious diseases, but prevent thousands of them well before pregnancy even begins. diseases that have stalked families for generations, like breast cancer, are being literally stopped in their tracks. scientists can do that by creating and testing embryos in a lab, then implanting into a mother's womb only the ones which appear healthy. while the whole field is loaded with controversy, those who are worried about passing on defective and potentially dangerous genes see the opportunity to breed out disease. did you ever envision that you would have the capability you have today? >> mark hughes: no, but that's the fun of science, it's constantly surprising you. wow, look at that!

>> o'donnell: dr. mark hughes is one of the scientists leading the way in a rapidly growing field known as reproductive genetics. he pioneered a technique called pre-implantation genetic diagnosis, or p.g.d... >> hughes: this one's got a minus-two. >> o'donnell: ...an embryo screening procedure that can identify deadly gene mutations and alter a child's genetic destiny. >> hughes: we all throw genetic dice when we have children, but when you know the dice are loaded and that there's a really reasonable chance that your baby will have an incurable, dreadful condition, you're looking for an alternative. >> o'donnell: dr. hughes helped develop p.g.d. two decades ago to screen embryos for one disease, cystic fibrosis. today, because of advances in the mapping of the human genome, he says it can be used to root out virtually any disease caused by a single defective gene. let me do a rapid fire yes or no. can you use p.g.d. for tay- sachs? >> hughes: yes. o'donnell: muscular dystrophy? >> hughes: yes. o'donnell: sickle cell anemia? >> hughes: yes. o'donnell: hemophilia?

>> hughes: yes. o'donnell: huntington's disease? >> hughes: it's one of the most common disorders we test for, yes. o'donnell: alzheimer's disease? >> hughes: if it's a mutation in a particular gene that causes early onset, we can test for it, yes. >> o'donnell: so you can test for alzheimer's. >> hughes: this is a small subset of a particular kind of alzheimer's that attacks very early in life. o'donnell: colon cancer? >> hughes: if we know which of the colon cancer genes, yes. o'donnell: breast cancer? >> hughes: we do it regularly. >> o'donnell: dr. hughes' lab is one of a handful in the country that provides this genetic testing, which is why 3,000 couples turn to him each year, among them, matt and melinda, who asked that we not use their last name. if they hadn't done the embryo screening procedure, their four- year-old son mason and his baby sister marian might very well have been born with a genetic mutation that increases the risk of breast, ovarian, prostate, and pancreatic cancer. it wasn't until melinda herself was diagnosed with an aggressive

form of breast cancer seven years ago that she found out she carried that gene mutation known as brca1. did you know what brca1 was? >> melinda: not a clue. >> o'donnell: but as it turned out, it had haunted her family for generations. at age 29, facing chemotherapy and a double mastectomy, melinda was afraid that if she had children one day, they would also be cursed with that potentially deadly mutation. what did doctors tell you about the risk of passing on this brca mutation? >> melinda: 50%, so flip a coin. >> o'donnell: and i bet that weighed on you even heavier. >> melinda: yes. it's a lifetime of having to worry about it, and i just didn't... i didn't want my kids to have to do that. >> o'donnell: the best way to ensure that was to do embryo screening for the brca1 gene mutation, which dr. hughes says is among the fastest-growing parts of his business. >> hughes: this takes the risk... for example, in breast

cancer, it takes the risk if you have this mutation from 50/50 of passing it to the next generation down to less than 1%. >> o'donnell: but the screening isn't easy. all couples, even fertile ones, must first go through in-vitro fertilization, the process in which a man's sperm is injected into a woman's eggs under a microscope to create embryos. then, five days later, a tiny tube just one 20th the diameter of a human hair is used to extract from each embryo one single cell to be genetically tested for disease. it's just one cell? >> hughes: yes. >> o'donnell: you can tell that much from one cell? >> hughes: you can tell an awful lot in one cell. >> o'donnell: that cell is packed up at fertility clinics across the country and shipped overnight in ordinary-looking boxes like these to screening labs. we followed the process at dr. hughes' lab, called genesis genetics, just outside detroit, where a team of scientists took over.

so what do you do with that one cell when it arrives here? >> hughes: well, we're busy. we have to break the cell open. they have to pull out this enormous encyclopedia of genetic information. >> o'donnell: he's talking about the cell's dna, our genetic code that scientists represent with four letters-- a, c, t and g. for a gene to work properly, the letters have to be strung together in the right order. if they're not, that could spell trouble. it's dr. hughes job to find the mutation, or "typo," in a gene that could cause disease. >> hughes: so you have to find that typo in, effectively, six billion letters. >> o'donnell: a typo in six billion letters? >> hughes: yeah. >> o'donnell: so how do you do that? >> hughes: technology is amazing. >> o'donnell: dr. hughes used the technology to screen matt and melinda's embryos in 2010, ruling out the ones that carried the brca1 mutation, which would have given their children a reasonable chance of getting breast or other cancers. about how many of them tested positive for the brca1 gene?

>> hughes: about half and, indeed, if you look at her embryos, here is an affected, an affected, an affected, an affected-- that's four. it's about half. it is just what you'd expect. it's just what you'd expect in nature. >> o'donnell: but with the powerful intervention of science, embryos that carry a harmful mutation are often discarded, which is one reason the decision to go ahead with the screening was a difficult one for matt and melinda. >> melinda: we prayed a lot about it. it's a hard decision to make. >> o'donnell: what did you struggle with? >> melinda: was it right? was it the right thing to do? is that... is it playing god? is it ethical? and the more we learnd about it and got comfortable with the idea, it was like, "yes, absolutely." >> o'donnell: you have said, "the breast cancer stops with me"? >> melinda: yes. it's not just my children-- it's their children and my grandchildren and great grandchildren, forever and for all time, in my bloodline, yeah. >> o'donnell: the entire process cost them around $16,000, a