a.j. couldly writing in 1994 after the trial came out after we found out this. and he said when we carry out the study we saw the increased death rate was an effective chance. the a member of the drug it wasn't one of the one use in the prescribing practices in the 80s. he's being optimistic. early warning of trouble ahead. again, this understatement by trouble ahead he means the potentially avoidable death of an estimated 130,000 u.s. citizens. is this unusual? well, no. and it has an impact on the every day treatment that we make, the overred decisions we make about treatment in medicine all of the time. to understand why missing clib call trial data is important you need to understand the -- how we use evidence as doctors to make decisions. you need to understand about something call a system attic review. it's kind of embarrassing to medicine it was inconveniented so recently. [laughter] up until the '80s, if you wanted to write a book chapter for a medical textbook or review article about the treatment of, you know,let say treatment of depression in patient