the paper that was published by the by the group in the lancet is the fact that we all have these adna virus infections all the time and therefore we have preexisting immunity our body's immune system already sees the virus and that can limit the ability of the vector to induce a strong immune response but the russia work shows quite nicely that by mixing and matching different human agner viruses you can generate a very strong immune response anyway this idea of mixing and matching because we know that one dose of a vaccine is usually not sufficient particularly for a vaccine like this which is in its 1st development you need 2 doses every individual should be given at least 2 doses and what's been done very nicely in this so-called prime boost effect which has been demonstrated very nicely in the paper from russia is that you can use one particular ad no virus vector for the initial vaccination and another type of adnan virus vector for daily probably the boost and this idea of mixing and matching different approaches to generating a strong immune response is a i think is going to be