it shows that there are flaws and invulnerability is to make us one of altavista. we have made trials inappropriately expensive. we have made them this particular exception and medicine. people are desperate to do everything they can to find a benefit. when we can do it is by trusting an ideal patient population. people that are younger, healthier, people who are on no other drugs and i'm no other medical problems in a much less chance of showing a benefit. once you have done this test in this perfect population, we say are the results of this trial really applicable to my population. consisting of a lady in her 70s it is actually working here it is so preposterous on a scale of the society between the world of the trial and the reality they took out 179 patients from family doctors in the uk who had to of have known whose treatment was being managed. the best practice guidelines are the decision trees that were used. they are informed. we have real-world patients were being treated in accordance with the results. and what proportion of them would've been eligible