we'll talk about memory loss, alzehimer's disease and biological basis of wisdom and maturity.s a look at our program airing wednesday evening. >> even as a young person the way our memory system works is that we are always going for the gist. we don't care so much about the details. thankfully we don't remember everything. >> that's very good, yes. >> so that makes it possible. and older people, that's something they can do. >> that might be wisdom. >> they're getting to the gist. >> we certainly feel as though we have more wisdom, don't we? (laughter) >> speak for yourself, john! >> there is another point that emerges from this which is very encouraging. first of all, memory research is really sort of a little bit more than half a century old. so it's a relatively new discipline science. we've learned an enormous amount from people sitting around this table but what's also interesting is we have a... i'm tempted to say profound understanding of early on set alzehimer's disease which probably to some degree spreads to late onset alzehimer's disease and we have been working-- n

we'll discuss memory loss, alzehimer's disease, and the biological basis for understand memory and otherin activities. tell me how you explain your remarkable things. >> yes, brenda! >> well, i'm going to have to put gene first because... >> rose: okay, gene's first. (laughter) >> because, you know, my mother who had a harder life than i did lived to be 95 and she worked... she was in music, different career all together and she worked at teaching. she taught music and singing and... to the age of 88 and she had to stop because she was getting deaf which, fortunately, i have escaped so far. and so otherwise she would have continued. >> rose: so genes is first. >> genes is first... genes are first. >> rose: yes, genes are first. (laughter) >> british training. >> rose: thank you. fair enough. >> i think engagement... i believe in engagement in kinds of activities but not... it's very important for me to be engaged with young people and as i say when i was young i liked to be engaged with older people across the spectrum of ages and some problem that excites with curiosity. i think my real