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Jun 4, 2024
06/24
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CSPAN2
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available -- i don't know if they are full treatments, but at least improvements in how to handle alzheimer's? dr. hodes: thank you very much. as noted, it is grifying to see convergence of technologies and approaches. in this case, the progress in the past years in alzheimer's has been remarkable with the first fda approval of a drug for treatment of early-stage. what we have learned from the series of successful and unsuccessful trials is that the effect is very strongly related to the degree of decrease that can be accomplished. studies in west virginia was that the use of targeted ultrasound in combination with an antibody to amyloid increased the effect in decreasing amyloid in the brain. preliminary data, which now will be followed up, with promise for making more effective in combination the treatments we have available. sen. capito: it can be done without nih and without the innovamove over to the nci designations and clinical trials. and i don't know who wants to answer this. but, there are 14 states including my state, that don't have an nci designated cancer center. you know, you h
available -- i don't know if they are full treatments, but at least improvements in how to handle alzheimer's? dr. hodes: thank you very much. as noted, it is grifying to see convergence of technologies and approaches. in this case, the progress in the past years in alzheimer's has been remarkable with the first fda approval of a drug for treatment of early-stage. what we have learned from the series of successful and unsuccessful trials is that the effect is very strongly related to the degree...
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Jun 20, 2024
06/24
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IRINN
tv
eye 14
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it is never too late to fight alzheimer's disease. thank you for accompanying today's world to the end tonight. wishing you a peaceful night. creative experience exchange event of pottery art and volume making. in relation to the necessity of such workshops, i must say that it is one of the most important events that, along with comfort facilities. and the money for the coaches we must consider such issues because there are serious potentials in relation to these people that in such meetings , in addition to the exchange of ideas, the exchange of experience can be realized and these capacities must be used in such a way that on the way the formation of creativity, the training of teachers of the center will definitely help a lot to improve the level of education of children and teenagers, and it will lead to the development of children and the emergence of creativity in their works. traditional integrated and discipline-oriented approach it is very important. it is either aesthetic knowledge or observation of works of art, which we ca
it is never too late to fight alzheimer's disease. thank you for accompanying today's world to the end tonight. wishing you a peaceful night. creative experience exchange event of pottery art and volume making. in relation to the necessity of such workshops, i must say that it is one of the most important events that, along with comfort facilities. and the money for the coaches we must consider such issues because there are serious potentials in relation to these people that in such meetings ,...
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Jun 30, 2024
06/24
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BBCNEWS
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eye 13
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why is this relevant for alzheimer's?, of this detritus that was washed away by the glymphatic system during sleep were things called beta—amyloid and tau protein, which are two of the culprits underlying alzheimer's. there is a silver lining in all of this story of dementia and sleep, because maybe we can do something about it. you don't start to see the decline in your deep sleep that is associated with alzheimer's risk in your 60s or 70s, it's already under way. it begins in your late 30s, we can start to detect that decline. so what if i could shift from a model of late—stage treatment to a model of midlife prevention, and could we start to help the brain at that midlife stage? and in doing so, could we bend the arrow of alzheimer's disease risk down on itself? it's notjust sleep that's coming under the spotlight. there's increasing research into the long—term impact of depression. what we've developed is a way to directly measure how your brain functions. and in doing that, we can understand the root causes of mental
why is this relevant for alzheimer's?, of this detritus that was washed away by the glymphatic system during sleep were things called beta—amyloid and tau protein, which are two of the culprits underlying alzheimer's. there is a silver lining in all of this story of dementia and sleep, because maybe we can do something about it. you don't start to see the decline in your deep sleep that is associated with alzheimer's risk in your 60s or 70s, it's already under way. it begins in your late 30s,...
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Jun 20, 2024
06/24
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IRINN
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eye 27
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it's never too late to fight alzheimer's disease. thank you for accompanying today's world to the end tonight. wishing you a peaceful night. the right of the people, all the rights of the people, including the right to choose, which definitely exists for the people in the matter of government, this comes from the divine decree, the decree of allah, the holy qur'an, where it is a violation of people's rights, such as the issue of riba, which is a violation of people's property. assaulting people's rights is a war against god, because people's rights are a divine duty, a right that god has determined for people, and it is a duty that god has given to those who are in charge of people's affairs. they are responsible for the people , they put it on their shoulders, the people are god , i don't want to say this on tv, do you think that when mr. khatami won with 20 million votes, some people weren't angry, so why are they angry? they are saying the same thing. that's it. therefore, the islamic republic, as it has been stated repeatedly , i
it's never too late to fight alzheimer's disease. thank you for accompanying today's world to the end tonight. wishing you a peaceful night. the right of the people, all the rights of the people, including the right to choose, which definitely exists for the people in the matter of government, this comes from the divine decree, the decree of allah, the holy qur'an, where it is a violation of people's rights, such as the issue of riba, which is a violation of people's property. assaulting...
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Jun 8, 2024
06/24
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KDTV
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eye 145
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la buena es que no tiene alzheimer. la mala es que es sordo, por eso no escucha que ya cantó.o: menos mal, ¿verdad? lo que sí es que de la pancita está como relojito. ¿mira nomás cómo me dejó? ni yo que comí ciruela pasa. oye, vanesita, cómo se llama... zafo limpiar. vanesa: ¡pedro! [música] fÉlix: estas son las principales noticias. mÁs de 25,000,000 de personas sigue en la alerta por la ola de calor el suroeste del paÍs. en las vegas las temperaturas pueden alcanzar 115° fahrenheit. aunque los cruce fronterizo continÚan, con la nueva medida de biden, los migrantes que entren tienen un plan de cuatro horas para conseguir un abogado o ser deportados. >> vamos a ver lo que se puede hacer para que una persona haga algo en cuatro horas. fÉlix: en una operaciÓn de fuerzas especiales de israel, fueron liberado cuatro secuestrados secuestrado por el grupo hamÁs desde 7 de octubre. esta noche mÉxico se enfrenta a brasil, el jaime lozano dice que no piensa renunciar contra la goleada que sufriÓ el pri contra uruguay. >> este es el noticiero univisiÓn fin de semana. fÉlix: continÚa la
la buena es que no tiene alzheimer. la mala es que es sordo, por eso no escucha que ya cantó.o: menos mal, ¿verdad? lo que sí es que de la pancita está como relojito. ¿mira nomás cómo me dejó? ni yo que comí ciruela pasa. oye, vanesita, cómo se llama... zafo limpiar. vanesa: ¡pedro! [música] fÉlix: estas son las principales noticias. mÁs de 25,000,000 de personas sigue en la alerta por la ola de calor el suroeste del paÍs. en las vegas las temperaturas pueden alcanzar 115°...
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Jun 24, 2024
06/24
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KTVU
tv
eye 92
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but not all memory issues are alzheimer's disease. give an analogy like if i asked you to go get bread and milk and you come back with the bread and i say, where's the milk? if you say, oh, i forgot the milk, that's probably normal. that's that happens to me. sure. but if i ask the same question and you say you never asked me about the milk, and if that happens over and over again, that might be a red flag for you to speak to your doctor. >> yeah. if there's that kind of disconnect. that's right. yeah. you know, we talk about all the research that's being done to try to develop a cure where where do you see things going here in the near future? >> i think in the next ten years, there's going to be an explosion of interventions. we are looking at trying to clean up the plaque, the gunk that's in the brain. and so i think the next phase of medications that will be out there for us is going to be those types of medications. the antibodies that go in and try to target the things that are not supposed to be there. that's the next phase. >>
but not all memory issues are alzheimer's disease. give an analogy like if i asked you to go get bread and milk and you come back with the bread and i say, where's the milk? if you say, oh, i forgot the milk, that's probably normal. that's that happens to me. sure. but if i ask the same question and you say you never asked me about the milk, and if that happens over and over again, that might be a red flag for you to speak to your doctor. >> yeah. if there's that kind of disconnect....
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Jun 6, 2024
06/24
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CNBC
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eye 72
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blockbuster alzheimer's drug.decision that could reshape the alzheimer's treatment landscape. right after this. you're watching "fast money" from the nasdaq market site in times square. times square. we're back right after this. and 5g solutions from t-mobile for business. t-mobile connects 100,000 delta airlines employees, powers tractor supply's on game changing innovation. this is how business goes further with t-mobile for business. she runs and plays like a puppy again. his #2s are perfect! he's a brand new dog, all in less than a year. when people switch their dog's food from kibble to the farmer's dog, they often say that it feels like magic. but there's no magic involved. (dog bark) it's simply fresh meat and vegetables, with all the nutrients dogs need— instead of dried pellets. just food made for the health of dogs. delivered in packs portioned for your dog. it's amazing what real food can do. ♪♪ sandals jamaica sale is now on! blockbuster alzheimer's drug. ga, the advanced form of dry age-related macula
blockbuster alzheimer's drug.decision that could reshape the alzheimer's treatment landscape. right after this. you're watching "fast money" from the nasdaq market site in times square. times square. we're back right after this. and 5g solutions from t-mobile for business. t-mobile connects 100,000 delta airlines employees, powers tractor supply's on game changing innovation. this is how business goes further with t-mobile for business. she runs and plays like a puppy again. his #2s...
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Jun 10, 2024
06/24
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KGO
tv
eye 73
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one of the hallmarks of alzheimer's disease. and so it's an infusion in that would be given to patients in the earliest stages of the of the disease. that helps to reduce that build up of plaque, which in turn has shown in clinical trials to uh- to have an impact on the underlying biology of alzheimer's disease. >> so, fda drug reviewers said last week that if approved, anonymous risk of brain swelling and bleeding would be described in the box warning. reports have indicated three people in the trial did die from complications linked to the treatment. so how would you compare the risks and side effects between this drug versus the recently approved luchembe? >> yes. so it's pretty similar. and what they're describing is something that's known as aria or amyloid related uh- uh- imaging abnormality. that's just going to be a result of any of these monoclonal antibodies, any of these anti amyloid drugs. this is going to be a potential risk. i think every family and patient has to make those decisions based on their own. but in som
one of the hallmarks of alzheimer's disease. and so it's an infusion in that would be given to patients in the earliest stages of the of the disease. that helps to reduce that build up of plaque, which in turn has shown in clinical trials to uh- to have an impact on the underlying biology of alzheimer's disease. >> so, fda drug reviewers said last week that if approved, anonymous risk of brain swelling and bleeding would be described in the box warning. reports have indicated three people...
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63
Jun 13, 2024
06/24
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KTVU
tv
eye 63
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so alzheimer's disease is due to the accumulation of this protein called amyloid. and it's the first thing that changes in the brains of people with alzheimer's disease and leads to those symptoms of memory loss and cognitive changes. and what donanemab does, it's an immunotherapy. so it clears that amyloid by stimulating the immune system and it slows the progression down. it's not a cure. and it doesn't stop progression. but it's the first time we're really seeing meaningful slowing of alzheimer's disease. keeping patients at an earlier stage longer where they get less functional declines. and that's very meaningful for patients. they can stay in the community, they can continue to drive. they can continue to enjoy their lives with keeping them in that earlier stage longer. >> so as an expert in this field, are you going to be looking at this particular drug as something maybe you can push forward and maybe extend memory for a lot longer, or clearing out the plaque that's causing the memory issues? >> yeah. so this is the second medication that's been shown to do
so alzheimer's disease is due to the accumulation of this protein called amyloid. and it's the first thing that changes in the brains of people with alzheimer's disease and leads to those symptoms of memory loss and cognitive changes. and what donanemab does, it's an immunotherapy. so it clears that amyloid by stimulating the immune system and it slows the progression down. it's not a cure. and it doesn't stop progression. but it's the first time we're really seeing meaningful slowing of...
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63
Jun 15, 2024
06/24
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CSPAN2
tv
eye 63
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alzheimer's disease, which has an increased risk in women. meerall.he menopause transition.al heah a normal time of life, but the change in hormones can be incredibly disruptive, and there are also long-term health still haven't developed the treatments and approaches that we need, although we have made. and then, finally, what is our approach? we are taking, instead of a bit by bit approach, we want to take a lifespan approach to women's health. a much more comprehensive and lifespan approach that coordinates across all our sen. murray: i appreciate your attention to that and i thinkpeak on behalf of many of us that we really want to see what we can do to make sure that nih is focusing on it. with a number of women senators making sure that we have the research and knowl coordinate what we are doing here and have a better focus. i think it was senator murkowski who said to us, if men went through menopause we would have an institute at nih. we aren't askingt. we are just asking to make sure we really focus on it. so, thank you. chair baldwin: vice ch
alzheimer's disease, which has an increased risk in women. meerall.he menopause transition.al heah a normal time of life, but the change in hormones can be incredibly disruptive, and there are also long-term health still haven't developed the treatments and approaches that we need, although we have made. and then, finally, what is our approach? we are taking, instead of a bit by bit approach, we want to take a lifespan approach to women's health. a much more comprehensive and lifespan approach...
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Jun 11, 2024
06/24
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KNTV
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eye 72
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to slow cognitive decline and memory problems due to alzheimer's.er this year, a different drug was pulled from the market. so i imagine many at home are wondering how effective are these drugs and how do we know what exhale works? >> we know how they work because of the clinical studies that were done. the traditional placebo-controlled trial. both drugs, i think the encouraging part, the one previously approved, it looks like it may get approval later this year. they both slowed progression of disease. we see this conceptis of getting rid of the deposits in the brains in alzheimer's. was that going to slow the disease down. now we have two separate studies that indicate that. it's pretty exciting. it's just the beginning. the effects are modest. but we're excited that we have something that affects the disease. >> at least there's nothing now. >> 7 million nearly americans are living with alzheimer's and dementia. talk about the early warning signs and how do doctors, is there a way to test for alzheimer's coming on? >> sure. i think we have incre
to slow cognitive decline and memory problems due to alzheimer's.er this year, a different drug was pulled from the market. so i imagine many at home are wondering how effective are these drugs and how do we know what exhale works? >> we know how they work because of the clinical studies that were done. the traditional placebo-controlled trial. both drugs, i think the encouraging part, the one previously approved, it looks like it may get approval later this year. they both slowed...
115
115
Jun 9, 2024
06/24
by
KDTV
tv
eye 115
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fÉlix: la comunidad cientÍfica mundial reconoce estudios sobre el mal de alzheimer. ♪ ♪ [mÚsica] ♪ ♪r. vivimos para monitorear precios de vuelos al paraíso. salonpas lidocaine flex. un parche superdelgado y flexible con la máxima concentración de lidocaína de venta libre... que se adapta al cuerpo para aliviar el dolor justo donde duele. además, es superadherente. salonpas. es buena medicina. ¿qué estamos celebrando? con t-mobile, podemos obtener muchísimos beneficios, y aún así ahorrar. ¿quién no ama las sorpresas? cámbiate a t-mobile y puedes obtener beneficios y ahorros. descubre cómo con nuestra calculadora de ahorros. además, obtén el samsung galaxy s24 por cuenta nuestra. ♪♪ ella le agrega downy unstopables a su carga. ahora olerá fresco todo el día. aún fresco. aún fresco. todavía fresco. frescura 6 veces más duradera y protección contra los olores con downy unstopables. "you've got a friend in me. you've got a friend in me you just remember what your old pal said frescura 6 veces más duradera y protección contra boy, you've got a friend in me." cada momento en pixar fest es u
fÉlix: la comunidad cientÍfica mundial reconoce estudios sobre el mal de alzheimer. ♪ ♪ [mÚsica] ♪ ♪r. vivimos para monitorear precios de vuelos al paraíso. salonpas lidocaine flex. un parche superdelgado y flexible con la máxima concentración de lidocaína de venta libre... que se adapta al cuerpo para aliviar el dolor justo donde duele. además, es superadherente. salonpas. es buena medicina. ¿qué estamos celebrando? con t-mobile, podemos obtener muchísimos beneficios, y aún...
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85
Jun 11, 2024
06/24
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KGO
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eye 85
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. >> new developments tonight in the fight against alzheimer's. a new treatment just got an early green light from fda advisers. the newest experimental drug is called donanemab. it targets plaque build up in the brain. studies found it slowed cognitive decline for patients in the early stages of alzheimer's. the drug does have significant safety risks, including swelling and bleeding in the brain. today, an fda committee found the consequences of alzheimer's are severe enough that any benefit outweighs those dangers. >> that potentially gives them more time to stay independent, to make decisions for themselves and to live well with alzheimer's disease. >> an estimated 7 million americans are living with alzheimer's. the fda still has to give final approval for the new drug. >> meantime, the fda is teaming up with the department of justice to crack down on the sale of illegal vapes. they're creating a task force to enforce tobacco laws, which can result in felony convictions, criminal fines as well. it comes just after the fda sent out over a thou
. >> new developments tonight in the fight against alzheimer's. a new treatment just got an early green light from fda advisers. the newest experimental drug is called donanemab. it targets plaque build up in the brain. studies found it slowed cognitive decline for patients in the early stages of alzheimer's. the drug does have significant safety risks, including swelling and bleeding in the brain. today, an fda committee found the consequences of alzheimer's are severe enough that any...
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156
Jun 20, 2024
06/24
by
KDTV
tv
eye 156
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la seÑora llegÓ a 70 sin padecer alzheimer.mutaciÓn, una copia de la mutaciÓn y de eso 121.27 tenÍan las dos. >> esos datos han arrojado excelente informaciÓn, segÚn explica la doctora. aunque la seÑora falleciÓ, los cientÍficos se han concentrado en tratar de replicar esa protecciÓnse produce la naturaleza. >> un medicamento que se desarrolle, copio replique bÁsicamente que copie esos 27 tenÍa, puede tener un efecto no sÓlo para los que estÁn en riesgo genÉtico como en colombia, sino para la poblaciÓn en general. >> se ha comenzado a experimentar con ratas de laboratorio. >> estÁ todavÍa en estudios experimentales, pero demuestra que puede ser efectiva futuro. >> pero menos del 1% ha trasmitido de generaciÓn en generaciÓn que desencadena la enfermedada edades inusualmente tempranas . regreso contigo. elian: a partir de julio millones de personas verÁn una reducciÓn en sus pagos por deudas estudiantiles. serÁn gracias al mayor cambio en el sistema federal de deudas estudiantiles que ha aportado el gobierno. nuevo plan ofrece pl
la seÑora llegÓ a 70 sin padecer alzheimer.mutaciÓn, una copia de la mutaciÓn y de eso 121.27 tenÍan las dos. >> esos datos han arrojado excelente informaciÓn, segÚn explica la doctora. aunque la seÑora falleciÓ, los cientÍficos se han concentrado en tratar de replicar esa protecciÓnse produce la naturaleza. >> un medicamento que se desarrolle, copio replique bÁsicamente que copie esos 27 tenÍa, puede tener un efecto no sÓlo para los que estÁn en riesgo genÉtico como...
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156
Jun 19, 2024
06/24
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CNNW
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eye 156
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how much of alzheimer's is preventable yeah, that's a great question. and i think if you had to put a number on it i'd say around 40% and this is based on not only data here in the united states, but all over the world. >> you've had richard isaacson has this preventive neurology clinic, but there are these preventive neurologist places in different places around the world where they've been looking at people saying, okay, we're going to implement certain lifestyle changes. and let's see what happens to people who do that versus people who don't some of the lifestyle changes we can just throw them up on the screen are going to sound pretty basic. but here's the thing. we now know when you do these things for about 20 weeks about five weeks, people who went through these lifestyle changes versus those who didn't either didn't progress in terms of cognitive impairment or anderson, they even gop better. >> it was able to reverse the signs of cognitive impairment early cognitive impairment. >> and people who had been diagnosed with alzheimer's. so vegan die
how much of alzheimer's is preventable yeah, that's a great question. and i think if you had to put a number on it i'd say around 40% and this is based on not only data here in the united states, but all over the world. >> you've had richard isaacson has this preventive neurology clinic, but there are these preventive neurologist places in different places around the world where they've been looking at people saying, okay, we're going to implement certain lifestyle changes. and let's see...
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70
Jun 11, 2024
06/24
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KGO
tv
eye 70
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one of the hallmarks of alzheimer's disease.'s an infusion in that would be given to patients in the earliest stages of the of the disease. that helps to reduce that buildup of plaque, which in turn has shown in clinical trials to have an impact on the underlying biology of alzheimer's disease. >> so, fda drug reviewers said last week that if approved, an enemy's risk of brain swelling and bleeding would be described in the box warning reports have indicated three people in the trial did die from complications linked to the treatment. so how would you compare the risks and side effects between this drug versus the recently approved leckenby? >> yes. so it's pretty similar. and what they're describing is something that's known as aria or amyloid related uh- uh- imaging abnormality. that's just going to be a result of any of these monoclonal antibodies, any of these anti-amyloid drugs. this is going to be a potential risk. i think every family and patient has to make those decisions based on their own. but in some of the clinical
one of the hallmarks of alzheimer's disease.'s an infusion in that would be given to patients in the earliest stages of the of the disease. that helps to reduce that buildup of plaque, which in turn has shown in clinical trials to have an impact on the underlying biology of alzheimer's disease. >> so, fda drug reviewers said last week that if approved, an enemy's risk of brain swelling and bleeding would be described in the box warning reports have indicated three people in the trial did...
SFGTV: San Francisco Government Television
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37
Jun 16, 2024
06/24
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SFGTV
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eye 37
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especially the alzheimer's? >> no, there is no income eligibility requirement, but the target population is low income and many of the centers providing sliding scale to allow those two participants and as you know, some of the centers may have receiving funding from cms, center for medi-cal medicaid to reimburse the service they provide so that doesn't count into the participants to present. those are really the one fill thg gap they need support and may not afford and our organization really making the effort to make that affordable and to approve the grants, we allow the city continue to save this infrastructure in our community. >> someone hears about this, they should see if they can take advantage of it and shouldn't be inhibited thinking it is only low income and have a idea what that might mean and should check it out, right? >> yes. >> that's good to understand. >> other questions by commission? so, i just want to make sure the last comment was really on point. i want to make sure i understand, because
especially the alzheimer's? >> no, there is no income eligibility requirement, but the target population is low income and many of the centers providing sliding scale to allow those two participants and as you know, some of the centers may have receiving funding from cms, center for medi-cal medicaid to reimburse the service they provide so that doesn't count into the participants to present. those are really the one fill thg gap they need support and may not afford and our organization...
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207
Jun 25, 2024
06/24
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KGO
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eye 207
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. >>> and the famous actress now battling alzheimer's. >>> first tonight, that severe storm threat from the midwest to the northeast. dangerous thunderstorms, possibly damaging winds. ginger zee standing by with the forecast. >>> the high stakes earliest ever presidential debate, just 48 hours away now, thursday night. president biden and the mock 90-minute debates at camp david. donald trump and what he's saying about biden's ability on that debate stage. and about the new rules involving mics and no audience. >>> tonight, special counsel jack smith revealing never before seen photos showing classified documents and how they were allegedly stored at mar-a-lago, amid accusations from trump's team that fbi agents mishandled the documents. and in new york tonight, the gag order partially lifted in the hush money case, where a jury convicted donald trump. so, what does this mean now that he can talk about it with this debate coming? >>> tonight, for the first time, martha raddatz on the $230 million u.s.-built pier off gaza. she is there to report on this being built to deliver humanitaria
. >>> and the famous actress now battling alzheimer's. >>> first tonight, that severe storm threat from the midwest to the northeast. dangerous thunderstorms, possibly damaging winds. ginger zee standing by with the forecast. >>> the high stakes earliest ever presidential debate, just 48 hours away now, thursday night. president biden and the mock 90-minute debates at camp david. donald trump and what he's saying about biden's ability on that debate stage. and about...
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Jun 11, 2024
06/24
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CNBC
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eye 53
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they are working with a very exciting alzheimer's drug. the fda's peripheral and central nervous systems drugs advisory committee held a media. the results passed all expectations. this one is new. i know viewers along with the investing club they give my endless endorsements of the stock. it's a very good outcome. the advisory committee voted unanimously on the questions voted. they said one the drug is effective and the benefits of the negative outweigh the risk. because there's something of these happening. we didn't know how the advisory committee would rule. it wasn't a given. they released background documents ahead of the media with a couple of areas. it looked like his drug could potentially get a ding on safety crafts. three patients died from a condition. there were zero deaths from that cause in the placebo group. more deaths generally in the group that got the drug been in the placebo group which is a sign that something is going to get approved. you never want to see more deaths in the aftermath of the medication so they fear
they are working with a very exciting alzheimer's drug. the fda's peripheral and central nervous systems drugs advisory committee held a media. the results passed all expectations. this one is new. i know viewers along with the investing club they give my endless endorsements of the stock. it's a very good outcome. the advisory committee voted unanimously on the questions voted. they said one the drug is effective and the benefits of the negative outweigh the risk. because there's something of...
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55
Jun 14, 2024
06/24
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FBC
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eye 55
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stuart: fda to i approve eli lilly's alzheimer drug and they want it on the market.ed [inaudible] and similar to another one already on the market and when the fda advisers say approve, they're going to approve and it'll be available and useful for once a month and center for medicare and medicaid services made what can be available already and cover it had and they're going to make this available and cover it but the catch is may not be able to afford all the copays and tests to qualify for it and, stuart, it's got a lot of side effects and leads to brain swelling and can lead to brain bleeding and how does it work you ask? it's stops plaque formation of the beta amyloid plaques in the brain that are associated with alzheimer and not all that alzheimer is about and also about pro teen and inplay makers nation and have a long way to go before they figure this out and decreases progression by about 35% and is it worth the risk of the swelling i talked about? that's a one-on-one question and i'm glad it's going on the market. stuart: the centers for disease control war
stuart: fda to i approve eli lilly's alzheimer drug and they want it on the market.ed [inaudible] and similar to another one already on the market and when the fda advisers say approve, they're going to approve and it'll be available and useful for once a month and center for medicare and medicaid services made what can be available already and cover it had and they're going to make this available and cover it but the catch is may not be able to afford all the copays and tests to qualify for it...
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13
Jun 4, 2024
06/24
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RUSSIA24
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, he believes that he rules the world, it’s not alzheimer’s who really rules the world, but it’s notiving embodiment of alzheimer should feel like the ruler of the world, well by the way, this is what they have in common, they generally... somehow are not on friendly terms, they don’t understand what they are saying, here they say that the russians are completely rude, they question our hegemony, they challenge us in other parts of the world, says some idiot. soldier, they betrayed him, they betrayed the officer corps, they betrayed the military-industrial complex, they considered themselves in the nineties to almost save humanity, they filled the countries from which they left with blood, they stopped supporting the middle east, they forgot about africa, they surrendered all their allies for once , they allowed to destroy yugoslavia, the war in iraq, zero reaction, they gave up afghanistan. class, well, grandfather dementar is happy, that’s it, they are already calling openly to defeat us, win, and promote peace and democracy, in general they have such an interesting definition peac
, he believes that he rules the world, it’s not alzheimer’s who really rules the world, but it’s notiving embodiment of alzheimer should feel like the ruler of the world, well by the way, this is what they have in common, they generally... somehow are not on friendly terms, they don’t understand what they are saying, here they say that the russians are completely rude, they question our hegemony, they challenge us in other parts of the world, says some idiot. soldier, they betrayed him,...
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Jun 11, 2024
06/24
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KGO
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. >> new developments tonight in the fight against alzheimer's. new treatment just got an early green light from fda advisers. the newest experimental drug is called donanemab. it targets plaque build up in the brain. studies found it slowed cognitive decline for patients in the early stages of alzheimer's. the drug does have significant safety risks, including swelling and bleeding in the brain. today, an fda committee found the consequences of alzheimer's are severe enough that any benefit outweighs those dangers. >> that potentially gives them more time to stay independent, to make decisions for themselves and to live well with alzheimer's disease. >> an estimated 7 million americans are living with alzheimer's. the fda still has to give final approval for the new drug. >> meantime, the fda is teaming up with the department of justice to crack down on the sale of illegal vapes. they're creating a task force to enforce tobacco laws, which can result in felony convictions, criminal fines as well. it comes just after the fda sent out over a thousa
. >> new developments tonight in the fight against alzheimer's. new treatment just got an early green light from fda advisers. the newest experimental drug is called donanemab. it targets plaque build up in the brain. studies found it slowed cognitive decline for patients in the early stages of alzheimer's. the drug does have significant safety risks, including swelling and bleeding in the brain. today, an fda committee found the consequences of alzheimer's are severe enough that any...
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Jun 12, 2024
06/24
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KDTV
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eye 156
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y muy triste porque no reconoce a sus hijos y su esposo dice que su cuÑada sufre de alzheimer y que lade alimentos y medicamentos recomendÓ que aprueben para tratar el alzheimer y todos los medicamentos que tenemos es para mejorar los sÍntomas, pero no cambiaba el curso de la enfermedad y hacemos posible que podemos decrecer el curso de la enfermedad o pararla. demostraron que puede combatir la agresiva enfermedad al mostrar su agresiÓn y algo que no se habÍa logrado en tres dÉcadas de intentos fallidos y hacemos posibles que desee provoca anticuerpos y que ataque y la destruyan porque es la causante por lo cual las neuronas mueren y el fÁrmaco no es una cura y el tratamiento puede causar inflamaciÓn y sangrado en algunos pacientes puede ser grave e incluso mortal y si la fda da la aprobaciÓn, el fÁrmaco se sumarÍa a otro medicamento que ya estÁ en el mercado y los pacientes serÍan tratados por medio de inclusiones y los estudios revelaron que la mayorÍa de pacientes podrÍa suspender el tratamiento en tan sÓlo un aÑo. presentadora: muchÍsimas gracias a todos, o y con impotencia los due
y muy triste porque no reconoce a sus hijos y su esposo dice que su cuÑada sufre de alzheimer y que lade alimentos y medicamentos recomendÓ que aprueben para tratar el alzheimer y todos los medicamentos que tenemos es para mejorar los sÍntomas, pero no cambiaba el curso de la enfermedad y hacemos posible que podemos decrecer el curso de la enfermedad o pararla. demostraron que puede combatir la agresiva enfermedad al mostrar su agresiÓn y algo que no se habÍa logrado en tres dÉcadas de...
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Jun 19, 2024
06/24
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CNNW
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there are new tools to battle the disease sanchez latest documentary, the last alzheimer's patient is now streaming on max, part of our parent company good luck in the five years of making this documentary, the 20-year-old newlyweds i've met with patients all around the country who were dying like nose toward high risk for this devastating disease. do remember this time in your life, my it made me really start to think about my own brain i have a family history of alzheimer's as well sometimes i feel a little rusty sometimes i worry that i make mistake seeks that maybe my friends and family are too polite to tell me about your body composition. so that's why i decided to do something quite personal. >> your muscle mass your body fat, quite revealing that weapon quite right. i went through a battery of tests to assess my own risk. >> it's like we get a cholesterol test every year and check your blood pressure. >> i do the same thing for the brain. and what did i find? >> i'll just say it joining me now, neurosurgeon, cnn chief medical correspondent, dr. sanjay gupta. so should people b
there are new tools to battle the disease sanchez latest documentary, the last alzheimer's patient is now streaming on max, part of our parent company good luck in the five years of making this documentary, the 20-year-old newlyweds i've met with patients all around the country who were dying like nose toward high risk for this devastating disease. do remember this time in your life, my it made me really start to think about my own brain i have a family history of alzheimer's as well sometimes...
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Jun 7, 2024
06/24
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FOXNEWSW
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your mother died from alzheimer's and her family as well. what do i have to do. how do you explain what you put this group through? >> well, it's the same lifestyle program that we use in all of our settings over the last 445 years. it's essentially a whole foods plant based diet low in fat and sugar. moderate exercise, both resistance training and aerobic, meditation and other stress management techniques and support groups to reduce essence to eat well, move more, stress less and love more. i think that what our unique contribution over the last 45 years has been to use these very high tech, state of the art scientific measures to prove how powerful these simple lifestyle changes can often be. >> steve: what you noticed with this group is they actually seemed to improve after 20 weeks on the program. the thing about the program, dean, is it's free. it's free to walk around the neighborhood. it's free to change your diet. it's free to talk to your family. >> we designed it that way. all you need is a pair of walking shoes, maybe a yoga mat,
your mother died from alzheimer's and her family as well. what do i have to do. how do you explain what you put this group through? >> well, it's the same lifestyle program that we use in all of our settings over the last 445 years. it's essentially a whole foods plant based diet low in fat and sugar. moderate exercise, both resistance training and aerobic, meditation and other stress management techniques and support groups to reduce essence to eat well, move more, stress less and love...
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Jun 29, 2024
06/24
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CSPAN
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eye 25
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we will see innovative paents.nts available f we hav for alzheimer's and disease therapies that make he different trajectories are cures in a way4u face a lifetime of procedures and hospitalizations driving up costs■x a therapy could reduce need so when you look at all of that how do you assess new therapies and determine howey should be covered? >> one is we have a complex system so insurance, of insurance is based on employers. if you change jobs you may change health plans and one issue that emerges is when you have therapy use money, it will not save the person paying for the therapy so it can be challenging and if your employer you are thinking is this person going health plan in three years, in 10 years? so that is a challenge for a payer, whether it is the commercial market or medicare to stepping role is limited. in markelace private sector plans decide coverage, they are required to cover it. ■i■imedicaid, have a bargain with drug companies. bnthe drug will be provided if they give money to the federal government. it is been challenging to afford incredible therapies which i
we will see innovative paents.nts available f we hav for alzheimer's and disease therapies that make he different trajectories are cures in a way4u face a lifetime of procedures and hospitalizations driving up costs■x a therapy could reduce need so when you look at all of that how do you assess new therapies and determine howey should be covered? >> one is we have a complex system so insurance, of insurance is based on employers. if you change jobs you may change health plans and one...
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Jun 19, 2024
06/24
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1TV
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epilepsy, alzheimer's, parkinson's for tens of thousands of people who have been helped at the centers time, these diagnoses are no longer a death sentence. unique operations, new directions, treatment technologies, about what is still within the reach of the country's leading specialists, in the report by yulia onishchenko. when he writes, yes, he holds a pen, the hand spasms, so today we will have an operation that will allow all these symptoms eliminate. it is not just difficult for a forty-year-old patient to write, the woman experiences discomfort, weakness, pain without exaggeration, this disease twists her arms, the cause of brain damage, until recently, the only and often unsuccessful treatment was pills, but now there is a breakthrough, the latest technique is used in the neurotechnology center of the fmba, with a beam ultrasonic beams without incision. the technology also helps people with parkinson’s disease; of course, the problem does not completely go away, but tremors or hand trembling become less. need to say, here, treatment is selected individually for each patient.
epilepsy, alzheimer's, parkinson's for tens of thousands of people who have been helped at the centers time, these diagnoses are no longer a death sentence. unique operations, new directions, treatment technologies, about what is still within the reach of the country's leading specialists, in the report by yulia onishchenko. when he writes, yes, he holds a pen, the hand spasms, so today we will have an operation that will allow all these symptoms eliminate. it is not just difficult for a...
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Jun 20, 2024
06/24
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CNNW
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alzheimer's is the focus of dr.ta is latest documentary, the last alzheimer's patient, which is now streaming on max yesterday. >> we asked you to submit questions that you might have for sanjay. >> and today the doctor is in. >> so let me bring in cnn's chief medical correspondent, dr. sanjay gupta, also a neurosurgeon. so gita from houston asks you sanjay, quote can daily mental exercises are doing words with friends or paper-based crossword puzzles, reduce your odds of getting dementia. that's actually my question to sanjay, because i'm doing these word games and such, because i read somewhere that keeping your brain active can help is that, is that real yeah. >> well, i think it can help. i think what if keith us asking can it actually reduce your risk of dementia later on in life? that would tell you, i think the evidence is less clear on that. what what were you seem to here is that if you're doing a lot of crossword puzzles, it may help a little bit with your working memory but what it mainly does is making g
alzheimer's is the focus of dr.ta is latest documentary, the last alzheimer's patient, which is now streaming on max yesterday. >> we asked you to submit questions that you might have for sanjay. >> and today the doctor is in. >> so let me bring in cnn's chief medical correspondent, dr. sanjay gupta, also a neurosurgeon. so gita from houston asks you sanjay, quote can daily mental exercises are doing words with friends or paper-based crossword puzzles, reduce your odds of...
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Jun 19, 2024
06/24
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CNNW
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welcome to the lean on jake tapper this hour, there are new signs of hope in the fight against alzheimer, which in fact nearly 7 million americans, cnn's dr. sanjay gupta is here to break it all down for us. plus, i'm going to be joined by two parents on a mission to bring their son home, hertz golden for poland was kidnapped by hamas at the nova music festival october 7. and now his mom and dad are back in washington in studio with a message for the world's leading this hour, so many americans are wondering just how safe air travel is as we keep hearing flight controls getting jammed as pilots try to land or an entire piece of a plane billowing out mid-flight. today, we're hearing from a boeing whistleblower, a former senior manager at the company you said on cnn that the manufacturing at boeing is rushed and employees are under pressure to get planes in the air. whistleblower ed pearson also slammed boeing leadership calling the ceo david calhoun greedy and invasive. pearson is so concerned he won't even fly on boeing, max planes anymore i did four a plane and i actually had to get off
welcome to the lean on jake tapper this hour, there are new signs of hope in the fight against alzheimer, which in fact nearly 7 million americans, cnn's dr. sanjay gupta is here to break it all down for us. plus, i'm going to be joined by two parents on a mission to bring their son home, hertz golden for poland was kidnapped by hamas at the nova music festival october 7. and now his mom and dad are back in washington in studio with a message for the world's leading this hour, so many americans...
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Jun 27, 2024
06/24
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BLOOMBERG
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but i would say alzheimer's is a tough space. one of the things that's very hard is you need to interview very early because it's a very slowly progressing disease. identifying what to treat the patients with is really difficult. david: cancer related drugs, there are cancer related drugs and i guess you have some as well, they tend to deal with cancer. once you have cancer they tried to ameliorate the side effects of it. what about something that prevents cancer? david: that is something of heavy interest in the field. in our country we got great data that could be given to women who have had their breast and then to prevent recurring where there's a lot of interest right now is can you identify things in the blood, things are circulating, circulating tumor dna that would show the cancer is starting to happen in the body but well before being detectable in any kind of scan. if we could get those tests up to an adequate level of decision -- precision, you could treat patients well before cancer shows up, that would be the big opp
but i would say alzheimer's is a tough space. one of the things that's very hard is you need to interview very early because it's a very slowly progressing disease. identifying what to treat the patients with is really difficult. david: cancer related drugs, there are cancer related drugs and i guess you have some as well, they tend to deal with cancer. once you have cancer they tried to ameliorate the side effects of it. what about something that prevents cancer? david: that is something of...
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Jun 10, 2024
06/24
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CNBC
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they talked about how they're living relatively normal lives despite having alzheimer's.weigh that against potentially deadly brain swefling and bleeding. now, we have to wait and see how the fda moves forward with these recommendations. melissa? >> who is it approved for, angelica? and do people who take it, do they have to be scanned for tau? that was sort of seen as a barrier, because that would increase the cost, because you would have to have pet scans, et cetera. >> the drug is not currently approved, that's what we're waiting to see here, but the panelists were against the idea of scanning for tau, because they thought that it would make it inaccessible, particularly in communities, in rural areas, where they might not have access to this specific monitoring. so, the panelists recommended a broad approval for this drug, and no specific monitoring. >> okay, so, that's good news for lilly. angelica, thank you. so, we've discussed this before, and jared holz was just on this morning saying he thinks this is, in terms of the competitor in the market already, it's a goo
they talked about how they're living relatively normal lives despite having alzheimer's.weigh that against potentially deadly brain swefling and bleeding. now, we have to wait and see how the fda moves forward with these recommendations. melissa? >> who is it approved for, angelica? and do people who take it, do they have to be scanned for tau? that was sort of seen as a barrier, because that would increase the cost, because you would have to have pet scans, et cetera. >> the drug...
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Jun 17, 2024
06/24
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KGO
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she developed agitation that may happen with dementia due to alzheimer's disease. sometimes she'd fidget with her fingers, get suddenly overwhelmed, and even throw things. and that was just never her. so we asked her doctor what else we could do. rexulti is the only fda-approved medication proven to reduce agitation symptoms that may happen with dementia due to alzheimer's disease. rexulti can cause serious side effects. elderly dementia patients have increased risk of death or stroke. report fever, stiff muscles, and confusion, which can be life-threatening, or uncontrolled muscle movements, which may be permanent. high blood sugar which can lead to coma or death; weight gain; increased cholesterol; low white blood cells; unusual urges; dizziness on standing; falls; seizures; trouble swallowing, or sleepiness may occur. rexulti helped reduce my mom's symptoms. take action for your loved one. ask their doctor about rexulti. (man) every time i needed a new phone, take action for your loved one. i had to switch carriers... (roommate) i told him...at verizon, everyone
she developed agitation that may happen with dementia due to alzheimer's disease. sometimes she'd fidget with her fingers, get suddenly overwhelmed, and even throw things. and that was just never her. so we asked her doctor what else we could do. rexulti is the only fda-approved medication proven to reduce agitation symptoms that may happen with dementia due to alzheimer's disease. rexulti can cause serious side effects. elderly dementia patients have increased risk of death or stroke. report...
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Jun 30, 2024
06/24
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BLOOMBERG
tv
eye 61
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i would say alzheimer's is a tough space. one thing that is hard is you need to intervene very early, because it's a slowly-progressing disease. and identifying which patients to intervene on and figuring out what to treat them with is very difficult. david: cancer-related drugs. there are some cancer-related drugs -- and i guess you have some as well, but they tend to deal with cancer. once you have cancer, they try to ameliorate the side effects of it or the effects of it. what about something that prevents cancer? is that realistic in my lifetime? dr. narashimhan: that is something that's a heavy interest of the field, and at our company we just got great data on a breast cancer drug that can be given to women who have had breast cancer, and prevent it from recurring. where there's a lot of interest right now is can you identify things in the blood, things that are circulating, tumor dna, that would show the cancer is starting to happen in the body but well before it would be detectable in any scan? if we can get those tes
i would say alzheimer's is a tough space. one thing that is hard is you need to intervene very early, because it's a slowly-progressing disease. and identifying which patients to intervene on and figuring out what to treat them with is very difficult. david: cancer-related drugs. there are some cancer-related drugs -- and i guess you have some as well, but they tend to deal with cancer. once you have cancer, they try to ameliorate the side effects of it or the effects of it. what about...
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Jun 5, 2024
06/24
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KPIX
tv
eye 75
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she developed agitation that may happen with dementia due to alzheimer's disease. suddenly overwhelmed, and even throw things. and that was just never her. so we asked her doctor what else we could do. rexulti is the only fda-approved medication proven to reduce agitation symptoms that may happen with dementia due to alzheimer's disease. rexulti can cause serious side effects. elderly dementia patients have increased risk of death or stroke. report fever, stiff muscles, and confusion, which can be life-threatening, or uncontrolled muscle movements, which may be permanent. high blood sugar which can lead to coma or death; weight gain; increased cholesterol; low white blood cells; unusual urges; dizziness on standing; falls; seizures; trouble swallowing, or sleepiness may occur. rexulti helped reduce my mom's symptoms. take action for your loved one. ask their doctor about rexulti. ♪ ♪ >> james: finally, tonight's "heart of america" and the power of mentoring. in the nation's largest school district, where more than 70% of the students are low income, hundreds gather
she developed agitation that may happen with dementia due to alzheimer's disease. suddenly overwhelmed, and even throw things. and that was just never her. so we asked her doctor what else we could do. rexulti is the only fda-approved medication proven to reduce agitation symptoms that may happen with dementia due to alzheimer's disease. rexulti can cause serious side effects. elderly dementia patients have increased risk of death or stroke. report fever, stiff muscles, and confusion, which can...
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Jun 11, 2024
06/24
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KGO
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eye 57
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disease is an estimated 7 million americans are living with alzheimer's.ll has to give a final approval for that new drug. >> a bike ride nearly ends in tragedy for a bay area native. about three months ago, she was in a coma and now juney smith is back on her feet. a driver hit juney while she was on a bike ride near the campus of uc davis. >> that was in march. jenny ended up with a head injury so bad that she lost her memory. her teammates on the uc davis cycling team say jenny was riding in a tricky spot when that crash happened. the head injury landed jenny in a coma for five weeks. it has been a long recovery process. now she is finally back home in san francisco, getting support from her older sister and family. >> like a few weeks ago, you couldn't remember what had happened like five minutes ago. so really? yeah wow. >> the chp says the driver stayed on the scene and wasn't intoxicated. investigators think jenny failed to stop at the intersection. jenny can't remember any part of that crash to give her side of the story. her teammates at uc davis
disease is an estimated 7 million americans are living with alzheimer's.ll has to give a final approval for that new drug. >> a bike ride nearly ends in tragedy for a bay area native. about three months ago, she was in a coma and now juney smith is back on her feet. a driver hit juney while she was on a bike ride near the campus of uc davis. >> that was in march. jenny ended up with a head injury so bad that she lost her memory. her teammates on the uc davis cycling team say jenny...
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Jun 13, 2024
06/24
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KRON
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eye 46
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and last september was world alzheimer's awareness month.ose that has something to go and support community with all timers affects one in 3 seniors that live in alameda county. so we wanted to help get the word out about that raise funds and awareness. but yet still have an event that was exciting the jack london square to intense. we had drone show that had very cool images to support all timers awareness and what else to do. >> have planned for the rpcommunity because that some o what? attracted the group that recognize to do with this award is that they love the things that you're doing to provide for the community. >> the key. so what we did was for the home and we had different activity is going home. we had a little puzzled by set out in one of the areas of the center. people would come take pazos leave pazos give them they're elderly family members. the puzzles help he of all timers keep their memory lasting longer because they have to put the public's together used brain functions that support their memory. so we wanted to definitel
and last september was world alzheimer's awareness month.ose that has something to go and support community with all timers affects one in 3 seniors that live in alameda county. so we wanted to help get the word out about that raise funds and awareness. but yet still have an event that was exciting the jack london square to intense. we had drone show that had very cool images to support all timers awareness and what else to do. >> have planned for the rpcommunity because that some o what?...
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120
Jun 26, 2024
06/24
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KNTV
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it was us, reveals she's been privately fighting alzheimer's in real life. her son's touching message just ahead. those stories, plus panda express, the adorable giant panda is about to take the us by storm, ready to make the long journey from china today. and we're with them. live and one month to go. the countdown to the paris olympics reaches a major milestone. the iconic venues almost ready. we really welcome the world to come and to join us this summer. the stars of team usa set to shine terry richardson 1070. and we're celebrating live in paris and right here in studio one a today, wednesday, june 26th, 2024 from nbc news. this is today with savannah guthrie and hoda kotb from studio one-a in rockefeller plaza. hi there. good morning and welcome to today, wednesday morning, 7 a.m. on the west coast. i have no idea what time it is in paris, but it's 30 days away till the olympics. i cannot believe we're one month away. the team is taking shape. tirico mike tirico is going to be here to tell us who to watch out for. it's going to be really good. we got a
it was us, reveals she's been privately fighting alzheimer's in real life. her son's touching message just ahead. those stories, plus panda express, the adorable giant panda is about to take the us by storm, ready to make the long journey from china today. and we're with them. live and one month to go. the countdown to the paris olympics reaches a major milestone. the iconic venues almost ready. we really welcome the world to come and to join us this summer. the stars of team usa set to shine...
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143
Jun 26, 2024
06/24
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KGO
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eye 143
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suffer with alzheimer's.ding to the cdc, alzheimer's disease affects parts of the brain that control thought, memory and language. it's a progressive disease that can lead to the loss of ability to carry a conversation and respond to an environment. >> we are gathering more and more evidence that lifestyle really matters here. we love to recommend about 20 minutes of brisk walking each day. getting your seven or eight hours of sleep. working on stress management strategies. >> you're wonderful. >> reporter: rowlands, now 94, made her film debut in the high cost of living in 1958 going on to work closely with her husband and legendary filmmaker john for decades. in 2015 she was presented with an honorary oscar for contribution in films in one of her last public appearances. but for her son nick, one of his fondest memories is the film they made together saying, after 20 years it holds up pretty good. i'm just happy that it exists. >> there is a reason that so many books and movies tell stories of patients with
suffer with alzheimer's.ding to the cdc, alzheimer's disease affects parts of the brain that control thought, memory and language. it's a progressive disease that can lead to the loss of ability to carry a conversation and respond to an environment. >> we are gathering more and more evidence that lifestyle really matters here. we love to recommend about 20 minutes of brisk walking each day. getting your seven or eight hours of sleep. working on stress management strategies. >>...
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294
Jun 11, 2024
06/24
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KNTV
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thank you. >>> still ahead, new hope in the fight against alzheimer's.d to know about a promising drug that could slow the disease that just moved one step closer to approval. >>> plus our exclusive and emotional interview with celine dion. the music icon opening up on her battle with stiff person syndrome. the toll it's taken on her life her career and that legendary voice and why she says she is determined to return to the stage. but, first, this is "today" on c. nb it's time to get away and cash in at cache creek casino resort. to rock and to roll. to go all out or go all in with four stars and rising stars. northern california's premier casino resort is the perfect place to do as much... or as little as you want. make your getaway now and cache in at cache creek casino resort. funniest guys in hollywood. >> will farrell stopping by studio 1a. we'll talk about his villainous role in "despicable me 4." he is campaigning to be the sexiest man alive. he's funny and, oh, is he sexy. to help support nearly three hundred-fifty thousand patients facing cance
thank you. >>> still ahead, new hope in the fight against alzheimer's.d to know about a promising drug that could slow the disease that just moved one step closer to approval. >>> plus our exclusive and emotional interview with celine dion. the music icon opening up on her battle with stiff person syndrome. the toll it's taken on her life her career and that legendary voice and why she says she is determined to return to the stage. but, first, this is "today" on c....
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Jun 11, 2024
06/24
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CNBC
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eye 84
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>> el lie lilly's alzheimer's drug get
>> el lie lilly's alzheimer's drug get