therapy", "the journal of biological chemistry" and "arthritis and rheumatism" from the american college of rheumatology use in over five hundred thousand medical procedures along with clinical trials that proves they do in fact work. every day that goes by your movements wear on joints and cartilage in your body so there must be a rebuilding process. as you grow older, you may stop making bone activating proteins. when they are not present they don't activate the replenishing cells around the bones that form new bone and cartilage. the rebuilding process stops and the end result can be weaker bones as well as painful joints. when the bone activating proteins are present they activate replenishing cells around the bones so that they can actually use the