we came here because amgen, who competes with us in the markets, and genentech are fighting ever space there. there was a short time when at the ranch in south san francisco was higher than the ranch here. the total cost here was still higher, but that one moment i knew only happen once every couple decades. so we jumped on it. we got the board to agree to let us come here. the shorenstein family built this building. they did a very good job. but when we got here, we were alone, and it was an economic crisis time. we had this idea that if we had a quality building and $100 million of improvements that there would be a lot of young companies that would prefer this environment to the alternative, which might be a garage or might be a lousy building down in south city somewhere. for recruiting people lot of ucsf, in particular, this is a tricky issue. we thought we had would be valued. turned out we were right. and it turned out we were wrong. we were right in the sense that a lot of ucsf demand came. we had many venture firms support us and say, this is a great idea. because people hit t

when we started, we came from south san francisco, and we came here because amgen, who competes with us in the markets, and jenentech were fighting over space there. there was a period of time when the rents in san francisco were higher than the rent here. the total cost here was still higher, but that one moment, i knew only happened once every couple decades. and so we jumped on it. we got our board to agree to let us come peer. the shorensteen family built this building. they did a very, very good job, but when we got here, we were alone and it was an economic crisis, a period of time. and we had this idea that if we had a quality building and $100 million of improvements, that there would be a lot of young companies that would prefer this environment to the alternative, which might be a garage and clean tech. or might be a lousy building in south city somewhere. this is a tricky issue. we thought what we had would be valued. it turned out that we were right and it turned out we were wrong. we were right in the sense that a lot of u.c.f. demand came -- we had many venture firms su

amgen jumped on biotech's up to $5 billion stock buyback. dish network rose.er the bell, priceline sank on below expectation results. >>> a judge approved a $400 million settlement on claims bank of america charged more than $13 million debit card users of excessive overdraft fees over the past decade. another judge blocked rules requiring graphic images of dead and diseased smokers on cigarette packs next year. >>> u.p.s. says holiday procrastinators will have it shipping 6% more this year in its peak week with its busiest day december 22nd. >>> no one is safe. finally faced with a drastic budget shortfall, suffolk county, new york, laid off santa. an 83-year-old world war ii vet who greeted kids as st. nick for nine years has gotten his pink sleep. >>> up next, a boxing legend passes. you think hockey players get a little carried away? wait until you see this coach. >>> the bears come in to philly and maul the eagles. your first look at sports is straight ahead. you're watching "first look" on msnbc. >>> in sports last night the boxing world lost an epic hea

. >>> next year, the race course for the amgen course will be different.next may, riders will finish the second stage of the race in santa cruz. the race sponer wa ee esor wantn backdrop. another change for next year, instead of starting at lake tahoe, the race will begin in santa rosa. it ends in southern california. >>> get ready to crack open some crab. saturday marks the beginning of crab season which begins on time for the first time in three years. the department of fish and game expects the harvest to be robust. great news for fishermen. and it's good news for your wallet. wh harvest subpoena plentiful, the price of crab goes down. >>> sit the thrill of a lifetime or the scare of a lifetime? another man meets whale in our local waters. watch carefully. a surfer and kayakers hanging about -- oh, my goodness. they were just hanging about in santa cruz when a humpback whale surfaces and almost engulfs the entire group. that's amazing. >> yeah. close call. >> one of several recent very close sightings near santa cruz where a pod of whales has been feedi

. >>> host cities for the 2012 amgen tour of california announced this morning. >> the race will startnta rosa. the hometown ofthree-time race winner levi leipheimer and will end in los angeles. stops will include san francisco, santa cruz and san jose. the race starts may 13. >>> a great white shark released into the pacific ocean by the monterey bay aquarium has died. and... in other news, we have closing arguments in the trial of michael jackson's doctor. howconrad murray's defense lawyers plan to sway the jury. >> amazon.com has a change of heart. why it's eager to collect sales tax in california >>> if you notice a problem with your iphone 4s, what apple is doing about reports of poor battery life. >>> from sunny and warm to cool and gray, big changes in our weather today even some raindrops. we'll talk more about that coming up. ,, keurig has a wide variety of gourmet coffee and tea to choose from. keurig is the way to brew fresh, delicious coffee in under a minute. way to brew. so with keurig, every cup tastes like it's brewed just for you. because it is. hey, jessica, jerry neu

when we started, we came from south san francisco, and we came here because amgen, who competes with us in the markets, and jenentech were fighting over space there. there was a period of time when the rents in san francisco were higher than the rent here. the total cost here was still

those donated toys will be distributed to by area children. >>> organizers aft amgen race unveiled this the 13 official host cities. the 2012 tour will start on may 13thin santa rosa. the competition also includes stops in san francisco, santa clara, and you? santa cruz counties. the race ends may 20th in los angeles. levi will hope hoeft the first race. >>> sal is watching 880. >> we're seeing and remembering the oakland freeways are not affected by what going on on city streets. 880 is slow past the coliseum. bay bridge toll plaza backed up four 25 to 30-minute delay. and 101 san francisco emergency guardrail repair near 80 split westbound. now let's go to steve. >> we have some sun left but most to the south as clouds continue to increase. that will lead to a much cooler day. some light rain but more cold than anything else rain tonight into friday. clearing friday night, saturday. more rain comes in sunday. cold! >> cold! all right. >> thank you, steve. that's our report this morning. thank you for trusting ktvu channel 2 news. we'll see you at noon with more!

that its real story of an intel of amgen or a southwest is that there is the ability to build great organizations, that are able to replicate innovations at great scale and be able to, whether that be organization, manufacturing, whatever, think about fo and motorcar is that an innovation story or a scaling story? what we do really well is we scale innovation, here is what is scary. what happens if we focus on the innovation? ut we lose our ability to scale? and what if ouability to scale innovation is our real distinctive advantage? where is that going to leave us? >> rose: so when you look at leadership tell me the four things that you have found? that have defined? because i believe, you know, that leadership makes a difference. it is crucial. >> yes. >> rose: in every circumstance. and you can -- i can show you company after company after company. >> yes. >> rose: and you can test these things. >> so first of all there this notion of focus and curiosity i want to briefly comment on the focus part. one of the greatest, probably the greatest rock climber of this generation as you know i have be

biotech giant amgen jumping after announcing plan to buy back its stock.arket is still flat, companies that survive the downturn will be lean, mean, and likely to prosper. that's it from cnbc, first in business worldwide. now back to "hardball." >>> welcome back to "hardball." the latest nbc news/"wall street journal" poll is out, and while it shows that president obama is still underwear in his approval ratings, he manages to beat a generic republican in head-to-head match up. chuck todd is a msnbc political director and kris cillizza is the author of postpolitics.com. where we see a generic matchup, republicans haven't settled on a candidate just yet, but the nbc poll shows that romney and herman cain are virtually tied as the front-runners while rick perry has taken a tumble and now ties newt gingrich for fifth. where are we at right now, chuck? >> i think where we're at, we still have the republican party split into two camps. your establishment business wing is gravitating towards mitt romney, and the tea party populist conservative sort of outsider p