the onyx connection is that we had an opportunity to start a clinical trial with carfilzomib, the realriver for their valuation, that really drove the sale to amgen recently. we had an opportunity to pair our drug with their drug early before it was approved and we're one of the few compounds now that is actually in substantial clinical trials. we're going to give an update on that data at a.s.h., the big blood cancer conference, at the end of the year and around the end of the year be able to tell folks what our plans are for 520, the multiple myeloma drug for next year. and there is a lot of reason to believe that the data will really encourage us to go forward into pivotal trials. >> i know a lot of people close to home have asthma. and i know that this is a faraway drug, but is it already worth talking about because it's such a huge opportunity? >> you know, you can't avoid one really exciting thing about the drug. we call it 502. it's a stage 2 antagonist, a new mechanism in asthma. what's incredible, it's oral, and it showed a statistically significant efficacy in a robust trial.