astrazeneca, that makes me feel good. how is the phase two study going? it actually just started, right? three study, the peripheral neuropathy indication and then what's particularly exciting is our partner gsk is beginning the first cardiovascular outcome study with an rna targeted drug. that's a big 500 patient phase three study. these are very exciting times for our ttrx drug. >> is this a 2017 or 2018 drug if it goes well? >> no, it's sooner than that. peripheral neuropathy, the phase three study is now finished enrollment and that's a 15-month study. we'll have those data in early 2017. we'll hope if they're positive, we'll file right away for that indication. >> we spent time in the past talking about your clotting disorder drug. how's that going? >> very well. as you remember, we licensed that to bare for high 20% royalties and the first step was to get experience with patients in renal dysfunction, which we're getting now. patients who can't take existing anti-thrombotic drugs and that's rolling nicely. begin. so

if you can't afford your medication, astrazeneca may be able to help. >>> coming up tonight beginning at 5 is big brother watching you? the iphone feet you you might not know about tracking your every move. and then at 6 major changes at yankees stadium. an expensive improvement making the game better for players and fans. tonight we go on a behind the scenes tour. those stories and more beginning at 5. >>> puppies are always something special but this litter is more special than most. the seven are the first born from invite roe. litter of dogs have all failed scientists managed to do it in july. >> it will have a lot of applications in vet medicine for working dogs, show dogs or animals that people love and want to breed. >> the first litter includes five beagles and two bockers a beagle cocker spanel mix and golden retrievers you can take that cancer out so that doesn't become an issue anymore. >> they are precious. that's our first at noon. for john and the entire news team i'm mary calvie. >> and i'm chris ragie.

if you can't afford your medication, astrazeneca may be able to help. . >>> in today's health alert, now that thanksgiving abehind us, the holidays are kicking into gear. its a joyous time for celebrations with lots of food but for kids with food allergies, it can be a challenge. 11 year old zach churchill has severe food allergies. >> actually just yesterday i had an issue with that. i bit into an egg roll and even though i'm technically okay with eggings, i had a little issue. reporter: zach's not alone. on average, two children per class room have food allergies. >> it's a stressful time for our patients. we stress being prepared and having a plan in place. reporter: dr. bj lancer is an allergist in denver. he has four tips. first, don't go anywhere without medication, never eat anything you're sure is safe. . >> question need to have that available any time you could come in contact with food you're allergic too. reporter: make sure to talk to the host about safe foods for your child or host the party yourself. >> asking guests to bring paper goods or games or craft projects inst

if you can't afford your medication, astrazeneca may be able to help. . >>> it was a big ole boom. the lights went out, the doors flew open. >> pretty scary. clean up is under way in washington state after it was battered by a rare tornado. the pacific northwest has been slammed by wicked weather for the last few weeks weeks. >> it's ripping whole trees up dude. reporter: thursday's tornado had winds topping 104 miles per hour. it uprooted dozens of trees. >> it does appear a tornado did go through. multiple trees down, multiple lines. reporter: about 36 homes and a pair of businesses were damaged. vanessa works at a mini mart. >> the wind came through the doors, pushed those doors out, in and back out and then water started pouring through the roof. reporter: wooden stakes sliced through one home like daggerses. >> it looked like the wizard of oz out here. there was debris flying everywhere, trees flying down the road. reporter: heavy rain and winds have been pounding the northwest for a week now. some areas have been soaked with as much as 18 inches of water. construction crews h

if you can't afford your medication, astrazeneca may be able to help. >>> investigators in boston areooking into whether someone tampered with a safety device and caused a train to leave the station white house an operator. it happened just before 6:00 this morning, train personnel had to cut power to the train to stop it in its tracks, fortunately nobody was injured and the train is out of service while the investigation is underway. >>> a sheriff deputy will survive despite being shot in the head during a standoff at an apartment complex. they were responding to a possible robbery at the complex this morning, they found a man pointing a gun at them and the gunman fired a shot hitting the deputy in the head and the second deputy fired back wounding the deputy. and the second deputy will be okay and the other deputy is on administrative leave following the investigation into the shooting. >>> an atlanta man died after jumping from the balcony of his apartment to escape robbers, this is the surveillance video of three men leaving jose green's apartment after a home invasion, he jumped

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call or go online to learn more about a free trial offer. your medication, astrazeneca may be able to help. it's easy to buy insurance and forget about it. but the more you learn about your coverage, the more gaps you might find. like how you thought you were covered for all this... when you're really only covered for this. hot dog? or how you may think you're covered for this... but not for this... whoa! no, no, oh , oh! ...or this... ...or this. ...or that... talk to farmers and see what gaps could be hiding in your coverage. my heaven! we are farmers bum - pa - dum. bum - bum - bum - bum lives remembered. it's the holidays. which means a house full of people -- who all want to get online. so it's the perfect time for verizon fios. it has the fastest internet and wifi available. with speeds from 50 to 500 megs. and right now, you'll get 50 meg fios internet, tv and phone for 79.99 a month online for your first year. and with a 2 year agreement, we'll give you all the premium movie channels for a year. plus, 400 dollars back. so go online or call now.

if you can't afford your medication, astrazeneca may be able to help. anncr: when the attacks come here... ...the person behind this desk will have to protect your family. will he be impulsive and reckless, like donald trump? will he have voted to dramatically weaken counter-terrorism surveillance, like ted cruz? will he have skipped crucial national security hearings and votes just to campaign, like marco rubio? 27 generals and admirals because jeb has the experience and knowledge to protect your family. right to rise usa is responsible for the content of this message. >> zshgs a first in this country, connecticut's governor says he will ban people on the federal no-fly list from buying guns in his state by issuing an executive order. governor daniel malloy says the gun will deny permits. last year the u.s. senate stopped a bill. >>> chipotle, the outbreak of a norovirus stomach bug linked to one of its boston location is up to 141 cases. in the fallout and an earlier one involving e. coli, the ceo appeared on "today" to apologize. nbc's tom costello h

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if you can't afford your medication, astrazeneca may be able to help. >>> the attack in san bernadino underscore as very big challenge facing u.s. intelligence and law enforcement agencies. trying to find potential extremists here at home. american citizens who may become radicalized through the internet, flying quietly under the radar while plotting to launch an attack. nbc's tom costello looks io the staggering task. >> reporter: with overseas terror tacks in mali and paris serving as fresh evidence of jihadi-inspired brutality, federal law enforcement has an all-consuming priority, tracking home grown suspects who could become radicalize s d ooer the internet and engage in lone wolf attacks at home. the fbi tracking 900 potential suspects, 50 >> the threat here focuses primary on troubled souls in america being inspired or enabled online to do something violent for isil. >> reporter: we don't know if san bernadino suspect syed farook had terror ties, but he represents the challenge facing law enforcement today. he was off the radar, american born, no criminal record, not on the ter

if you can't afford your medication, astrazeneca may be able to help. >> zshgs a first in this country, connecticut's governor says he will ban people on the federal no-fly list from buying guns in his executive order. governor daniel malloy says the gun will deny permits. last year the u.s. senate stopped a bill. >>> chipotle, the outbreak of a norovirus stomach bug linked to one of its boston location is up to 141 cases. in the fallout and an earlier one involving e. coli, the ceo appeared on "today" to apologize. nbc's tom costello has more on what the company is doing to keep its customers safe. >>> it's a chipotle pledge, food with integrity. but that pledge is now under the microscope with chipotle in crisis, the ceo today talked to matt lauer on "today." >> first, i have to say i'm sorry for the people who got sick. they're having a tough time. >> reporter: chipotle's trouble began two months ago, an e. coli outbreak sickened 52 people. now boston college. the number of students sickened with the norovirus today jumped to 141. the restaurant involved cited for three held code vi

if you can't afford your medication, astrazeneca may be able to help.earn aboutnd your coverage,t. the more gaps you might find. like how you thought you were covered for all this... when you're really only covered for this. hot dog? or how you may think you're covered for this... but not for this... whoa! no, no, oh , oh! ...or this... ...or this. ...or that... talk to farmers and see what gaps could be hiding in your coverage. my heaven! ♪ we are farmers bum - pa - dum. bum - bum - bum - bum ♪ >>> finally tonight here, 14 lives remembered. ♪ ♪ ♪ >> thank you for watching here on a friday night. on a friday night. another difficult both: we could be your secret santa. what we win... ...you win. we've given away thousands in fabulous vacations, cars, and cash. and you could be next... the sears secret santa swpstakes continues tonight. wheel... of... fortune! ladies and gentlemen, here are the stars of america's game -- pat sajak and vanna white. that would be us. that was jim thornton, by the way, announcing. thank you. hi there. how you doing, folks?

if you can't afford your medication, astrazeneca may be able to help.earn aboutnd your coverage,t. the more gaps you might find. like how you thought you were covered for all this... when you're really only covered for this. hot dog? or how you may think you're covered for this... but not for this... whoa! no, no, oh , oh! ...or this... ...or this. ...or that... talk to farmers and see what gaps could be hiding in your coverage. my heaven! ♪ we are farmers bum - pa - dum. bum - bum - bum - bum ♪ >>> finally tonight here, 14 lives remembered. ♪ ♪ ♪ >> thank you for watching here on a friday night. sure, tv has evolved over the years. it's gotten squarer. brighter. bigger. thinner. even curvier. but what's next? for all binge watchers. movie geeks. sports freaks. x1 will change the way you experience tv. call and switch to x1 from xfinity today. catch holiday-cookie cheer on the tip of your tongue with dunkin' donuts' holiday- cookie-flavored coffees. from 2:00 to 6:00 p.m., enjoy any medium latte or macchiato for $1.99. this is "jeopardy!" introducing to

if you can't afford your medication, astrazeneca may be able to help. it's easy to buy insurance and forget about it. but the more you learn about your coverage, the more gaps you might find. like how you thought you were covered for all this... when you're really only covered for this. hot dog? or how you may think you're covered for this... but not for this... whoa! no, no, oh , oh! ...or this... ...or this. .or that... could be hiding in your coverage. my heaven! we are faers bum - pa - dum. bum - bum - bum - bum indianapolis. hawkeyes coach kirk ferentz weighs in the day before the big 10 championship. brad: weather ad lib >>> final tonight here, 14 >> thank you for watching here on a friday night. another dare iowa's most accurate weather team and we start with your forecast first." brad/wx wall what is better than a friday in the 50s? maybe a saturday in the 50s! look for clear to partly cloudy skies as we head through the night. temps will not fall as much as last night thanks to southerly winds of 5- 10 mph, but some refreezing will be likely ou

if you can't afford your medication, astrazeneca may be able to help.nking of new ways to make treat time fun. (vo) at the friskies playhouse, the cats and us are always busy. that's how we came up with new friskies pull 'n play. with tender string treats cats can eat. that part was their idea. lucy always thought strings should be edible. chloe thought the same. and charlie, well, he's up for anything as long it's fun. new friskies pull 'n play with tender strings. the whole new way to treat 'n play. it's gotten squarer. over the years. brighter. bigger. thinner. even curvier. but what's next? for all binge watchers. movie geeks. sports freaks. x1 from xfinity will change the way you experience tv. >> thank you, in new orleans. the latest on the investigations san bernardino shooting as well as understanding what it means when our secretary of defense says we're a nation at war. we didn't need a loan. we needed short-term funding fast. building 18 homes in 4 ½ months? that was a leap. but i knew i could rely on american express to help me buy those bui

if you can't afford your medication, astrazeneca may be able to help. >> pelley: in minneapolis this morning, police and firefighters tore down a protest encampment the protesters had been there almost three weeks. later in the day they demonstrated at city hall over the fatal shooting of a black man by a white police officer. at issue is whether the suspect was handcuffed when he was shot. the u.s. military is looking for a few good women. today defense secretary ash carter ordered the armed forces to open all combat jobs to women. he said any woman who meets the standard should be allowed to serve on the front lines and in special forces. all branches have until january 1st to submit plans for the historic change. a south african appeals court today found oscar pistorius guilty of murder. they threw out his conviction on the lesser charge of manslaughter. pistorius, the olympic athlete known as "the blade runner," shot and killed his girlfriend, reeva steenkamp. he could face 15 when he's resentenced next year. in a moment explaining violence to children when we struggle to underst

if you can't afford your medication, astrazeneca may be able to help. (vo) what'scorn? food's first ingredient? wheat? in new purina one true instinct grain free, real chicken is always #1. no corn, wheat or soy. support your active dog's whole body health with purina one. toto the nation's capitalut to support an important cause that can change the way you live for years to come. how can you help? by giving a little more, to yourself. i am running for my future. people sometimes forget to help themselves. the cause is retirement, and today thousands of people came to race for retirement and pledge to save an additional one percent of their income. if we all do that we can all win. prudential bring your challenges® >>> we turn now to the other headlines tonight. defense secretary ash carter announcing all combat roles will now be open to women. his decision overruling the marines, which asked to continue the ban. >>> also tonight, a scathing congressional report blasting the secret service as an agency, quote, in crisis. citing improper behavior and stunning security br

if you can't afford your medication, astrazeneca may be able to help.earn aboutnd your coverage,t. the more gaps you might find. like how you thought you were covered for all this... when you're really only covered for this. hot dog? or how you may think you're covered for this... but not for this... whoa! no, no, oh , oh! ...or this... ...or this. ...or that... talk to farmers and see what gaps could be hiding in your coverage. my heaven! ♪ we are farmers bum - pa - dum. bum - bum - bum - bum ♪ >>> finally tonight from southern california, after the horror inside this complex, the 14 lives remembered. ♪ ♪ ♪ >>> thank you for watching here on a friday night. and finishing a difficult week with us. i'm david muir. i hope to see you right back here on monday night. good night. >>. >>> was this police shooting justified? we're going to take you live to the town hall meeting underway live in san francisco. the chief will face the heat. plus... >> we're now investigating these horrific acts as an act of terrorism. >> the san bernardino shooting rampage take

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