biomarin.develop enzyme replacement therapies for genetic diseases that can often sell for $300,000 a year because the patients and their insurance providers have no alternative. they have multiple drugs including three for different types of mps. a group of disorders that can cause horrific damage at a cellular level and a drug for severe neurological issues and a disorder that leadses to muscle weakness. it hases the strongest pipeline in the orphan drugs and will get one more late stage drug candidate for a fatal disorder known as duchesne. the offer was created today. they have given us a 45% gain since we spoke to the ceo this september. if you value the company the way shire valued nps it would be worth $22 billion, substantially more than the current cap of $14.4le billion. let's check in with the ceo of biomarin pharmaceutical to find out more. welcome back to "mad money." >> thank you. great to be back. >> okay. j.j. i was on your website today looking at what vimazin can do. it really

biomarin, strongest stock, that stock's the great untold orphan drug story. novavax.han drug, immunotherapy, the future on our show. the future is now. >> stay focused. >> i'm trying. >> see you tonight on "mad money." philly fed after the break. being a keen observer of the world has gotten you far but what if you could see more of what you wanted to know? with fidelity's new active trader pro investing platform, the information that's important to you is all in one place, so finding more insight is easier. it's your idea powered by active trader pro. another way fidelity gives you a more powerful investing experience. call our specialists today to get up and running. >>> good thursday morning. welcome back to "squawk on the street." i'm carl quintanilla with sara eisen, simon hobbs, david faber. crazy day for markets. stocks going for fifth day down. dow's down 89 points. a lot of action in the swiss currency, bank earnings to work with retail news as well. oil's going to drive action currently down one and a third percent. >> to rick santelli at cme with breaking n

halo biomarin have been stars, relypsa up 300%.ay hear me talking about it like regeneron and celgene. >> really? >> what's their main therapy, sorry? >> something may be better for biogen and a crohn's disease cure. >> green bay seattle, new england. >> not an issue. brady turns 38 this summer. you want to go with new england? absolutely. and they're begging you -- i know you're not supposed to talk spread jimmy the greek -- but begging you to take green bay. pete carroll, get 7 1/2 and be safe. >> enjoy the weekend. see you tonight. >> consumer sentiment after the break. e my life special by being apart of it. (everyone) cheers! glad you made it buddy. thanks for inviting me. thanks again my friends. for everything for all your help. through all life's milestones our trusted advisors are with you every step of the way. congratulations! thanks for helping me plan for my retirement. you should come celebrate with us. i'd be honored. plan for your goals with advisors you know and trust. so you can celebrate today and feel confident

biomarin did a big deal that's an orphan drug play and they did a deal it went through syndicate bid.'s some people doing great things who wereare executives and making money for shareholders. >> great coverage on the sector. >> thank you. >> "stop trading" in a moment. dow down 25. >>> time for cramer and "stop trading." >> i think tech semis have been o'daywe okay other part of data storage. f5 a disaster today, this is japan. and xilinx used to be one of the most consistent companies in the industry hideous numbers. be aware that there's undercurrent of communication software and also communications hardware and also data storage hardware that is -- you call it into question. don't hide in tech. know your stuff. >> whats on "mad." key with the monster quarter, united reynolds company did well. harmon acquisition. cyprus semi tjrodgers. i can't wait until tonight. never have four guests. >> a big show. >> wow. see you tonight. >> waking up at 3:00 to learn these things. >> when we come back more on ecb, unprecedented stimulus plan and head of union pacific. you can find a new fronti