and, now there is blowfish, not the poisonous fish, an over the counter drug that promises to uprightt it, it is effervescent. so for one thing, it forces, the sufferer to hydrate. >> bytox and blow fish, two of a growing list of anti-hangover product. tried and tested by researchers who turned themselves into lab rats. >> i had at least 12 shots of tequila. >> the typical scientific protocols for testing didn't exactly apply. >> surprised how great i felt. >> authors of a 2005 study in british medical journal found no convincing evidence that any conventional remedies can cure a hangover. dr. grossman doesn't dispute that. >> not a cure. a prevention. >> reporter: while the science is debatable, the novelty of selling a cure for a hangover is not. for "nightline," i'm lindsay

i puff up like one of those blowfish. >> no. stage in front of people. >> but it can be very distracting if something goes wrong. it can get in your head. >> but, you know, it's very interesting the first time -- like i was on tv and -- >> yeah. >> as a guest. and -- >> it looks so easy. >> the first couple of times i was hosting a show here a decade ago -- >> yeah, you told me this story. >> oh, it was horrible. things in my ear. i didn't -- i'm a control freak so i didn't know who was on the other side of that. >> you have no control. >> and you have no control and it really was -- i can actually relate to that. for the first like three years, it was like -- >> oh! >> no, it was. i remember thinking oh, my god, this is how people feel that get in front of crowds and are -- it's a feeling i never had. i have great empathy for that. if you're just not comfortable doing something, the lights are bright, you know. >> something can throw you off. >> bay posted a statement on his website, apologizing saying, quote, i guess live show

what makes blowfish more effective than just aspirin and a cup of coffee. >> the thing that's speciales the sufferer to hydrate. >> reporter: bytoxin and blowfish 24 of a growing list of anti-hangover products. tried and tested by researchers who turned themselves into lab rats. >> i had at least 12 shots of tequila. >> reporter: admittedly, the typical scientific protocols for testing didn't exactly apply. >> i was just surprised the next morning how great i felt. >> reporter: but the authors of a 2005 study in the british medical journal found no convincing evidence that any conventional remedies can cure a hangover. and dr. grossman doesn't exactly dispute that. >> it's not a cure. it's only a prevention. >> reporter: while the science is debatable, the novelty of selling a cure for a hangover is not. for "nightline," i'm linsey davis in new york. >> do you know of any hangover cures? >> chocolate cake. >> chocolate cake? >> pizza. i just feel eat something and maybe it will feel better. i don't know. >> mine is a good wing man. have somebody who is going to tell you your limit. >>

a lot of viewers will recognize him from hootie and the blowfish.ll get geeked up, too. >> i don't doubt it. >> listen in. >> this is going to be a little crazy, mccartney is going to be there. it's going to be tough for me not to go all fan girl. >> hey, who would you like to collaborate, other than paul mccartney, maybe, that you haven't got around to or you're bashful to ask? >> i'd love to work, of course, mccartney, reba mcentire. miranda, jay z. that's one of my bucket list things to sing a hook on a big rap song. >> why can't you? >> i don't know. no one's ever called me. >> not until now. >> he said he's too bashful to hit people to him them to collaborate. >> i understand that. >> yeah. >> he crosses such borders, too. because it wasn't -- he didn't come out with hootie as country. now, he's county. now, he's talking about doing rap. >> i hope people are able to watch this special. because you'll also hear, we did ask him, will there be any more projects with hootie and the blowfish? i'm not going to tell you what the answer is. >> she know