on the desk,teve grasso, bonawyn eison and michael khouw. supersized losses today. the the stock falling more than 5% to its lowest level since march 2020 after they announced they're pullg the plug on their weight loss pill. they say patientstruggle to deal with the side effect os thisedicine. for the year, down 43%. badly lagging its obesity drug rivals. eli lilly and norvo nordisk. >>fizer's ambitionin the obesity space falling behind after the drug caused gh rates of side effects for trial participants. more than 70% reported nausea, half experienced vomiting, and a arter experienced -- that in addition tthe side effects for too much to overcome. pfizer says it will keep working on a once daily formulation of this pill. the company is expecting data on this in the first half of next year. it still puts pfizer further >> what's the difference between the once daily formulation, which is a time release formulation and twice daily? why will it yield different side effects? maybe fewer side effects? bustill, the side effects in terms of the percentagof patients thae

on the desk tonight, tim seymour, carter worth, bonawyn eison and julie biel. but first, we start with another winning day on wall street. the dow jumping 159 points. the nasdaq and s&p 500 finishing the day higher. the s&p 500 within striking distance of its all-time high hit back in january of 2022, just about a percent or so away from there. and take a look at the nasdaq 100. locking in on an all-time high and record close. it's now on the cusp of its best year since 1999. >> oh. >> yeah. >> the dot com era. that's all the way back to when bill clinton was still president, this year, it's up 54%. with three trading days left in 2023, can the market's winning streak carry straight into the new year? we'll start with you, tim, about the momentum, a lot of folks think it can keep going. >> welcome, merry christmas. >> merry christmas. >> thank you for coming here. crazy times square. it's crazier after christmas. >> it's nuts. >> and you can make an argument this market's as crazy as it was back in 2002, because, and this is really the setup, and great to have