theseis have cystic fibrosis, or you have these is in the eye that are causing you to go blind, yougenerations. what the experiment that took place in china did was to say we're going change genes in embryos and they will affect children and their descendents, that's called gene that line engineering and that's a whole other step first of all we have not done much of that or consecutive of all there is no ability to consent to it by children yet to come. to be clear it's a whole other is that because we don't yet know what the risks associated with this would be? correct. you might say i'm going to try and do an experiment in a person to see if i can fix cystic fibrosis cells that are wrong and if it doesn't work we stop. you alter the genes of an embryo, there's no turning back, there's no saying oh my goodness, we sniff out something we should not have or the genes we try to put in went the wrong place, and they are causing a birth defect. there is no reversibility. are you concerned i guess that doctor hay might be the canary in the coal mine on this one but it's almost inevitabl

or cystic fibrosis is recessive, or diabetes or many, and it takes up to 20 generations for recessive mutations to express themselves. so we're talking about eons of timeme for expression of genetic disease--that's the second thing. the third thing is if the man's got plutonium in his testicles--and every mamale in e northern hemisphere has a tiny load in his gonad--it's from weapons testing days, and plutonium i is still falllling . and the man is cremated,d, the smoke goes up the e chimney with the plutonium,m, so you can breathe it in, another man can, and it's ad infinitum because plutonium has a half-life of 24,400 years and laststs for a long time. but the other thing is that thee body thinks plutonium is iroron--it's an irn analogue--so it's stored in the liver, where it causes liver cancer. it's stored in the bone marrow to cause--to produce hemoglobin in the red blood cells, but it causes leukemia or bone cancer. it crosses the placenta into the developing embryo--which lets nothing through it, incidentally, except plutonium and a few other nasties. it's stored in the testicl

like playing a woman with cystic fibrosis and a drama about assisted suicide and even my mum. or the survivor of a killing spree who knew the murder. lift lisa flea's was born in berlin in one thousand nine hundred her career started when a boyfriend gave her a flyer from an acting school. i chose to i was one of the family for its most complete insanity to t.o.b. was. to is not an easy job as shown by this film about an artist's colony in which leslie sophie's plays jen an idealist struggling for true freedom when you know this is bizarre oh my he didn't ask me. the u.s. entertainment magazine variety has named her one of europe's top acting talents and we agree. he's been acting since he was eleven louise hoffman has even been a guest at the oscars. yeah ok do this. now another david letterman of mine in which he plays a german p.o.w.'s assigned to clear mines after world war two was nominated for an oscar. and she appeared in dark a mystery drama and the first german series produced by netflix. i mean if you want to be an i want to like eric deuce on the edge i really enjoy

and he has seen it now not a cystic an arrogant. because all the promises of the reforms years undertaking you will not be of use in the next few years but those people who loses actually. see the loss of income immediately it's a difficult time for this presidency but he's got three and a half more years and elizabeth move in paris thanks for joining me. now to some of the other stories making news around the world thousands of turned out in hong kong for the city's annual pride parade marches demonstrated for equal rights and an end to discrimination against the l g b t community hong kong judges recently ruled that same sex partners are entitled to visas even though the territory doesn't recognize same sex unions. tension between the u.s. and china has overshadowed the asia pacific economic summit in pop and you give me some that's become the latest stage for disputes between the two countries over trade and regional security washington warned members that china's plans for a new trade routes threaten their sovereignty to. argent

work with the secretary of state health [indiscernible] desperate to relieve their symptoms from cystic fibrosis. pm may: can i say to the honorable lady, my honorable friend she has raised what i recognize is a concern, and i know about the length of time this issue is being worked on. the department of social care is working with nih and nhs. the single best biggest offer to the pharmaceutical company. they need to work with them to get this approved. i will ensure the concern she has -- that has been expressed in relation to this matter is fully made clear to the department of health and social care and the work they are doing with the pharma company to make sure the result is one which is a benefit to those patients who are looking desperately for the drug. mr. bercow: sir vincent cable. the withdrawal agreement says in the arbitration panel on a dispute on any aspect, the chair who has the decisive vote .ill be chosen by lots i know they are close to the gathering industry, but isn't it reckless to leave this under the withdrawal agreement [indiscernible] pm may: can i say to the h

this isa for a cystic fibrosis sufferer. asking for transparency on finances to break the impasse we have to do something differently. looking at the huge global profits for this company i ask the prime minister she would personally work with the set just minister she would personally work with the setjust read four has to break the impasse and get drugs to those patients who are desperate to relieve cystic fibrosis symptoms. i say to my honourable friend that she has raised what i know has been an important question raised in this house before. i recognise the concern about the length of time this issue is being worked on. the department for health and social ca re department for health and social care is working with mice and the nhs, they have made the single biggest drug offered being the nhs history to the farmer company, and the company now need to work with the company now need to work with the institute for clinical excellence to get disapproved. i assure her that her concern is thoroughly made clear to the departmen

the cystic fibrosis foundation has been very successful, you know. host: anything else? caller: that is it, thank you. guest: thank you. host: we will hear from barbara from harrisburg, pennsylvania for antonio regalado. hi, barbara. hi.er: i wonder, because i have a son with schizophrenia, do i have any hope in thinking that perhaps gene therapy might be effective for that mental disorder? thank you very much. guest: it is a question. schizophrenia is what they call a complex disease. it does not have a unique genetic cause. in the case of gene therapy, they are aiming at diseases called matt mainly in diseases -- matt mainly in diseases. is one disease with an error. they are using gene therapy to replace after something like schizophrenia is much more organic. the cause is not known, there is no singular cause, and so that makes it unlikely to be addressed by gene therapy in the near future. maybe in the distant future, it could be. talking with antonio regalado, biomedicine science editor at mic "technology review." -- at m.i.t. technology review. hear about this par

hemophilia, we wilnot fix huntington's disease, we we are not going to not edit out for all-time cysticis -- not only do i think it is in our n future, i hope it isr future, and i think it is mandatory that we tried to get it into our future. what this experiment did is it scares people. it looks like a renegade scientist is doing whatever he wants. and it is likely to o a backlash in the form of less funding and maybe some prohibitions to one of the most exciting areas of science out there. laura: thank you so much for joining us. dr. caplan: my pleasure. laura: now, with the holidays approaching, many of us are eyeing the latt gadgets, but ones andpens to the tv's which have fallen out of favor? a lot of electronic waste is shipped abroad, endi africa. in the nation of togo, o gadgets are big business. from the capital, lome, this report. reporter: a child's toy from anu unlikelye, made from other people's unwanted waste. >> this is plastic, so we printed it with a 3-d printer. reporter: you made this 3-d printer? >> yeah, we made a 3-d printer from waste material. we recycle old prin

then just forget and i think reading stories and being able to look at a person and maybe forget the cystic and just see the human stories is a lot more powerful i think you know there are people out there people that read the right wing press whether that's the sun or the daily mail and people that buy those you know papers you know they're not inhumane they're not evil for reading that stuff but i think in order to reach those sort of audiences you need human stories you need to be able to you know win hearts and minds and i don't think that's the to sticks always do that whereas i think stories are very powerful way of trying to board the next project also involving dear this concert yeah i mean what we'd like to do is create a platform called immiscible britain and what that would that platform would do would be to try and enable people from marginalized communities to amplify their voices and so in tandem with that run training scheme a mentorships game so that people from working class backgrounds from disadvantaged backgrounds find it easier to enter the arts and media we do so you k

but the proudest thing that i did bill who had a little girl that has cystic fibrosis and she was going to be denied a lung transplant because she was ten years old and not 12. a lung transplant because she was ten years old and not 12. education bill that they talk about that started in the thompsonville. i saw before you even saw as i am glad you sign on to our bill. thank you. >> from florida to georgia we have seen new voting restrictions with voter suppression aimed at african-american voters. in 2012 the proposed pennsylvania voter id requirement with little to no actual evidence of fraud why is the republican party so worried about voter fraud quick. >> i think there is a lot of focus in washington about making sure we are protecting our elections with all the focus on the russians involvement it is natural we would also say there is no voter fraud. and then with interference in the elections until we say let's not be too careful whether somebody can vote or not whether it's from foreign countries interference or fraud on the homeland. . >> there were only three reported cases of

was, you know, ushered off into the nv icu immediaicu imme >> reporter: megan's daughter has multi-cysticher other kidney would be enough. >> the doctor came up and said yore 6-day-old daughter is in kidney failure. >> reporter: she began to improve. >> her remaining kidney grew hardly at all within the year. >> reporter: any way whether the doctors can predict when she needs a kidney transplant, do they know. >> in they don't know. that's what's from us trarkts and this is something that we'll have to -- a bridge that we'll have to cross at some point. >> reporter: today deli is two and a half years old and if she ever needs a kidney transplant the odds are against her. of the 100,000 people waiting for a kidney last year only 100% received an organize sean. not deciding to wait they have decided to do something you've never heard of. her grandmother, jamie mcneil, donating her kidney >> it's essentially a gift certificate for an orr organ. in this case that gift will come from jamie as part of the national kidney voucher program. >> you call that being chronologically imcompatible. >> b

she is the mother of a 7-year-old boy named jack with the pre-existing condition of cystic fibrosis.is program and told us this time she'd be voting for jennifer wexton in her congressional race. wexton crushed the incumbant when we come back, tonight's winner, congresswoman elect jennifer wexton and health care voter tasha nelson. sha nelson sha nelson ♪ ♪ i'm all for my neighborhood. i'm all for backing the community that's made me who i am. i'm all for my theatre, my barbershop and my friends. because the community doesn't just have small businesses, it is small businesses. and that's why american express founded small business saturday. so, this year let's all get up, get out and shop small on november 24th. i got croissant. small business saturday. a small way to make a big difference. this is not a screensaver.game. this is the destruction of a cancer cell by the body's own immune system, thanks to medicine that didn't exist until now. and today can save your life. ♪ ♪ why didn't you book your on a travel site?on at hilton.com, i get the price match guarantee. and i can choose

a young woman in her 30's actively researching funeral plans, because she has cystic fibrosis and there is no cure. this was an event organized by my honorable friend. conversation the -- for the last three years >> by honorable friend has raised an important question in this house before. i recognize the concern about the length of time this issue is being worked on. the department of health and social care is working with the nhs. they have made the single company.ffer to the they need to work to get this approved, but i will ensure that the concern that she has -- that has been expressed, and i know it fits in relation to this matter, is fully made clear to the department of health and social care and the work they are doing with the pharma company to ensure the result is one which is of benefit to those patients who are looking desperately for this drug. this drug. the withdrawal agreement. it says that in the event of deadlock in the arbitration panel. they have the decisive vote. i know they are close to that industry. the crucial decisions of natural importance. the things that y

the proposed work will be in conformance of the requirements of article ten and the cystic -- secretary of the interior interior his standards for rehabilitation. we find although the rear addition that is proposed to be removed potentially dates the house initial construction, no information has been located to suggest the addition has acquired historical significance in its own right. the existing addition process simple design does not have a notable architectural feature that contribute to the cut -- the property process of defining features as a whole. the proposed replacement of the existing rear addition with a new rear addition will maintain the footprint and reform of the existing rear additions and will not impact any character defining features of the building. the newer addition will be minimally visible over the existing rear fence and will be compatible with the historic elements of the property through its simple and contemporary design. all exterior proportions of the historic brick chimney that currently attaches to the rear elevation of the property will be retained an

she's the mother of a 7-year-old boy named jack with a pre-existing condition of cystic fibrosis. she joined us on this program and told us she was a swing voter this time she'd be voting for jennifer wexton. she crushed the republican incumbent barbara comstock 56-43. when we come back, tonight's winner, congresswoman elect jennifer wexton and health care voter tasha nelson. yeah, this is bob barnett in chicago. (john foley) i was there when bob barnett made the first commercial wireless phone call. we were both working on that first network that would eventually become verizon's. that call opened the door to the billions of mobile calls that we've all made since. i'm proud i was part of that first call, and i'm proud that i'm here now as we build america's first and only 5g ultra wideband network that will transform how we all live, once again. (bob) the first call that we've made on the cellular system. i'm at this wing joint telling people that geico has been offering savings for over 75 years. that's longer than the buffalo wing's been around. dozen wings. and did you know th

she is the mother of a 7-year-old boy named jack with the pre-existing condition of cystic fibrosis.old us this time she'd be voting for jennifer wexton in her congressional race. when we come back, tonight's winner, congresswoman elect jennifer wexton and health care voter tasha nelson. th care voter tasha nelson ♪ ♪ i'm all for my neighborhood. i'm all for backing the community that's made me who i am. i'm all for my theatre, my barbershop and my friends. because the community doesn't just have small businesses, it is small businesses. and that's why american express founded small business saturday. so, this year let's all get up, get out and shop small on november 24th. i got croissant. small business saturday. a small way to make a big difference. (engine roaring) (horn honking) okay, okay, okay... (clatter) ( ♪ ) feeling unsure? oh... (nervous yelp) what if you had some help? introducing the new 2019 ford edge with the confidence of ford co-pilot360 (tm) technology. the most available driver assist technology in its class. ( ♪ ) the new 2019 ford edge. ( ♪ ) we've frozen out...o

. >> bob anderson, former a cystic comic assistant fbi director specializing in hacking, spine, and espionage said the bureau is badly outnumbered by china. >> ministry of state security, think of it as their fbi without any rules. there are 35,000 men and women in the fbi. there are 400,000 in the am as f. >> >> october, the justice department indicted a member for allegedly targeting u.s. aerospace and aviation technology. earlier this month, the department took the unusual step of singling out a tiny state owned company after a 20 month investigation. the fbi now has chinese economic espionage cases in almost all 50 states. while it's hard to quantify the economic cost, this independent commission on intellectual property theft found the damage could run as high as 600 billion annually. anderson said it doesn't stop there. >> specifically with china and russia, there has been alliances between them. you have to look at that with a weary eye because when you put two countries of that magnitude with the amount of intelligence organizations that they have against our country, it is unbelievab

he has cystic fibrosis. when he was 3 years old he say on 18 different medications taking 38 pills a day. now one of the 14 medications jack needs to live costs over $13,000 a year. jack's mom, tasha nelson, describes herself as a swing voter who leaned republican. that was until the republicans voted to repeal the affordable care act. tasha and her son jack's lives changed when president obama signed the affordable care act. she says it wasn't until the full protection of the aca took effect in january 2014 that for felt safe. for the first time since jack was born insurance companies couldn't discriminate against him. republican now realize ripping health insurance and health care away from kids like jack is cruel and inhuman and, oh, by the way a political loser. and so they are lying about what they have tried to do and what they want to do. and the worst pathological liar in the history of american politics tweeted this today. republicans will protect people with pre-existing conditions far better than

she's the mother of a 7-year-old boy named jack with a pre-existing condition of cystic fibrosis. she joined us on this program and told us she was a swing voter this time she'd be voting for jennifer wexton. she crushed the republican incumbent barbara comstock 56-43. when we come back, tonight's winner, congresswoman elect jennifer wexton and health care voter tasha nelson. ♪ while you dwell within it ♪ you are ever happy there daddy, it's christmas! ♪ childhoods, joyland never let go of your dreams. the mercedes-benz winter event is back. lease the glc 300 for $459 a month at your local mercedes-benz dealer. mercedes-benz. the best or nothing. it's a revolution in sleep. the new sleep number 360 smart beds are on sale now during ultimate sleep number week. it senses your movement, and automatically adjusts to keep you both effortlessly comfortable. it can even warm your feet to help you fall asleep faster. so you wake up ready to spin into the holiday season. don't miss ultimate sleep number week. it's the last chance to save 50% on the new sleep number 360 limited edition smar

she's the mother of a 7-year-old boy named jack with a pre-existing condition of cystic fibrosis. and told us she was a swing voter who usually voted republican but this time she'd be voting for jennifer wexton. she crushed the republican incumbent barbara comstock 56-43. when we come back, tonight's winner, congresswoman elect jennifer wexton and health care voter tasha nelson. (music throughout) 74% italian. and i found out that i'm from the big toe of that sexy italian boot! so this holiday season it's ancestrydna per tutti! order your kit now at ancestry.com jimmy's gotten used to his whole yup, he's gone noseblind. odors. he thinks it smells fine, but his mom smells this... luckily for all your hard-to-wash fabrics... ...there's febreze fabric refresher. febreze doesn't just mask, it eliminates odors you've... ...gone noseblind to. and try febreze unstopables for fabric. with up to twice the fresh scent power, you'll want to try it... ...again and again and maybe just one more time. indulge in irresistible freshness. febreze unstopables. breathe happy. what's the #1 new skinc

provided those cystic support five persons also it was also established that that command that the task. with the negotiators and. why did the false. to the chief intelligence the afaik that the victim left the consulate building live as the negotiations with him has failed now open the floor to questions. in a shift. so nobody called and said i want from the side some other people cannot have a lot of television an issue. could limited to. one in every. case and from now and then what i can't tell him that counts given other. what he called. a changing of the bill if you are the reason i never said i did you mean first of all we should take into consideration the crime scene and that it was outside. and more that accounts given are based on the state is a billion by those detained and at the beginning they were afraid from providing any statement as a result. was submitted by a misleading report was submitted. was submitted to the chief. spy after that the interrogation took deal of course and that's why the accounts are coming out differently. by leak out of news. media and. what real

for so many of our loved ones who have diabetes, high blood pressure, cystic fibrosis, epilepsy, or other chronic health care conditions, prescription drugs are a basic necessity for their living. without pharmaceutical treatment or cures, too many of family gatherings at thanksgiving just past arguably would have never -- would have had fewer plates at the table this holiday season. as a nation we're incredibly blessed to live in a country where investment and innovation unlocks cures and treatments. and yet the escalating price of prescription drugs are consuming concerns for too many millions of americans, including even iowans who bring up this subject regularly at my county meetings. i've come to the floor of the senate to address the sticker shock that greets consumers when they pick up their medicine at the pharmacy or open their medical bills after a hospital visit. rising drug costs -- rising drug prices that americans pay for out of pocket and as taxpayers are gobbling up a bigger share of income. for some people on fixed income, sky high drug prices are eating up every spare pe

. >> you are focused on red diseases like lupus, cystic fibrosis. that is a big market in itself.ter some of the bigger autoimmune conditions like arthritis? yuval: the thing we believe at corbus's restart with these orphan diseases, which get tens of thousands of patients. the patients are very, very ill. high morbidity, significant mortality. we can make this week and it makes much more sense for a copy of our size to target those with experimental drugs. if they make it into the market as pharmaceuticals, moving to more common diseases becomes much more tangible. one of our compounds will start clinical studies next year. pharma, i'mg looking at this and i think, hold on, when did these products could target -- one day these things could target some thing like arthritis. why don't they just build up in this space? yuval: what is interesting about the system is that the biology has been there for a decade but there have not been any drugs. big pharma has shied away from it, focusing on other areas. we have a competitor with johnson & johnson, but what is interesting is that it i

is that it can be used to treatment deadly diseases that are inherited so it's being studied for cystic things will be. it's actually being studied intensively for use in food and agriculture to make certain products less susceptible to viruses and that kind of thing. >> so, let's talk about the risks and the ethical debate. >> the risks, when you talk about this, you have to understand this is not perfect. there can be inaccuracy. it can miss the target. if you take a gene out, future generations can be affected and then you could wind up with a situation where you have a lot of people with a disability or not a disability and is there a result in stigma? and then, if you really take this gene out on a widespread basis, will there be major inequalities that are now more emphasized? there are a lot of risks here, and when you talk about this done for optional reasons -- i want dark eyes, i want blonde hair, then you get into a slippery slope and that's why for cosmetic reasons or nonlife threatening indications, this is not even being discussed. >> there is so much controversy surroundi

it has sal cystic acid. tree tree oil and other essential oils. basically, it works.but this is the kind of the glitter explosion mask. this is lava magic. all of their serums are fabulous and have great names like glow and megaglow in give me the zit zapper. >> keep it for me till later. all of these are beautiful, packaging and just good formulas which i like. so they range from $18 to $42 at retail but everything is half off so $9 to $21. >> okay, so let's try to get to this. we have homemade jewelry. >> this is from stone and stick. all made by women in a teeny town in tennessee, population, 1500. their ware of house is a converted garage and they make everything hand beaded wood and brass ago symptoms. there's short neck llacesnecklae 26 to 70 retail but slashed more than in half so everything is 12 to $22. and finally the "gma" favorite. >> makes you want to wear after thanksgiving. >> this is like the perfect thanksgiving dress. but these pieces are great. this is their brand-new linen dress with pockets but long sleeve tanks you can wear underneath. everything

the cystic fibrosis foundation has been very successful, you know. host: anything else?aller: that is it, thank you. guest: thank you. host: we will hear from barbara from harrisburg, pennsylvania for antonio regalado. hi, barbara. hi.er: i wonder, because i have a son with schizophrenia, do i have any hope in thinking that perhaps gene therapy might be effective for that mental disorder? thank you very much. guest: it is a question. schizophrenia is what they call a complex disease. it does not have a unique genetic cause. in the case of gene therapy, they are aiming at diseases called matt mainly in diseases -- matt mainly in diseases. is one disease with an error. they are using gene therapy to replace after something like schizophrenia is much more organic. the cause is not known, there is no singular cause, and so that makes it unlikely to be addressed by gene therapy in the near future. maybe in the distant future, it could be. talking with antonio regalado, biomedicine science editor at mic "technology review." -- at m.i.t. technology review. hear about this parti

tell people what you are doing has to be in a life or death case you have diseases huntington's, cysticon that this gentlemen did it in secret hospital wasn't aware university was not aware in total secrecy to prevent or at least hope to prevent an infection a future infection with hiv not life or death we have treatments for hiv, hivi no longer a killer disease a chronic illness we can control with neegs he said he at rered a gene embryos for seven couples during fertility treatment. >> has not been independently reviewed sounds true there was a doctor from united states a scientist working with him on this, that claimed this happened. but there has been huge outrage in about scientific community rightfully so because this is ununprecedented going to be problem might have generation people warrior about immigration economics but gene editing stuff of nightmares, you can literally create biological warfare diseases that are not affected by our current treatments, you can create soldiers with this can be stronger -- there are opportunity endless scary. >> under umbrella as if you are hel

they are conditions like cystic fibrosis and a.l.s. and because any one of these orphan conditions affects relatively few people, the economics of developing a treatment for them really didn't work and from 1973 to 1983, the f.d.a. actually approved only ten orphan therapies over ten years for all of the hundreds and hundreds of orphan diseases that afflict millions of people cumulatively. as chairman of the committee on labor and human resources, the predecessor to the help committee, senator hatch worked across chambers and across the aisle with representative henry waxman and in 1983 they passed the orphan drug act and it increased incentive for developing drugs for these rare but really problematic conditions. and since that time, there have literally hundreds and hundreds of for fan -- orphan products that have been approved and come on the market. while that law has been updated over the years to reflect changing technology and changing dynamics in medicine, the fact is the orphan drug act that senator hatch authored as a relativ

evacuation order and we are able to go back but the conditions of the smoke are not good, my son has cystice press issues. hejust said case, the freedom of the press issues. he just said that the white house did not follow procedures, and did not provide sufficient justification for revoking the press pass. there will be further hearings down the line to get more of that but meantime, the harm done tojim acosta, he ruled, was greater than any potential harm done to the white house by having jim acosta in there in the press conference and access to the white house press room. this judge was appointed byjohn update —— appointed by donaldj trump? judge was appointed byjohn update -- appointed by donald] trump? yes, this is a relatively new federal judge at the district court level, the lowest level in the judiciary. he took at least an early temporary order going against the administration. people view that as administration. people view that as a good sign that even though donald trump was appointed over 80 federal judges, it doesn‘t mean that the independent branch of the us government will