. >> the discovery of the genes responsible for cystic fibrosis and muscular dystrophy, and a noninvasive test for colon cancer. [ticking] >> elissa montanti is unlike almost anyone we've ever met. with the help of some very charitable american doctors, she's changed the lives of more than 100 kids like this one, a boy from iraq who needed an arm, a leg, and an eye. >> i love you, wa'ad. >> you'll follow his transformation... >> look at him. he looks beautiful. >> which is a wonder to watch. [ticking] >> welcome to 60 minutes on cnbc. i'm morley safer. in this edition, we look at the serious business of philanthropy. bill and melinda gates take us inside their foundation, we examine the unintended legacy of howard hughes, and meet a staten island woman helping children maimed by war. we begin with bill and melinda gates. with their plan to give away $60 billion, they're the most generous philanthropists in the world. they want to make american kids among the best-educated on earth. and while they're doing that, they also intend to save millions of lives worldwide. the gates shun publicity