[ applause ] >> reporter: daniel jacobs stepped into the ring, a world title on the line. [ bell ] >>toughest fight. that came about three years ago. >> that's how i looked at cancer. i looked at it as an opponent. >> reporter: when doctors diagnosed jacobs with a rare type of bone cancer, he barely heard a word. one sentence stuck out -- >> the only thing i remember was, "i don't think you'll be able to box again, daniel." it was mind-blowing. >> reporter: the cancer left him partially paralyzed. losing boxing, he says, broke his heart. jacobs did what he knows best -- he turned to his training. >> you got to get back up. you got to continue to fight. >> reporter: through therapy and radiation, jacobs built back his strength all the way to the top of his middleweight division. he wasn't given the nickname "miracle man," he earned it. >> working the body -- >> reporter: saturday night in his hometown of brooklyn, he again came out swinging. >> fletcher in the corner and down he goes. daniel jacobs, who went through 25 rounds of radiation treatment -- >> reporter: took five rounds to g