david lou is one of the inventors of base editing. he's professor and director of the american institute of transformative technologies and health care at harvard university. i asked earlier to explain just how base editing works. sure, so. so base editors are machines, molecular machines that we engineered, drawing from components in nature. and in our laboratory that convert one d n. a letter to a different letter of our choosing. in the vast genome. they can be targeted to a specific sequence of interest where they then rearrange the atoms and one d n a base to instead become a different dna base. so they senators can correct the misspellings that cause genetic disease or make other kinds of precise single letter changes that can be useful for finding disease such as the t cell leukemia. that was that. so if you're, if you're correcting then the mistakes in which that's what we understand cancer cells to be any way the result of a mistake in cellular reproduction. are we talking about then being a step closer to having a cure for c

yeah, i feel like david lou sure. a bottom near the light out and he pushed it over with the correspondent. i other it doesn't loom auto see here with see like of all of it is by nit operable. he would put his lewis. i forget what that all got double sided. i was like, it was through cars can sniper bridges, i pitch with with o is your media reflection of reality in the world transformed what will make you feel safer? isolation for community. are you going the right way? or are you being led to somewhere? direct? what is true? what is faith in the world corrupted? you need to descend a join us in the depths or remain in the shallows. ah, ah, well never be a victory for russia. wait solution with my truly not done by she look at 8 me. crane war is a proxy war. this is a war between russia and the united states. milan are made, it comes to not shoot kids then in carbon dioxide. america forces are and you're not in your engage in conflict with russian forces. the american forces are here and defend nato ally that brings,

j script. besides, i feel like david lou, sure. it's a bottom near the light out and he pushed it over with the correspondent. i other it doesn't loom auto see, have a good fit and it seems like of all of it is by nit preferable. he would put his louis, i bet what that all got a 32 cards came sniper bridges. i bench with with ah, in 1834 france invaded algeria, and straight away the french started inhabiting it to strengthen their position. the colonists, known as p a no ours took the best land from day one, the local population was put into an unequal position and was brutally exploited. this gauze, mazda is content. the people of algeria began their long term fight for independence . in 1954, the banner of freedom was raised by the national liberation front. a guerrilla war against the occupants broke out. the french tried to suppress to rebellion using cruel measures. all villages were wiped out acts of georgia and executions of civil people, including pregnant women, children, and old people took place more than 2000000 people

we appreciate your time and your insights tonight, professor david lou from harvey for your interest. thank you. thank you. when out to south america, bruce, new president is to ask congress to bring elections forward by 2 years. the liberal artes announcement followed protests that were sparked by the impeachment last week of her predecessor, pedro castilian demonstrations over the weekend turned violence to teenagers died at least 5 people were injured in a remote community in the and these mel thorough is political tension, spilling over is protesters and police clash? these crowds in lima, among thousands of people who turned out across the country, demanding that president dina polity stand down. minority has only been in the jobs since wednesday. she was sworn in to replace lyft as president pedro castillo after he tried to dissolve congress and was later arrested, outraging his supporters. it. but only that company. at 1st, we demand the freedom of our president pedro castillo, 2nd. that congress. this rotten corrupt congress is closed, that a constitutional assembly is convene

david harper. ama: have a great night. >> lou: from hollywood, it's "jimmy kimmel live!" sa ann walter, and music from thee sacred souls. with cleto and the cletones. and now, jimmy kimmel! [ cheers and applause ] ♪ >> jimmy: hello. i'm jimmy. i'm the host of the show. thank you for watching. thank you for coming on the last day of november. notch is november is done. december is minutes awaynd

david: perhaps the most favorite person who had als was lou gehrig.e people still call it lou gehrig's disease. another famous person who had it was stephen hawking and he lived for some 30 plus years with it. how do you explain that sometimes people can live for 30 years plus? dan: a couple percent of people live beyond 10 years. one of the decisions that i'm going to face, because my major symptom is respiratory, and that's why people ultimately die, is to get a tracheostomy. which means that you cannot breathe independently. you also can't eat and you also generally cannot talk. so, you communicate by looking and spelling out words on a computer screen. and, you know, a lot of people don't want to live that way. i think i probably would. i want to see my grandchildren grow up. i still think i could be engaged in things. again, that's sort of my optimistic nature. that it is not just about believing there's a cure but it is sometimes about believing that the better of two bad alternatives is something worth doing. so, you know, faced with that choic

>> lou: from hollywood, it's "jimmy kimmel live!" tonight -- david harbour, lisa ann walter, and music from thee sacred souls. with cleto and the cletones. and now, jimmy kimmel! [ cheers and applause ] ♪ >> jimmy: hello. i'm jimmy. i'm the host of the show. thank you for watching. thank you for coming on the last day of november. notch is november is done. december is minutes away and they got the festivities started in our nation's capital tonight. the president and first lady took part in the 100th lighting of the national christmas tree. tonight, thousands of americans gathered outside the white house to watch an old man flip a lightswitch. [ laughter ] this year, the tree is 27 feet tall. they did not chop it down. it is a live white fir tree that was planted last october, after the previous national christmas tree was removed in may of 2021 because it had a fungal disease. the second time that year that a fungus had to be removed from the white house. [ laughter ] [ cheers and applause ] the ceremony was hosted by joe biden, dr. jill biden, and

jimmy kimmel is next >> lou: from hollywood, it's "jimmy kimmel live"! tonight, kristen bell, david shrigley, and music from noah kahan. with cleto and the cletones. and now, jimmy kimmel! [ cheers and applause ] ♪ >> jimmy: thank you. thank you, thank you. very nice. welcome, welcome. that's very nice. [ cheers and applause ] thanks a whole lot. i'm jimmy, i'm the host of the show. thank you for watching. thank you for coming. thank you for joining us on a happy taco tuesday, everybody. i have to say, when i was a kid, thanksgiving was my least-favorite holiday because there were no presents. but now i love thanksgiving because there are no presents. [ laughter ] it's just cooking and eating and football and drinking. it's like being guillermo for a day. >> guillermo: yeah! [ cheers ] >> jimmy: are you still making chicken for thanksgiving instead of turkey? >> guillermo: yes, we love chicken. [ laughter and applause ] >> jimmy: this year, i'm vaping the turkey. [ laughter ] smoking was too much work. the bad thanksgiving news is, everybody's sick. three viruses are on the rise. co

jimmy kimmel is next >> lou: from hollywood, it's "jimmy kimmel live"! tonight, kristen bell, davidnoah kahan. with cleto and the cletones. and now, jimmy kimmel! [ cheers and applause ] ♪ >> jimmy: thank you. thank you, thank you. very nice. welcome, welcome. that's very nice. [ cheers and applause ] thanks a whole lot. i'm jimmy, i'm the host of the show. thank you for watching. thank you for coming. thank you for joining us on a happy taco tuesday, everybody. i have to say, when i was a kid, thanksgiving was my least-favorite holiday because there were no presents.

lou . this is my sure my david is my david true for merkel still and i didn't receive the column for the qualification which i guess i can go. of course i was very disappointed. this is also part of the football and you have to accept this and you just have to continue the work. i'm switch up your mind and shoot. just show that you can be there and play every week and show yourself and try to receive a call up. ah, ah, overseeing it a shot the compare. just from saw and i think now to have a son bought assist with 6 and okay. the kitchen and my, when days was maximum when it came ship and the key kitchen walked out, the skinny. i well i like that money. ah, no. it's not hundreds or digital numbers for money. ah ah good can i doesn't once said had my chest camp after the dead. oh, i was in a scheme shown by lab, but last god, i saw that, but she's gone to cities. you've got about, i've gotta to myself headed off not a dilemma. the she stopped in most delicate. i am at the best of my shed delivery governments, our lab, and victor already came to us. there's the bone or tomorrow on foil blue. hadn't as y

lou has been blasted by elon musk after he once again went after the twitter files. give me the details. >> reporter: democrats lead this tweet, addressed to the journalist david zweig who dispatched the latest twitter files, the tweet you cite is misleading. people at high risk from covid will benefit from vaccine this. prior natural immunity may only last a few months. covid is a leading cause of death in children. elon musk himself became one of the many fact checkers on that, ted is looking to misleading data. that was more than an error. ashley: once you put it out there you can try to delete it but great stuff. let's bring in our market guy, david, we are modestly higher, the numbers this year are pretty ugly, the nasdaq down 34% by the dow off 3.7% which consideration is not bad. as we look at 2,023, do we take another leg lower, do we get new lows? >> i believe we will hit new lows in 2023. 55% of bloomberg respondents believe we are going into a recession. visa and fannie mae were in that group. 85% believer session next year. the market is looking at challenges as we look at the future. ultimately we are looking at the federal reserve bubble. the federal r

lou sal marina is a 15 minute drive away. this private house boat is operated by 974 cruises. david and sam have rented it for 2 nights at the bed and air conditioning, which is very important. and then we have a little kitchen, which i think you can even cook in which you know, i don't plan on doing it proximity till the sale stadium was a deciding factor for the couple who flew in from dubai. it was his idea. i was skeptical, actually, and now i'm realizing he was completely right. so i actually did this once in finland, helsinki and my friends rented a house boat and i thought the idea and i heard from word of mouth of this thing existed, demand for accommodation was highest during the group stage. when 32 teams were playing 4 match his a day, the organizing committee says that in terms of bookings on the official cattle 2022 portal, the top 3 countries so far have been the united states, mexico and argentina. on peak days, there were more than a $100000.00 bookings with less than a week left. as the tournament organizers say, they're ready for new visitors to arrive, especially