well, today i talked to david rubinstein, professor of molecular rural, new or genetics at cambridge university and were talking about the mysterious phenomena of a ta for g. it's so great to have you on our program today. so it is like the top caravans talking about it, lots of met, surround it. so the figure, it will just ask you straight away, what is all that fuss about? am from what i understand. so correct me for iraq. a ta for g, like process where cells deprived of nutrients, they sort of get rid of damage structures and develop nuance. is this a correct explanation? i clarify with f l, so it's a process that occurs inside cells and it occurs outside the nucleus. so in the cytoplasm and it's a process where cells form these double membrane structures which are like sax, which capture push over side of plasm and then deliver them to water, the incinerator of the cell, the lies a zone for degradation. so that's a little tougher. g as a, as a process. um, the idea that it's stimulated by starvation is something that is conserved from his to people. but it's not always induced by

some of the grandkids piled onto air force one last night bound for private equity billionaire david rubinstein'sanfront compound in massachusetts worth a reported $30 million. >> you are president no matter where you are. he will conduct his work from wherever he is on any vacation or any time he is in delaware, camp david or wherever he may be spending time with his loved ones. he has secure phone capabilities. he has staff traveling with him and i this i the american people can be assured that he will continue to press to lower their costs and insure they have more breathing room. >> the first vacation the bidens have taken like this since taking office and remains unclear why they didn't want to get together at the white house or some of their houses because he is concerned with main street, not wall street and said as of yesterday he knows this is a tough time for many supporters paying now more than ever for things they need. >> president biden: i will do what needs to be done to reduce the price you pay at the pump. from the middle class and working families spending much too much and it i

vacationing at this $30 million waterfront estate owned by a private equity billionaire businessman david rubinstein. we're told they are renting the house but bringing a lot of scrutiny because it's happening amid soaring inflation and crippling gas prices. republicans tweeted joe biden is enjoying his thanksgiving at a billionaire's home. regular america enjoy the expensive gas and groceries. this year's dinner is costing more than ever before and affecting the president's polling. a new poll shows biden hits a fresh low in the survey, 42% approving of the overall job he is doing. 50% disace prove and 52% disapproving and inflation the top spot among voter concerns. after expressing willingness to raise rates sooner than anticipated if conditions continue to worsen, the president understands how difficult even a small increase in costs can be to working families and communities like the ones he grew up in in scranton, pennsylvania and delaware. he has full confidence in chairman powell's ability to maintain low inflation and stable prices. he supports the independence of the federal reserve. the a

family is staying at the 13 acre $30 million compound that is owned by private equity billionaire david rubinstein who made it available during this visit. >> as the president wraps up his thanksgiving day, he will head back to washington with some pretty big issues on the agenda. what are you looking at? >> reporter: for sure. he'll go back this weekend and there are big challenges waiting in washington and the top priority will be trying to get his social spending package through the senate and we know the white house acknowledges that will be tough to do. plus, the country reaches a new debt ceiling borrowing limit that happens before christmas. and the administration is grappling with how to deal with inflation just as americans are working on their own shopping list kristen, peter >> kelly, thank you. >>> time now for our first look at the holiday weather forecast heading into the weekend janice is in for al this morning. janice, it was spectacular for a parade yesterday with fingers crossed that decent weather holds for the weekend. >> for a lot of places, it will. for shoppers and travelers

the latest book of our guest, david rubinstein.have something put out. we keep turning forward. we are talking about earlier today about it how it was black women and now milwaukee and detroit and atlanta and philadelphia who for some of us believed it's democracy. there are twists and turns that you lay out beautifully. >> thank you very much, joe. thank you for having me. i would say i want to remind people that this country is an experiment in representing democracy. nothing like this ever been done before. people came together and said after the revolutionary war we got to create a government that actually works. when they did that. we had some flaws in it. we didn't allow blacks to be citizens or women to vote. we could not vote directly for the united states and we still could not sfoochlt what i did in the book is trying to interview people who are experienced this in. and so that's what i was trying to do in the book, remind people about our history and the fact that we are still ongoing an experiment. the most recent was t

and that's the purpose of this we had going with the philanthropist david rubinstein called "luna, whichtics which is a binary system on or off, where somehow everything is black or white, it's either wrong or right. and things are much more interesting, complicated. there's undertow and in the sand creek massacre, it was labeled for years and years as a battle. it wasn't, volunteer arm guys just after president lincoln's re-election went in and massacred 150 unarmed cheyenne and arapaho mostly women and children and elderly people. and it got listed in a roll call of battles thought to liberate the state of colorado. to the great credit of our nation, night horse campbell, a republican, joe, fought for the creation of the sand creek massacre. people, school kids visit there, soldiers visit there. nobody is diminished by having a complicated past. people are enriched. our country is in fact greater for acknowledging the things it's gonen wrong as well as celebrating things we've gotten right. you're right. my work is i'm uninterested in the cloying unpatriotism and but revisionism. our h

still be se odd to do i also use ah, ah and were bad was dated. rubinstein hair in cambridge talking about the phenomena of a, tufty david. whatever the brain itself. i'm not talking about degenerative diseases like alzheimer's or parkinsonian dementia. but how does it affect our grain if it could be practiced on a human body? so there is a literature which suggests that a ta for g might be important in a whole lot in your own functions. i'm. it can, i'm removed, there is toxic proceeds as we've discussed. it can also help remodeling. so can, i've changed our capacity to remember, potentially um, it's can, ah, this also literature that it's suggest that it might impact various psychiatric diseases will bo, the literature will that these will work. so i, i would say that this, this suggestions which need further work to validate. so i think it might affect a wide range of different cognitive as well as emotional functions. well, and thinking cancer, because you're saying what are the functions as to anti inflammatory affection. so what can i do for cancer? so the cancer literature is complicated and the likely plays diffe