when she was autopsied, alzheimers did the autopsy and found three features davidnd alison will describe. there's a shrinkage of the brain, the cerebral cortex and plaque outside the nerve cell and tangles within the nerve cell. many people think this is the only dementia, as you pointed out, there are a number of other dementias, vascular dementia and a decade before heim described it frontal temporal dementia and it's a fantastically interesting disease because it involves at least at the beginning very selective regions. so in addition to memory loss if you have damage to the frontal lobe as you indicated you have a disinhibition. people who never drank before will start and those who never gambled before will start to gamble. if it spread back to the temporal back and other areas get involvementof langua as well. there are a number of things you want to know about this which particularly allison will have a lot to say and that is what do we understand about these diseases. are there genes that have been identified or small genes or larger genes with larger effect? we also want to und